Programme 2024

Preliminary Programme 2024

·       A novel fluorescent substrate for P-glycoprotein-mediated vesicular and cellular transport assays

·       Targeted Lipid Nanoparticles for delivery of mRNA into Central Nervous System

·       Rational Selection and Design of Combinational Liposomes Using Phytochemicals

·       The possible role of sodium/proton exchangers in exocrine fluid secretion

·       Comparative analysis of clinically used paclitaxel formulations with a focus on the extent of paclitaxel transport across the CNS and PNS barriers

·       Translational aspects of oxycodone brain delivery via the proton-coupled organic cation (H+/OC) antiporter in rats and pigs

·       Slc23a3: the long sought ascorbate release carrier!

·       TNFα modulation of secretion and Ca2+ signaling in small intestinal murine organoids

·       Manipulating the microbiota with vancomycin and high-fibre diet affects SCFA/FFA receptor signalling in rat caecum

·       Striatal blood-brain barrier permeability fluctuates perinatally

·       Ticagrelor modestly raises plasma riboflavin concentration in humans and inhibits riboflavin transport by BCRP and MRP4

·       Functional characterization of wild-type and mutant MDR1 P-glycoprotein from cats and dogs

·       In vitro model to predict CNS drug delivery

·       Increased expression of transferrin receptor 1 in the brain cortex of mouse model of familial Alzheimer’s disease is associated with activation of HIF-1 signalling pathway

·       SLC Transporter: The Metabolic Gate of Immune Cells

·       Computational Biopharmaceutics: Biopredictive Technologies in the Nanomedicine Design Space

·       A blood-brain barrier model for liposomal drug targeting - Characterisation of hiPSC-derived endothelial cells used for in vitro modelling of the BBB

·       Ox26-immunoliposomes to target the blood-brain-barrier

·       Tracing the substrate translocation mechanism in P-glycoprotein

·       OATP2B1-mediated transport of drugs and endogenous compounds at the Blood-Brain Barrier

·       Innovative nanobody formulations – CPP conjugates for improved pharmacokinetics and increased oral bioavailability

·       Application of Lyso-Phosphatidylcholine (LysoPC) to Patients with Cancer

·       MemCross: molecular dynamics simulations of passive permeation and co-permeation

·       The ABCG2 transporter affects plasma levels and tissue distribution of lumichrome, a natural derivative of riboflavin

·       Involvement of the ABCG2 membrane protein in the in vitro transport and milk secretion of the main metabolite of the xenobiotic thiabendazole

·       The ABCG2 membrane transporter plays a key role in biodistribution and secretion into milk of the flukicide nitroxynil in mice

·       Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1

·       Accuracy, Utility, and Rank-Order Assessment (AURA) for Data-Driven Decision Making

·       Multi-omics approach to unravel the blood-brain barrier in ependymoma

·       Use of human iPSC-derived Blood Brain Barrier model to study Late Onset Alzheimer’s disease

·       Blood Cell Hitchhikers reaching the Tumor Site: Unraveling the Complex Journey of Doxorubicin-Loaded PLG Nanoparticles

·       Dual targeting immunoliposomes for drug delivery to the brain

·       MsbA in dozen environments

·       The role of drug transporters in rifampicin and CoCl2 mediated changes in the efficiency of CYP450 metabolism in microfluidic and conventional tissue culture liver models

·       Insights into structure and function of the sodium/proton antiporter NhaA from Salmonella Typhimurium

·       Matrix-Free Human Organoid Monolayers Recapitulate Duodenal Barrier and Transport Properties

·       Computational prediction of functional solute carrier (SLC)-lipid interactions

·       Predicting intrinsic membrane permeability by the solubility-diffusion model

·       Establishment of a fast and efficient extraction method for lysophosphatidylcholine by dual centrifugation

·       The pH-dependence of efflux ratios determined with bidirectional transport assays across cellular monolayers

·       Investigating Drug-Mucus Interactions on Permeability using In Vitro Models

·       Inhibition study with the clinically relevant organic anion transporter OAT1 to analyze the reliability of the fluorescent substrate 6-carboxyfluorescein (96-well) in comparison to the 3H-labeled substrate PAH (24-well)

·       Revealing Molecular Insights into New Claudin-10b Mutations in HELIX Syndrome Patients

·       EVALUATION OF A CNS TARGET-ACTIVATED TNFR2 AGONIST DELIVERY THROUGH TRANSFERRIN RECEPTOR-MEDIATED TRANSPORT (RMT) ACROSS THE BLOOD-BRAIN BARRIER.

·       Microfluidic Production of Lipid Nanoparticles

·       Generation of an ABCB1/ABCG2 knockout platform for substrate characterization using CRISPR/Cas9-genome editing

·       Liposomal formulations of the vancomycin derivative FU002 improve pharmakokinetics and enable oral delivery

·       Methods for dermal delivery of nucleic acids using lipid nanoparticles

·       Renal aging in the African turquoise killifish

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Programme 2023

• Molecular-structural basis for target repurposing strategies to explore orphan transporters and modes of action

• ABC of cellular transporters in zebrafish embryos – relevance for toxicokinetics

• Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21

• Combating transporter-mediated anticancer drug resistance: new strategy against an old foe

• Altered protein expression of ABC and SLC transporters in isolated cerebral microvessels and brain cortex of familial Alzheimer’s disease animal models

• Formulation of blood-brain-barrier targeting immunoliposomes

• Development of a liposomal system for the oral delivery of Teriparatide

• Cell penetrating liposomes enable the oral delivery of vancomycin 

• Impact of Sodium Arsenite on ABC Transport Proteins in renal proximal tubules

• A hiPSC – derived blood-brain-barrier model for the evaluation of nanocarrier targeting properties

• In silico-guided optimisation of CNS-targeted therapeutic antibodies

• New insights into the intrinsic permeability of organic chemicals through biological membranes 

• Investigation of mitochondrial function in neurovascular cell models of PARK2 copy number variation carriers with adult ADHD

• Improvement of workflows and assay reproducibility by the introduction of “assay-ready” culturing of MDCK cells for transport studies

• Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy

• Mucin-protected Caco-2 assay to study drug permeation in the presence of complex biorelevant media

• Drug repurposing strategies and network polypharmacology to identify transporter modulators and overcome therapy failure

• ISMICAP: a model for delving into blood-brain barrier mysteries

• Impact of Neisseria meningitidis infection on the efflux transporter P-glycoprotein in brain endothelial cells using induced pluripotent stem cell-derived brain endothelial cell mode 

• Blood-brain barrier on-a-chip for high-throughput barrier and transport studies. 

• Intestinal tissue models representing the in vivo situation to a high degree

• The metalloprotease meprin β is a regulator of blood-brain barrier integrity

• Revised extraction of intrinsic permeabilities from apparent permeabilities in Caco-2/MDCK cells 

• The effect of the unstirred water layer (UWL) and filter on the efflux ratio in MDCK permeability assays 

to be continued