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The Rosenzweig laboratory is interested in why the heart fails. Heart failure is an enormous and growing cause of death and disability throughout the world. In addition, the heart provides a model system for studying fundamental cellular processes from cell growth and programmed death, to cell-lineage determination and regeneration.
Recently we’ve been interested in understanding how exercise protects the heart against heart failure. A variety of high throughput profiling techniques are being used to identify pathways differentially regulated in heart growth associated with exercise in comparison to the heart growth that precedes heart failure. These screens have identified interrelated transcriptional (Cell, 2010) and microRNA pathways (Cell Metabolism, 2015), which appear to mediate many of the phenotypic effects of exercise in vivo.
Anthony Rosenzweig, MD
Anthony Rosenzweig, MD
Principal Investigator
Dr. Rosenzweig attended Harvard Medical School and completed his medical residency and cardiology fellowship at Mass General. His clinical interests include noninvasive clinical cardiology, cardiovascular genetics, and cardiovascular disease prevention.
At Mass General, Dr. Rosenzweig practiced cardiology, where he studied causes of heart failure and served as the director of the Cardiovascular Gene Therapy Program. He joined Beth Israel Deaconess Medical Center in 2006 as the director of cardiovascular research and associate chief of the Cardiovascular Division where he led the recruitment of investigators in the cardiovascular research program.
Additionally, Dr. Rosenzweig is a widely published expert on mechanisms of heart failure and the benefits of exercise and presents internationally on his research. He is also a member of numerous medical societies and has served in leadership roles within these institutions. He has published more than 150 scientific papers and his research has been continuously funded for more than twenty years.
Dr. Rosenzweig has held various leadership roles, including American Coordinator for a Leducq Foundation Network of Research Excellence, comprising 11 laboratories in Europe and the United States. He was also an associate editor of the New England Journal of Medicine from 2003 to 2013 and has served on numerous editorial boards including Cell Metabolism and Circulation Research.
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