SELECTED ARTICLES IN PEER-REVIEWED JOURNALS  

1.   Xia X.D., Gill G., Lin H., Roth, D.M., Gu H.M., Wang X.J., Su F.Y., Alabi A., Alexiou M., Zhang Z., Wang G.Q., Graf D., and Zhang D.W. Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis. Matrix Biology. 2023, Aug 18; S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. PMID: 37598898.

2. Sabir U., Gu H.M., and Zhang D.W. Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases (MMPs) in liver fibrosis. Phytotherapy Research. 2023 Jul 17. doi: 10.1002/ptr.7959. 

3. Wang, S., Long, H., Hou, L., Feng,  B., Ma, Z., Ying, W., Yu, Z., Cai, J., Zhang, D.W. and Zhao, G.  The mitophagy pathway and its implications in human diseases. Signal Transduction and Targeted Therapy. 2023, 8, 304 (2023). https://doi.org/10.1038/s41392-023-01503-7 (co-corresponding author). 

4. Tao G., Wang H., Shen Y., Zhai L., Liu B., Wang B., Chen W., Xing S., Chen Y., Gu H.M., Qin S., and Zhang D.W. Surf4 deficiency reduces intestinal lipid absorption and secretion and decreases metabolism in mice. Arterioscler Thromb Vasc Biol. 2023 Apr;43(4):562-580. doi: 10.1161/ATVBAHA.123.318980.

5. Amadi P.U., Gu H.M., Yin K., Jiang X.C., and Zhang D.W. Editorial: Lipid Metabolism and human diseases. Front. Physiol. 2022. doi: 10.3389/fphys.2022.1072903.

6. Shen Y., Gu H.M., Qin S., Zhang D.W. Surf4, cargo trafficking, lipid metabolism, and therapeutic implications. J Mol. Cell Biol. 2022. Nov 29. 14 (9): mjac063. doi: 10.1093/jmcb/mjac063. PMID: 36574593.

7. Shen Y, Gu HM, Zhai L, Wang B, Qin S, Zhang DW. The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE−/− mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Oct; 1867(10): 159196. doi: 10.1016/j.bbalip.2022.159196. Epub 2022 Jul 5.

8. Wang M., Alabi A., Gu H.M., Gill G., Zhang Z., Jarad S., Xia X.D., Shen Y., Wang G.Q., and Zhang D.W. Identification of amino acid residues in MT1-MMP important for its ability to cleave LDLR. Front. Cardiovasc. Med.  2022 Aug 25; 9:917238. doi: 10.3389/fcvm.2022.917238. eCollection 2022. PMID: 36093157

9. Jiang M, Zhao XM, Jiang ZS, Wang GX, Zhang DW. Protein tyrosine nitration in atherosclerotic endothelial dysfunction. Clin Chim Acta. 2022 Feb 9; 529:34-41. doi: 10.1016/j.cca.2022.02.004.

10. Chang X., Zhao Y., Qin S., Wang H., Wang B., Zhai L., Liu B., Gu H.M., Zhang D.W Loss of hepatic Surf4 depletes lipid droplets in the adrenal cortex but does not impair adrenal hormone production. Frontiers in Cardiovascular Medicine. 2021.  Nov 11;8:764024. doi: 10.3389/fcvm.2021.764024. eCollection 2021. PMID: 34859075.

11. Xia X.D., Peng Z.S., Gu H.M., Wang M., Wang G.Q., Zhang D.W. Regulation of PCSK9 expression and function: mechanisms and therapeutic implications. Frontiers in Cardiovascular Medicine. Front. Cardiovasc. Med., 2021 Oct 15;8:764038. doi: 10.3389/fcvm.2021.764038. eCollection 2021. PMID: 34782856.

