Wednesday April 10
Read 6.1 and answer the textbook questions.
6.1 Page 272 #1, 3, 4, 6, 7
Not watched
What Is the Secret of Life? A History of Biology and Genetics 49 minutes on learn 360.
or PBS DNA 53 minutes https://www.youtube.com/watch?v=D8DDenDpiSU
Thursday April 11
Started: 6.1 and 6.2 - The molecular basis of inheritance and the discovery of DNA slide show: https://docs.google.com/presentation/d/1REP6YIdN-EesJHI22FqzMw_kgBKAG9CdEDn3YLqjdl4/edit?usp=sharing
Please read section 6.2, page 279, and answer questions at end of chapter.
Friday April 12
Take up yesterday's homework
Intro to DNA replication: Video: Ameoba sisters DNA replication: https://www.youtube.com/watch?v=Qqe4thU-os8&t=3s
Blooklet on DNA replication: https://dashboard.blooket.com/set/6148b870b5ecf6002fd1cc4e
Read chapter 6.4 - DNA replication, and answer questions at the end of the chapter.
Go over 6.4 - Powerpoint - 6.4 DNA replication: https://docs.google.com/presentation/d/1AIUnTF5fU521RQD9QqIUNY6ve42d8KO4opklKGX8FjU/edit?usp=sharing
Optional:
Mr. Anderson DNA Replication, 10 minutes: https://www.youtube.com/watch?v=FBmO_rmXxIw
Monday April 15
Take up weekend's homework
Learning skills self-assessment: https://docs.google.com/forms/d/e/1FAIpQLSdeBGxvF7tpaeiNY3euqw9v_v022XQWivpbrX73WNRi8_slEg/viewform?usp=sf_link
Return labs
Return tests
Send grades
Build DNA and copy it- folder for the teacher with paper models: https://drive.google.com/drive/folders/1BFvVrb-oSDxkzaCS84RHc6AsWiJogCNS?usp=sharing. Make a strand 10 nucleotides long. Make the complementary strand. Open a replication bubble (but leave the last two nucleotides on either end attached) and start copying the DNA in a 5' to 3'. Next, open up the end of the strand and realize which was the lagging strand.
Please watch Protein Synthesis. Amoeba Sisters 9 min. https://www.youtube.com/watch?v=oefAI2x2CQM
Blooket OR Kahoot: 25 Questions on DNA structure and replication:
https://create.kahoot.it/details/dna-structure-dna-replication/68faa466-8bff-468b-bfe6-7d7e7e06e7e5
Tuesday April 16
Watched yesterday - Protein Synthesis. Amoeba Sisters 9 min. https://www.youtube.com/watch?v=oefAI2x2CQM
Optional: How to read a codon chart. Amoeba Sisters. 7 min
https://www.youtube.com/watch?v=LsEYgwuP6ko
7.1 - From Gene to Protein - discussion of Thursday's reading and take up homework
https://docs.google.com/presentation/d/14Mh8Y_XtN1nqhCaVJgIFLGRu0BAVX1TS3pqJfQFjODI/edit?usp=sharing
Please read chapter 7.1 and answer the questions.
Wednesday April 17
Take up homework
Blooket: https://dashboard.blooket.com/set/6554045a5521082749c55868
Gizmo on protein synthesis
Formative quiz on Thursday: 6.1, 6.2, 6.4 and 7.1
Thursday April 18
Expected test dates
Unit test Friday April 26
Lab test date Thursday May 2
6.1, 6.2, 6.4 and 7.1 Quiz (formative). Question 15 does not have enough information to answer it. Question 17 right answer is not worded well.
https://docs.google.com/forms/d/e/1FAIpQLSf3luYDIwNfByPTmuJbpAcmd9d9atLDKrFDofPIozPjV5s34w/viewform?usp=sf_link
AP assigned reading chapters over the weekend: 6.5 and 6.6
Take up questions from homework
Lesson on figure 2 page 321. Although the entire of this chapter (7.2) is not required for our test, you must understand this figure.
https://docs.google.com/document/d/1qYQzAKGOoQ0WMI_OVG9gmB80NqCEgpwS2Hu7adPyxls/edit?usp=sharing
Note with writing: https://drive.google.com/file/d/1q_Lif2zqHcIs4-H165sM9ADR7SbTJrSB/view?usp=sharing
What you need to know:
Print handout for student notes of image 7.2
What are introns?
