Publication

主要論文

Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.

Sasaki L, Hamada Y, Yarimizu D, Suzuki T, Nakamura H, Shimada A, Nguyen Pham KT, Shao X, Yamamura K, Inatomi T, Morinaga H, Nishimura EK, Kudo F, Manabe I, Haraguchi S, Sugiura Y, Suematsu M, Kinoshita S, Machida M, Nakajima T, Kiyonari H, Okamura H, Yamaguchi Y, Miyake T, Doi M.

Nature Aging, 2022;2:105-114. doi: https://doi.org/10.1038/s43587-021-00167-8

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.

Haraguchi S*, Kamata M, Tokita T, Tashiro KI, Sato M, Nozaki M, Okamoto-Katsuyama M, Shimizu I, Han G, Chowdhury VS, Lei XF, Miyazaki T, Kim-Kaneyama JR, Nakamachi T, Matsuda K, Ohtaki H, Tokumoto T, Tachibana T, Miyazaki A, Tsutsui K.

eLife. 2019;8:e45306 doi: 10.7554/eLife.45306

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis.

Ubuka T, Haraguchi S, Tobari Y, Narihiro M, Ishikawa K, Hayashi T, Harada N, Tsutsui K.

Nat Commun. 2014;5:3061 doi: 10.1038/ncomms4061

A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras.

Maekawa F, Sakurai M, Yamashita Y, Tanaka K, Haraguchi S, Yamamoto K, Tsutsui K, Yoshioka H, Murakami S, Tadano R, Goto T, Shiraishi J, Tomonari K, Oka T, Ohara K, Maeda T, Bungo T, Tsudzuki M, Ohki-Hamazaki H.

Nat Commun. 2013;4:1372 doi: 10.1038/ncomms2372

Possible role of pineal allopregnanolone in Purkinje cell survival.

Haraguchi S, Hara S, Ubuka T, Mita M, Tsutsui K.

Proc Natl Acad Sci USA. 2012 Dec 18;109(51):21110-5. doi: 10.1073/pnas.1210804109

Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways.

Hatori M, Hirota T, Iitsuka M, Kurabayashi N, Haraguchi S, Kokame K, Sato R, Nakai A, Miyata T, Tsutsui K, Fukada Y.

Proc Natl Acad Sci USA. 2011 Mar 22;108(12):4864-9. doi: 10.1073/pnas.1015959108

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.

Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, Emoto N, Okuno Y, Tsujimoto G, Kanematsu A, Ogawa O, Todo T, Tsutsui K, van der Horst GT, Okamura H.

Nat Med. 2010 Jan;16(1):67-74. doi: 10.1038/nm.2061.

【全業績】

（１）原著論文

Expression and localization of the neuropeptide Y-Y4 receptor in the chick spleen: mRNA upregulation by high ambient temperature.

Nishimura H, Elhussiny MZ, Ouchi Y, Haraguchi S, Itoh TQ, Gilbert ER, Cline MA, Nishimura S, Hosaka YZ, Takahashi E, Cockrem JF, Bungo T, Chowdhury VS.

Neuropeptides. 2024;107:102459. doi: 10.1016/j.npep.2024.102459.

Motor coordination is partially impaired in neonatal mice with moderate hypothyroidism but not with mild hypothyroidism.

Kokubo M, Amano I, Yajima H, Miyazaki W, Takatsuru Y, Haijima A, Haraguchi S, Koibuchi N.

Thyroid Science. 2024;1:100005. doi: https://doi.org/10.1016/j.thscie.2023.100005

Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13.

Miyauchi A, Noguchi M, Lei XF, Sakaki M, Kobayashi-Tanabe M, Haraguchi S, Miyazaki A, Kim-Kaneyama JR.

Sci Rep. 2023;13:7446. doi: 10.1038/s41598-023-34659-x.

Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.

Nature Aging, 2022;2:105-114. doi: https://doi.org/10.1038/s43587-021-00167-8

Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking.

Miyazaki T, Taketomi Y, Higashi T, Ohtaki H, Takaki T, Ohnishi K, Hosonuma M, Kono N, Akasu R, Haraguchi S, Kim-Kaneyama JR, Otsu K, Arai H, Murakami M, Miyazaki A.

Arterioscler Thromb Vasc Biol. 2023;43:e66–e82. doi: https://doi.org/10.1161/ATVBAHA.122.317781

Intracerebroventricular injection taurine changes free amino acid concentrations in the brain and plasma in chicks.