12. Xia X.D., Alabi A., Wang M., Gu H.M., Yang R., Wang G., Zhang D.W. Membrane-type I matrix metalloproteinase (MT1-MMP), lipid metabolism and therapeutic implications. J Mol. Cell Biol. 2021, Oct 21;13(7):513-526. doi: 10.1093/jmcb/mjab048. PMID: 34297054 

13. Wang B., Shen Y., Zhai L., Xia X., Gu H.M., Wang M., Zhao Y., Chang X., Alabi A., Xing S., Deng S., Liu B., Wang G., Qin S., Zhang D.W. Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4. J Lipid Res. 2021, June 9. 62:100091  doi.org/10.1016/j.jlr.2021.100091 PMID: 34118252 

14. Hu, M.; Jana, S.; Kilic, T.; Wang, F.; Shen, M.; Winkelaar, G.; Oudit, G. Y.; Rayner, K.; Zhang, D. W.; Kassiri, Z. Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels. Arterioscler Thromb Vasc Biol. 2021 Jun; 41(6):1874-1889 doi:10.1161/ATVBAHA.120.315522 

15. Alabi A., Xia XD, Gu H.M., Wang, F., Deng S.J., Yang N., Adijiang A., Douglas D.N., Kneteman N.M., Xue Y., Chen L., Qin S., Zhang D.W. Membrane type 1 matrix metalloproteinase promotes ectodomain shedding of low-density lipoprotein receptor and accelerates the development of atherosclerosis. Nature Communications. 2021 Mar 25;12(1):1889. doi: 10.1038/s41467-021-22167-3. PMID: 33767172 

16. Guo S., Xia X., Gu HM., Zhang DW. Proprotein Convertase Subtilisin/Kexin-Type 9 and Lipid Metabolism. Adv Exp Med Biol. 2020;1276:137-156. doi: 10.1007/978-981-15-6082-8_9. PMID: 32705598

17. Deng SJ, Shen Y, Gu HM, Guo S, Wu SR, Zhang DW. The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jun;1865(6):158660. doi: 10.1016/j.bbalip.2020.158660. Epub 2020 Feb 11. PMID: 32058034

18. Shen Y, Wang B, Deng S, Zhai L, Gu HM, Alabi A, Xia X, Zhao Y, Chang X, Qin S, Zhang DW. Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158555.doi: 10.1016/j.bbalip.2019.158555. Epub 2019 Oct 30. PMID: 31676436 

19. Ou X, Gao JH, He LH, Yu XH, Wang G, Zou J, Zhao ZW, Zhang DW, Zhou ZJ, Tang CK. Angiopoietin-1 aggravates atherosclerosis by inhibiting cholesterol efflux and promoting inflammatory response. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct 31;1865(2):158535. 

20. Gao JH, He LH, Yu XH, Zhao ZW, Wang G, Zou J, Wen FJ, Zhou L, Wan XJ, Zhang DW, Tang CK. CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway. J Lipid Res. 2019 Oct 29. pii: jlr.RA119000100. doi: 10.1194/jlr.RA119000100. [Epub ahead of print]

21. Xie W, Li L, Gong D, Zhang M, Lv YC, Guo DM, Zhao ZW, Zheng XL, Zhang DW, Dai XY, Yin WD, Tang CK. Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo. Atherosclerosis. 2019 Aug 26;289:143-161.

22. Deng SJ, Alabi A, Gu HM, Adijiang A, Qin S, Zhang DW. Identification of amino acid residues in the ligand-binding repeats of LDLR important for PCSK9 binding. J Lipid Res. 2019 Mar;60(3):516-527. doi: 10.1194/jlr.M089193. Epub 2019 Jan 7. PMID: 30617148 

23. Tang SL, Zhao ZW, Liu SM, Wang G, Yu XH, Zou J, Wang SQ, Dai XY, Fu MG, Zheng XL, Zhang DW, Fu H, Tang CK. Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation. Circ J. 2019 Feb;83(3):515-523. 

24. Yu XH, Zhang DW, Zheng XL, Tang CK. Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis. Prog Lipid Res. 2018 Jan; 73:65-91. 

25. Gong D, Zhang Q, Chen LY, Yu XH, Wang G, Zou J, Zheng XL, Zhang DW, Yin WD, Tang CK. Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression. Eur J Pharmacol. 2019 Jan;843:177-189   

26. Yu XH, Zhang DW, Zheng XL, Tang CK. Itaconate: an emerging determinant of inflammation in activated macrophages. Immunol Cell Biol. 2019 Feb; 97(2): 134-141 

27. Yu XH, He LH, Gao JH, Zhang DW, Zheng XL, Tang CK. Pregnancy-associated plasma protein-A in atherosclerosis: Molecular marker, mechanistic insight, and therapeutic target. Atherosclerosis. 2018 Nov; 278:250-258. 

