About Dr. Tall

Gregory Tall, Ph.D.

Associate Professor

I am an Associate Professor at the Department of Pharmacology at the University of Michigan Medical Center. My primary research interests focus on G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. The effort in my lab has elucidated the biochemical function of a newly discovered G protein activator, Ric-8A, and how it activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. Another focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell.

Education:

Ph.D., Biomedical Sciences, University of Texas Southwestern Medical Center, 2000
B.S., Cell Biology/Biochemistry, Bucknell University, 1994

Post-Doctoral Training:

Research Fellow, U.T. Southwestern Medical Center, Dallas, TX, 2000-2006

Interests:

G protein-coupled receptor (GPCR) signaling
Translational hematology
Mechanism of Adhesion-GPCR Action
Heterotrimeric G protein Biosynthesis
G protein somatic mutation diseases
Alternative Functions of Ric-8 proteins

Teaching Experience:

(2019) Dental Pharmacology 503 *Course Director
(2018) Dental Pharmacology 503 *Course Co-Director
(2018) Chemical Biology 502
(2018) Research Responsibility and Ethics PIBS 503
(2018) Pharmacology 601
(2017) Dental Pharmacology 503
(2017) Research Responsibility and Ethics PIBS 503
(2017) Introduction to Scientific Communication PIBS 502

Research Funding:

2016-2019 NIH/NIGMS RO1 GM120110. Mechanisms of Adhesion GPCR Action. G. Tall, PI, 25% FTE. $976,500
2018-2022 NIH/NINDS RO1 NS103946. Development of Chemical Probes to Investigate Adhesion GPCR Tethered Agonism. G. Tall, PI, 25% FTE. $1,736,591
2019-2023 NIH/NIGMS R01 GM088242-11. Regulation of heterotrimeric G proteins by non-receptor activators. G. Tall, PI, 35% FTE. $1,287,875
2019-2021 NIH/NHLBI F32 Postdoctoral Fellowship to J. Yeung Postdoc, PI (G. Tall, Sponsor)
2018-2019 University of Michigan Proteomics Resource Facility Pilot Project Program. Adhesion GPCR Peptide Agonist Intramolecular Binding Site Identification by Photo-affinity Labeling / Mass Spectrometry. G. Tall, PI. $3900

Pending:

2020-2025 NIH/NIGMS RO1 GM120110-4. Mechanisms of Adhesion GPCR Action. G. Tall, PI, 25% FTE. $1,745,000 Percentile 3.0, Impact Score 18.
2020-2023 NIH/NHLBI F31 Predoctoral Fellowship to A. Vizurraga, Graduate Student, PI (G. Tall, Sponsor) Percentile 16.0, Impact Score 24.

Completed:

2019 Administrative Supplement GM120110-02 Mechanisms of Adhesion GPCR Action. $48,203
2014-2018 NIH/NIGMS R01 GM088242-08. Regulation of heterotrimeric G proteins by non-receptor activators. G. Tall, PI, 35% FTE. $1,287,875.
2014-2015 PhRMA Foundation Pre-doctoral Fellowship in Pharmacology/Toxicology to H. Stoveken, Graduate Student, PI. (G.Tall, Sponsor) $40,000.
2016-2017 PhRMA Foundation Pre-doctoral Fellowship in Pharmacology/Toxicology to M. Papasergi, Graduate Student, PI. (G.Tall, Sponsor) $40,000.
2009-2014 NIHGMS. RO1GM088242. Regulation of heterotrimeric G proteins by non-receptor activators. G. Tall, PI, 31-40% FTE. $1,597,750
2012 URMC Drug Development Delivery Pilot Award Early Exploratory Study. “Inhibiting the Ric-8 and Heterotrimeric G protein a Subunit Protein-Protein Interaction as a Means to Ameliorate Disease Pathogenesis Driven by Oncogenic and Mutant G protein subunits”. G. Tall, PI, $4,000.
2009-2010 NYSDOH Stem Cell IDEA Award (NYSTEM) C024307. “Deciphering the role of mammalian Ric-8 proteins in stem cell (asymmetric) division”. G. Tall, PI, 20% FTE, $232,000. (R21 equivalent).
2003-2005 AHA Postdoctoral Fellowship –Texas Affiliate Grant # 0325033Y, $84,000.

