Previous topics

Program 2025

• Integrating Predicted Efflux into the Screening Process

• Interaction of man-made compounds with ABC drug transporters determined with cell-based and with protein-based assays

• New model describing the proton gradient driven activity of MATEs transporters

• Microthrombi as Size-Selective Gateways for Nanoparticle Delivery to the Brain

• Inhibition of Clostridium botulinum C2 toxin by fibrinogen

• Binding Kinetics of Bacterial Periplasmic Substrate-Binding Proteins and Their Role in Nutrient Acquisition

• Vascular transferrin receptor expression and function in the young and aged brain

• Energy-driven permeability threshold for active transport

• Blood brain barrier: a bridge between nutrition and brain lipid homeostasis 

• Multifunctional peptide nanocarrier for targeted reduction of metastatic breast carinoma-induced osteolysis

• Cystic Fibrosis: why sodium hyperabsorption is a wrong concept 

• The role of the blood-brain barrier in neurodegenerative diseases

• Cell penetrating peptide modified liposomes: A technology for oral peptide delivery

• New insights into the role of ABC transporters in amyloid beta clearance

• New strategies against ABC transporter-mediated anticancer drug resistance

• The Prototypical Oligopeptide Transporter YdgR from E. coli Exhibits a Strict Preference for ß-Ala-Lys(AMCA)

• Optimisation of an NVU-on-chip microfluidic platform for AAV vector screening.

• Predicting the intrinsic membrane permeability of the BBB

• Mucosal Vaccination via Colloidal Carrier Systems

• Exploration of the mechanism of Occludin co-polymerization within Claudins' strands in the Tight junctions

• Core-Shell Bioactive-Loaded Melanin-Like Nanoformulation for Neuroinflammation Therapy

• Insight into the size of liposomes separated by magnetic separation

• In vivo evaluation of blood-brain-barrier-targeting Ox26-immunoliposomes

• Media Type and mRNA Transfection: Comparing Lipofectamine MessengerMAX and Lipid Nanoparticles in HEK-293 Cells

• Comparative analysis of paralogous peptide transporters (PepT) in Mozambique tilapia

• Dissecting the structure-function relationship of paracellular channels formed by claudin-10b and claudin-15

• Microfluidic generation and investigation of asymmetric liposomes as model systems

• Lyophilization of RNA-loaded lipid nanoparticles - Storage stability and impact of process parameters

• Liposomal formulation of antibiotic-peptide conjugates enables improved pharmacokinetics

• Transcriptomic changes in the kidney of Nothobranchius furzeri are closely linked to the decline of ABC transporters during aging

• Lysophosphatidylcholine and nutritional supplementation – A clinical trial

• Renal tubular transporter inhibition as a mechanism for elevated plasma creatinine during tuberculosis treatment

• Project proposal: Oral delivery of leuprolide with tetraether lipid liposomes

• Protein-based phosphate biosensors for monitoring ATPase activity

• Electrophysiological Evaluation of Salivary Gland Barrier and Transport Properties

• A blood-brain barrier model for liposomal drug targeting - Characterisation of hiPSC-derived endothelial cells used for in vitro modelling of the BBB

• Aryl hydrocarbon receptor ligands increase ABC transporter expression in killifish (Fundulus heteroclitus) renal proximal tubules

• Enhancing drug delivery of rosuvastatin to the brain using polymer nanocapsules for the treatment of SYNGAP1-related disorders

• Hepatic Na+/taurocholate co-transporting polypeptide (NTCP): Analysis of the fluorescent-coupled substrate NBD-TCA as alternative to 3H-TCA 

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Program 2024

•       A novel fluorescent substrate for P-glycoprotein-mediated vesicular and cellular transport assays

•        Targeted Lipid Nanoparticles for delivery of mRNA into Central Nervous System

•        Rational Selection and Design of Combinational Liposomes Using Phytochemicals

•        The possible role of sodium/proton exchangers in exocrine fluid secretion

•        Comparative analysis of clinically used paclitaxel formulations with a focus on the extent of paclitaxel transport across the CNS and PNS barriers

•        Translational aspects of oxycodone brain delivery via the proton-coupled organic cation (H+/OC) antiporter in rats and pigs

•        Slc23a3: the long sought ascorbate release carrier!