28. Yu XH, Zhang DW, Zheng XL, Tang CK. C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential. Atherosclerosis. 2018 276:109

29. Chen LY, Xia XD, Zhao ZW, Gong D, Ma XF, Yu XH, Zhang Q, Wang SQ, Dai XY, Zheng XL, Zhang DW, Yin WD, Tang CK. MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice. Circ J. (2018) 82(11):2861-2871.

30. Wang JL, Gong D, Hu XY, Wu S, Zheng XL, Wu J, Tang XE, Zhang DW, Tang CK. ApoA-1 Mimetic Peptide ELK-2A2K2E Decreases Inflammatory Factor Levels via the ABCA1-JAK2-STAT3-TTP Axis in THP-1-Derived Macrophages. J Cardiovasc Pharmacol. (2018) 72: 60-67

31. Zhao ZW, Zhang M, Chen LY, Gong D, Xia XD, Yu XH, Wang SQ, Ou X, Dai XY, Zheng XL, Zhang DW, Tang CK. Shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway. Biochim Biophys Acta--molecular and cell biology of lipid.(2018) 1863:806

32. Gao JH, Zeng MY, Yu XH, Zeng GF, He LH, Zheng XL, Zhang DW, Ouyang XP, Tang CK. Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-κB/miR-33a pathway in THP-1 macropahge-derived foam cells. Biochem Biophys Res Commun. (2018) 500:318

33. Gu H.M., Wang F., Alabi A., Deng S., Qin S., and Zhang D.W. Identification of an amino acid residue critical for plasma membrane localization of ATP-binding cassette transporter G1. Arterioscler Thromb Vasc Biol. (2016) 36: 253.

34. Gu H.M., Zhang D.W.  Hypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9 J. J Biomed Res. (2015) 29(5):356-61 

35. Yao S., Tian H., Miao C., Zhang D.W., Zhao L., Li Y., Yang N., Jiao P., Sang H., Guo S., Wang Y., Qin S. (2015) D4F alleviates macrophage-derived foam cell apoptosis by inhibiting endoplasmic reticulum stress-CHOP pathway. J. Lipid Res. 2015 56:836-847 

36. Wang X, Berry E, Hernandez-Anzaldo S, Sun D, Adijiang A, Li L, Zhang D, Fernandez-Patron C. (2015) MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells. FEBS Lett. 2015 589:490-496.

37. Wang F.Q. Gu H.M and Zhang D.W.  (2014) The role of ATP-binding cassette transporters in cell cholesterol efflux. Chemistry of Life. (Invited review. Senior author). 43: 354-365

38. Wang F., Gu H.M., and Zhang D.W. (2014) Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux. (2014) Cardiovasc Hematol Disord Drug Targets. 14: 142-8 

39. Gu H. M., Wang F.Q. and Zhang D.W.  (2014) Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux. Biochim Biophys Acta--molecular and cell biology of lipid. 1841: 847-58  (Senior author)  

40. Li Y, He PP, Zhang DW, Zheng XL, Cayabyab FS, Yin WD, Tang CK. (2014) Lipoprotein lipase: from gene to atherosclerosis. Atherosclerosis. 2014; 237:597-608 

41. Lv YC, Tang YY, Peng J, Zhao GJ, Yang J, Yao F, Ouyang XP, He PP, Xie W, Tan YL, Zhang M, Liu D, Tang DP, Cayabyab FS, Zheng XL, Zhang DW, Tian GP, Tang CK. (2014) MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis. 236:215-226. 

42. Zhang M, Wu JF, Chen WJ, Tang SL, Mo ZC, Tang YY, Li Y, Wang JL, Liu XY, Peng J, Chen K, He PP, Lv YC, Ouyang XP, Yao F, Tang DP, Cayabyab FS, Zhang DW, Zheng XL, Tian GP, Tang CK (2014) MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Atherosclerosis. 234:54-64. 

