Conference Abstracts & Posters

A Russo, M Javey, M Hiemenz, BG Kaplan, SJ Yaung, RSP Huang, CD Rolfo. "Molecular profiling across histologies in lung cancer: Time to change WHO nomenclature?" Journal of Clinical Oncology  42:8532, 2024. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. May 31 - June 4, 2024. 

AK Foerster, C Kronenthaler, L Ranganathan, S Bandara, C Woestmann, S Yaung, S Bleul, C Klingler, J Mitschke, J Wehrle, R Wäsch, J Duyster, T Struessmann, J Finke, B Su, R Marks, F Scherer. "Early Prediction of Treatment Response By Circulating Tumor DNA Profiling in Patients with Diffuse Large B-Cell Lymphoma Receiving CAR T-Cell Therapy." Poster presented at 65th American Society of Hematology Annual Meeting, San Diego, California. December 2023. 

C Woestmann, H Lin, S McNamara, M Shin, C Bermejo, S Hammer, E Heitzer, P Blombery, S Yaung, B Su. "Inter-site Performance Comparison of a Next Generation Sequencing (NGS) Assay for Minimal Residual Disease Detection Research in Diffuse Large B-Cell Lymphoma (DLBCL) Using Plasma Circulating Tumor DNA (ctDNA)." Poster presented at American Association for Cancer Research Annual Meeting, Orlando, Florida. April 2023.

SJ Yaung, J Shabbeer, V Melnikova, R Patel, G Heilek, JF Palma. "NAVIFY Mutation Profiler applied to annotation of somatic cancer variants: automated identification of significant targets and variant interactions in cell-free DNA from colorectal cancer." Poster presented at Association for Molecular Pathology Annual Meeting, Virtual. November 2021.

I Caldwell, M Ingbritsen, J Kuzich, J Callahan, K Howlett, R Arnolda, R Legaie, D Croning, N O'Leary, SJ Yaung, A Minson, M Hofman, M Dickinson, E Thompson, P Blombery. "ctDNA Measurements Highly Correlate with Disease Response and Predict Progression in Patients with B-NHL Undergoing CAR T-Cell Therapy." Poster presented at European School of Haematology: 6th Translational Research Conference on Lymphoid Malignancies, Virtual. October 2021.

SJ Yaung, S Krishna, S Scudder, M Schmid, JF Palma. "Comparison of variant classification between molecular diagnostics experts and decision support software." Poster at American Association for Cancer Research Annual Meeting, Virtual. April 2021.

S Yaung, J Li, A Pek, L Niu, J Palma, M Schmid. "Evaluation of an Up-To-Date Knowledge Base to Aid in Interpreting Somatic Mutations Detected in NGS Testing of Lung Cancer." Poster presented at 2020 World Conference on Lung Cancer, Virtual. January 28-31, 2021.

SJ Yaung, A Pek, L Niu, J Li, JF Palma, M Schmid. "Feasibility of a decision support software to aid in the interpretation of somatic mutations detected in hematologic malignancies." Poster presented at 62nd American Society of Hematology Annual Meeting, Virtual. December 2020. Recording of 5-minute poster presentation

C Woestmann, C Ju, B Hinzmann, S Yaung, M Thomas, CP Heussel, M Kriegsmann, M Meister, MA Schneider, F Herth, T Muley, B Wehnl, J Jiang, JF Palma. "Classification methods for germline and somatic single nucleotide variant (SNV) in circulating tumor DNA (ctDNA) of small cell (SCLC) and non-small cell lung cancer (NSCLC)." Poster presented at Association for Molecular Pathology Annual Meeting, Virtual. November 2020.

SJ Yaung, J Li, A Pek, L Niu, JF Palma, M Schmid. “Evaluation of a regularly updated knowledge base and automated variant interpretation tool for somatic mutations detected in solid tumors.” Poster presented at European Society for Medical Oncology 2020 Congress, Virtual. September 2020.

C Woestmann, C Ju, B Hinzmann, S Yaung, S Gattam, M Thomas, CP Heussel, M Kriegsmann, M Meister, MA Schneider, F Herth, T Muley, B Wehnl, JF Palma, J Jiang. "Disease Monitoring and TKI Resistance Mutations of EGFR Mutation-Positive NSCLC Patients via ctDNA." Poster presented at European Society for Medical Oncology 2020 Congress, Virtual. September 2020.

C Woestmann, C Ju, B Hinzmann, S Yaung, M Thomas, CP Heussel, M Kriegsmann, M Meister, MA Schneider, F Herth, T Muley, B Wehnl, JF Palma, J Jiang. "Concordance between treatment-naive tissue and circulating tumor DNA (ctDNA) in late stage non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)." Poster presented at European Society for Medical Oncology 2020 Congress, Virtual. September 2020.

