Program 2026

Selected topics:

Computational analysis of blood-brain barrier targets and trafficking toward the design of brain-penetrant therapeutics

Exploring dura hydrodynamics: The Role of the Meningeal Lymphatic Vessels in Brain Clearance

Membrane-active Peptides as Vectors for Receptor-mediated Endosomal Escape

Antimicrobial peptides derived from human β2-microglobulin protect the gut barrier from effects mediated by Clostridioides difficile toxins TcdA and TcdB

The importance of isoleucine residues within ß2-microglobulin derived peptides for the inhibition of TcdB from Clostridioides difficile

Development of a Human OSTα/β-Mediated Fluorescent Bile Acid Uptake Assay for the Assessment of Drugs with a Potential Risk of Inducing Liver Injury

Multi-scale modeling of fluid transport in brain parenchyma

TEER is not solely a barrier property: Medium-dependent effects in epithelial monolayers (MDCK & 16HBE14o⁻)

Characterizing P-glycoprotein and Breast Cancer Resistance Protein interactions of asciminib among other 2 tyrosine kinase inhibitors used in chronic myeloid leukemia

Characterizing transcellular transport mechanisms across the blood-brain barrier

Distinct membrane proteomic changes in brain microvasculature of mouse models of tauopathy and amyloid-β pathology

In-depth Substrate Characterization using a CRISPR/Cas9-derived Knockout Platform for ABC Transporters

Efficacy testing of antibody-loaded, surface-crosslinked gelatin nanoparticles on an in vitro co-culture model simulating inflammatory bowel disease

Linking Global Flux and Local Leak Events in Epithelial Barrier Models

Generation of an ABC-Transporter Blood-Brain-Barrier Model using CRISPR/Cas9 Genome Editing

Differentiation and characterization of astrocyte and endothelial cells from Induced Pluripotent Stem Cells of Alzheimer’s disease Patients which show altered BBB intregrity

Predicting Caco-2/MDCK intrinsic membrane permeability from HDM-PAMPA-derived hexadecane/water partition coefficients

Observing individual leaks in live epithelia

Application of Hydroxyapatite Microcapsules in Oromucosal Drug Delivery

The Cystine/Glutamate Antiporter System Xc− as a target for overcoming endocrine therapy resistance in ER+ breast cancer

Binary bacterial AB-type toxins as tools for cytosolic delivery of protein cargo

From uptake to extrusion: reconstructing transporter-dependent toxicokinetics of environmental contaminants in vivo using Oatp1d1 and Abcg2a zebrafish mutants

A vinblastine-selected permanent fish cell line overexpressing an unknown P-gp

Loss of the Oatp1d1 Transporter Disrupts Pigmentation, Hormone Homeostasis, and Xenobiotic Response

Unraveling the Structural Determinants of Polyspecific Ligand Recognition in ABC Transporters

From Molecular Interactions to Formulation Design: Platinum Prodrug Incorporation into Lipid Nanocarriers

Intestinal Organoids as a Predictive Model for Evaluating Oral Nano Drug Delivery Systems

Age-dependent changes of renal ABC transporters

to be continued