43. Wu JF, Wang Y, Zhang M, Tang YY, Wang B, He PP, Lv YC, Ouyang XP, Yao F, Tan YL, Tang SL, Tang DP, Cayabyab FS, Zheng XL, Zhang DW, Zeng GF, Tang CK. (2014) Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3-K/PKCζ/SP1 pathway in THP-1 macrophages. Biochem Biophys Res Commun. 444: 325-31 

44. Tian G.P., Tang Y.Y., He P.P., Lv Y.C., Ouyang X.P., Zhap G.J., Tang S.L., Wu J.F., Wang J.L., Peng J., Zhang M., Yuan-Li, Cayabyab F.S., Zheng X.L., Zhang D.W., Yin W.D., Tang C.K. (2013) The effects of miR-467b on lipoprotein lipase (LPL) expression, pro-inflammatory cytokine and lipid levels and atherosclerotic lesions in apolipoprotein E knockout mice. Biochem Biophys Res Commun. 2014, 443: 428-34 

45. Wang F., Li G., Gu H.M., and Zhang D.W. (2013) Characterization of the role of a highly conserved sequence in ATP binding cassette transporter G (ABCG) family in ABCG1 stability, oligomerization and trafficking. Biochemistry. 52: 9497-509 (senior author) 

46. Gu H.M. Adijiang A., Mah M., and Zhang D.W. (2013) Characterization of the role of EGF-A of low-density lipoprotein receptor in PCSK9 binding. Journal of Lipid Research. 54: 3345-57 (Senior author) 

47. Li G., Gu H.M., and Zhang D.W. (2013) ATP-binding cassette transporters and cholesterol translocation. IUBMB Life. 65: 505-12 (Invited Critical Review, Senior author) 

48. Gu H.M., Li G, Gao X, Berthiaume LG and Zhang D.W. (2013) Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function. BBA-molecular and cell biology of lipid. 1831:1067-78 (Senior author) 

49. Zhao G.J., Tang S.L., Lv Y.C., Ouyang X.P., He P.P., Yao F., Chen W.J., Lu Q., Tang Y.Y., Zhang M., Fu Y., Zhang D.W., Yin K., Tang C.K. Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression. PLoS One. 2013 Sep 25;8(9):e74782. doi: 10.1371/journal.pone.0074782. 

50. Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK. (2014) Apelin and its receptor APJ in cardiovascular diseases. . Clin Chim Acta. 428C:1-8 (15)

51. Yu XH, Fu YC, Zhang DW, Yin K, Tang CK (2013) Foam cells in atherosclerosis. Clin Chim Acta. 424: 245-52 

52. Lu Q, Tang SL, Liu XY, Zhao GJ, Ouyang XP, Lv YC, He PP, Yao F, Chen WJ, Tang YY, Zhang M, Zhang DW, Yin K, Tang CK. Tertiary-Butylhydroquinone Upregulates Expression of ATP-Binding Cassette Transporter A1 via Nuclear Factor E2-Related Factor 2/Heme Oxygenase-1 Signaling in THP-1 Macrophage-Derived Foam Cells. Circ J. 2013; 77(9): 2399-408 

53. Lv YC, Yin K, Fu YC, Zhang DW, Chen WJ, Tang CK. Posttranscriptional Regulation of ATP-Binding Cassette Transporter A1 in Lipid Metabolism. DNA Cell Biol. 2013 Jul;32(7):348-58 

54. Liu XY, Lu Q, Ouyang XP, Tang SL, Zhao GJ, Lv YC, He PP, Kuang HJ, Tang YY, Fu Y, Zhang DW, and Tang CK (2013) Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells. Atherosclerosis  226:398-407 

55. Chen W.J. Zhang M., Zhao G.J., Fu Y., Zhang D.W., Zhu H.B., and Tang C.K. (2013) MicroRNA-33 in atherosclerosis etiology and pathophysiology. Atherosclerosis  227: 201-8 

56. Gao X, Gu H.M, Li G, Rye K.A., and Zhang D.W. (2012) Identification of an amino acid residue in ATP-binding cassette transport G1 critical for mediating cholesterol efflux. BBA-molecular and cell biology of lipid. 1821:552-9 (Senior author) 

57. Tian G.P., Chen W.J., He P.P., Tang, S.L., Zhao G.J., Lv Y.C., Ouyang X.P., Yin K., Wang P.P., Cheng H., Chen Y., Huang S.L., Fu Y., Zhang D.W., Yin, WD., and Tang C.K. (2012) MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion. Biochimie. 94: 2749-55. 

