Tall Lab
Welcome to the Tall Laboratory!
Welcome to the Tall Laboratory!
The Tall lab broadly studies G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling. We study G protein assembly including functional elucidation of the molecular chaperones, Ric-8A, and Ric-8B that fold all G protein alpha subunits. We develop GPCR / G protein coupling assays using purified components, which led to the discovery of the tethered-peptide-agonist activation mechanism of the 33-member adhesion GPCR family. We are developing chemical probes for adhesion GPCRs and investigating how the receptors are activated in physiological contexts. This includes identification of a platelet adhesion GPCR that senses collagen and shear force to initiate platelet shape change.
The Tall lab broadly studies G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling. We study G protein assembly including functional elucidation of the molecular chaperones, Ric-8A, and Ric-8B that fold all G protein alpha subunits. We develop GPCR / G protein coupling assays using purified components, which led to the discovery of the tethered-peptide-agonist activation mechanism of the 33-member adhesion GPCR family. We are developing chemical probes for adhesion GPCRs and investigating how the receptors are activated in physiological contexts. This includes identification of a platelet adhesion GPCR that senses collagen and shear force to initiate platelet shape change.
Latest News:
Latest News:
Dr. Gregory Tall's abstract entitled “GPR56 is a Platelet Collagen-Responsive GPCR and Hemostatic Sensor of Shear Force” has been selected to be presented in an Oral Communication Session at the ISTH 2020 Virtual Congress that will take place on Sunday, July 12, 2020 at 10:15 - 11:30 U.S. Eastern Time.
Dr. Gregory Tall's abstract entitled “GPR56 is a Platelet Collagen-Responsive GPCR and Hemostatic Sensor of Shear Force” has been selected to be presented in an Oral Communication Session at the ISTH 2020 Virtual Congress that will take place on Sunday, July 12, 2020 at 10:15 - 11:30 U.S. Eastern Time.