研究業績（論文）

Futai E, Shiina M, Dai Y, Daoudi K, Hidaka M, Ogawa T (2025) Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase, J. Vis. Exp., 24:(220). doi:10.3791/67733.

Osathanunkul M, Thanaporn S, Karapetsi L, Nteve GM, Pratsinakis E, Stefanidou E, Lagiotis G, Avramidou E, Zorxzobokou L, Tsintzou G, Athanasiou A, Mpelai S, Constandinidis C, Pantiora P, Merino M, Mullor JL, Dobrovic L, Cerasino L, Ogawa T, Tsaousi M, Rodrigues AMC, Cardoso H, Pires R, Figueiredo D, Costa IF, Anjos C, Labrou NE, Madesis P (2025) Diversity of Bioactive Compounds in Microalgae: Key Classes and Functional Applications, Mar. Drugs.,23:222. doi:10.3390/md23060222.

Wan YC, Kong ZL, Wu YS, Huang CN, Ogawa T, Lin JT, Yang DJ (2025) Establishment of appropriate conditions for the efficient determination of multiple mycotoxins in tea samples and assessment of their drinking risks, Food Chem., 463:141438. doi:10.1016/j.foodchem.2024.141438. 

二井 勇人, 小川 智久 (2025) ヘビ毒成分によるアルツハイマー病予防への期待　ベノミクス創薬の可能性（解説），化学と生物，63巻8号: p361-368.

Wang Z, Yang Z, Shishido M, Daoudi K, Hidaka M, Tateno H, Futai E, Ogawa T (2024) Microcystis viridis NIES-102 Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein-Protein Interaction, Int. J. Mol. Sci. 25:6696. doi:10.3390/ijms25126696.

Hua Z, Watanabe R, Fukunaga T, Matsui Y, Matsuoka M, Yamaguchi S, Tanabe SY, Yamamoto M, Tamura-Kawakami K, Takagi J, Kajita M, Futai E, Shirakabe K (2024) C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility, Biochem. Biophys. Res. Commun., 696:149504. doi: 10.1016/j.bbrc.2024.149504.

Sato T, Futai E, Hidaka M, Ogawa T. Identification of disulfide-rich peptides from habu venom to regulate the activity of integrins.  Peptide Sciense 2023 33-36 (2024). 

Futai E, Kawasaki H, Sato S, Daoudi K, Hidaka M, Tomita T, Ogawa T (2023) A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site, Toxins (Basel), 15:500. doi: 10.3390/toxins15080500.

Suzuki R, Takahashi H, Yoshida C, Hidaka M, Ogawa T, Futai E, Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production, Int. J. Mol. Sci., 24:3970. doi: 10.3390/ijms24043970.

Watari H, Kageyama H, Masubuchi N, Nakajima H, Onodera K, Focia PJ, Oshiro T, Matsui T, Kodera Y, Ogawa T, Yokoyama T, Hirayama M, Hori K, Freymann DM, Imai M, Komatsu N, Araki M, Tanaka Y, Sakai R (2023) A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation, Nat. Commun, 13:7262. doi: 10.1038/s41467-022-34921-2.

Watanabe H, Yoshida C, Hidaka M, Ogawa T, Tomita T, Futai E (2022) Specific Mutations in Aph1 Cause γ-Secretase Activation, Int. J. Mol. Sci., 23:507. doi: 10.3390/ijms23010507.

Isomoto A, Shoguchi E, Hisata K, Inoue J, Sun Y, Inaba K, Satoh N, Ogawa T, Shibata H (2022) Active Expression of Genes for Protein Modification Enzymes in Habu Venom Glands, Toxins (Basel), 14:300. doi: 10.3390/toxins14050300.

Ghanem N, Kanagami N, Matsui T, Takeda K, Kaneko J, Shiraishi Y, Choe CA, Uchikubo-Kamo T, Shirouzu M, Hashimoto T, Ogawa T, Matsuura T, Huang PS, Yokoyama T, Tanaka Y (2022) Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain, FEBS J., 289:3505-3520. doi: 10.1111/febs.16354. Epub 2022 Feb 16.

Ogawa T, Tobishima Y, Kamata S, Matsuda Y, Muramoto K, Hidaka M, Futai E, Kuraishi T, Yokota S, Ohno M, Hattori S (2021) Focused Proteomics Analysis of Habu Snake (Protobothrops flavoviridis) Venom Using Antivenom-Based Affinity Chromatography Reveals Novel Myonecrosis-Enhancing Activity of Thrombin-Like Serine Proteases, Front. Pharmacol., 12:766406. doi: 10.3389/fphar.2021.766406. 

Ogawa T, Sato R, Naganuma T, Liu K, Sato S, Sakaue S, Osada M, Yoshimi K, Muramoto K (2021) Diversified Biomineralization Roles of Pteria penguin Pearl Shell Lectins as Matrix Proteins, Int. J. Mol. Sci., 22:1081. doi: 10.3390/ijms22031081.

Ishida K, Tsukamoto Y, Horitani M, Ogawa T, Tanaka Y. (2021) Biochemical properties of CumA multicopper oxidase from plant pathogen, Pseudomonas syringae, Biosci. Biotechnol. Biochem., 85:1995-2002. doi: 10.1093/bbb/zbab123.

Watari H, Kageyama H, Masubuchi N, Nakajima H, Onodera K, Focia PJ, Oshiro T, Matsui T, Kodera Y, Ogawa T, Yokoyama T, Hirayama M, Hori K, Freymann DM, Komatsu N, Araki M, Tanaka Y, Sakai R.  (2021) Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety. bioRxiv 2021.10.29.466502: https://doi.org/10.1101/2021.10.29.466502