Elhussiny MZ, Tran PV, Wang Y, Ouchi Y, Haraguchi S, Gilbert ER, Cline MA, Bungo T, Furuse M, Chowdhury VS.

Amino Acids. 2023;55:183-192. doi: 10.1007/s00726-022-03216-7.

Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis.

Akasu R, Miyazaki T, Elhussiny MZ, Sugiura Y, Tomitsuka Y, Haraguchi S, Otsu K, Chowdhury VS, Miyazaki A.

J Biol Chem. 2022;298:101953. doi: 10.1016/j.jbc.2022.101953.

Intracerebroventricular injection of taurine induces hypothermia through modifying monoaminergic pathways in chicks.

Elhussiny MZ, Nishimura H, Tran PV, Haraguchi S, Gilbert ER, Cline MA, Bungo T, Furuse M, Chowdhury VS.

Eur J Pharmacol. 2022;928:175092. doi: 10.1016/j.ejphar.2022.175092.

Oral administration of L-citrulline changes brain free amino acid and monoamine metabolism in heat-exposed broiler chickens.

Chowdhury VS, Han G, Elhussiny MZ, Ouchi Y, Tran PV, Nishimura H, Haraguchi S, Cockrem J, Bungo T, Furuse M.

Front. Anim. Sci., 2022;3:875572. doi: 10.3389/fanim.2022.8755728

Central taurine attenuates hyperthermia and isolation stress behaviors augmented by corticotropin-releasing factor with modifying brain amino acid metabolism in neonatal chicks.

Elhussiny MZ, Tran PV, Tsuru Y, Haraguchi S, Gilbert ER, Cline MA, Bungo T, Furuse M, Chowdhury VS.

Metabolites, 2022;12:83. doi: https://doi.org/10.3390/metabo12010083

Adult-onset hypothyroidism causes mechanical hypersensitivity due to peripheral nerve hyperexcitability based on voltage-gated potassium channel downregulation in male mice.

Suda M, Takatsuru Y, Amano I, Haraguchi S, Koibuchi N.

J Neurosci Res, 2022;100:506-521. https://doi.org/10.1002/jnr.25001

Liver metabolomic analysis in broiler chicks: profiling the metabolites after oral administration of L-citrulline.

Chowdhury VS, Ouchi Y, Haraguchi S, Bungo T.

Anim Sci J, 2021;92:e13609. doi: https://doi.org/10.1111/asj.13609

Oral administration of L-citrulline changes the concentrations of plasma hormones and biochemical profile in heat-exposed broilers.

Chowdhury VS, Ouchi Y, Han G, Eltahan HM, Haraguchi S, Miyazaki T, Shiraishi J, Sugino T, Bungo T.

Anim Sci J, 2021;92:e13578. doi: https://doi.org/10.1111/asj.13578

Central GABAA receptor mediates taurine-induced hypothermia and possibly reduces food intake in thermo-neutral chicks and regulates plasma metabolites in heat-exposed chicks.

Elhussiny MZ, Tran PV, Pham CV, Nguyen LTN, Haraguchi S, Gilbert ER, Cline MA, Bungo T, Furuse M, Chowdhury VS.

J Therm Biol. 2021;98:102905. doi: 10.1016/j.jtherbio.2021.102905.

Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis.

Gao L, Lei XF, Miyauchi A, Noguchi M, Omoto T, Haraguchi S, Miyazaki T, Miyazaki A, Kim-Kaneyama JR.

Sci Rep. 2020;10:19105. doi: 10.1038/s41598-020-76095-1

Effects of L-leucine in ovo feeding on thermotolerance, growth and amino acid metabolism under heat stress in broilers.

Han G, Ouchi Y, Hirota T, Haraguchi S, Miyazaki T, Arakawa T, Masuhara N, Mizunoya W, Tatsumi R, Tashiro K, Bungo T, Furuse M, Chowdhury VS.

Animal, 2020;14:1701-1709. doi: 10.1017/S1751731120000464

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.

eLife. 2019;8:e45306 doi: 10.7554/eLife.45306

Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.

Miyauchi A, Kim-Kaneyama JR, Lei XF, Chang SH, Saito T, Haraguchi S, Miyazaki T, Miyazaki A.

Sci Rep. 2019;9:15770. doi: 10.1038/s41598-019-52301-7

L-Leucine increases the daily body temperature and affords thermotolerance in broiler chicks.

Han G, Yang H, Wang Y, Haraguchi S, Miyazaki T, Bungo T, Tashiro K, Furuse M, Chowdhury VS.

