Center imaging technologies use resources and expertise not readily available at outside institutions.  Funded investigators will be invited to participate as CPs to perform pre-clinical and clinical studies using TRD1-3 technologies (push).  CPs will provide new directions to advance Center technologies (pull).  These collaborations are expected to lead to new funding opportunities, joint publications, and intellectual property.  A set of inaugural CPs have been identified based on alignment with TRD1-3 deliverables.  These 8 institutions combined with the 5 SPs are located over a national geographic distribution.

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The Center aims to support funded SPs performing biomedical research that can be enhanced with use of mature microsystems technologies, including devices, microendoscopes, and algorithms.  The Center serves as a unique national resource for the design, fabrication, and testing of microsystems components using silicon-based materials.  The Center offers resources for microsystems scan mechanisms and transducer technologies based on thin-film PZT and parametric resonance and for novel 2D nanostructured materials assemblies that are not commercially available.  The Center will leverage the batch fabrication nature of microsystems methods to generate devices in quantity for use by SPs.  The Center will also serve as a resource for expertise and materials required to integrate and test microsystems-based imaging systems.  This may include consultation on packaging and assembly, instrument operating procedures, and adaptations of operating and image analysis software. 

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Our scientists regularly publish findings and frequently present at scientific conferences.

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TR&D1 will achieve synergy with TR&D2 by providing microsystems scan mirror using parametric resonance, thin-film PZT, and electrothermal mechanisms for assembly in microendoscopes developed TR&D2.  Synergy with TR&D3 will be accomplished by generating in vivo fluorescence images at high frame rates in horizontal and vertical planes for analysis with computational tools.  TR&D2 will achieve synergy with TR&D1 by packing the microsystems scan mirrors in the post-objective position (distal end) of microendoscopes to collect fluorescence images in 3-axis and with random access scans.  Synergy with TR&D3 will be accomplished by generating multispectral fluorescence images from multiple optical reporters to perform lineage tracing.  TR&D3 will achieve synergy with TR&D1 by providing quantitative image analysis methods to mitigate motion artifact, segment in vivo images, and interpret random access scans generated by microsystems scan mirrors.  Synergy with TR&D2 will be accomplished by performing spectral deconvolution of multiplexed images, implementing lineage tracing, and generating 3D fluorescence images from the microendoscopes.