Biographical Sketch
 

Current Status:

 

Assistant Professor

Dr. Panjwani Center for Molecular Medicine & Drug Research

International Center for Chemical & Biological SciencesUniversity of Karachi,

Karachi-75210, Pakistan

 

 

Research Interest:

 

  • Design of new bio-active molecules using computer aided modeling techniques 
  • Modeling of small organic molecules, proteins, and protein-ligand interactions 
  • Ligand based and structure based pharmacophore design 
  • Generation and screening of large virtual combinatorial compound libraries 
  • Molecular activity determination using 3D-QSAR or quantum chemistry calculations 
  • Molecular Dynamics (MD) simulations studies of protein-ligand complex

 

 

Academics:

 

Postdoctoral Fellow,

Advisor Prof. Dr. DDDr. h. c. Bernd Michael Rode, (2002-2003)

University of Innsbruck, Innsbruck, Austria, (MD Simulation, Docking, Modelling and QSAR studies)

 

Ph. D.  (Chemistry)  

Advisor Prof. Dr. Atta-ur-Rahman, (1998- 2002)

Minister of Science and Technology, Director H.E.J. Research Institute of Chemistry,

University of Karachi. (Isolation, Purification and Structural Elucidation of Bio-active Natural Products)

 

M.Phil. / Ph.D. courses at HEJ University of Karachi  (1998-1999)

 

M. Sc. (Organic Chemistry), University of Karachi, Pakistan.   (1996-1998)

                                              

B. Sc. (Hons.) (Chem., Biochem. & Physiology) University of Karachi, Pakistan. (1993-1996)

 

Experience:

Assistant Professor           (March 2004 - Till present)

Dr. Panjwani Center for Molecular Medicine and Drug Research,

International Center for Chemical and Biological Sciences

University of Karachi.

http://www.iccs.edu




AvH Scholarship (Visiting Scientist)    (Oct 2010 - till date)
Molecular and Cellular Modeling Group
Heidelberg Institute of Theoretical Studies 
Schloss-Wolfsbrunnenweg 35
69118 Heidelberg, Germany

 

Visiting Scientist    (Jan 2010 - Feb 2010)
Computational Inorganic Chemistry Group
Inorganic Chemistry Laboratory
University of Oxford, UK

 

Visiting Scientist (Dec 2008 -Jan 2009)

Department of Theoretical Chemistry

Institute of General, Inorganic and Theoretical Chemistry,

University of Innsbruck, Innrain 52a, A-6020 Innsbruck, AUSTRIA

 

Senior Fulbright Fellow     (Sept 06 - June 07)
Department of Chemistry & Biochemistry

Center for Computational Sciences

Pittsburgh, PA

 

eCheminfo Advanced Training (July 3-7 2006)

Latest Advances in Drug Discovery Design & Planning Methods

Chemistry Research Laboratory

Oxford University, Oxford, UK.

 

Visiting Scientist (May 2006 -June 2006)

Institute of Pharmacy, Department of Pharmaceutical Chemistry

Leopold-Franzens-University Innsbruck

Josef-Moeller-Haus, Innrain 52c, 6020 Innsbruck, AUSTRIA

 

Visiting Scholar (May 2005 -July 2005)

Institute of Pharmacy, Department of Pharmaceutical Chemistry

Leopold-Franzens-University Innsbruck

Josef-Moeller-Haus, Innrain 52c, 6020 Innsbruck, AUSTRIA

 

Visiting Scholar (13th – 21st June, 2005)

Pharmaceutical Biosciences,

Division of Pharmaceutical Pharmacology,

Uppsala Univerysity, Uppsala, Sweden

Contact Person: Prof. Jarl ES Wikberg

 

Senior Research Officer (2003-2004)

H.E.J. Research Institute of Chemistry,

University of Karachi.

 

Postdoctoral Fellow (2002-2003)

Advisor Prof. Dr. DDDr. h.c. Bernd Michael Rode

University of Innsbruck, Innsbruck, Austria.

(MD Simulation, Docking, Modelling and QSAR studies)

 

Research Associate: (2001-2002)

Pakistan Science Foundation PSF-S-Ku/Chem Project

Principle Investigator Dr. Ahsana Dar

HEJ Research Institute of Chemistry

 

 

Scholarship and Awards:

 
·         INSPIRE for the Talented Researcher Exchange Award (2009) 

·         Prof. Atta-ur-Rahman Gold Medal in Chemistry (2008)

·         Award of “Star Laureate 2007” by South Asia Publication  ( 2008)

·         Cash Award of Research Productivity allowance (RPA)  (2007) 

·         Occasional Lectrue Program (OLP) Award (2007) 

·         Senior Fulbright Scholarship (2006)

·         Cash Award of Research Productivity allowance (RPA)  (2005)

·         Cash Award of Research Productivity allowance (RPA).  (2004)

·         IBRO Fellowship on Cholinesterase (Italy)  (2004)

·         Austrian Postdoctoral Fellow ship (2002)

·         First Prize for Best Poster in 7th EuroAsia Conference  (2002)

·         Fellowship of H.E.J. (1997 - 2002)

·         Vice-chancellor scholarship (1997)

·         Vice-chancellor scholarship (1996)

·         President cum talent scholarship (1995)

 

 

Proficiencies:

 

·         Preliminary understanding of computational chemistry theory, and very proficient in the operation of most computational chemistry software.

·         Detailed knowledge of computers operating system including UNIX, Linux, Macintosh and Windows, Installation, maintenance and repairing. All major word processing, presentation, and database manipulation software packages.