Asian Austral J Aanim. 2019;32:842-848. doi: 10.5713/ajas.18.0677

Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing.

Miyazaki T, Haraguchi S, Kim-Kaneyama JR, Miyazaki A.

FASEB J. 2019;33:2037-2046. doi: 10.1096/fj.201800588RR

Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.

Nozaki M, Haraguchi S*, Miyazaki T, Shigeta D, Kano N, Lei XF, Kim-Kaneyama JR, Minakata H, Miyazaki A, Tsutsui K.

Sci Rep. 2018;8:2167. doi: 10.1038/s41598-018-20226-2

The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.

Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Miyauchi A, Li S, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.

Oncogene 2018;37(9):1205-1219. doi: 10.1038/s41388-017-0033-y

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.

Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanai Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI.

Sci Rep. 2017;7:41912. doi: 10.1038/srep41912

7α-Hydroxypregnenolone regulates diurnal changes in sexual behavior of male quail.

Ogura Y, Haraguchi S*, Nagino K, Ishikawa K, Fukahori Y, Tsutsui K.

Gen Comp Endocrinol. 2016;227:130-5. doi: 10.1016/j.ygcen.2015.11.010

7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon.

Haraguchi S, Yamamoto Y, Suzuki Y, Hyung Chang J, Koyama T, Sato M, Mita M, Ueda H, Tsutsui K.

Sci Rep. 2015;5:12546. doi: 10.1038/srep12546

Nucleotide sequence and expression of relaxin-like gonad-stimulating peptide gene in starfish Asterina pectinifera.

Haraguchi S, Ikeda N, Abe M, Tsutsui K, Mita M.

Gen Comp Endocrinol. 2016;227:115-9. doi: 10.1016/j.ygcen.2015.06.017

A new relaxin-like gonad-stimulating peptide identified in the starfish Asterias amurensis.

Mita M, Daiya M, Haraguchi S, Tsutsui K, Nagahama Y.

Gen Comp Endocrinol. 2015;222:144-9. doi: 10.1016/j.ygcen.2015.07.002

Possible hormonal interaction for eliciting courtship behavior in the male newt, Cynops pyrrhogaster.

Toyoda F, Hasunuma I, Nakada T, Haraguchi S, Tsutsui K, Kikuyama S.

Gen Comp Endocrinol. 2015;224:96-103. doi: 10.1016/j.ygcen.2015.06.016

A gonad-stimulating peptide of the crown-of-thorns seastar, Acanthaster planci.

Mita M, Ikeda N, Haraguchi S, Tsutsui K, Nakamura M.

Invert Reprod Dev. 2015;59:224-229. doi: 10.1080/07924259.2015.1086828

Relaxin-like gonad-stimulating substance is a highly conservative peptide in starfish Asterina pectinifera.

Ikeda N, Uzawa H, Daiya M, Haraguchi S, Tsutsui K, Mita M.

Invert Reprod Dev. 2015;59:212-217. doi: 10.1080/07924259.2015.1091388

Involvement of Gαs-proteins in the action of relaxin-like gonad-stimulating substance on starfish ovarian follicle cells.

Mita M, Haraguchi S, Watanabe M, Takeshige Y, Yamamoto K, Tsutsui K.

Gen Comp Endocrinol. 2014;205:80-7. doi: 10.1016/j.ygcen.2014.06.003

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis.

Ubuka T, Haraguchi S, Tobari Y, Narihiro M, Ishikawa K, Hayashi T, Harada N, Tsutsui K.

Nat Commun. 2014;5:3061. doi: 10.1038/ncomms4061

Contribution of de novo synthesis of Gαs-proteins to 1-methyladenine production in starfish ovarian follicle cells stimulated by relaxin-like gonad-stimulating substance.

Mita M, Haraguchi S, Uzawa H, Tsutsui K.

Biochem Biophys Res Commun. 2013;440:798-801. doi: 10.1016/j.bbrc.2013.10.038

A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras.

Nat Commun. 2013;4:1372. doi: 10.1038/ncomms2372

Possible role of pineal allopregnanolone in Purkinje cell survival.

Haraguchi S, Hara S, Ubuka T, Mita M, Tsutsui K.

Proc Natl Acad Sci USA. 2012;109:21110-5. doi: 10.1073/pnas.1210804109

Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes.

Shima Y, Miyabayashi K, Haraguchi S, Arakawa T, Otake H, Baba T, Matsuzaki S, Shishido Y, Akiyama H, Tachibana T, Tsutsui K, Morohashi K.