Patents and Licenses:

License of Heterotrimeric G protein Purification Technology to Kerafast.com -Total Sales to date (2012-2016): $48,919
License of Ric-8B antiserum to EMD/Millipore -$1500 + 25% sales royalty to URMC.
Novel anti-coagulants based on the GPR56 collagen-binding domain -Provisional application in progress.
Ric-8 Inhibitors for Treating Disease Associated with Oncogenic or Mutant G Proteins -Provisional application filed.

Grant Referee:

NIH, Small Business: Neuroscience Assay, Diagnostics and Animal Model Development ETTN (13), July 2019
NIH, Molecular and Integrative Signal Transduction (MIST) study section, Ad hoc member, June, 2019
American Heart Association SIGNALING 1 Peer Review Committee, Permanent Member, (2017 - )
NIH, Molecular and Integrative Signal Transduction (MIST) study section, Ad hoc member, June, 2015
Discovery Grant Proposal, National Sciences and Engineering Research Council of Canada (NSERC), 2010

Ad-hoc Reviewer of various manuscripts: Journal of Biological Chemistry, Biochemistry, Science Signaling, Cell: Structure, Mechanisms of Development, ACS Pharmacology and Translational Science, Molecular Biology of the Cell, Naunyn-Schmiedeberg's Archives of Pharmacology, Journal of Pharmacology and Experimental Therapeutics, FASEBJ, Experimental Cell Research, Molecular Psychiatry, Cell Reports, Nature Communications.

External Committees and Leadership Experience:

Editorial Advisory Board, Molecular Pharmacology (2016- )
Chairperson-Elect/Acting/Past, American Society of Pharmacology and Experimental Therapeutics (ASPET), Molecular Pharmacology Division (2015-2017)
Programming Committee Member, American Society of Pharmacology and Experimental Therapeutics (ASPET) (2016-2019)
Member of the Executive Committee, American Society of Pharmacology and Experimental Therapeutics (ASPET), Molecular Pharmacology Division (2012-2019)
President, American Society of Pharmacology and Experimental Therapeutics, Upstate NY Chapter (2014-2015)
Co-Chairperson (2018) ASPET Symposium: “Adhesion GPCRs as Neurotherapeutic Targets” Speakers: Piao, X., Arac, D., Hall, RA., Tall, GG., Sudhof, TM San Diego, CA. April, 2018
Meeting Co-chairperson 19th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. October 25-27 th, 2018. University of Michigan, Ann Arbor and Detroit, MI
Meeting Co-chairperson 10th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. October 15-18th, 2009. Memorial Art Gallery, Rochester, NY
Meeting Chairperson 4th Annual Upstate New York State Pharmacology Society (ASPET Chapter) Meeting May 19th, 2015. University of Rochester Medical Center, Rochester, NY
Session Chairperson: “Early Stage Investigator Symposium”, Upstate NY ASPET Chapter Meeting. Buffalo, NY May 19th, 2014
Session Chairperson: “G protein Signaling”, 10th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. Memorial Art Gallery, Rochester, NY October 15-18th, 2009
Session Chairperson: “GPCR Signaling in Cancer”, 13th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. London, Ontario, CA. October 17-19th, 2012
Session Chairperson: “GPCR Signaling Systems”, 18th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. Ottawa, Ontario, CA. October 19-21st, 2017
Chapter Councilor, American Society of Pharmacology and Experimental Therapeutics, Upstate NY Chapter

Memberships and Awards:

American Society of Pharmacology and Experimental Therapeutics (ASPET), Regular Member
American Society for Biochemistry and Molecular Biology (ASBMB), Regular Member
Upstate NY Pharmacology Society, Regular Member, and Chapter Councilor 2011-2013.
American Society for Cell Biology, Past Member
Sigma Xi Research Society and Award
Burpee Summer Undergraduate Research Fellowship in Plant Molecular Biology
Graduate Student Organization Travel Scholarship
UTSW Biochemistry Departmental Poster Session, Grand Prize

Service:

