Publications
2023
Goldstein DR, Abdel-Latif A. Immune mechanisms of cardiac aging. J Cardiovasc Aging. 2023;3(2). doi: 10.20517/jca.2023.02. Epub 2023 Mar 9. PubMed PMID: 37092016; PubMed Central PMCID: PMC10121185. (Link to PubMed Article)
Song J, Farris D, Ariza P, Moorjani S, Varghese M, Blin M, Chen J, Tyrrell D, Zhang M, Singer K, Salmon M, Goldstein DR. Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis. Aging Cell. 2023 Jan 23;:e13783. doi: 10.1111/acel.13783. [Epub ahead of print] PubMed PMID: 36683460. (Link to PubMed Article)
2022
Gong HH, Worley MJ, Carver KA, Goldstein DR, Deng JC. Neutrophils drive pulmonary vascular leakage in MHV-1 infection of susceptible A/J mice. Front Immunol. 2022;13:1089064. doi: 10.3389/fimmu.2022.1089064. eCollection 2022. PubMed PMID: 36685578; PubMed Central PMCID: PMC9853883. (Link to PubMed Article)
Hindy G, Tyrrell DJ, Vasbinder A, Wei C, Presswalla F, Wang H, Blakely P, Ozel AB, Graham S, Holton GH, Dowsett J, Fahed AC, Amadi KM, Erne GK, Tekmulla A, Ismail A, Launius C, Sotoodehnia N, Pankow JS, Thørner LW, Erikstrup C, Pedersen OB, Banasik K, Brunak S, Ullum H, Eugen-Olsen J, Ostrowski SR, Haas ME, Nielsen JB, Lotta LA, Engström G, Melander O, Orho-Melander M, Zhao L, Murthy VL, Pinsky DJ, Willer CJ, Heckbert SR, Reiser J, Goldstein DR, Desch KC, Hayek SS. Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis. J Clin Invest. 2022 Dec 15;132(24). doi: 10.1172/JCI158788. PubMed PMID: 36194491; PubMed Central PMCID: PMC9754000. (Link to PubMed Article)
Chen J, Deng JC, Goldstein DR. How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions. Trends Mol Med. 2022 Dec 28;(12):1100-1111. doi: 10.1016/j.molmed.2022.09.008. [Epub ahead of print] Review. PubMed PMID: 36216643. (Link to PubMed Article)
Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein DR, Carty SA, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis CA. OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment. Sci Immunol. 2022 Nov 25;7(77):eabm8182. doi: 10.1126/sciimmunol.abm8182. PubMed PMID: 36399539. (Link to PubMed Article)
Chen J, Deng JC, Zemans RL, Bahmed K, Kosmider B, Zhang M, Peters-Golden M, Goldstein DR. Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection. Nat Commun. 2022 Nov 9;13(1):6759. doi: 10.1038/s41467-022-34593-y. PubMed PMID: 36351902; PubMed Central PMCID: PMC9643978. (Link to PubMed Article)
Frieler RA, Vigil TM, Song J, Leung C, Goldstein DR, Lumeng CN, Mortensen RM. Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice. Obesity (Silver Spring). 2022 Sep;30(9):1818-1830. doi: 10.1002/oby.23509. PubMed PMID: 35927796; PubMed Central PMCID: PMC9541899. (Link to PubMed Article)
Kelley WJ, Wragg KM, Chen J, Murthy T, Xu Q, Boyne MT, Podojil JR, Elhofy A, Goldstein DR. Nanoparticles reduce monocytes within the lungs to improve outcomes after influenza virus infection in aged mice. JCI Insight. 2022 Aug 8;7(15). doi: 10.1172/jci.insight.156320. PubMed PMID: 35737459; PubMed Central PMCID: PMC9462478. (Link to PubMed Article)
Hammer Y, Blin MG, Goldstein DR. Failing mitochondria and coronary allograft vasculopathy. J Heart Lung Transplant. 2022;S1053-2498(22)01829-0. doi: 10.1016/.PubMed PMID: 35339375. (Link to PubMed Article)