Mol Endocrinol. 2013;27:63-73. doi: 10.1210/me.2012-1256

Involvement of the neurosteroid 7α-hydroxypregnenolone in the courtship behavior of the male newt Cynops pyrrhogaster.

Toyoda F, Hasunuma I, Nakada T, Haraguchi S, Tsutsui K, Kikuyama S.

Horm Behav. 2012;62:375-80. doi: 10.1016/j.yhbeh.2012.07.001

Acute stress increases the synthesis of 7α-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts.

Haraguchi S, Koyama T, Hasunuma I, Okuyama S, Ubuka T, Kikuyama S, Do Rego JL, Vaudry H, Tsutsui K.

Endocrinology 2012;153:794-805. doi: 10.1210/en.2011-1422

Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways.

Hatori M, Hirota T, Iitsuka M, Kurabayashi N, Haraguchi S, Kokame K, Sato R, Nakai A, Miyata T, Tsutsui K, Fukada Y.

Proc Natl Acad Sci USA. 2011;108:4864-9. doi: 10.1073/pnas.1015959108

Expression of cytochrome P450 side-chain cleavage enzyme mRNA and production of pregnenolone in the brain of the red-bellied newt Cynops pyrrhogaster.

Takase M, Haraguchi S, Hasunuma I, Kikuyama S, Tsutsui K.

Gen Comp Endocrinol. 2011;170:468-74

Estrogen biosynthesis in the gonad of the frog Rana rugosa.

Isomura T, Haraguchi S, Miyamoto K, Tsutsui K, Nakamura Y, Nakamura M.

Gen Comp Endocrinol. 2011;170:207-12. doi: 10.1016/j.ygcen.2010.10.015

Prolactin increases the synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts.

Haraguchi S, Koyama T, Hasunuma I, Vaudry H, Tsutsui K.

Endocrinology 2010;151:2211-22. doi: 10.1210/en.2009-1229

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.

Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, Emoto N, Okuno Y, Tsujimoto G, Kanematsu A, Ogawa O, Todo T, Tsutsui K, van der Horst GT, Okamura H.

Nat Med. 2010;16:67-74. doi: 10.1038/nm.2061

Diurnal changes in the synthesis of the neurosteroid 7α-hydroxypregnenolone stimulating locomotor activity in newts.

Koyama T, Haraguchi S, Vaudry H, Tsutsui K.

Ann N Y Acad Sci. 2009;1163:444-7. doi: 10.1111/j.1749-6632.2008.03622.x

Seasonal changes in the synthesis of the neurosteroid 7α-hydroxypregnenolone stimulating locomotor activity in newts.

Haraguchi S, Matsunaga M, Koyama T, Do Rego JL, Tsutsui K.

Ann N Y Acad Sci. 2009;1163:410-3. doi: 10.1111/j.1749-6632.2008.03621.x

Discovery of a novel avian neurosteroid, 7α-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail.

Tsutsui K, Inoue K, Miyabara H, Suzuki S, Ogura Y, Tobari Y, Haraguchi S.

Gen Comp Endocrinol. 2009;163(1-2):117-22. doi: 10.1016/j.ygcen.2009.04.005

Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa.

Sakurai N, Maruo K, Haraguchi S, Uno Y, Oshima Y, Tsutsui K, Matsuda Y, Do Rego JL, Pelletier G, Vaudry H, Nakamura M.

J Steroid Biochem Mol Biol. 2008;112(1-3):5-12. doi: 10.1016/j.jsbmb.2008.07.002

7α-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.

Tsutsui K, Inoue K, Miyabara H, Suzuki S, Ogura Y, Haraguchi S.

J Neurosci. 2008;28:2158-67. doi: 10.1523/JNEUROSCI.3562-07.2008

Mode of action and functional significance of estrogen-inducing dendritic growth, spinogenesis, and synaptogenesis in the developing Purkinje cell.

Sasahara K, Shikimi H, Haraguchi S, Sakamoto H, Honda S, Harada N, Tsutsui K.

J Neurosci. 2007;27:7408-17.

（２）総説論文

Potential role of amino acids in the adaptation of chicks and market-age broilers to heat stress.

Chowdhury VS, Han G, Eltahan HM, Haraguchi S, Gilbert ER, Cline MA, Cockrem JF, Bungo T, Furuse M.

Front Vet Sci. 2021;7:610541. doi: 10.3389/fvets.2020.610541

Pineal neurosteroids: biosynthesis and physiological functions.

Haraguchi S*, Tsutsui K.