58. Yu X.H., Jiang H.L., Chen W.J., Yin K., Zhao G.J., Mo Z.C., Ouyang X.P., Lv Y.C., Jiang Z.S., Zhang D.W., and Tang C.K. (2012) Interleukin-18 and Interleukin-12 Together Downregulate ATP-Binding Cassette Transporter A1 Expression Through the Interleukin-18R/Nuclear Factor-κB Signaling Pathway in THP-1 Macrophage-Derived Foam Cells. Circulation J. 76: 1780-91. 

59. Zhang D.W., Garuti R., Tang W., Cohen J.C., and Hobbs H.H. (2008) Structural Requirements for PCSK9-Mediated Degradation of the Low Density Lipoprotein Receptor. Proc. Natl. Acad. Sci. U S A. 105:13045-50. 

60. Wang J., Zhang D.W., Lei Y., Xu F., Cohen J.C., Hobbs H.H., and Xie X.S. (2008) Purification and reconstitution of sterol transport by native mouse ABCG5 and ABCG8. Biochemistry. 47:5194-204. (

61. Zhang D.W., Lagace T.A., Garuti R., Zhao Z., McDonald M., Horton J.D., Cohen J.C., and Hobbs H.H. (2007) Binding of PCSK9 to EGF-A repeat of LDL receptor decreases receptor recycling and increases degradation. J. Biol. Chem. 282: 18602-12. 

62. Wang J., Sun F., Zhang D.W., Ma Y., Xu F., Belani J.D. Cohen J.C., Hobbs H.H., and Xie X.S.(2006) Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution. J. Biol.  Chem. 281: 27894-904. 

63. Zhang D.W., Graf G.A., Gerard R.D., Cohen J.C., Hobbs H.H., and Xie X.S.(2006) Functional asymmetry of nucleotide binding domains (NBD) in ABCG5 and ABCG8. J. Biol. Chem. 281: 4507-16. 

64. Zhang D.W., Nunoya K., Vasa M., Gu H.M., Cole S.P.C. and Deeley R.G. (2006) Characterization of the role of polar amino acid residues within predicted transmembrane helices 10 and -16 in determining the substrate specificity of Multidrug Resistance Protein 1 (ABCC1).  Drug Metab. Dispos. 34: 539-46. 

65. Zhang D.W., Nunoya K., Vasa M., Gu H.M., Theis A., Cole S.P.C., and Deeley R.G. (2004) Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1. Biochemistry. 43: 9413-25. 

66. Situ D., Haimeur A., Conseil G., Sparks K.E., Zhang D.W., Deeley R.G., and Cole S.P.C. (2004) Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. J. Biol. Chem. 279: 38871-80. 

67. Zhang D.W., Gu H.M, Situ D., Haimeur A., Cole S.P.C., and Deeley R.G. (2003) Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. J.  Biol.  Chem. 278: 46052-63. 

68. Zhang D.W., Gu H.M, Vasa M., Muredda M., Cole S.P.C., and Deeley R.G. (2003) Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of Multidrug Resistance Protein 3 (ABCC3). Biochemistry. 42: 9989-10000. 

69. Nunoya K., Grant C.E., Zhang D.W., Cole S.P.C., and Deeley R.G. (2003) Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab. Dispos. 31: 1016-26. 

70. Qian Y.M., Grant C.E., Westlake C.J., Zhang D.W., Lander P.A., Shephard R.L., Dantzig A.H., Cole S.P.C., and Deeley R.G. (2002)  Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione. J.  Biol. Chem. 277: 35225-35231. 

71. Zhang D.W., Cole S.P.C., and Deeley R.G. (2002) Determinants of the substrate specificity of multidrug resistance protein1 (MRP1): Role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. J. Biol. Chem. 277:  20934-20941. 

72. Zhang D.W., Cole S.P.C., and Deeley R.G. (2001) Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17. J. Biol. Chem. 276: 34966-34974. 

73. Zhang D.W., Cole S.P.C., and Deeley R.G. (2001) Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. J. Biol. Chem. 276: 13231-13239.