Tyrrell DJ, Chen J, Li BY, Wood SC, Rosebury-Smith W, Remmer HA, Jiang L, Zhang M, Salmon M, Ailawadi G, Yang B, Goldstein DR. Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm. 2022 Aug;42(8):1060-1076 . doi: 10.1161/ATVBAHA.122.317643. (Link to PubMed Article)
Liu AY, Aguayo-Ortiz R, Guerrero-Serna G, Wang N, Blin MG, Goldstein DR, Michel Espinoza-Fonseca L. Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane. Comput Struct Biotechnol J. 2022;20:380-384. doi: 10.1016/j.csbj.2021.12.031. eCollection 2022. PubMed PMID: 35035790. (Link to PubMed Article)
2021
Song J, Frieler RA, Vigil TM, Ma J, Brombacher F, Goonewardena SN, Goldstein DR, Mortensen RM. Inactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling. J Am Heart Assoc. 2021 Jul 6;10(13):e017329. doi: 10.1161/JAHA.120.017329. Epub 2021 Jun 16. PubMed PMID: 34132103. (Link to PubMed Article)
Gilroy DW, De Maeyer RPH, Tepper M, O'Brien A, Uddin M, Chen J, Goldstein DR, Akbar AN. Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19. Pharmacol Ther. 2021 May;221:107745. doi: 10.1016/j.pharmthera. PubMed PMID: 33188794. (Link to PubMed Article)
Peltier D, Radosevich M, Ravikumar V, Pitchiaya S, Decoville T, Wood SC, Hou G, Zajac C, Oravecz-Wilson K, Sokol D, Henig I, Wu J, Kim S, Taylor A, Fujiwara H, Sun Y, Rao A, Chinnaiyan AM, Goldstein DR, Reddy P. RNA-seq of human T cells after hematopoietic stem cell transplantation identifies Linc00402 as a regulator of T cell alloimmunity. Sci Transl Med. 2021 Mar 17;13(585). doi: 10.1126/scitranslmed.aaz0316. PubMed PMID: 33731431. (Link to PubMed Article)
Aslam S, Goldstein DR, Vos R, Gelman AE, Kittleson MM, Wolfe C, Danziger-Isakov L. COVID-19 vaccination in our transplant recipients: The time is now. J Heart Lung Transplant. 2021 Mar;40(3):169-171. doi: 10.1016/j.healun.2020.12.009. Epub 2021 Jan 2. PubMed PMID: 33487534. (Link to PubMed Article)
Tyrrell DJ, Goldstein DR. Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6. Nat Rev Cardiol. 2021 Jan;18(1):58-68. doi: 10.1038/s41569-020-0431-7. Epub 2020 Sep 11. Review. PubMed PMID: 32918047. (Link to PubMed Article)
2020
Goldstein DR. A tough act to follow: Taking JHLT into the future. J Heart Lung Transplant. 2021 Jan;40(1):1-2. doi: 10.1016/j.healun.2020.09.010. Epub 2020 Sep 25. PubMed PMID: 33069571. (Link to PubMed Article)
Song J, Frieler RA, Whitesall SE, Chung Y, Vigil TM, Muir LA, Ma J, Brombacher F, Goonewardena SN, Lumeng CN, Goldstein DR, Mortensen RM. Myeloid interleukin-4 receptor α (IL4Rα) is essential in post-myocardial infarction healing by regulating inflammation and fibrotic remodeling. Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H323-H337. doi: 10.1152/ajpheart.00251.2020. Epub 2020 Nov 8. PubMed PMID: 33164548. (Link to PubMed Article)
Kelley WJ, Zemans RL, Goldstein DR. Cellular senescence: friend or foe to respiratory viral infections? Eur Respir J. 2020 Dec;56(6). doi: 10.1183/13993003.02708-2020. Print 2020 Dec. PubMed PMID: 33033152. (Link to PubMed Article)
Tyrrell DJ, Blin MG, Song J, Wood SC, Goldstein DR. Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature. J Am Heart Assoc. 2020 Dec;9(23):e017820. doi: 10.1161/JAHA.120.017820. Epub 2020 Nov 23. PubMed PMID: 33225820. (Link to PubMed Article)