Front Endocrinol. 2020;11:549. doi: 10.3389/fendo.2020.00549

Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells.

Tsutsui K, Haraguchi S.

FASEB BioAdvances. 2020;2:129-159. doi: 10.1096/fba.2019-00055.

Pineal allopregnanolone saves cerebellar Purkinje cells from apoptosis.

Haraguchi S*.

Electrophoresis letters. 2019;63(1):19-23. doi: 10.2198/electroph.63.19.

7α-Hydroxypregnenolone regulating locomotor behavior identified in the brain and pineal gland across vertebrates.

Tsutsui K, Haraguchi S, Vaudry H.

Gen Comp Endocrinol. 2018;265:97-105. doi: 10.1016/j.ygcen.2017.09.014.

Brain and pineal 7α-hydroxypregnenolone regulating locomotor behavior: discovery, progress and prospect.

Tsutsui K, Haraguchi S, Ubuka T.

Neuropsychiatry (London). 2018;8(4):1150–1159. doi: 10.4172/Neuropsychiatry.1000442

Biosynthesis and biological action of pineal allopregnanolone.

Tsutsui K, Haraguchi S.

Front Cell Neurosci. 2014;8:118. doi: 10.3389/fncel.2014.00118.

Breakthrough in neuroendocrinology by discovering novel neuropeptides and neurosteroids: 2. Discovery of neurosteroids and pineal neurosteroids.

Tsutsui K, Haraguchi S.

Gen Comp Endocrinol. 2014;205:11-22. doi: 10.1016/j.ygcen.2014.03.008.

Biosynthesis and biological actions of pineal neurosteroids in domestic birds.

Tsutsui K, Haraguchi S, Hatori M, Hirota T, Fukada Y.

Neuroendocrinology. 2013;98(2):97-105. doi: 10.1159/000353782.

Brain and pineal 7α-hydroxypregnenolone stimulating locomotor activity: identification, mode of action and regulation of biosynthesis.

Tsutsui K, Haraguchi S, Fukada Y, Vaudry H.

Front Neuroendocrinol. 2013;34(3):179-89. doi: 10.1016/j.yfrne.2013.05.002.

New biosynthesis and biological actions of avian neurosteroids.

Tsutsui K, Haraguchi S, Inoue K, Miyabara H, Ubuka T, Hatori M, Hirota T, Fukada Y.

J Exp Neurosci. 2013;7:15-29. doi: 10.4137/JEN.S11148.

Estradiol promotes Purkinje dendritic growth, spinogenesis, and synaptogenesis during neonatal life by inducing the expression of BDNF.

Haraguchi S, Sasahara K, Shikimi H, Honda S, Harada N, Tsutsui K.

Cerebellum. 2012;11(2):416-7. doi: 10.1007/s12311-011-0342-6.

7α-Hydroxypregnenolone, a new key regulator of amphibian locomotion: discovery, progress and prospect.

Tsutsui K, Haraguchi S, Matsunaga M, Koyama T, Do Rego JL, Vaudry H.

Gen Comp Endocrinol. 2012;176(3):440-7. doi: 10.1016/j.ygcen.2011.11.020.

Control of circadian activity of birds by the interaction of melatonin with 7α-hydroxypregnenolone, a newly discovered neurosteroid stimulating locomotion.

Tsutsui K, Haraguchi S, Inoue K, Miyabara H, Suzuki S, Ubuka T.

J Ornithol. 2012;153(Suppl 1): 235. doi: 10.1007/s10336-011-0795-x.

Biosynthesis, mode of action, and functional significance of neurosteroids in the Purkinje cell.

Tsutsui K, Ukena K, Sakamoto H, Okuyama S, Haraguchi S.

Front Endocrinol. 2011;2:61. doi: 10.3389/fendo.2011.00061.

Mode of action and functional significance of 7α-hydroxypregnenolone stimulating locomotor activity.

Haraguchi S, Matsunaga M, Vaudry H, Tsutsui K.

Front Endocrinol. 2011;2:23. doi: 10.3389/fendo.2011.00023.

Identification of 7α-hydroxypregnenolone, a novel bioactive amphibian neurosteroid stimulating locomotor activity, and its physiological roles in the regulation of locomotion.

Tsutsui K, Haraguchi S, Matsunaga M, Koyama T, Do Rego JL, Vaudry H.

Gen Comp Endocrinol. 2010;168(2):275-9. doi: 10.1016/j.ygcen.2010.01.024.

7α-hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates: identification, mode of action, and functional significance.

