Welcome to our Ethical Considerations in Research for Animal Subjects page. This webpage will walk you through the essential principles of ethics for both human and animal subjects. We aim to help you navigate the ethical complexities of research, empowering you to conduct studies that are both responsible and impactful.*
Along your educational journey, supplemental material (external to this website) may be linked for additional clarification or consideration. This supplemental material is recommended but not required. At the end of the module please choose one of two options, to move to the next module (Research Methodology) or take the Ethical Considerations Exam for Animal Subjects.
There is a table of contents to improve the navigability of this material.
If you have questions about the material provided please email irb@transy.edu.
TABLE OF CONTENTS
Ethical considerations in animal subject research are paramount to ensuring that the ethical treatment and welfare of animal subjects are respected and protected. Adhering to ethical guidelines safeguards animals from harm and enhances the credibility and integrity of research findings. By understanding and implementing ethical principles, researchers can foster trust, uphold the highest standards of scientific inquiry, and contribute to the advancement of knowledge responsibly and respectfully.*
In the following two presentations, you will be introduced to the IACUC -- the Institutional Animal Care and Use Committee. Following that are links to government resources mentioned in the videos.
Now that you know a little bit about the IACUC, this next video (to the right) will talk you through the governing principles that guide the work, recommendations, and decisions of IACUCs.
Next, below, you will find guidelines about the ethical handling of animals in laboratory settings which comes from The Guide for the Care and Use of Laboratory Animals published by the Office of Laboratory Animal Welfare.
Directly from the Office of Laboratory Animal Welfare
The Guide for the Care and Use of Laboratory Animals (Guide) includes standards and practice standards.
Guide_8th_v1 “Recommendations in the Guide are based on published data, scientific principles, expert opinion, and experience with methods and practices that have proved to be consistent with both high-quality research and humane animal care and use.” (Guide, Preface)
The Guide is intended to provide institutions in caring for and using animals in ways judged to be scientifically, technically, and humanely appropriate. The guide includes descriptions of institutional responsibilities and professional standards.
Institutional responsibilities include monitoring animal care and use, provisions for veterinary care, training for personnel, and the establishment of an appropriate occupational health and safety program.
Professional standards encompass the animal environment, animal husbandry and management, veterinary care, and design and construction of animal facilities.
Familiarity with the standards and recommendations of the Guide is important because the PHS Policy mandates that institutions use the Guide as a basis for developing and implementing an animal care and use program.
When institutions house animals they become responsible for many apsects of their care, including veterinary care. Below are guidelines that IACUCs use to determine that adequate veterinary care is being provided to such animals.
This comes directly from the Office of Laboratory Animal Welfare:
Veterinary care is important to provide for all animals housed at the intuition, or animals that may experience pain or distress as a result of the planned activities.
Each institution will have their own arrangements for veterinary care. Some will have full time veterinarians to care for the animals – generally larger research institutions and universities. Others may have part-time veterinarians or consultant veterinary services.
According to the Office of Laboratory Animal Research, the veterinary care program should contain the following components: access to all animals and periodic assessment of animal well-being; appropriate facilities, personnel, equipment, and services; treatment of diseases and injuries, and the availability of emergency, weekend and holiday care; guidelines for animal procurement and transportation; preventive medicine; presurgical planning, training, monitoring, and postsurgical care; relief of pain and distress including selection of analgesics, anesthetics, and tranquilizers; methods of euthanasia; and drug storage and control.
The attending veterinarian has authority to implement the veterinary care program, and to oversee the adequacy of all other aspects of animal care and use, e.g, animal husbandry, nutrition, sanitation practices, zoonosis control, and hazard containment.
The American College of Laboratory Animal Medicine's (ACLAM) Guidelines for Adequate Veterinary Care is a recommended reference on the topic of veterinary care.
In addition to providing veterinary care instiutitons must also house animals, which includes providing adequate enclosures for them, adequate enrichment, and best practices for ensuring santary and safe environments.
According to the Office of Laboratory Animal Welfare, a program of animal care and use will include attention to:
--aspects of the physical plant where animals are housed such as location, components, construction, management, and operation;
--the physical and social environment of the animals;
--animal husbandry which encompasses food, water, bedding, sanitation, waste disposal, and pest control;
--animal identification, genetic monitoring, and animal health records; and
--daily observation of and care for animals, including weekends and holidays.
Some studies involve potential for pain and death to the aninals that participate in them. For these studies it is crucial that a plan for humane euthansai be in place to protect the welfare of the animals involved.
The PHS Policy requires that euthanasia be conducted in a manner that is consistent with the professional guidance for relieving pain and suffering of animals found in the American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals (PDF). These Guidelines are updated from time to time.
The Guidelines discuss only methods and agents supported by data from scientific studies. They emphasize professional judgment, technical proficiency, and humane handling of the animals. Deviations from the Guidelines are permitted by the PHS Policy only if the IACUC determines that they are justified for scientific reasons.
Animals can sometimes pose a risk to the safety and welfare of the people who work with them. Therefore, it is important to consider safety for staff as well.
According to the Office of Laboratory Animal Welfare, an effective occupational health and safety program must encompass all personnel that have contact with animals. Depending on the facility, research activities, hazards, and animal species involved, the program may not affect all personnel equally.
Minimally, the program should include: pre-placement medical evaluation; identification of hazards to personnel and safeguards appropriate to the risks associated with the hazards; appropriate testing and vaccinations; training of personnel regarding their duties, any hazards, and necessary safeguards; policies and facilities that promote cleanliness; provisions for treating and documenting job-related injuries and illnesses; facilities, equipment, and procedures designed, selected, and developed to reduce the possibility of physical injury or health risk to personnel; good personal hygiene practices, prohibiting eating and drinking, use of tobacco products, and application of cosmetics and/or contact lenses in animal rooms and laboratories; and personal protective equipment (PPE).
In this video you will find information about applying for IACUC approval at Transy. It will talk you through the different sections of the IACUC and what will happen once you submit an application. Below you will find links to the application as well as a sample IACUC.
Note: References are hyperlinked to original sources. Written text that ends with an "*" was created in part using OpenAI. (2023). ChatGPT 4o [Large language model]. https://chat.openai.com/chat or Anthropic. (2023) Claude Opus [Large language model]. https://claude.ai/chats