What are exons?
What is a poly A tail?
What is a 5' cap?
What is alternative splicing?
Handout to complete (homework):
Template strand and coding strand transcription and translation worksheet - the importance of direction: https://docs.google.com/document/d/1vFspQHwoWhdVgubfCB-xED8L3iDfKRqlO2X2CvoTEJM/edit?usp=sharing
Answers - Take up direction worksheet (note that the first question may have changed): https://docs.google.com/document/d/1pu_W8rFha4PncDhYlkPOgMXjDG_LZIze9wgUOcjtceY/edit?usp=sharing
Optional videos:
Good overview of the whole process - Khan Academy 10 min Transcription and Translation: https://www.youtube.com/watch?v=JQIwwJqF5D0
Viruses Amoeba Sisters - 6 min: https://www.youtube.com/watch?v=8FqlTslU22s
Animation of transcription: https://www.youtube.com/watch?v=WsofH466lqk
Amoeba Sister DNA vs RNA 5 min: https://www.youtube.com/watch?v=JQByjprj_mA
Viruses Amoeba Sisters - 6 min: https://www.youtube.com/watch?v=8FqlTslU22s
From DNA to protein 3D - 4 min: https://www.youtube.com/watch?v=gG7uCskUOrA
Translation 5 min: https://www.youtube.com/watch?v=kmrUzDYAmEI
Friday April 19
Take up homework
Image of transcription and translation in e coli: https://schaechter.asmblog.org/.a/6a00d8341c5e1453ef017ee8c01716970d-400wi
Note that the information is amplified - we see 1 gene, but ~8 transcripts and ~50 ribosomes making proteins
Amoeba sisters on Lac Operon https://www.youtube.com/watch?v=h_1QLdtF8d0|
Optional:
3 min on Lac Operon: https://www.youtube.com/watch?v=oBwtxdI1zvk
Mr. Anderson on transcription and translation: https://www.youtube.com/watch?v=UHE8oniorCo
Trp Operon 3min: https://www.youtube.com/embed/8aAYtMa3GFU
Blooket. Great one that we found in class. There are some obscure questions. https://dashboard.blooket.com/set/625cccc707bac9a8732bc003
7.4 Gene regulation PPT
https://docs.google.com/presentation/d/1dbzzkiuF2uqmlzNkGoiUdS2c3diZTOUhhQFpQNKLRlI/edit?usp=sharing
Homework: Please read 7.4 and answer the questions.
Monday April 22
Kahoot on Operons (A very good one, question 12 we didn't cover): https://create.kahoot.it/details/operons/ed081e6f-26b4-433e-8e09-04284f302c41
Good Kahoot on translation:
Amoeba sisters mutations: https://www.youtube.com/watch?v=vl6Vlf2thvI
7.5 Mutations
https://docs.google.com/presentation/d/1btVPC2zdgLgTCFGmK7wHpvIXLtcwsFJLYFYaxaMv92A/edit?usp=sharing
Homework: Pg.345 #1 to 10 (requires online research on smoking)
Tuesday April 23
Review day for the test on Friday
Mutations Kahoot: https://create.kahoot.it/details/mutations/77d906e4-a6dd-4ce1-91b6-4fff6b945921
Take up homework
Assigned reading for AP class, optional for others: Read 7.2, 7.3, 7.6
N- and C-terminus of proteins: https://docs.google.com/document/d/1z_Hzx_dnlmXehrRh148Dfuf49xOoVhasWcBPNHsdrrk/edit?usp=sharing
Didn't watch: Amoeba sisters, epigenetics 8 min: https://www.youtube.com/watch?v=MD3Fc0XOjWk
About the test: https://docs.google.com/document/d/14KH-ULjR-qXJkbMf4nHGKocQQ__ZIGEt7aWOFTbXtS8/edit?usp=sharing
Review work assigned for the next few days.