•        TNFα modulation of secretion and Ca2+ signaling in small intestinal murine organoids

•        Manipulating the microbiota with vancomycin and high-fibre diet affects SCFA/FFA receptor signalling in rat caecum

•        Striatal blood-brain barrier permeability fluctuates perinatally

•        Ticagrelor modestly raises plasma riboflavin concentration in humans and inhibits riboflavin transport by BCRP and MRP4

•        Functional characterization of wild-type and mutant MDR1 P-glycoprotein from cats and dogs

•        In vitro model to predict CNS drug delivery

•        Increased expression of transferrin receptor 1 in the brain cortex of mouse model of familial Alzheimer’s disease is associated with activation of HIF-1 signalling pathway

•        SLC Transporter: The Metabolic Gate of Immune Cells

•        Computational Biopharmaceutics: Biopredictive Technologies in the Nanomedicine Design Space

•        A blood-brain barrier model for liposomal drug targeting - Characterisation of hiPSC-derived endothelial cells used for in vitro modelling of the BBB

•        Ox26-immunoliposomes to target the blood-brain-barrier

•        Tracing the substrate translocation mechanism in P-glycoprotein

•        OATP2B1-mediated transport of drugs and endogenous compounds at the Blood-Brain Barrier

•        Innovative nanobody formulations – CPP conjugates for improved pharmacokinetics and increased oral bioavailability

•        Application of Lyso-Phosphatidylcholine (LysoPC) to Patients with Cancer

•        MemCross: molecular dynamics simulations of passive permeation and co-permeation

•        The ABCG2 transporter affects plasma levels and tissue distribution of lumichrome, a natural derivative of riboflavin

•        Involvement of the ABCG2 membrane protein in the in vitro transport and milk secretion of the main metabolite of the xenobiotic thiabendazole

•        The ABCG2 membrane transporter plays a key role in biodistribution and secretion into milk of the flukicide nitroxynil in mice

•        Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1

•        Accuracy, Utility, and Rank-Order Assessment (AURA) for Data-Driven Decision Making

•        Multi-omics approach to unravel the blood-brain barrier in ependymoma

•        Use of human iPSC-derived Blood Brain Barrier model to study Late Onset Alzheimer’s disease

•        Blood Cell Hitchhikers reaching the Tumor Site: Unraveling the Complex Journey of Doxorubicin-Loaded PLG Nanoparticles

•        Dual targeting immunoliposomes for drug delivery to the brain

•        MsbA in dozen environments

•        The role of drug transporters in rifampicin and CoCl2 mediated changes in the efficiency of CYP450 metabolism in microfluidic and conventional tissue culture liver models

•        Insights into structure and function of the sodium/proton antiporter NhaA from Salmonella Typhimurium

•        Matrix-Free Human Organoid Monolayers Recapitulate Duodenal Barrier and Transport Properties

•        Computational prediction of functional solute carrier (SLC)-lipid interactions

•        Predicting intrinsic membrane permeability by the solubility-diffusion model

•        Establishment of a fast and efficient extraction method for lysophosphatidylcholine by dual centrifugation

•        The pH-dependence of efflux ratios determined with bidirectional transport assays across cellular monolayers

•        Investigating Drug-Mucus Interactions on Permeability using In Vitro Models

•        Inhibition study with the clinically relevant organic anion transporter OAT1 to analyze the reliability of the fluorescent substrate 6-carboxyfluorescein (96-well) in comparison to the 3H-labeled substrate PAH (24-well)

•        Revealing Molecular Insights into New Claudin-10b Mutations in HELIX Syndrome Patients

•        EVALUATION OF A CNS TARGET-ACTIVATED TNFR2 AGONIST DELIVERY THROUGH TRANSFERRIN RECEPTOR-MEDIATED TRANSPORT (RMT) ACROSS THE BLOOD-BRAIN BARRIER

•        Microfluidic Production of Lipid Nanoparticles

•        Generation of an ABCB1/ABCG2 knockout platform for substrate characterization using CRISPR/Cas9-genome editing

•        Liposomal formulations of the vancomycin derivative FU002 improve pharmakokinetics and enable oral delivery

•        Methods for dermal delivery of nucleic acids using lipid nanoparticles

•        Renal aging in the African turquoise killifish

to be continued