The Grillo-Hill

Cell Biology Lab

at San José State University


The Grillo-Hill lab is working to understand how changes in acid levels inside a cell, also called intracellular pH, can change the behavior of cells. Cell generate acids as a result of normal cellular processes, and acid production can increase in responses to certain stresses or cues. The resulting change in acid levels can cause the cell to behave differently, and may contribute to progression of diseases such as cancer.

Our lab is staffed by a very talented group of diverse students who are undergraduate and masters level students at SJSU. We investigate a variety of different research directions, including: (1) identifying pH-sensitive molecules; (2) characterizing changes in protein biochemistry at different pH levels; (3) bioenginering fluorescent probes and tools to measure and alter intracellular pH; and (4) investigating pH dynamics during development and in disease states. We use a broad range of techniques to address our questions, including Drosophila genetics, mammalian cell biology, light and fluorescent confocal microscopy, and protein biochemistry.

If you are a current or future SJSU student interested in joining the lab, please go to the Contact page and read more.