Challenging Practice MC test: https://drive.google.com/file/d/1HHw5JXmOHrTzYuW-D0MoveFFANQjtJRE/view?usp=sharing
Practice test entry form (submit to check your answers): https://docs.google.com/forms/d/e/1FAIpQLSf5g0FjSCNAuKZZ_cuPgxs0blhwphZAFG-0xp6P1xgWDmyYlQ/viewform?usp=sf_link
Practice test answers: https://drive.google.com/file/d/1ltjxJDV-ciRphS84CQ7PdneHeqNhwQ_K/view?usp=sharing
Chapter 6 Self-quiz and review - page 303
Chapter 7 Self-quiz and review - Page 357 (but we didn't cover the last two chapters)
Wednesday April 24
Got lactase activity:
Watch the 15 minutes video "Got Lactase?" https://www.biointeractive.org/classroom-resources/interactive-assessment-got-lactase-co-evolution-genes-and-culture (if watching as a class, maybe the video can be paused and groups can discuss the questions before the teacher inputs the consensus answer).
Watch the 1 minute video on how lactose is digested: https://www.biointeractive.org/classroom-resources/lactose-digestion-infants
Students individually do the click and learn: https://www.biointeractive.org/classroom-resources/regulation-lactase-gene
Students answer these questions on lactase persistence - just the questions on page 8. https://www.biointeractive.org/sites/default/files/Lactase_Pedigrees_Patterns_Inheritance_Student.pdf -
Thursday April 25
Discuss review so far.
Watched leading vs lagging strand 2min: https://www.youtube.com/watch?v=WCliyI4__cM
Wonderful and challenging questions assigned on myAP - this will take most of the period and is required by everyone. Skip question 7, unless you know what gel electrophoresis is. https://apclassroom.collegeboard.org/6/assessments/assignments/54801742
Intro to pGLO lab:
Mr. Anderson teaching about transformation lab (just the first half of the video) just to the 5 min mark. 8 min. https://www.youtube.com/watch?v=OZyFX9megs8
Presentation - students must read: https://docs.google.com/presentation/d/1mmTP699jAOclmRiW8Qa63y_MxpPx0VbD/edit?
Lab instructions for students (print for lab day): https://drive.google.com/file/d/1Hy2ssvHHMgXfu-AiFM6b0KIGVyO-SHK2/view?usp=sharing
Optional resources:
Lab steps video (if you were absent): https://www.youtube.com/watch?v=c40UudFIlGw
Note (option to print): https://docs.google.com/document/d/1RfLcyyGAIR2-Nmt9GdqOTrzuB-cSrQw3SmfnOHJnm2Y/edit?usp=sharing
Optional reading: Student Guide: https://drive.google.com/file/d/1EmILPnfbCl2c-L__KJVJUYGcYMreTQgQ/view?usp=sharing
Answer guide to the student guide: https://drive.google.com/file/d/1vgfB1_E45NQAbUqLVQwRjTs3HUzrYHFp/view?usp=sharing
Lab test: Friday December 8
Friday April 26
Unit Test
Old stuff from pervious years:
Note (needs to be edited): https://docs.google.com/document/d/1lNfUcDK67EeOxTiIdUf4vGLPgFcLIB6c_gV_tAOARtY/edit?usp=sharing
vote for a game:
DNA History and structure Kahoot. Note the structure questions were from the optional reading chapter 6.5: https://create.kahoot.it/details/4a129ded-0122-4610-ae47-491fa228002a
Transcirption blooket? https://dashboard.blooket.com/set/61918998b86afc6576678978
Kahoot - 10 questions on Transcription: https://create.kahoot.it/details/transcription/c5dbbf42-b879-4536-a39d-9b45e0bac7f6
Previous days homework: Read 7.2 and answer the questions
Talk through 7.2, take up questions
7.2 Transcription:
https://docs.google.com/presentation/d/1xx7Iq1DqFYl7hpLz5eE7I8sqkCJwTLJoMiH3CymRvA0/edit?usp=sharing
---------
Talk through 7.3 (what you did yesterday)
7.3 Translation PPT:
https://docs.google.com/presentation/d/1ofW0oAl3aPAtNEZsEhcTAjlvNbTN188tbrTpXTyIE7o/edit?usp=sharing
Not done in class - Good Kahoot on translation:
Blooket on operons and transcription (some questions are not great): https://dashboard.blooket.com/set/625cccc707bac9a8732bc003
Page 331 #1-8.