·         Experience in Medicinal Chemistry packages including Amber, Sybyl, Autodock, Rasmol, Molmol, , FlexX, Gaussian, GaussView, Molden, CS Chem Office, software compilation, desktop publishing, and hardware assembly.

·         Detailed knowledge of almost all organic laboratory equipment, especially NMR (including 19F-NMR, 2D-NMR, and chiral shift reagents), FT-IR, GC, GC-MS, LC-MS, HPLC (analytical and prep), chromatography, photochemical apparatus, low temperatures, inert atmospheres.

·         Isolation, degradation, and derivatisation of natural products. Structure elucidation with modern NMR techniques including acquisition of 2D NOE and inverse detected experiments. Use of current analytical and predictive tools including HPLC, GCMS, LCMS and Counter current chromatography.

·         Proficient with the operation, maintenance, and small repairs of technical and sensitive lab equipment (HPLC pumps, rotary chromatotrons, vacuum apparatus)

·         Success as a laboratory and tutorial instructor in general and organic chemistry, Experienced working in a multidisciplinary team. Appropriate organization, record keeping, verbal and written communication skills.

 
 

 

Manuscript Reviewer:

 

Journal of Medicinal Chemistry

Journal of Chemical Information and Computer Sciences 

Journal of Bio-organic and Medicinal Chemistry Letters

Egyptian Pharmaceutical Journal

 

 

Recent Presentations:
 
Ø  Participated and deliver Invited Lecture in “A Journey from Natural Product Chemistry to Computational Medicinal Chemistry, Invited lecture at the Inorganic Chemistry Laboratory, University of Oxford, Oxford, UK, Feb 10, 2010.
Ø  Participated and deliver Invited Lecture in “1st Junior National Chemistry Conference under the age of 35” Department of Chemistry, Muzaffarabad, from October 19-22, 2008.

Ø  Participated and deliver presentation in “International Workshop on Biotechnology for Development” held in Kohat University of Science and Technology, Kohat, from March 4-5, 2008.

Ø  Participated and deliver presentation in “The 18th National Chemistry Conference” held in The Punjab University, Lahore from  February 25-27, 2008.

Ø  Zaheer-ul-Haq, Lead Discovery through Combination of Natural Product and Computational Chemistry. Invited lecture at the Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, March 26, 2007.  

Ø  Zaheer-ul-Haq, M. Arif Lodhi and M. Iqbal Choudhary, Insights into the metal chelating mechanism in urease inhibitors using molecular docking simulation and 3-D-QSAR analysis. Presented at the 233rd ACS National Meeting at Chicago, IL, March 25-29, 2007.

Ø  Zaheer-ul-Haq, Lead Discovery through Combination of Natural Product and Computational Chemistry. Invited lecture at the Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, March 26, 2007.

Ø  Zaheer-ul-Haq, A Computational Approach for Exploiting Bioactive Natural Products, Invited lecture at the Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA, March 16, 2007.

Ø  Zaheer-ul-Haq, Metal Chelating Mechanism in Bis-coumerine Interaction Using Molecular Docking Simulation and Comparative Field Analysis. Presented at the 20th Darmstadt Molecular Modeling Workshop, Computer-Chemie-Centrum, Erlangen, Germany, May 23-24, 2006.

Ø  Zaheer-ul-Haq, Computational Chemistry for Beginners. Invited lecture at the Department of Chemistry, Jinnah University for Women, Karachi, August 2, 2006.

Ø  Participated and deliver presentation in “The 6th International & 16th National Chemistry  Conference” held in Bahauddin Zakariya University, Multan from  April 6-8, 2006

Ø  Zaheer-ul-Haq, The Role of Computational Chemistry in the Process of Drug Discovery. Invited lecture at the Department of Chemistry, Quaid-e-Azam University, Islamabad, March 22, 2006.

Ø  Participated and delivered lecture in “The 10th International Symposium on Natural Product Chemistry, Karachi, Pakistan, January 06-09, 2006.

Ø  Zaheer-ul-Haq, Structure-Based Drug Design using 3D-QSAR and Molecular Docking Techniques. Invited lecture at the Pharmaceutical Biosciences, Division of Pharmaceutical Pharmacology, Uppsala University, Uppsala, Sweden,  June 14, 2005.

Ø  Participated and delivered presentation in “The second international conference of pharmaceutical and drug industries division” National Research Centre (NRC), Cairo, Egypt, March 7-9, 2005.

Ø  Participated and delivered presentation in “8th International Symposium on Protein Structure Function Relationship. Karachi, Pakistan, Jan. 7-10, 2005.

Ø  Participated and deliver presentation in the 5th International and 15th National Chemistry Conference at Islamabad from 24th to 27th of Nov 2004

Ø  Participated in the 9th International Symposium on Natural Product Chemistry, Karachi, Pakistan, January 10-13, 2004.

Ø  Participated in the 7th Euroasia Conference on Chemical Sciences, Karachi, Pakistan, March 9-12, 2002.

Ø  Participated in the 8th International Symposium on Natural Product Chemistry, Karachi, Pakistan, Jan. 18-22, 2000.

Ø  Participated in the 6th International Symposium on Protein Structure-Function Relationship, Karachi, Pakistan, Feb. 5-7, 1999.

Ø  Participated and presented lecture and poster in the 9th National Chemistry Conference, Karachi, Pakistan, Dec. 4-6, 1998.

Ø  Participated in the 7th International Symposium on Natural Product Chemistry, Karachi, Pakistan, from Dec. 28, 1997 to Jan. 1, 1998.