Bugie's Publications

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Action of Antibiotic Substances Upon Ceratostotnella ulmi (1943)

Determined the effect of seven antibiotic substances upon Ceratostmella ulmi, the causative agent of Dutch elm disease.
Found that actinomycin and clavacin had a strong effect upon the fungus, while penicillin and streptothricin had no effect.
Determined that certain nutrients in the medium provide a neutralizing effect of the antibiotics to C. ulmi.

Action of Antibiotic Substances Upon Ceratostotnella ulmi.pdf

Strain Specificity and Production of Antibiotic Substances. II. Aspergillus flavus-oryzae Group (1943).pdf

Strain Specificity and Production of Antibiotic Substances. II. Aspergillus flavus-oryzae Group (1943)

Compared different strains of fungi in the Aspergillus flavus-oryzae group.
Investigated whether these strains could produce antibiotic substances.
Demonstrated that not all strains behave the same and some produce useful antimicrobial compounds, while others do not.

Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria (1944)

Introduced streptomycin as a newly discovered antibiotic produced by Streptomyces griseus.
Demonstrated activity against both Gram-positive and Gram-negative bacteria.
Compared its effectiveness to other antibiotics, showing broader antibacterial activity.

Streptomycin, a Substance Exhibiting Antibiotic Activity against Gram-Positive and Gram-Negative Bacteria.pdf

Bacteriostatic and Bactericidal Properties of Antibiotic Substances with Special Reference to Plant-Pathogentic Bacteria (1944) .pdf

Bacteriostatic and Bactericidal Properties of Antibiotic Substances with Special Reference to Plant-Pathogenic Bacteria (1944)

Examined how antibiotic substances inhibit or kill different types of bacteria.
Demonstrated that antibiotics vary in their effectiveness depending on the organism.
Introduced the idea of an “antibiotic spectrum,” describing how certain antibiotics selectively act on certain bacteria.

Chaetomin, A New Antibiotic Substance Produced by Chaetomium cochliodes (1944)

Identified chaetomin, an antibiotic produced by the fungus Chaetomium cochliodes.
Demonstrated C. cochliodes can produce substances that inhibit microbial growth.
Contributed to early efforts to explore microorganisms as sources of antibiotics.

CHAETOMIN, A NEW ANTIBIOTIC SUBSTANCE PRODUCED BY CHAETOMIUM COCHLIODES.pdf

Micromonosporin, An Antibiotic Substance From A Little-Known Group of Microorganisms (1946) .pdf

Micromonosporin, An Antibiotic Substance From A Little-Known Group of Microorganisms (1946)

Identified a new antibiotic, micromonosporin, from Micromonospora bacteria.
Tested its antibacterial activity, mainly against Gram-positive bacteria.
Described how the antibiotic is produced, extracted, and its chemical properties.

The Effect of Penicillin On The Growth of Mycobacterium tuberculosis in Dubos Medium (1948)

Tested how penicillin affects the growth of Mycobacterium tuberculosis.
Found that high concentrations of penicillin could inhibit M. tuberculosis.
Showed effectiveness depends on bacterial amount (with smaller samples being more sensitive).

The Effect of Penicillin On The Growth of Mycobacterium Tuberculosis in Dubos Medium (1948) .pdf

Masters Thesis: Production of antibiotic substances by Aspergillus flavus and Chaetomium cochliodes (1944)

References

Bugie E, Waksman SA. 1943. Action of Antibiotic Substances Upon Ceratostotnella ulmi. Proceedings of the Society for Experimental Biology and Medicine. 54(1):79-82. https://journals.sagepub.com/doi/abs/10.3181/00379727-54-14310

Bugie E. 1944. Production of antibiotic substances by Aspergillus flavus and Chaetomium cochliodes [thesis]. Rutgers University. https://rutgers.primo.exlibrisgroup.com/discovery/fulldisplay?vid=01RUT_INST:01RUT&docid=alma991014836289704646

Waksman SA, Bugie E. W. Strain Specificity and Production of Antibiotic Substances: II. Aspergillus Flavus-Oryzae Group. Proc Natl Acad Sci USA. 29(9):282-288. https://doi.org/10.1073/pnas.29.9.282

Schatz A, Bugle E, Waksman SA. 1944. Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria. Proceedings of the Society for Experimental Biology and Medicine. 55(1):66–69. https://doi.org/10.3181/00379727-55-14461

Solotorovsky M, Bugie EJ, Frost BM. 1948. The Effect of Penicillin on the Growth of Mycobacterium tuberculosis in Dubos’ Medium. J Bacteriol. 55(4):555–559. https://doi.org/10.1128/jb.55.4.555-559.1948

Waksman SA, Bugie E. 1944. Chaetomin, a New Antibiotic Substance Produced by Chaetomium cochliodes: I. Formation and Properties. J Bacteriol. 48(5):527-530. https://doi.org/10.1128/jb.48.5.527-530.1944

Waksman SA, Bugie E, Reilly HC. 1944. Bacteriostatic and Bactericidal Properties of Antibiotic Substances, with Special Reference to Plant-Pathogenic Bacteria. Bulletin of the Torrey Botanical Club. 71(2):107-121. https://doi.org/10.2307/2481411

Waksman SA, Geiger WB, Bugie E. 1947. Micromonosporin, an Antibiotic Substance from a Little-known Group of Microorganisms. J Bacteriol. 53(3):355–357. https://doi.org/10.1128/jb.53.3.355-357.1947

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