Member, Faculty Recruitment Committee, Department of Pharmacology, University of Michigan (2019- ).
Member, Graduate Education Committee, Department of Pharmacology, University of Michigan (2017- ).
Member, Graduate Admissions Committee, Department of Pharmacology, University of Michigan (2016-2017, 2018- ).
Member, Graduate Admissions Committee, Chemical Biology, University of Michigan (2016-2018).
Member, Faculty Internet Technologies Advisory Committee, University of Michigan (2018)
Chair, Departmental Equipment Committee, Pharmacology, University of Michigan (2018- )
Director, Graduate Admissions Committee, Cellular and Molecular Pharmacology and Physiology, University of Rochester (2011-
Grant Referee, University of Rochester Medical Center Internal Interim Funding Proposals (2).
Member, Assistant Professor Promotion Committee (1), University of Rochester Medical Center, 2016.
Member, URMC, Department of Pharmacology and Physiology Faculty Search Committees (2008-2009, 2015-2016).
Departmental Seminar Coordinator, URMC, Department of Pharmacology and Physiology (2008-2011).
Co-Coordinator, URMC Signal Transduction Journal Club (2008-2009).

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About Dr. Tall

Gregory Tall, Ph.D.

Associate Professor

Education:

Ph.D., Biomedical Sciences, University of Texas Southwestern Medical Center, 2000

B.S., Cell Biology/Biochemistry, Bucknell University, 1994

Post-Doctoral Training:

Research Fellow, U.T. Southwestern Medical Center, Dallas, TX, 2000-2006

Interests:

G protein-coupled receptor (GPCR) signaling

Translational hematology

Mechanism of Adhesion-GPCR Action

Heterotrimeric G protein Biosynthesis

G protein somatic mutation diseases

Alternative Functions of Ric-8 proteins

Teaching Experience:

(2019) Dental Pharmacology 503 *Course Director

(2018) Dental Pharmacology 503 *Course Co-Director

(2018) Chemical Biology 502

(2018) Research Responsibility and Ethics PIBS 503

(2018) Pharmacology 601

(2017) Dental Pharmacology 503

(2017) Research Responsibility and Ethics PIBS 503

(2017) Introduction to Scientific Communication PIBS 502

Research Funding:

2016-2019 NIH/NIGMS RO1 GM120110. Mechanisms of Adhesion GPCR Action. G. Tall, PI, 25% FTE. $976,500

2018-2022 NIH/NINDS RO1 NS103946. Development of Chemical Probes to Investigate Adhesion GPCR Tethered Agonism. G. Tall, PI, 25% FTE. $1,736,591

2019-2023 NIH/NIGMS R01 GM088242-11. Regulation of heterotrimeric G proteins by non-receptor activators. G. Tall, PI, 35% FTE. $1,287,875

2019-2021 NIH/NHLBI F32 Postdoctoral Fellowship to J. Yeung Postdoc, PI (G. Tall, Sponsor)

2018-2019 University of Michigan Proteomics Resource Facility Pilot Project Program. Adhesion GPCR Peptide Agonist Intramolecular Binding Site Identification by Photo-affinity Labeling / Mass Spectrometry. G. Tall, PI. $3900

Pending:

2020-2025 NIH/NIGMS RO1 GM120110-4. Mechanisms of Adhesion GPCR Action. G. Tall, PI, 25% FTE. $1,745,000 Percentile 3.0, Impact Score 18.

2020-2023 NIH/NHLBI F31 Predoctoral Fellowship to A. Vizurraga, Graduate Student, PI (G. Tall, Sponsor) Percentile 16.0, Impact Score 24.

Completed:

2019 Administrative Supplement GM120110-02 Mechanisms of Adhesion GPCR Action. $48,203

2014-2018 NIH/NIGMS R01 GM088242-08. Regulation of heterotrimeric G proteins by non-receptor activators. G. Tall, PI, 35% FTE. $1,287,875.

2014-2015 PhRMA Foundation Pre-doctoral Fellowship in Pharmacology/Toxicology to H. Stoveken, Graduate Student, PI. (G.Tall, Sponsor) $40,000.

2016-2017 PhRMA Foundation Pre-doctoral Fellowship in Pharmacology/Toxicology to M. Papasergi, Graduate Student, PI. (G.Tall, Sponsor) $40,000.

2009-2014 NIHGMS. RO1GM088242. Regulation of heterotrimeric G proteins by non-receptor activators. G. Tall, PI, 31-40% FTE. $1,597,750

2012 URMC Drug Development Delivery Pilot Award Early Exploratory Study. “Inhibiting the Ric-8 and Heterotrimeric G protein a Subunit Protein-Protein Interaction as a Means to Ameliorate Disease Pathogenesis Driven by Oncogenic and Mutant G protein subunits”. G. Tall, PI, $4,000.