Lab stuff
Intro to pGlo lab:
Mr. Anderson teaching about transformation lab (just the first half of the video) just to the 5 min mark. 8 min. https://www.youtube.com/watch?v=OZyFX9megs8
Lab steps video: https://www.youtube.com/watch?v=c40UudFIlGw
Note (print): https://docs.google.com/document/d/1RfLcyyGAIR2-Nmt9GdqOTrzuB-cSrQw3SmfnOHJnm2Y/edit?usp=sharing
Presentation: https://docs.google.com/presentation/d/1mmTP699jAOclmRiW8Qa63y_MxpPx0VbD/edit?usp=sharing&ouid=116878137606048956010&rtpof=true&sd=true
Simplified flow chart (print): https://drive.google.com/file/d/1oJV2LIBUDpE7aVGcJvkdkFb42DIkOP1q/view?usp=sharing
Even shorter Quick guide: https://drive.google.com/file/d/1pXaK4bwC84UPXa9t2jDOQPI19dx9y8nY/view?usp=sharing
Student background information: https://drive.google.com/file/d/1ixArCk9cFeT_nWjSfvbd65iljs7xRmyO/view?usp=sharing
pGlo map: https://drive.google.com/file/d/1KFwiHbqJH8STFC72toeUyGBbDJInFR7M/view?usp=sharing
GFP background: https://drive.google.com/file/d/1URaEWlM_nefBDzl2sfbQM-Q1xtHkMsxM/view?usp=sharing
Instructor guide: https://drive.google.com/file/d/1HEdN_shUmhxlDkjrlvCFpBGK1I_VDRrV/view?usp=sharing
Student worksheet for after the lab (print or make google doc to fill in): https://drive.google.com/file/d/1OZeorCXHHrBDKJYMogKeOWpXJHwqdH0C/view?usp=sharing
Pglo lab kahoot: https://create.kahoot.it/details/63dfb5c2-8813-4c6e-9c4a-b019ca05df2a
Old 6.1 and 6.2 slide show with more details: https://docs.google.com/presentation/d/1sGYD4OSUiGGZbwCw9nYTCWBJL1MFj9SlH1pC8z44Awc/edit?usp=sharing
videos:
Videos that go with this lesson that we watched:
Gene regulation and transcription factors: Professor Dave 13 minutes https://www.youtube.com/watch?v=J9jhg90A7Lw
Good Transcription and translation animation video 7 min: https://www.youtube.com/watch?v=8_f-8ISZ164
Extra information on all the transcription factors in the diagram in our textbooks: https://www.youtube.com/watch?v=2K2XcdLKMZo
Examples of mutations to discuss:
Point mutation - changes the amino acid - sickle cell anemia: https://www.medicalhomeportal.org/diagnoses-and-conditions/sickle-cell-disease
Cystic Fibrosis delt508 - removing an amino acid (whole codon)
-video clip showing the the proper functioning of the CFTR gene https://www.biointeractive.org/classroom-resources/cystic-fibrosis-mechanism-and-treatment
- video clip of effect of deletion 3 min: https://www.youtube.com/watch?v=Qk9Sw7e8fWE
- picture showing a whole codon is deleted: https://www.researchgate.net/figure/The-aF508-deletion-11_fig2_265454554
Tay-Sachs disease - Frames-shift and non-sense: https://docs.google.com/document/d/1_jIoV4hkSRwTnLcLkTWNzyEkrOkyrcrjlBEOfZBSKQM/edit?usp=sharing
List of diseases caused by Frame shift mutations: https://www.biologyonline.com/dictionary/frameshift-mutation
Lesson: Eukaryotic regulation of gene expression (over two days) - takes the place of reading the textbook chapters
**Lesson with homework questions: https://docs.google.com/document/d/1W2Mbcn6yVXPaD8J8uG5-PAOUCRFEumkVjQ_iMiBovnM/edit?usp=sharing
Mutations Kahoot:
https://create.kahoot.it/details/mutations/77d906e4-a6dd-4ce1-91b6-4fff6b945921
Good Kahoot on translation, 24 questions (question 1 and 25 are bad): https://create.kahoot.it/details/sbi4u-u3-protein-synthesis-review/9b974ea9-5f2d-4329-b30e-01d14c695dd9
Podcast assignment: https://docs.google.com/document/d/1chwNXS9fiJgIiAa3zMEafocoPAZjAwoNqIs_EV2Lv2s/edit?usp=sharing
DNA and RNA and discovery experiments 12 min, Mr. Anderson. https://www.youtube.com/watch?v=qoERVSWKmGk
Griffith's experiment: https://upload.wikimedia.org/wikipedia/commons/thumb/6/6a/Griffith_experiment.svg/675px-Griffith_experiment.svg.png
What Is the Secret of Life? A History of Biology and Genetics 49 minutes on learn 360.
