Dr Meng-Jiun Lai
賴孟君
Laboratory of Medicine and Biotechnology
Tzu-Chi University
Title : Associate professor
EMAIL : monjou@mail.tcu.edu.tw
Tel : 2337 (Office) / 2338 (Lab)
Research interest
Using various bioinformatic tools working on biological data to answer biological questions.
Genome analysis of bacteriophages infecting Acinetobacter baumannii
Bioinformatic anlaysis of prokaryotes
Development of bioinformatic tools
Publications
1. Peng SY, You RI, Lai MJ, Lin NT, Chen LK, Chang KC. Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2. Sci Rep. 2017;7(1):11477. doi: 10.1038/s41598-017-11832-7. PubMed PMID: 28904355; PubMed Central PMCID: PMCPMC5597585.
2. Lai MJ, Chang KC, Huang SW, Luo CH, Chiou PY, Wu CC, et al. The Tail Associated Protein of Acinetobacter baumannii Phage PhiAB6 Is the Host Specificity Determinant Possessing Exopolysaccharide Depolymerase Activity. PLoS One. 2016;11(4):e0153361. doi: 10.1371/journal.pone.0153361. PubMed PMID: 27077375; PubMed Central PMCID: PMCPMC4831824.
3. Lai MJ, Liu CC, Jiang SJ, Soo PC, Tu MH, Lee JJ, et al. Antimycobacterial Activities of Endolysins Derived From a Mycobacteriophage, BTCU-1. Molecules. 2015;20(10):19277-90. doi: 10.3390/molecules201019277. PubMed PMID: 26506338.
4. Meng-Jiun Lai, Chih-Chin Liu, , Shinn-Jong Jiang, Po-Chi Soo, Anren Hu, Meng-Hsuan Tu, Jen-Jyh Lee , Kai-Chih Chang. Isolation and characterization of a novel mycobacteriophage, BTCU-1, and its antimycobacterial potential. 2014.
5. Lai MJ, Soo PC, Lin NT, Hu A, Chen YJ, Chen LK, et al. Identification and characterisation of the putative phage-related endolysins through full genome sequence analysis in Acinetobacter baumannii ATCC 17978. International journal of antimicrobial agents. 2013;42(2):141-8. doi: 10.1016/j.ijantimicag.2013.04.022. PubMed PMID: 23742833.
6. Chen LK, Liu YL, Hu A, Chang KC, Lin NT, Lai MJ, et al. Potential of bacteriophage PhiAB2 as an environmental biocontrol agent for the control of multidrug-resistant Acinetobacter baumannii. BMC microbiology. 2013;13:154. Epub 2013/07/10. doi: 10.1186/1471-2180-13-154. PubMed PMID: 23834712; PubMed Central PMCID: PMCPmc3710471.
7. Chang CJ, Lin JH, Chang KC, Lai MJ, Rohini R, Hu A. Diagnosis of beta-lactam resistance in Acinetobacter baumannii using shotgun proteomics and LC-nano-electrospray ionization ion trap mass spectrometry. Analytical chemistry. 2013;85(5):2802-8. Epub 2013/02/05. doi: 10.1021/ac303326a. PubMed PMID: 23374008.
8. Lai MJ, Lin NT, Hu A, Soo PC, Chen LK, Chen LH, et al. Antibacterial activity of Acinetobacter baumannii phage varphiAB2 endolysin (LysAB2) against both gram-positive and gram-negative bacteria. Appl Microbiol Biotechnol. 2011;90(2):529-39. Epub 2011/01/26. doi: 10.1007/s00253-011-3104-y. PubMed PMID: 21264466.
9. Chang KC, Lin NT, Hu A, Lin YS, Chen LK, Lai MJ. Genomic analysis of bacteriophage varphiAB1, a varphiKMV-like virus infecting multidrug-resistant Acinetobacter baumannii. Genomics. 2011;97(4):249-55. Epub 2011/01/19. doi: 10.1016/j.ygeno.2011.01.002. PubMed PMID: 21241792.
10. Chan SC, Lo SY, Liou JW, Lin MC, Syu CL, Lai MJ, et al. Visualization of the structures of the hepatitis C virus replication complex. Biochemical and biophysical research communications. 2011;404(1):574-8. Epub 2010/12/15. doi: 10.1016/j.bbrc.2010.12.037. PubMed PMID: 21147066.