A main objective in our lab is to define how protein synthesis modulates the division of cells. Because protein synthesis underpins much of cell growth and determines the rate at which cells proliferate. Understanding the role of protein synthesis during cell division will shed light on when cells will initiate a new cell cycle, how fast they will complete it, the number of successive cell cycles, and the coordination of cell proliferation with the available nutrients. These cellular decisions are often dysregulated in disease.
For a full list of our papers, see here. For a book on cell division Michael authored (ISBN: 978-1-119-93014-3) see here or on Amazon.
For a short introductory video made by AgriLife research about our lab, see here.
Some recent papers:
Cdk activation by phosphorylation: linking growth signals to cell cycle control (Biochem Soc Trans)
Patterns of protein synthesis in the budding yeast cell cycle: variable or constant? (Microbial Cell)
Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice (Life Science Alliance).
Translational control of MPS1 links protein synthesis with the initiation of cell division and spindle pole body duplication in Saccharomyces cerevisiae (Genetics).
Targeting APEX2 to the mRNA encoding fatty acid synthase β in yeast identifies interacting proteins that control its abundance in the cell cycle (MBoC).
Branched-chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast (EMBO Reports).
mRNA-binding proteins and cell cycle progression (Trends in Genetics).
Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division in Saccharomyces cerevisiae (Genetics).
Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity (eLife).
Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism (MBoC).
Scaling of G1 Duration with Population Doubling Time by a Cyclin in Saccharomyces cerevisiae (Genetics).
Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells (EMBO J).
We are immensely grateful to the various sponsors that have supported our research over the years.