2009-2010 NYSDOH Stem Cell IDEA Award (NYSTEM) C024307. “Deciphering the role of mammalian Ric-8 proteins in stem cell (asymmetric) division”. G. Tall, PI, 20% FTE, $232,000. (R21 equivalent).

2003-2005 AHA Postdoctoral Fellowship –Texas Affiliate Grant # 0325033Y, $84,000.

Patents and Licenses:

License of Heterotrimeric G protein Purification Technology to Kerafast.com -Total Sales to date (2012-2016): $48,919

License of Ric-8B antiserum to EMD/Millipore -$1500 + 25% sales royalty to URMC.

Novel anti-coagulants based on the GPR56 collagen-binding domain -Provisional application in progress.

Ric-8 Inhibitors for Treating Disease Associated with Oncogenic or Mutant G Proteins -Provisional application filed.

Grant Referee:

NIH, Small Business: Neuroscience Assay, Diagnostics and Animal Model Development ETTN (13), July 2019

NIH, Molecular and Integrative Signal Transduction (MIST) study section, Ad hoc member, June, 2019

American Heart Association SIGNALING 1 Peer Review Committee, Permanent Member, (2017 - )

NIH, Molecular and Integrative Signal Transduction (MIST) study section, Ad hoc member, June, 2015

Discovery Grant Proposal, National Sciences and Engineering Research Council of Canada (NSERC), 2010

External Committees and Leadership Experience:

Editorial Advisory Board, Molecular Pharmacology (2016- )

Chairperson-Elect/Acting/Past, American Society of Pharmacology and Experimental Therapeutics (ASPET), Molecular Pharmacology Division (2015-2017)

Programming Committee Member, American Society of Pharmacology and Experimental Therapeutics (ASPET) (2016-2019)

Member of the Executive Committee, American Society of Pharmacology and Experimental Therapeutics (ASPET), Molecular Pharmacology Division (2012-2019)

President, American Society of Pharmacology and Experimental Therapeutics, Upstate NY Chapter (2014-2015)

Co-Chairperson (2018) ASPET Symposium: “Adhesion GPCRs as Neurotherapeutic Targets” Speakers: Piao, X., Arac, D., Hall, RA., Tall, GG., Sudhof, TM San Diego, CA. April, 2018

Meeting Co-chairperson 19th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. October 25-27 th, 2018. University of Michigan, Ann Arbor and Detroit, MI

Meeting Co-chairperson 10th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. October 15-18th, 2009. Memorial Art Gallery, Rochester, NY

Meeting Chairperson 4th Annual Upstate New York State Pharmacology Society (ASPET Chapter) Meeting May 19th, 2015. University of Rochester Medical Center, Rochester, NY

Session Chairperson: “Early Stage Investigator Symposium”, Upstate NY ASPET Chapter Meeting. Buffalo, NY May 19th, 2014

Session Chairperson: “G protein Signaling”, 10th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. Memorial Art Gallery, Rochester, NY October 15-18th, 2009

Session Chairperson: “GPCR Signaling in Cancer”, 13th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. London, Ontario, CA. October 17-19th, 2012

Session Chairperson: “GPCR Signaling Systems”, 18th Annual Joint Meeting of the Great Lakes G Protein-Coupled Receptor Retreat and le Club des Récepteurs á Sept Domaines. Ottawa, Ontario, CA. October 19-21st, 2017

Chapter Councilor, American Society of Pharmacology and Experimental Therapeutics, Upstate NY Chapter

Memberships and Awards:

American Society of Pharmacology and Experimental Therapeutics (ASPET), Regular Member

American Society for Biochemistry and Molecular Biology (ASBMB), Regular Member

Upstate NY Pharmacology Society, Regular Member, and Chapter Councilor 2011-2013.

American Society for Cell Biology, Past Member

Sigma Xi Research Society and Award

Burpee Summer Undergraduate Research Fellowship in Plant Molecular Biology

Graduate Student Organization Travel Scholarship

UTSW Biochemistry Departmental Poster Session, Grand Prize

Service:

Member, Faculty Recruitment Committee, Department of Pharmacology, University of Michigan (2019- ).

Member, Graduate Education Committee, Department of Pharmacology, University of Michigan (2017- ).

**(2019) Dental Pharmacology 503 *Course Director**

**(2018) Dental Pharmacology 503 *Course Co-Director**