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Title : Professor
Title : Professor
EMAIL : wuws@mail.tcu.edu.tw
EMAIL : wuws@mail.tcu.edu.tw
Tel : 2328 (Office) / 2327 (Lab)
Tel : 2328 (Office) / 2327 (Lab)
Research interest
Research interest
Molecular and Cellular Biology, Oncology, Molecular Medicine, Gene Therapy
Current projects
Current projects
- Signal mechanisms for progression of hepatocellular carcinoma
- Preclinical trial of target therapy for prevention of metastasis of hepatocellular carcinoma
- Transcriptional upregulation of MMP9 and Zeb-1 by Snail for tumor invasion
- Signal mechanisms for dengue non-structure protein-1 (NS1) Ab triggering pathological effect on endothelial cell
Education
Education
Ph.D. Institute of Biochemistry, School of Medicine, National Taiwan University
Work experience
Work experience
Post-doctoral
•Department of Medical Research and Education, Veterans General Hospital, Taipei, Taiwan
•Department of Medical Research, Kaoshiung Medical University, Kaoshiung. Taiwan
Teaching
Teaching
•Department of Medical Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan
•Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien, Taiwan
Publications (2006-2013)
Publications (2006-2013)
1.Chi-Tan Hu, Tsu-Yao Chang, Chuan-Chu Cheng, Chun-Shan Liu, Jia-Ru Wu, Ming-Che Li1 and Wen-Sheng Wu* Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. FEBS Journal 2010, 277: 1202–1218 (IF:3.042)
2.Rong Kung Tsai, Ming Shan He, Zih-Yao Chen, Wen Chen Wu and Wen Sheng Wu* PKCd-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Mol Vis. 2011;17:1564-76.
3.Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Sindy Wang, Hsiao-Ting Wang, Ming-Che Lee, Ling-Jung Wang, Siou-Mei Pan, Tsu-Yao Chang, Wen-Sheng Wu*. Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. Clin Exp Metastasis. 2011 28(8):851-63.
4.Chen YJ, Tsai RK, Wu WC, He MS, Kao YH, Wu WS*. Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF. PLoS One. 2012;7(9):e44937.
5.Hu CT, Cheng CC, Pan SM, Wu JR, Wu WS*. PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2. Cell Signal. 2013;25(6):1457-67.
6.Hu CT, Wu JR, Wu WS*. The role of endosomal signaling triggered by metastatic growth factors in tumor progression. Cell Signal. 2013 l;25(7):1539-45.
7.Chi-Tan Hu, Tsu-Yao Chang, Chuan-Chu Cheng, Chun-Shan Liu, Jia-Ru Wu, Ming-Che Li1 and Wen-Sheng Wu* Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. FEBS Journal 2010, 277: 1202–1218 (IF:3.042)
8.Rong Kung Tsai, Ming Shan He, Zih-Yao Chen, Wen Chen Wu and Wen Sheng Wu* PKCd-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Mol Vis. 2011;17:1564-76.
9.Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Sindy Wang, Hsiao-Ting Wang, Ming-Che Lee, Ling-Jung Wang, Siou-Mei Pan, Tsu-Yao Chang, Wen-Sheng Wu*. Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. Clin Exp Metastasis. 2011 28(8):851-63.
10.Chen YJ, Tsai RK, Wu WC, He MS, Kao YH, Wu WS*. Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF. PLoS One. 2012;7(9):e44937.
11.Hu CT, Cheng CC, Pan SM, Wu JR, Wu WS*. PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2. Cell Signal. 2013;25(6):1457-67.
12.Hu CT, Wu JR, Wu WS*. The role of endosomal signaling triggered by metastatic growth factors in tumor progression. Cell Signal. 2013 l;25(7):1539-45.
•* corresponding author
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