Publications & Awards
Awards
AHA MERIT Award (PI: Rosenzweig)
Exercise pathways promoting repair and recovery after ischemic injury in hearts and brains
This project focuses on identifying concordant pathways mediating repair, recovery, and regeneration after ischemic injury in both heart and brains
1 Apr 2023 - 31 Mar 2026
Harrington Discovery Institute (PI: Rosenzweig)
Inhibition of lncExACT1 to promote cardiac function, repair, and regeneration
The goal of this project is translational development of lncExACT1 as a therapeutic target in heart disease by examining the effects of lncExACT1 inhibition in human iPSC-derived cardiomyocytes.
1 Oct 2023 - 30 Sep 2025
R35HL155318 (PI: Rosenzweig)
NHLBI Outstanding Investigator Award Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level This proposed research program aims to identify the heart cells affected by exercise, determine the key interactions among those cells and characterize the underlying mechanisms
25 Sep 2023 - 31 Dec 2027
R01AG061034 (PI: Rosenzweig)
NIH/NIA Role of Activin Type II receptor signaling in age-related heart failure The goal of this proposal is to define to test the hypothesis that Activin Type II signaling increases in aging and heart failure, contributing to the decline in cardiac function.
1 May 2023 - 30 Nov 2024
Articles
Science Translational Medicine
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human
17 April 2024
Publications
Select Publications
1. Boström P, Mann N, Wu J, Quintero PA, Plovie E, Gupta R, Xiao C, MacRae CA, Rosenzweig A* and Spiegelman BM* (*contributed equally, co-corresponding). C/EBPβ controls exercise induced cardiac growth and protects against pathological cardiac remodeling. Cell 2010;143:1072-1083. PMCID: PMC3035164
2. Mann N, Rosenzweig A. Can exercise teach us to treat heart disease? Circulation 2012; 126: 2625-2635. PMCID: 4000019
3. Das S, Aiba T, Hessler K, Rosenberg M, Xiao C, Quintero P, Ottaviano FG, Morissette M, del Monte F, Begley M, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A. The pathological role of SGK1 in adverse ventricular remodeling. Circulation 2012; 126: 2208-2219). PMCID: 3484211
4. Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. DSAGE Identifies Osteopontin as a Downstream Effector of Integrin-Linked Kinase (ILK) in Cardiac-Specific ILK Knockout Mice. Circulation Heart Failure (2014) 7(1): 184-193. PMCID: PMC3950354
5. Platt, C.*, Houstis, N.*, Rosenzweig, A. Using exercise to measure and modify cardiac function. Cell Metabolism 2015; 21(2): 227-36. PMCID: 4317572. *co-first authors; contributed equally.
6. Liu X*, Xiao J*, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, Zhang C, Spiegelman BM, and Rosenzweig A. miR-222 is Necessary for Exercise-induced Cardiac Growth and Protects Against Pathological Cardiac Remodeling. Cell Metabolism 2015; 21(4): 584-595. PMCID: 4393846. *co-first authors; contributed equally.
7. Bezzerides VJ, Platt C, Lerchenmüller C, Paruchuri K, Oh NL, Xiao C, Cao Y, Mann N, Spiegelman BM, Rosenzweig A. (2016) “CITED4 Induces Physiologic Hypertrophy and Promotes Functional Recovery After Ischemic Injury.” JCI Insight 2016; 1(9): 10.1172/jci.insight.85904.
8. Bezzerides, V.J., Zhang, A., Xiao, L., Simonson, B., Khedkar, S.A., Baba, S., Ottaviano, F., Lynch, S., Hessler, K., Rigby, A.C., Das, S*, Rosenzweig A*. (2017). Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Scientific Reports 7, 346. *Contributed equally, co-senior authors.
9. Vujic A*, Lerchenmüller C*, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT#, Rosenzweig A#. Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nature Communications 2018; 9(1):1659. PMCID: PMC5916892. *Co-first authors, contributed equally. #These authors co-supervised the work.
10. Lerchenmüller C, Rabolli CP, Yeri A, Kitchen R, Salvador AM, Liu LX, Ziegler O, Danielson K, Platt C, Shah R, Damilano F, Kundu P, Riechert E, Katus HA, Saffitz JE, Keshishian H, Carr SA, Bezzerides VJ, Das S, Rosenzweig A. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circulation Research 2020; 127(5):631-646.
11. Roh JD, Hobson R, Chaudhari V, Quintero P, Yeri A, Benson M, Xiao C, Zlotoff D, Bezzerides V, Houstis N, Platt C, Damilano F, Lindman BR, Elmariah S, Biersmith M, Lee SJ, Seidman CE, Seidman JG, Gerszten RE, Lach-Trifilieff E, Glass DJ, Rosenzweig A. Activin type II receptor signaling in cardiac aging and heart failure. Science Translational Medicine 2019; 11(482):eaau8680. PMCID: PMC7124007
