研究業績

主な研究業績（太字下線は当研究室の関係者　他の論文はPubMed）

<2026年>

Temperature-driven metabolic acceleration independent of cell growth enables high-level production of D-ribulose and shinorine in Streptomyces lividans  

Sakurai J, Nakahama A, Nakazawa K, Uchikura H, Taniguchi Y, Kato S, Yamamoto S, Tsuge Y

Biotechnology for Biofuels and Bioproducts, in press

Production of pure all-trans retinal from agricultural byproducts by metabolically engineered Corynebacterium glutamicum using two-phase cultivation

Hao W, Yamada S, Hirono-Hara Y, Hara KY, Tsuge Y

Bioresource Technology, 448:134264 (2026)

Regenerative immobilized lipase system activated by food-derived fatty acids for efficient hydrolysis of vegetable oils 

Komatsu T, Onozuka K, Senda Y, Nii T, Takahashi K, Tsuge Y

Journal of the American Oil Chemists' Society, in press 

<2025年>

Controlling the carbon flux between glycolysis and the pentose phosphate pathway via targeted protein degradation in Corynebacterium glutamicum

Takemoto N#, Hao W#, Matsuzawa H, Sakurai J, Tsuge Y

Journal of Bioscience and Bioengieering, 139(5):377–383 (2025) 

<2024年>

Microbial production of pyruvic, lactic, and 3-hydroxy propionic acid from renewable resources

Tsuge Y, Inui M

Handbook of Biorefinery Research and Technology: Production of Biofuels and Biochemicals, pp 231–253 (2024)

<2023年>

Enhanced production of itaconic acid from enzymatic hydrolysate of lignocellulosic biomass by recombinant Corynebacterium glutamicum

Hanh DD, Elkasaby T, Kawaguchi H, Tsuge Y, Ogino C, Kondo A

Journal of Bioscience and Bioengieering,  136(1):7–12 (2023) 

<2021年>

Physiological characteristics of Corynebacterium glutamicum as a cell factory under anaerobic conditions

Tsuge Y, Yamaguchi A

Applied Microbiology and Biotechnology, 105(16): 6173–6181 (2021)

Recent progress in production of amino acid-derived chemicals using Corynebacterium glutamicum

Tsuge Y, Matsuzawa H

World Journal of Microbiology and Biotechnology, 37(3):49 (2021)

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Wolf S, Becker J, Tsuge Y, Kawaguchi H, Kondo A, Marienhagen J, Bott M, Wendisch VF, Wittmann C

Essays in Biochemistry 65(2):197–212 (2021)

Elevated, non-proliferative temperatures change the profile of fermentation products in Corynebacterium glutamicum

Mizuno H, Tsuge Y

Applied Microbiology and Biotechnology, 105(1):367–377 (2021)

Enhanced methane production from cellulose using a two-stage process involving a bioelectrochemical system and a fixed film reactor

Sasaki K, Sasaki D, Tsuge Y, Kondo A

Biotechnology for Biofuels, 14(1):7 (2021)

有用物質生産における微生物中央代謝経路の炭素フラックス比の最適化

柘植 陽太 

化学と生物, 59:2–3 (2021)

<2020年>

Optimal ratio of carbon flux between glycolysis and the pentose phosphate pathway for amino acid accumulation in Corynebacterium glutamicum

Murai K#, Sasaki D#, Kobayashi S, Yamaguchi A, Uchikura H, Shirai T, Sasaki K, Kondo A, Tsuge Y

ACS Synthetic Biology, 9(7):1615–1622 (2020)

Requirement of de novo synthesis of pyruvate carboxylase in long-term succinic acid production in Corynebacterium glutamicum

Uchikura H, Ninomiya K, Takahashi K, Tsuge Y

Applied Microbiology and Biotechnology, 104(10):4313–4320 (2020)

Anaerobic glucose consumption is accelerated at non-proliferating elevated temperatures through upregulation of a glucose transporter gene in Corynebacterium glutamicum

Uchikura H, Toyoda K, Matsuzawa H, Mizuno H, Ninomiya K, Takahashi K, Inui M, Tsuge Y

Applied Microbiology and Biotechnology, 104(15):6719–6729 (2020)

Automatic redirection of carbon flux between glycolysis and pentose phosphate pathway using an oxygen-responsive metabolic switch in Corynebacterium glutamicum

Kobayashi S, Kawaguchi H, Shirai T, Ninomiya K, Takahashi K, Kondo A, Tsuge Y

ACS Synthetic Biology, 9(4):814–826 (2020)

<2019年>

Metabolic engineering of Corynebacterium glutamicum for hyper production of polymer grade L- and D-lactic acid

Tsuge Y, Kato N, Yamamoto S, Suda M, Jojima T, Inui M

Applied Microbiology and Biotechnology, 103(8):3381–3391 (2019)

Enhanced production of D-lactate from mixed sugars in Corynebacterium glutamicum by overexpression of glycolytic genes encoding phosphofructokinase and triosephosphate isomerase

Tsuge Y, Kato N, Suda M, Inui M

Journal of Bioscience and Bioengineering, 127(3):288–293 (2019)

<2018年>

Metabolic engineering of Corynebacterium glutamicum for production of sunscreen shinorine

Tsuge Y, Kawaguchi H, Yamamoto S, Nishigami Y, Sota H, Ogino C, Kondo A

Bioscience Biotechnology and Biochemistry, 82(7):1252–1259 (2018)

増えるために食べる～細胞増殖と中央代謝の接合点～

柘植 陽太 

生物工学会会誌 96 (5):272 (2018) 

酸素をスイッチとした二つの樹脂原料の微生物生産

小林 俊介、柘植 陽太 

アグリバイオ 2:70–72 (2018)