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￭ Human study
Healthy volunteer, obesity patients, and eating disorder patients are studied using electroceutical (transcranial electrical stimulation, TES, tDCS), fMRI, digital phenotyping, digital therapeutics, cognitive tests, questionnaire, eating behavior analysis to investigate the mechanism and novel therapeutics for eating behavior, eating related psychology, obesity and food addiction. In addition, based on newly developed technologies, we are on the process of founding new startup for geriatric sarcopenia obesity patients and comprehensive anti-aging therapies.
￭ Research Topics
- Elucidating the role of the brain regions in regulating body metabolism
- Understanding the relationship between eating behavior phenotypes and brain regions
- Identifying the pathogenesis of metabolic diseases such as obesity, diabetes, and eating disorders and developing treatment methods
- Developing effective treatment methods through digital therapy and electronic medicine
1) Neuroimaging: Functional MRI (food visual cue stimulated brain response, resting state), structural imaging MRI/CT/PET
2) Digital Healthcare: Digital phenotype assessment and digital therapeutics for metabolic diseases such as obesity/diabetes/eating disorders
3) Cognitive task (computerized task): Psychological/cognitive assessment and treatment of metabolic diseases through various cognitive psychological tasks such as food photo/verbal response, etc.
4) Lifestyle intervention therapy: coaching/digital therapies to improve eating habits, exercise habits, and daily routines/emotions/motivation
5) Electroceuticals: Transcranial Electrical Stimulation TES (tDCS, transcranial direct current stimulation)
6) Pharmaceutical Research: Study of effects and mechanisms of metabolic disease treatment agents
7) Questionnaires: Assessment of psychological, behavioral, cognitive, emotional, and medical conditions related to metabolic diseases such as obesity
8) Epidemiologic studies: Epidemiologic studies related to metabolic diseases
￭ Publications
Neuroimaging
Clinical Implication of Individually Tailored Segmentation Method for Distorted Hypothalamus in Craniopharyngioma
AR Hong, M Lee, JH Lee, JH Kim, YH Kim, HJ Choi
Frontiers in Endocrinology, 2021
https://www.frontiersin.org/articles/10.3389/fendo.2021.763523/full
Glucagon-like peptide-1 receptor agonist differentially affects brain activation in response to visual food cues in lean and obese individuals with type 2 diabetes mellitus
JH Bae, HJ Choi, KIK Cho, LK Kim, JS Kwon, YM Cho
Diabetes & metabolism journal 44 (2), 248-259, 2020
https://www.e-dmj.org/journal/view.php?doi=10.4093/dmj.2019.0018
Digial healthcare/lifestyle treatment intervention study
Machine Learning Analysis to Identify Digital Behavioral Phenotypes for Engagement and Health Outcome Efficacy of an mHealth Intervention for Obesity: Randomized Controlled Trial
M Kim, J Yang, WY Ahn, HJ Choi
Journal of medical Internet research 23 (6), e27218, 2021
https://www.jmir.org/2021/6/e27218/
Digital Therapeutics for Obesity and Eating-Related Problems
M Kim, HJ Choi
Endocrinology and Metabolism 36 (2), 220, 2021
https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.107
Clinical efficacy and plausibility of a smartphone‐based integrated online real‐time diabetes care system via glucose and diet data management: a pilot study
EJ Ku, JI Park, HJ Jeon, T Oh, HJ Choi
Internal medicine journal 50 (12), 1524-1532, 2020
https://onlinelibrary.wiley.com/doi/10.1111/imj.14738
Healthy Eating Behavior Change with Psychological Features and Insulin Resistance: Buffet and Food Diary App Analysis
M Kim, S Park, C Kim, HJ Choi, 2021
https://www.researchsquare.com/article/rs-140427/v1
Multidimensional cognitive behavioral therapy for obesity applied by psychologists using a digital platform: open-label randomized controlled trial
M Kim, Y Kim, Y Go, S Lee, M Na, Y Lee, S Choi, HJ Choi
JMIR mHealth and uHealth 8 (4), e14817, 2020
https://mhealth.jmir.org/2020/4/e14817
Epidemiological studies
Mental health of people with distorted body weight perception using medicinal remedies: A representative study
M Kim, S Kim, W Kim, HJ Choi
International Journal of Clinical and Health Psychology 21 (2), 100224, 2021
https://www.sciencedirect.com/science/article/pii/S1697260021000053
Parmaceutical research
Clinical effectiveness of liraglutide on weight loss in South Koreans: First real-world retrospective data on Saxenda in Asia
JS Park, J Kwon, HJ Choi, C Lee
Medicine 100 (2), 2021
Atypical Antipsychotics are Disproportionately Associated with Patients Reporting Increased Eating Drives
SY Yum, SK Yum, HJ Choi
Psychiatry Investigation 18 (3), 266, 2021
https://www.psychiatryinvestigation.org/journal/view.php?doi=10.30773/pi.2020.0431
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