Scientific Publications
Diploma and PhD Theses
Diploma thesis at the University of Applied Sciences in Coburg, 1996. Einsatz eines Bildverarbeitungssystems bei der Montage mit dem Roboter
Diploma thesis at the University of Bayreuth/Max-Planck-Institut für Plasmaphysik in Garching, 2001, Optimierung der ASDEX-Upgrade Lithiumstrahl-Diagnostik.
PhD thesis at the Department of Physics at the University of Bayreuth, 2008
Characterization of Oligonucleotide Microarray Hybridization: Microarray Fabrication by Light-Directed in situ Synthesis – Development of an Automated DNA Microarray Synthesizer, Characterization of Single Base Mismatch Discrimination and the Position-Dependent Influence of Point Defects on Oligonucleotide Duplex Binding Affinities.
Publications
T. Naiser, T. Mai, W. Michel, and A. Ott. Versatile maskless microscope projection photolithography system and its application in light-directed fabrication of DNA microarrays. Review of Scientific Instruments, 77(6):063711, 2006 Link
W. Michel, T. Mai, T. Naiser, and A. Ott. Optical study of DNA surface Hybridization reveals DNA surface density as a key parameter for microarray hybridization kinetics. Biophysical Journal, 92(3):999-1004, February 2007 Link
T. Naiser, O.Ehler, J.Kayser, T. Mai, W. Michel and A. Ott. Impact of point-mutations on the hybridization affinity of surface-bound DNA/DNA and RNA/DNA oligonucleotide-duplexes: comparison of single base mismatches and base bulges. BMC Biotechnology 2008, 8:48 Link
T. Naiser, T. Mai, W. Michel and A. Ott. A versatile maskless microscope projection photolithography system and its application in light-directed fabrication of DNA microarrays. arXiv:q-bio/0608038 Link
T. Naiser, O.Ehler, T. Mai, W. Michel and A. Ott. Hybridization to Surface-bound Oligonucleotide Probes: Influence of Point Defects.arXiv:q-bio/0612043v1 Link
T. Naiser, J.Kayser, T. Mai, W. Michel and A. Ott. Point defects and the stability of surface bound oligonucleotide duplexes – experiments and model. BMC Bioinformatics 2008, 9:509 Link
T. Naiser, J.Kayser, T. Mai, W. Michel and A. Ott. DNA hybridization to surface bound probes: point defects in experiment and model. Phys. Rev. Lett.102,218301 May 2009 Link
Poster Presentations and Talks
Recent Progress in the Lithium-Beam Diagnostic for Tokamak Edge Plasmas. Thomas Naiser, Hans-Werner Müller und Elisabeth Wolfrum für die EURATOM Assoziation-Kollaboration, DPG Frühjahrstagung, Berlin 2001
Einsatz neuronaler Netze bei Plasmaexperimenten. G. Pautasso, C. Tichmann, E. Wolfrum and T. Naiser. Kolloquium, Universität Rostock 2001
Improved Edge Density Profile Measurements by the Li-Beam Diagnostic on ASDEX Upgrade. H.W. Müller, E. Wolfrum, R. Drube, J.C. Fuchs, A. Kallenbach, B. Kurzan, T. Naiser, J. Neuhauser, J. Schweinzer, ASDEX Upgrade Team. 28th EPS Conference on Controlled Fusion and Plasma Physics Funchal, 18-22 June 2001. European Physical Society, ECA Vol. 25A: 421-424. Link
DNA Chips, Talk at Euroschool-PhysBio2, Non-equilibrium in Physics and Biology, Peyresq, September 2002
DNA Chips and DNA Microarrays - Tools to Watch the Genome at Work. Talk at the Biological Physics group-seminar at MPIPKS, Dresden, November 2004
In situ Synthesis of DNA Chips. Thomas Naiser, Timo Mai, Wolfgang Michel, and Albrecht Ott. DPG-Frühjahrstagung, Berlin 2005
Kinetics of Solid-Phase DNA Hybridization. Timo Mai, Thomas Naiser, Wolfgang Michel, Philipp Baske, and Albrecht Ott. DPG-Frühjahrstagung, Berlin 2005
Light-directed in situ Synthesis of DNA Chips and Hybridization Experiments. Talk at Albert Libchabers group seminar, Rockefeller University, New York, March 2006
Light-directed synthesis and characterization of DNA microarrays. Thomas Naiser, Oliver Ehler, Timo Mai, Wolfgang Michel, Albrecht Ott. 8th Minerva Winter School, Weizmann Institute of Science, Rehovot February 2006
Hybridization and melting experiments on oligonucleotide microarrays. Thomas Naiser and Albrecht Ott. DPG-Frühjahrstagung, Dresden, March 2006
Competitive DNA Hybridization: Experimental Results and Conclusions for Microarray Experiments. Timo Mai, Wolfgang Michel, Philipp Baaske, Thomas Naiser, and Albrecht Ott. High-Throughput Data and their Analysis, DPG Frühjahrstagung, Regensburg 2007
Optical Study of DNA surface hybridization reveals DNA surface density as a key parameter for interpretation of microarray data. Wolfgang Michel, Timo Mai, Thomas Naiser, and Albrecht Ott. High-Throughput Data and their Analysis, DPG Frühjahrstagung, Regensburg 2007
The impact of defects on the binding affinity of surface bound oligonucleotid duplexes. Thomas Naiser, Oliver Ehler, Jona Kayser, Timo Mai, Wolfgang Michel, Albrecht Ott. Molecular Recognition, DPG Frühjahrstagung Berlin 2008
DNA-Chips - Nanotech meets Biotech. Seminar talk at the Naturwissenschaftlich Medizinisches Institut (NMI) - Universität Tübingen, Reutlingen June 2008