Penke LR, Speth JM, Draije C, Zaslona Z, Judy Chen J, Mancuso P, Freeman CM, Curtis, JL, Goldstein DR, Peters-Golden M. PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking Life Sci Alliance. 2020 Aug 20; PMID 32820026. (Link to PubMed Article)
Kelley WJ, Zemans RL, Goldstein DR. Cellular Senescence: Friend or Foe to Respiratory Viral Infections?. Eur Respir J. 2020 Oct 8; [Epub ahead of print] PMID: 33033152. (Link to PubMed Article)
Chakrabarti A, Goldstein DR, Sutton NR. Age-associated arterial calcification: the current pursuit of aggravating and mitigating factors. Curr Opin Lipidol. 2020 Oct;31(5):265-272. PMID: 32773466. (Link to PubMed Article)
Tyrrell DJ, Blin MG, Song J, Wood S, Goldstein DR. Aging impairs mitochondrial function, mitophagy and elevates IL-6 within the cerebral vasculature. J Am Heart Assoc. 2020 Dec;9(23):e017820. Epub 2020 Nov 23. PMID: 33225820 (Link to PubMed Article)
Goldstein DR. A tough act to follow: Taking JHLT into the future. J Heart Lung Transplant. 2021 Jan;40(1):1-2. [Epub ahead of print] PMID: 33069571. (Link to PubMed Article)
Tyrrell DJ, Goldstein DR. Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6. Nat Rev Cardiol. 2021 Jan;18(1):58-68. [Epub ahead of print] Review. PMID: 32918047. (Link to PubMed Article)
Gilroy DW, De Maeyer RPH, Tepper M, O'Brien A, Uddin M, Chen J, Goldstein DR, Akbar AN. Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19. Pharmacol Ther. 2020 Nov 11:107745. 2020 [Epub ahead of print] Review. PMID: 33188794. (Link to PubMed Article)
Chen J, Kelley WJ, Goldstein DR. Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19. J Immunol. 2020 Jul 15;205(2):313-320. Epub 2020 Jun 3. PMID: 32493812. (Link to PubMed Article)
De Maeyer PH, van de Merwe RC, R. Louie, Bracken O, Devine OP, Goldstein DR, Uddin M, Akbar AN, & Gilroy DW. Blocking elevated p38 MAPK restores 1 efferocytosis and inflammatory resolution in the elderly. Nat Immunol. 2020 Jun;21(6):615-625. PMID 32251403. (Link to PubMed Article)
Lei L, Wang Z, Chen E, Ma PX, Huang W, Kim E, Lam HYK, Goldstein, DR, Aaronson KD, Pagani FD, Tang PC The Secret Life of Human Donor Hearts: An Examination of Transcriptomic Events During Cold Storage. Circ Heart Fail. 2020 Apr;13(4):e006409. PMID 32264717. (Link to PubMed Article)
Tyrrell DJ, Blin MG, Song J, Wood S, Zhang M, Beard D, Goldstein DR. Age-associated mitochondrial dysfunction accelerates atherogenesis Circ Res. 2020 Jan 31;126(3):298-314. Altmetric: 68. PMID 31818196. (Link to PubMed Article)
Sutton NR, Bouïs D, Mann KM, Rashid IM, McCubbrey ALm Hyman MC, M.D., Goldstein, DR, Mei A, Pinsky DJ, CD73 promotes age-dependent accretion of atherosclerosis. Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):61-71. PMID 31619062. (Link to PubMed Article)
2019
Smith CA, Tyrell DJ, Kulkarni UA, Wood S, Leng L, Zemans RL, Bucala R, Goldstein DR: Macrophage migration inhibitory factor enhances influenza-associated mortality in mice. JCI Insight. 2019 Jul 11;4(13):e128034. PMID:31292300 (Link to PubMed Article)
Smith CA, Kulkarni U, Chen J, Goldstein DR: Influenza virus inoculum volume is critical to elucidate age-dependent mortality in mice. Aging Cell. 2019 Apr;18(2):e12893. PMID: 30632262 (Link to PubMed Article)
