Objectives

Objective 1: Derive a firing-rate model of basal ganglia under photostimulation based on in vivo primate data

• Collection of optogenetics data on the basal ganglia of healthy and parkinsonian primates

• Identification of firing-rate model parameters from experimental data

• Matching between experimental data and numerical simulations

Objective 2: Provide formal analysis of pathological oscillations generation within basal ganglia

• Tight sufficient conditions for the pathological oscillations onset in the firing-rate model

• Tight sufficient conditions for the incremental stability of the basal ganglia network

• Validation based on healthy and PD experimental data

Objective 3: Design of innovative closed-loop stimulation signals

• • Development of closed-loop Deep Brain Stimulation signals (aiming at inhibition or frequency shifting) based on Local Field Potential measurements

  • Numerical and in vivo validation of these closed-loop Deep Brain Stimulation signals

Objective 4: In vivo validation

• • Efficient attenuation of pathological oscillations on parkinsonian primates based on photostimulation

  • Improvement of motor abilities of the treated parkinsonian primates.