PBS DNA 53 minutes https://www.youtube.com/watch?v=D8DDenDpiSU
Discovery of the double helix - 17 minutes: https://www.youtube.com/watch?v=1vm3od_UmFg
What is DNA? Mr. Anderson : https://www.youtube.com/watch?v=q6PP-C4udkA
Gel electrophoresis - Ameoba sisters: https://www.youtube.com/watch?v=ZDZUAleWX78
DNA sequencing - 5 min: https://www.youtube.com/watch?v=ONGdehkB8jU
Discuss 5' and 3' ends from this image: https://ars.els-cdn.com/content/image/3-s2.0-B9780123749840010871-f01087-01-9780123749840.jpg
Better 3D of replication - 4 min https://www.youtube.com/watch?v=TNKWgcFPHqw
- Read 24.3 - Homeostasis
Questions 15-22, written 32-35
- Read the student lab instructions handout
- Finish reading the presentation and come with any questions to class: https://docs.google.com/presentation/d/1mmTP699jAOclmRiW8Qa63y_MxpPx0VbD/edit?
Case study:
Start CRIPR case study (https://sciencecases.lib.buffalo.edu/collection/detail.html?case_id=1169&id=1169)
Skip all questions that reference Hwang et al - that paper is behind a paywall (skip part IV #7)
Living with Cystic Fibrois: https://www.youtube.com/watch?v=p2eaWTRCnp8
Cystic Fibrosis Visualization: https://www.youtube.com/watch?v=6IbP1ASGv9w
508 deletion mutation visualization: https://www.youtube.com/watch?v=Qk9Sw7e8fWE
delta Phe508 sequence data: https://www.ncbi.nlm.nih.gov/nuccore/NM_000492.2
CRISPR: https://www.youtube.com/watch?v=2pp17E4E-O8
4 min Crispr babies: https://www.youtube.com/watch?v=qUiNG1iW4Ww
Josiah Zayner - Bio Hacker - 6 min - https://www.youtube.com/watch?v=4vmHweDC5SY
What is CF: 4 min https://www.youtube.com/watch?v=8WUtkQCf_Ho
1 min CF gene editing: https://www.youtube.com/watch?v=nWj7Be6PSS4
OR
Lactose case study (Click through: https://www.biointeractive.org/classroom-resources/regulation-lactase-gene
Worksheet: https://www.biointeractive.org/classroom-resources/blood-glucose-data-analysis
15.5 - translation
Questions 21-16
Written 37-41 (39 has one letter amino acid codes that you need to look up).
Introduction to written assignment (due Sunday June 6).
Introduction to Biotechnology research project:
Instructions: https://docs.google.com/document/d/1u5WQVHhFu_6ZJxYu645bL-hPBHw5i_1WmE-dtMNeE78/edit?usp=sharing
Student Example: https://docs.google.com/document/d/1Vh5ci4Y9Zxcqf-vue_j8fBtDoOviUtFkY6O1vRMqjyc/edit?usp=sharing
Chapter 7 Review - page 358
Another review test with answers: https://drive.google.com/file/d/195izcLhz9SchsaWR7anrodMBRDEmd8iX/view?usp=sharing
Another review test with answers: https://drive.google.com/file/d/1diatenweKIAmW1lX2PIlNJ0MPOd5m7bH/view?usp=sharing
CRISPR lesson
4 min CRISPR babies in China: https://www.youtube.com/watch?v=qUiNG1iW4Ww
6 min Josiah Zayner - Bio Hacker: https://www.youtube.com/watch?v=4vmHweDC5SY
Howard Hughes interactive lesson:
https://www.biointeractive.org/classroom-resources/crispr-cas-9-mechanism-applications
Homework questions to go with above lesson:
https://docs.google.com/document/d/1nWDTLcbmu7OPmt9DNIC-DLuxtfim1IY833OE7_8zF_Y/edit?usp=sharing
Optional:
Mr. Anderson - CRISPR 7 min
https://www.youtube.com/watch?v=MnYppmstxIs
Short CRISPR article
http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
Longer articlehttp://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/