Kulkarni U, Zemans RL, Smith CA, Wood SC, Deng JC, Goldstein DR: Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. Mucosal Immunol. 2019 Mar;12(2):545-554. PMID: 30617300 (Link to PubMed Article)
2018
Kulkarni U, Goldstein DR: Divergent Roles for Neutrophils: Promoting and Resolving Inflammation? Transplantation. 2018 Apr;102(4):542-543. PMID 29557936 (Link to PubMed Article)
Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP: Future Research Directions in Pneumonia: NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. PMID: 29546996 (Link to PubMed Article)
2017
Goldstein DR, Jalife J. Synergistic Research Between the Center of Arrhythmia Research and the Michigan Biology of Cardiovascular Aging at the University of Michigan. Circ Res. 2017 Nov 10;121(11):1221-1223. PMID: 29122944 (Link to PubMed Article)
Anumonwo JM, Jalife J, Goldstein DR. Triple threat: adiposity, aging, atrial fibrillation. Aging (Albany NY). 2017 Nov 1;9(11):2235-2236. PMID: 29112501 (Link to PubMed Article)
Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR. Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. J Immunol. 2017 Aug 1;199(3):1060-1068. [Epub ahead of print] PMID: 28646038 (Link to PubMed Article)
Colvin MM, Smith CA, Tullius SG, Goldstein DR. Aging and the immune response to organ transplantation. J Clin Invest. 2017 Jun 30;127(7):2523-2529. [Epub ahead of print] PMID: 28504651 (Link to PubMed Article)
Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell. 2017 Jun;16(3):444-450. [Epub ahead of print] PMID: 28266167 (Link to PubMed Article)
Hasan R, Ela AAE, Goldstein D. Innovations in cardiac transplantation. Curr Opin Cardiol. 2017 May;32(3):336-342. PMID: 28306670. (Link to PubMed Article)
2016
Li W, Hsiao HM, Higashikubo R, Saunders BT, Bharat A, Goldstein DR, Krupnick AS, Gelman AE, Lavine KJ, Kreisel D. Heart-resident CCR2+/- macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling. JCI Insight. 2016 Aug 4;1(12):e87315. PMID: 27536731 (Link to PubMed Article)
Mori DN, Shen H, Galan A, Goldstein DR. Aged B cells alter immune regulation of allografts in mice. ur J Immunol. 2016 Nov;46(11):2650-2658. [Epub ahead of print] PMID: 27546296 (Link to PubMed Article)
Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez-Hernando C, Goldstein DR. Age-associated vascular inflammation promotes monocytosis during atherogenesis. Aging Cell. 2015 Aug; 15(4):766-77. Epub 2016 May 2. PMID: 27135421 (Link to PubMed Article)
Jane-Wit D, Fang C, Goldstein DR. Innate immune mechanisms in transplant allograft vasculopathy. Curr Opin Organ Transplant. 2016; 21(3):253-7. PMID: 27077602 (Link to PubMed Article)
Braza F, Brouard S, Chadban S, Goldstein DR. Role of TLRs and DAMPs in allograft inflammation and transplant outcomes. Nat Rev Nephrol. 2016 May;12(5):281-90. Epub 2016 Mar 30. Review. PMID: 27026348. (Link to PubMed Article)
2015
Shen H, Heuzey E, Mori DN, Wong CK, Colangelo CM, Chung LM, Bruce C, Slizovskiy IB, Booth CJ, Kreisel D, Goldstein DR. Haptoglobin enhances cardiac transplant rejection. Circ Res. 2015; 116(10):1670-9. PMID: 25801896 (Link to PubMed Article)
2014
Mori DN, Kreisel D, Fullerton JN, Gilroy DW, Goldstein DR. Inflammatory triggers of acute rejection of organ allografts. Immunol Rev. 2014 Mar;258(1):132-44. PMID: 24517430 (Link to PubMed Article)
Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ. The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells. Cancer Immunol Res. 2014 Jul;2(7):655-67. PMID: 24801837 (Link to PubMed Article)
2013
Kreisel D, Goldstein DR. Innate immunity and organ transplantation: focus on lung transplantation. Transpl Int. 2013; 26(1):2-10. PMID: 22909350 (Link to PubMed Article)
Wong C, Goldstein DR. Impact of aging on antigen presentation cell function of dendritic cells. Curr Opin Immunol. 2013 Aug;25(4):535-41. PMID: 23806201 (Link to PubMed Article)
Shen H, Kreisel D, Goldstein DR. Processes of sterile inflammation. J Immunol. 2013 Sep 15;191(6):2857-63. PMID: 24014880 (Link to PubMed Article)
Song Y, Shen H, Du W, Goldstein DR. Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages. Aging Cell. 2013 Oct;12(5):794-801. PMID: 23711292 (Link to PubMed Article)
Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013 Dec;13(12):875-87. PMID: 24157572 (Link to PubMed Article)
2012
Shen H, Song Y, Colangelo CM, Wu T, Bruce C, Scabia G, Galan A, Maffei M, Goldstein DR. Haptoglobin activates innate immunity to enhance acute transplant rejection in mice. J Clin Invest. 2012 Jan;122(1):383-7. PMID: 22156194 (Link to PubMed Article)
Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR. Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):103-9. PMID: 22034510 (Link to PubMed Article)
Decman V, Laidlaw BJ, Doering TA, Leng J, Ertl HC, Goldstein DR, Wherry EJ. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors.J Immunol. 2012 Feb 15;188(4):1933-41. PMID: 22246631 (Link to PubMed Article)
Goldstein DR. Role of aging on innate responses to viral infections. J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):242-6. PMID: 2204272 (Link to PubMed Article)
Goldstein DR. The graying of organ transplantation. Am J Transplant. 2012; 12(10):2569-70. PMID: 23009136 (Link to PubMed Article)
Walker WE, Bozzi AT, Goldstein DR. IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model. J Leukoc Biol. 2012 Dec;92(6):1261-8. PMID: 23048204 (Link to PubMed Article)
2011
Goldstein DR. Inflammation and transplantation tolerance. Semin Immunopathol. 2011 Mar;33(2):111-5. PMID: 21331502 (Link to PubMed Article)
Goldstein DR. T cell costimulation blockade and organ transplantation: a change of philosophy for transplant immunologists? J Immunol. 2011 Mar 1;186(5):2691-2. PMID: 21325217 (Link to PubMed Article)
Du W, Shen H, Galan A, Goldstein DR. An age-specific CD8+ T cell pathway that impairs the effectiveness of strategies to prolong allograft survival. J Immunol. 2011 Oct 1;187(7):3631-40. PMID: 2187352 (Link to PubMed Article)
Leng J, Stout-Delgado HW, Kavita U, Jacobs A, Tang J, Du W, Tussey L, Goldstein DR. Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection. Vaccine. 2011; 29(45):8147-55. PMID: 2185482 (Link to PubMed Article)
Shirali AC, Look M, Du W, Kassis E, Stout-Delgado HW, Fahmy TM, Goldstein DR. Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival. Am J Transplant. 2011; 11(12):2582-92. PMID:21883921 (Link to PubMed Article)
2010
Walker WE, Booth CJ, Goldstein DR. TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA. Mol Ther. 2010 Apr;18(4):775-84. PMID: 20145605 (Link to PubMed Article)
