Sickle Cell Disease (SCD) is a genetic condition which affects the hemoglobin of red blood cells (RBCs)4 and has high precedence in low income, rural communities. Current treatments include medications, blood transfusions, and sometimes bone-marrow transplants, but there are still no cures for the disease. The aim of this project was to develop an inexpensive, accurate, and time efficient method to detect and quantify the amount of sickled hemoglobin in a blood sample. The method for achieving these tasks was accomplished utilizing the electrochemical technique of cyclic voltammetry to differentiate the unique redox potentials of wild-type and sickled hemoglobin. Our design was based upon a miniature potentiostat featuring the LMP91000 potentiostat chip and SAMD21 microcontroller, which read potentials from a tri-electrode printed circuit board (PCB) setup.