J Jiang, C Ju, C Woestmann, S Gattam, L Xi,  S Yaung, B Hinzmann, M Thomas, CP Heussel, M Kriegsmann, M Meister, M Schneider, F Herth, T Muley, B Wehnl, J Palma. "Early Assessment of Treatment Effect in Small Cell Lung Cancer (SCLC) via ctDNA Analysis." Poster presented at American Association for Cancer Research Annual Meeting, Virtual. June 2020.

S Saelee, C Woestmann, L Xi, F Fuhlbrueck, K Mayol, A Harrell, J Lefkowitz, V. Van Dinh, J Jiang, X Ma, D Klass, S Yaung, A Lovejoy. "Optimized Conditions for Whole Blood Profiling with the AVENIO Analysis Kits Enable Filtering of Clonal Hematopoietic Variants from ctDNA Results." Poster presented at Association for Molecular Pathology Annual Meeting, Baltimore, Maryland. November 7-9, 2019.

DR Gandara, W Zou, J Jiang, S Yaung, F Fuhlbrück, J Wu, M Peterson, J Palma, M Ballinger, E Peters, D Shames, N Patil. "An exploratory analysis of on-treatment ctDNA measurement as a potential surrogate for overall survival for atezolizumab benefit in the OAK study." Poster presented at European Society for Medical Oncology 2019 Congress, Barcelona, Spain. September 27 - October 1, 2019

S Yaung, C Woestmann, L Xi, C Ju, B Hinzmann, M Thomas, F Lasitschka, M Meister, M Schneider, FJF Herth, T Muley, B Wehnl, J Palma, XM Ma. "Mutational profiling of tumour tissue and sequential plasma illustrates emergent clones during treatment in late stage small cell lung cancer (SCLC)." Poster presented at European Society for Medical Oncology 2019 Congress, Barcelona, Spain. September 27 - October 1, 2019.

S Yaung, L Xi, C Woestmann, C Ju, D Klass, F Casey, B Hinzmann, C Heussel, M Thomas, F Herth, T Muley, B Wehnl, J Palma, X Ma. "Assessing the Impact of Clonal Hematopoiesis in Disease Monitoring Using Targeted Cell-Free DNA (cfDNA) Sequencing Technology." Poster presented at World Conference on Lung Cancer, Barcelona, Spain. September 7-10, 2019.

S Yaung, X Ma, C Ju, C Woestmann, L Xi, B Hinzmann, M Thomas, C Heussel, F Lasitschka, M Meister, M Schneider, F Herth, T Muley, B Wehnl, J Palma. "Early Assessment of Therapy Response in Non-Small Cell Lung Cancer (NSCLC) via Longitudinal ctDNA Analysis." Poster presented at World Conference on Lung Cancer, Barcelona, Spain. September 7-10, 2019.

M Ma, S Yaung, L Xi, C Ju, J Palma, M Schmid. "Assessment of a highly-curated somatic oncology mutation database to facilitate identification of clinically important variants in NGS results." Poster presented at European Human Genetics Conference, Gothenburg, Sweden. June 15-18, 2019.

SJ Yaung, F Fuhlbrück, J Wu, F Casey, M Peterson, W Zou, JF Palma, NS Patil, Y Jiang. "Evaluation of clonal hematopoiesis in late stage NSCLC using a next-generation sequencing panel targeting cancer genes." Journal of Clinical Oncology  37:9050, 2019. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. May 31 - June 4, 2019.

Y Jiang, NS Patil, J Wu, W Zou, S Yaung, A Balasubramanyam, S Flynn, M Peterson, E Peters, PS Hegde, S Mocci, M Kowanetz, J Palma. "Circulating tumor DNA assessment in plasma samples collected in Atezolizumab versus docetaxel in subjects with previously treated non-small-cell lung cancer (OAK) study." Poster presented at Annual Meeting of Society for Immunotherapy of Cancer, Washington, D.C., November 9-11, 2018. 

XM Ma, C Ju, A Balasubramanyam, L Xi, S Yaung, D Klass, M Thomas, F Lasitschka, M Meister, M Schneider, F Herth, T Muley, B Wehnl, JF Palma. "Optimization of ctDNA Quantification Methods for Longitudinal Disease Monitoring in Lung Adenocarcinoma." Poster presented at Association for Molecular Pathology Annual Meeting, San Antonio, Texas. November 1-3, 2018. 

