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Aim: To ascertain the role of epigenetic mechanisms on the transgenerational inheritance of the phenotypes mediated by nutritional programming.
Aim: To ascertain the role of epigenetic mechanisms on the transgenerational inheritance of the phenotypes mediated by nutritional programming.
This WP will contribute to:
· Demonstrate the presence of trans-generationally inherited epigenetic marks associated to nutritional programming
Research questions:
· Are those epigenetic signatures induced by the nutritional programming persistent or do they fade over time?
· Are epigenetic changes induced by carbohydrate content and dietary fatty acid profile transmitted across generations?
· How long do the epigenetic signatures in last?
· Is the presence of certain lncRNAs key for the long-lasting and transgenerational effects observed?
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