Grant Barkelew

Closed-loop responsive neurostimulators, such as the NeuroPace RNS System, continuously monitor brain activity and deliver electrical stimulation in response to seizures detected in patients with drug-resistant epilepsy. Battery life constraints limit the sampling rate and bit precision of these devices, reducing the quality of EEG recordings. My research seeks to provide a means to convert high-resolution intracranial EEG obtained from inpatient monitoring into the same format and parameters produced by implantable devices like the RNS System. This will enable the development of patient-specific seizure detection parameters to investigate the long-term effects of neurostimulation therapy.