S Yaung, L Xi, C Woestmann, S McNamara, B Hinzmann, S Froehler, N Tikoo, C Ju, A Balasubramanyam, H-P Adams, M Thomas, F Lasitschka, M Meister, M Schneider, FJF Herth, T Muley, B Wehnl, J Palma, XM Ma. "170P Ecological diversity indices as measurements of tumor heterogeneity correlates with clinical outcomes in late stage small cell lung cancer (SCLC)." Annals of Oncology 29:suppl_8, 2018. Poster presented at European Society for Medical Oncology 2018 Congress, Munich, Germany. October 19-23, 2018.

P Vitazka, N Tikoo, A Balasubramanyam, L Xi, S Yaung, E Kwok, A Lovejoy, D Klass, M Heibeck, K Probst, A Rehfeldt, E Meldgaard, A Madsen, M Clement, J Palma, B Sorensen, P Meldgaard. "1373P Identification of subjects with locally advanced lung cancer who are likely to respond to standard-of-care chemoradiotherapy by a longitudinal monitoring of circulating tumor DNA (ctDNA) using a comprehensive ultra-sensitive NGS assay." Annals of Oncology 29:suppl_8, 2018. Poster presented at European Society for Medical Oncology 2018 Congress, Munich, Germany. October 19-23, 2018.

J Palma, P Vitazka, N Tikoo, A Balasubramanyam, L Xi, S Yaung, E Kwok, A Lovejoy, D Klass, M Heibeck, K Probst, A Rehfeldt, E Meldgaard, A Madsen, M Clement, B Sorensen, P Meldgaard. "1426P Longitudinal plasma monitoring of subjects treated with EGFR-TKIs allows better understanding of evolution of acquired resistance and can inform optimal treatment strategies." Annals of Oncology 29:suppl_8, 2018. Poster presented at European Society for Medical Oncology 2018 Congress, Munich, Germany. October 19-23, 2018.

S Yaung, N Tikoo, A Nicholas, N Sommer, JC Bendell, H Hurwitz, R Price, JF Palma, JJ Lee, F Casey. "Correlation of measurements of tumor heterogeneity based on next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) with clinical outcomes in STEAM, a prospective, randomized, multicenter study in metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 36:3545, 2018. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 1-5, 2018.

S Yaung, L Xi, C Woestmann, S McNamara, B Hinzmann, S Fröhler, N Tikoo, C Ju, A Balasubramanyam, P Vitazka, A Pati, AF Lovejoy,  DM Klass, H Adams, M Thomas, F Herth, T Muley, B Wehnl, JF Palma, XM Ma. "Mutation count, a potential surrogate for tumor mutation load, of circulating tumor DNA (ctDNA) using targeted panel sequencing correlates with clinical outcomes in late stage lung adenocarcinoma and small cell lung cancer." Journal of Clinical Oncology 36:12045, 2018. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 1-5, 2018.

JF Palma, C Woestmann, S McNamara, B Hinzmann, S Fröhler, H Adams, M Feldkamp, S Siemann, M Lange, A Blüher, S Yaung, L Xi, N Tikoo, A Balasubramanyam, C Ju, A Pati, B Wehnl, T Muley, XM Ma, F Herth. "Early assessment of therapy response in small cell lung cancer via longitudinal ctDNA analysis." Journal of Clinical Oncology 36:8577, 2018. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 1-5, 2018.

XM Ma, L Xi, S Yaung, N Tikoo, A Balasubramanyam, C Ju, D Klass, AF Lovejoy, A Pati, O Solberg, Y Jiang, H Adams, B Wehnl, M Thomas, F Lasitschka, M Meister, M Schneider, F Herth, JF Palma, T Muley. "Early assessment of treatment effect in advanced lung adenocarcinoma via longitudinal ctDNA analysis." Journal of Clinical Oncology 36:12088, 2018. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 1-5, 2018.

XM Ma, N Tikoo, C Ju, A Balasubramanyam, L Xi, S Yaung, D Klass, AF Lovejoy, A Pati, O Solberg, Y Jiang, H Adams, M Thomas, F Lasitschka, M Meister, M Schneider, F Herth, T Muley, B Wehnl, JF Palma. "Longitudinal ctDNA analysis to enable early assessment of prognosis in lung adenocarcinoma in the absence of matched tissue biopsy." Journal of Clinical Oncology 36:12077, 2018. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 1-5, 2018.

P Lal, J Lee, H Adams, L Yao, F Fuhlbrück, S Yaung, S McNamara, C Wöstmann, S Fröhler, L Fang, R Kube, F Marusch, M Heise, T Steinmüller, M Pross, R Mantke, J Palma, André Rosenthal. "Concordance of genomic single-nucleotide variations (SNV) by next-generation sequencing (NGS) in paired tumor tissue and plasma in colorectal cancer (CRC)." Oral presentation at American Association for Clinical Research, Chicago, Illinois. April 14-18, 2018.

