Dr Ren-In You

尤仁音

Laboratory of Medicine and Biotechnology

Tzu-Chi University


Contact

Address

E306, 701 Sec 3 Zhong-Yang Road, Hualien 97004, Taiwan

Phone number

+886-3-8565301 ext 2339 (office) ext 2340 (Lab)

E-mail

yri100@gms.tcu.edu.tw

Research interest

Drug resistance and immunomodulation in cancers.

Host immune response and regulation in pathogen infection.


Project

  • Investigation of epigenetic regulation mechanism of RNA granules in anticancer drug resistance
  • Establishment, validation and application of a mouse immune-modulatory platform
  • Viral factors-IRFs-IDO induction loop in HCV persistence regulate host immune response and virus replication
  • Molecular mechanisms for FIP on multiple RTKs via targeting to carbohydrate modified motif

Techniques

  • Molecular biology (RT-qPCR, Western blot, ELISA, EMSA, ChIP)
  • Cellular biology (Confocal microscopy, Flow cytometry, IHC, IF)
  • High throughput screening validation (DNA methylation array, miRNA array, lectin array, lectin blot)

Useful Links

Lab members

Chen CS

Project Manager / Taiwan Cancer Accurate Medical Program (Colorectal Cancer and Microbial Phase)

Project Manager / Biotechnology and Pharmaceutical Translation Innovation Development Program (TSPA) - International Cooperation Group

Contact information

Techniques: Animal model, dendritic cell culture, ELISA, RT-qPCR, Western blot

IMG_8142.MOV

Video

Simarmata A

Cell Biologist /Formulatrix Indonesia biotechnology company, Dept. Mechanical Engineering

Techniques: Cell stable clone, colony formation, flow cytometry, RT-qPCR

Contact information

Chen CY

Military training (Taiwan)

Techniques: Animal model, intestine analysis, flow cytometry, Mass

Contact information

Malathy Ravinath D

Master training (Taiwan)

Techniques: Primary muscle cell culture, EMSA, flow cytometry, RT-qPCR, Western blot

Su FY

Medical technologist/Hualien Tzu Chi Hospital

Contact information

Techniques: http://lms.tzuchi.com.tw/hl/moodle19/

Publications

  • A benzenoid 4,7-dimethoxy-5-methyl-l,3-benzodioxole from Antrodia cinnamomea attenuates dendritic cell-mediated Th2 allergic responses in a mouse food allergy model.

You RI, Lee YP, Su TY, Lin CC, Chen CS, Chu CL. (Submitted)

  • Involvement of N-glycan in multiple receptor tyrosine kinases targeted by Ling-Zhi-8 for suppressing HCC413 migration

You RI, Wu WS, Cheng CC, Wu JR, Pan SM, Chen CW, Hu CT. (Revised)

Chen CS, Chen CY, Ravinath DM, Bungahot A, Cheng CP, You RI.

BMC Plant Biol. 2018 Jan 3;18(1):3. doi: 10.1186/s12870-017-1222-0.

Wu WS, You RI, Cheng CC, Lee MC, Lin TY, Hu CT.

Sci Rep. 2017 Dec 19;7(1):17753. doi: 10.1038/s41598-017-18101-7.

Peng SY, You RI, Lai MJ, Lin NT, Chen LK, Chang KC.

Sci Rep. 2017 Sep 13;7(1):11477. doi: 10.1038/s41598-017-11832-7.

Shen CL, Liu CD, You RI, Ching YH, Liang J, Ke L, Chen YL, Chen HC, Hsu HJ, Liou JW, Kieff E, Peng CW.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2229-34.

Wu JR, Hu CT, You RI, Pan SM, Cheng CC, Lee MC, Wu CC, Chang YJ, Lin SC, Chen CS, Lin TY, Wu WS.

Oncotarget. 2015 Oct 20;6(32):32526-44. doi: 10.18632/oncotarget.5322.

Wu JR, Hu CT, You RI, Ma PL, Pan SM, Lee MC, Wu WS.

PLoS One. 2015 Jan 21;10(1):e0114495. doi: 10.1371/journal.pone.0114495. eCollection 2015.

Chang TY, Huang TS, Wang HW, Chang SJ, Lo HH, Chiu YL, Wang YL, Hsiao CD, Tsai CH, Chan CH, You RI, Wu CH, Tsai TN, Cheng SM, Cheng CC.

BMC Genomics. 2014 Sep 18;15:802. doi: 10.1186/1471-2164-15-802.

Dai MS, Vassaux G, Xu M, You RI, Hsieh YF, Ouisse LH, Lo KY, Sytwu HK, Chao TY.

Vaccine. 2012 Nov 6;30(48):6903-11. doi: 10.1016/j.vaccine.2012.09.001. Epub 2012 Sep 14.

You RI, Chang YC, Chen PM, Wang WS, Hsu TL, Yang CY, Lee CT, Hsieh SL.

Blood. 2008 Feb 1;111(3):1480-8. Epub 2007 Nov 15.

You RI, Chen MC, Wang HW, Chou YC, Lin CH, Hsieh SL.

Cancer Res. 2006 Mar 15;66(6):3051-61.

Sun KH, Tang SJ, Wang YS, Lin WJ, You RI.

Rheumatology (Oxford). 2003 Jan;42(1):154-61.