Goldstein DR. Aging, imbalanced inflammation and viral infection. Virulence. 2010 Jul-Aug;1(4):295-8. PMID: 2117845 (Link to PubMed Article)
Leng J, Goldstein DR. Impact of aging on viral infections. Microbes Infect. 2010 Dec;12(14-15):1120-4. PMID: 20849976 (Link to PubMed Article)
2009
Tesar BM, Du W, Shirali AC, Walker WE, Shen H, Goldstein DR. Aging augments IL-17 T-cell alloimmune responses. Am J Transplant. 2009; 9(1):54-63. PMID: 18976294 (Link to PubMed Article)
Shen H, Tesar BM, Du W, Goldstein DR. Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation. PloS one. 2009; 4(1):e4097. PMID: 19119314 (Link to PubMed Article)
Shen H, Goldstein DR. IL-6 and TNF-alpha synergistically inhibit allograft acceptance. J Am Soc Nephrol. 2009 May;20(5):1032-40. PMID: 19357252 (Link to PubMed Article)
Kovacs EJ, Palmer JL, Fortin CF, Fülöp T Jr, Goldstein DR, Linton PJ. Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors. Trends Immunol. 2009 Jul;30(7):319-24. PMID: 19541536 (Link to PubMed Article)
Walker WE, Goldstein DR. B cells are dispensable for neonatal transplant tolerance induction. Transplantation. 2009; 88(7):874-8. PMID: 19935457 (Link to PubMed Article)
Stout-Delgado HW, Du W, Shirali AC, Booth CJ, Goldstein DR. Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe. 2009 Nov 19;6(5):446-56. PMID: 19917499 (Link to PubMed Article)
2008
Shirali AC, Goldstein DR. Activation of the innate immune system by the endogenous ligand hyaluronan. Curr Opin Organ Transplant. 2008 Feb;13(1):20-5. PMID: 18660702 (Link to PubMed Article)
Shirali AC, Goldstein DR. Tracking the toll of kidney disease. J Am Soc Nephrol. 2008 Aug;19(8):1444-50. PMID: 18579638 (Link to PubMed Article)
Alegre ML, Goldstein DR, Chong AS. Toll-like receptor signaling in transplantation. Curr Opin Organ Transplant. 2008 Aug;13(4):358-65. PMID: 18685330 (Link to PubMed Article)
Shen H, Tesar BM, Walker WE, Goldstein DR. Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation. J Immunol. 2008 Aug 1;181(3):1849-58. PMID: 18641322 (Link to PubMed Article)
Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol. 2008 Sep 15;181(6):3804-10. PMID: 18768833 (Link to PubMed Article)
Stout-Delgado HW, Yang X, Walker WE, Tesar BM, Goldstein DR. Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol. 2008 Nov 15;181(10):6747-56. PMID: 18981092 (Link to PubMed Article)
2007
Shen H, Goldstein DR. Role of Toll-like receptors in transplantation tolerance. Expert Rev Clin Immunol. 2007 Mar;3(2):139-44. PMID: 20477103 (Link to PubMed Article)
Tesar BM, Goldstein DR. Toll-like receptors and their role in transplantation.Front Biosci. 2007 May 1;12:4221-38. PMID: 17485369 (Link to PubMed Article)
Tesar BM, Goldstein DR. Acute allograft rejection occurs independently of inducible heat shock protein-70. Transplantation. 2007; 83(11):1513-7. PMID: 17565327 (Link to PubMed Article)
Goldstein DR. The identity of innate immune activators in organ transplantation: origins from within or exterior to the host? Am J Transplant. 2007; 7(7):1692-4. PubMed [journal] PMID: 17524077 (Link to PubMed Article)
Walker WE, Goldstein DR. Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity. J Immunol. 2007 Aug 1;179(3):1700-10. PMID: 17641036 (Link to PubMed Article)