I Garcia-Murillas, P Proszek, C Fribbens, L Yuan, H Bye, M Hubank, J Jiang, S Yaung, J Palma, S Johnston, A Ring, N Turner. "Circulating tumor DNA analysis with ultra-high sensitivity sequencing in metastatic breast cancer." Poster presented at San Antonio Breast Cancer Symposium, San Antonio, Texas. December 5-9, 2017.

Y Jiang, H Adams, L Yao, S Yaung, F Fuhlbrueck, S Froehler, L Fang, P Lai, J Achenbach, O Oster, O Schega, R Kruegel, J Palma, A Rosenthal. "Concordance of Genomic Alterations by Next Generation Sequencing (NGS) in Tumor Tissue versus Cell-Free DNA in Stage I-IV NSCLC." Poster presented at Association for Molecular Pathology Annual Meeting, Salt Lake City, Utah. November 16-18, 2017.

AF Lovejoy, A Pati, A Munoz, S Yaung, J Jin, D Klass. "In-depth Assessment Reveals Powerful Performance and Flexibility of AVENIO ctDNA Analysis Kits." Poster presented at Association for Molecular Pathology Annual Meeting, Salt Lake City, Utah. November 16-18, 2017.

J Jiang, H Adams, M Lange, S Siemann, M Feldkamp, S Schulze, S Froehler, S Yaung, L Yao, A Balasubramanyam, N Tikoo, HJ Achenbach, R Krügel, J Palma, A Rosenthal. "Longitudinal Mutation Monitoring in Plasma by Deep Sequencing as a Potential Predictor of Disease Progression in NSCLC." Oral presentation at World Conference on Lung Cancer, Yokohama, Japan. October 15-18, 2017.

JJ Lee, JF Palma, L Yao, AF Lovejoy, S Yaung, D Zhang, N Wingate-Pearse, M Yau, C Williams, M Pimentel, A Munoz, K Mayol, C Mancao, A Nicholas, N Sommer, JC Bendell, H Hurwitz, U Rohr. "Evaluation of clinical outcomes by analysis of mutations in tumor tissue and circulating plasma DNA using next-generation sequencing (NGS) from STEAM, a prospective, randomized, multicenter study in metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 35:11510, 2017. Poster presented and discussed at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 2-6, 2017.

M Diehn, AA Alizadeh, H Adams, JJ Lee, S Klassen, JF Palma, B Hinzman, AF Lovejoy, AM Newman, L Yao, S Yaung, A Balasubramanyam, U Rohr, A Rosenthal, R Kube, T Steinmuller, F Marusch, R Mantke, M Heise, M. "Early prediction of clinical outcomes in resected II and III colorectal cancer (CRC) through deep sequencing of circulating tumor DNA (ctDNA)." Journal of Clinical Oncology 35:3591, 2017. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 2-6, 2017.

S Yaung, A Lovejoy, D Klass, F Casey, A Arcot, M Loyzer, W Chiu, N Azhar, S Beckert, M Lange, S Siemann, S Froehler, S Gunn, JF Palma. "Inter-site comparison of performance of an ultra-sensitive sequencing technology for circulating tumor DNA." Poster presented at American Association for Cancer Research Annual Meeting, Washington, D.C. April 1-5, 2017.

SJ Yaung, L Deng, N Li, JL Braff, GM Church, L Bry, HH Wang, GK Gerber. "Temporal functional metagenomics sequencing to improve microbial fitness in the mammalian gut." HST Forum, Boston, Massachusetts. April 16, 2015.

SJ Yaung, HH Wang, KM Esvelt, GM Church. "Engineering Gene Transfer Networks in the Human Microbiome." Wyss Institute Annual Retreat, Boston, Massachusetts. November 19, 2012.

PB Matthews, S Yaung, AN Azadani, N Jaussaud, C Jhun, JM Guccione, TS Guy, EE Tseng. "Pulmonary Autograft Wall Stress Calculation With Finite Element Modeling." Biennial Meeting of the Society for Heart Valve Disease, Berlin, Germany. June 27-30, 2009.

P Dhawan*, S Yaung*, H Uppal*, D Puppala, M Sweeney, J Murray, P Hajek, E Oquendo, C Wilson, N Priedigkeit, D Goldstein, D Misner, S Platz, R Capaldi, K Kolaja. "The Role of Mitochondrial Toxicity in the Cardiotoxicity of Small Molecule Kinase Inhibitors." Annual Meeting of the Society of Toxicology, Baltimore, Maryland. March 15-19, 2009.