Resources

Lurie Nano Fabrication (LNF) facility: This facility will be used in TR&D1 to fabricate the miniature scanning mechanisms.  The LNF facility contains a 6,000 sq. ft. cleanroom for microelectronics processing, a 10,000 sq. ft. teaching lab for training undergraduate and graduate students, and a testing room for characterizing performance of fabricated devices.  Within the LNF, complete facilities exist for solid-state device and circuit fabrication.  These facilities include equipment for mask making, photolithography, oxidation and diffusion, dry pattern transfer (plasma etching such as reactive ion etching (RIE) and deep reactive ion etching (DRIE)), ion-beam deposition and milling, vacuum evaporation and sputtering, chemical vapor deposition, and molecular-beam epitaxy.  It is a combination of class 1,000/100/10 cleanroom space and is equipped with over 120 major state-of-the-art tools for 4″ and 6″ wafer processing.  The LNF is available for use by outside investigators on a fee-for-service basis.  The LNF is internationally recognized as a leader in microelectronics, MEMS, and optoelectronics research, with major research thrusts in integrated sensors, automated semiconductor manufacturing, compound semiconductor materials, and ultra-high-speed microwave and millimeter-wave devices.  

Center for Molecular Imaging (CMI):  This state-of-the-art small animal imaging center located on Level D in the BSRB.  This resource provides systems, instruments, and services for performing in vivo imaging research.  A) A 7T horizontal bore MRI scanner provides state-of-the-art instrumentation with a broad range of image acquisition capabilities.  B) An Olympus FV1000-MPE intra-vital microscope is equipped to perform repetitive in vivo small animal imaging with sub-cellular resolution.    Scanning modes can be performed with pixel sizes that range from 64×64 to 4096×4096 pixels with scan speeds (pixel time) of 2 s to 5 ms.  High-speed scanning can be performed up to 16 frames per sec (256×256).  An ultra-fast laser (MaiTai HP DS, Spectra-Physics) produces ultra-short (<100 fs) pulses with tunable excitation from 690-1040 nm to generate multi-photon excited fluorescence images.  C) A 2D ultrasound scanner (SonixTablet, Ultrasonix) is equipped with a 40 MHz bandwidth ultrasound transducer with 5 MHz center frequency, and provides a field of view of 12×12 mm2 with an in-plane pixel resolution of 50×50 μm2. A variety of optical imaging instruments are available, including 4 optical Xenogen bioluminescent & fluorescence imaging systems, a Concorde MicroPET systems, D) an ImTek MicroCT system, a Gamma Medica animal PET/SPECT/CT system, a Visen small animal near Infrared system, fluorescence veterinary endoscope, and a Nikon confocal microscope. A Siemens Inveon preclinical imaging platform performs integrated small animal PET, SPECT and CT scans.  

Medical Procedures Unit (MPU):  A) The MPU offers over 60 medical endoscopes with instrument channels that vary in diameter from 2.7 to 3.8 mm that can be used to clinical translate the microendoscopes developed in TR&D2 for use as an accessory.  B) This state-of-the-art endoscopy facility has 12 procedure rooms, including 2 that provide fluoroscopy, to support completion of over 30,000 procedures per year in patients with gastrointestinal diseases.  A wide range of diagnostic and therapeutic services are performed routinely, including sclerotherapy, banding, ERCP, EUS, EMR, ESD, balloon-assisted endoscopy, and radio-frequency ablation.  Michigan Medicine is a major referral center forGI diseases, and is widely recognized as a Center of Excellence for the treatment of digestive tract diseases.  The major teaching hospitals include the University Hospital and the Ann Arbor VA Medical Center, which have 960 and 420 beds, respectively.  In addition, the GI Physiology Lab provides various tests, such as manometry, pH monitoring, and impedance testing for evaluation of functional gastrointestinal diseases.