Griffith JW, O'Connor C, Bernard K, Town T, Goldstein DR, Bucala R. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis. 2007 Nov 15;196(10):1553-64. PMID: 18008236 (Link to PubMed Article)
2006
Obhrai J, Goldstein DR. The role of toll-like receptors in solid organ transplantation. Transplantation. 2006; 81(4):497-502. PMID: 16495791 (Link to PubMed Article)
Walker WE, Nasr IW, Camirand G, Tesar BM, Booth CJ, Goldstein DR. Absence of innate MyD88 signaling promotes inducible allograft acceptance. J Immunol. 2006 Oct 15;177(8):5307-16. PMID: 17015716 (Link to PubMed Article)
Tesar BM, Jiang D, Liang J, Palmer SM, Noble PW, Goldstein DR. The role of hyaluronan degradation products as innate alloimmune agonists. Am J Transplant. 2006; 6(11):2622-35. PMID: 17049055 (Link to PubMed Article)
Goldstein DR. Toll like receptors and acute allograft rejection. Transpl Immunol. 2006 Dec;17(1):11-5. PMID: 17157206 (Link to PubMed Article)
Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging cell. 2006; 5(6):473-86. PMID: 17129212 (Link to PubMed Article)
2005
Goldstein DR, Palmer SM. Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation. J Heart Lung Transplant. 2005 Nov;24(11):1721-9. PMID: 16297771 (Link to PubMed Article)
Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005 Nov;11(11):1173-9. PMID: 16244651 (Link to PubMed Article)
Askenase PW, Itakura A, Leite-de-Moraes MC, Lisbonne M, Roongapinun S, Goldstein DR, Szczepanik M. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol. 2005 Nov 15;175(10):6390-401. PMID: 1627 (Link to PubMed Article)
2004
Goldstein DR, Tesar BM. Toll-like receptors and allograft rejection. Am J Respir Crit Care Med. 2004 Apr 15;169(8):971; author reply 971-2. PMID: 15072988 (Link to PubMed Article)
Tesar BM, Zhang J, Li Q, Goldstein DR. TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein. Am J Transplant. 2004 Sep;4(9):1429-39. PMID: 15307830 (Link to PubMed Article)
Tesar BM, Chalasani G, Smith-Diggs L, Baddoura FK, Lakkis FG, Goldstein DR. Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs. J Immunol. 2004 Oct 1;173(7):4377-86. PMID: 15383567 (Link to PubMed Article)
Goldstein DR. Toll-like receptors and other links between innate and acquired alloimmunity. Curr Opin Immunol. 2004 Oct;16(5):538-44. PMID: 15341996 (Link to PubMed Article)
2003
Goldstein DR, Coffey CS, Benza RL, Nanda NC, Bourge RC. Relative perioperative bradycardia does not lead to adverse outcomes after cardiac transplantation. Am J Transplant. 2003 Apr;3(4):484-91. PMID: 12694073 (Link to PubMed Article)
Goldstein DR, Tesar BM, Akira S, Lakkis FG. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest. 2003 May;111(10):1571-8. PMID: 12750407(Link to PubMed Article)
2002
2001
Goldstein DR, Thomas JM, Kirklin JK, George JF. An essential role for natural killer cells in augmentation of allograft survival mediated by donor spleen cells. Transplantation. 2001; 72(5):954-6. PMID: 11571465 (Link to PubMed Article)
Goldstein DR, Thomas JM, Kirklin JK, George JF. Indefinite allograft survival mediated by donor bone marrow is dependent on the presence of a functional CD95 (Fas) gene in recipients. J Heart Lung Transplant. 2001; 20(10):1132-5. PMID: 11595570 (Link to PubMed Article)