Programme 2024
Preliminary Programme 2024
TBD
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Programme 2023
Molecular-structural basis for target repurposing strategies to explore orphan transporters and modes of action
ABC of cellular transporters in zebrafish embryos – relevance for toxicokinetics
Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21
Combating transporter-mediated anticancer drug resistance: new strategy against an old foe
Altered protein expression of ABC and SLC transporters in isolated cerebral microvessels and brain cortex of familial Alzheimer’s disease animal models
Formulation of blood-brain-barrier targeting immunoliposomes
Development of a liposomal system for the oral delivery of Teriparatide
Cell penetrating liposomes enable the oral delivery of vancomycin
Impact of Sodium Arsenite on ABC Transport Proteins in renal proximal tubules
A hiPSC – derived blood-brain-barrier model for the evaluation of nanocarrier targeting properties
In silico-guided optimisation of CNS-targeted therapeutic antibodies
New insights into the intrinsic permeability of organic chemicals through biological membranes
Investigation of mitochondrial function in neurovascular cell models of PARK2 copy number variation carriers with adult ADHD
Improvement of workflows and assay reproducibility by the introduction of “assay-ready” culturing of MDCK cells for transport studies
Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy
Mucin-protected Caco-2 assay to study drug permeation in the presence of complex biorelevant media
Drug repurposing strategies and network polypharmacology to identify transporter modulators and overcome therapy failure
ISMICAP: a model for delving into blood-brain barrier mysteries
Impact of Neisseria meningitidis infection on the efflux transporter P-glycoprotein in brain endothelial cells using induced pluripotent stem cell-derived brain endothelial cell mode
Blood-brain barrier on-a-chip for high-throughput barrier and transport studies.
Intestinal tissue models representing the in vivo situation to a high degree
The metalloprotease meprin β is a regulator of blood-brain barrier integrity
Revised extraction of intrinsic permeabilities from apparent permeabilities in Caco-2/MDCK cells
The effect of the unstirred water layer (UWL) and filter on the efflux ratio in MDCK permeability assays
to be continued