Tsutsui K, Haraguchi S, Matsunaga M, Inoue K, Vaudry H.

Front Endocrinol. 2010;1:9. doi: 10.3389/fendo.2010.00009.

Identification, biosynthesis, and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in nonmammalian vertebrates.

Tsutsui K, Haraguchi S, Inoue K, Miyabara H, Suzuki S, Ogura Y, Koyama T, Matsunaga M, Vaudry H.

Ann N Y Acad Sci. 2009;1163:308-15. doi: 10.1111/j.1749-6632.2009.04426.x.

Hormone-mediated reproductive behavior in the red-bellied newt.

Kikuyama S, Hasunuma I, Toyoda F, Haraguchi S, Tsutsui K.

Ann N Y Acad Sci. 2009;1163:179-86. doi: 10.1111/j.1749-6632.2009.04449.x.

Discovery of a novel avian neurosteroid, 7α-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail.

Tsutsui K, Inoue K, Miyabara H, Suzuki S, Ogura Y, Tobari Y, Haraguchi S.

Gen Comp Endocrinol. 2009;163(1-2):117-22. doi: 10.1016/j.ygcen.2009.04.005.

（３）著書など

Tsutsui K, Haraguchi S.

Neurosteroids. In: Handbook of Hormones, 2nd Edition. Ando H, Ukena K, Nagata S (eds), Elsevier,

pp 955-966 (2021).

Tsutsui K, Haraguchi S.

Neurosteroids. In: Handbook of Hormones, 1st Edition. Takei Y, Ando H, Tsutsui K (eds), Elsevier,

pp 537-545 (2015).

（３）その他、和文原著、和文総説など

在宅訪問看護利用者の主観的幸福感とその関連要因の解析

平田裕也・原口省吾・宮崎章

日本在宅医療連合学会誌 vol. 4, no. 4, 1-8 (2023).

カルシウム-塩化物泉がヒト表皮の遺伝子発現に引き起こす変化

原口省吾

日本健康開発雑誌 vol. 44, 75-80 (2023). doi: https://doi.org/10.32279/jjhr.202344J03

ニューロステロイド

原口省吾

比較内分泌学 vol. 45, no. 167, 64-68 (2019).

―2学会合同若手研究者シンポジウム―

松果体におけるニューロステロイドの生合成と生理作用

原口省吾、産賀崇由、時田巧磨、田代渓一郎、三田雅敏、筒井和義

比較内分泌学 vol. 40, no. 152, 63-65 (2014).

松果体で合成・放出されたアロプレグナノロンは発達期の小脳プルキンエ細胞の生存に不可欠である

原口省吾、原桜子、産賀崇由、三田雅敏、筒井和義

比較内分泌学 vol. 39, no. 148, 44-48 (2013). [表紙に選出]

第36回日本比較内分泌学会大会 -若手研究者最優秀発表賞を頂いて-

ストレスが誘導する脳内7α-ヒドロキシプレグネノロン合成の変動とその制御機構

原口省吾

比較内分泌学 vol. 38, no. 144, 24-26 (2012).

自発運動を制御する新規ニューロステロイド7α-ヒドロキシプレグネノロンの作用機構と発現制御機構

原口省吾

比較内分泌学 vol. 37, no. 141, 95-98 (2011).

（４）招待講演・シンポジウムなど

・国際

8th Asia and Oceania Society for Comparative Endocrinology

Haraguchi S, Tachibana T, Tokumoto T, Matsuda K, Tsutsui K.

State-of-the-art lecture: Pineal allopregnanolone saves cerebellar Purkinje cells from apoptosis via a

membrane progestin receptor-mediated mechanism.

Seoul, Korea; June 20-24, 2016.

27th Conference of European Comparative Endocrinologist

Haraguchi S, Tsutsui K.

State-of-the-art lecture: Integrated neuroendocrine control of newt locomotor behavior.

Rennes, France; August 25-29, 2014.

17th International Congress of Comparative Endocrinology

Haraguchi S, Hara S, Ubuka T, Mita M, Tsutsui K.

Pineal allopregnanolone saves cerebellar Purkinje cells from apoptosis.

Barcelona, Spain; July 15-19, 2013.

10th International Symposium on Avian Endocrinology

Haraguchi S, Inoue K, Miyabara H, Suzuki S, Ogura Y, Tsutsui K.

Melatonin regulates diurnal changes in locomotor activity by regulating 7α-hydroxypregnenolone synthesis in quail.

Gifu, Japan; June 5-9, 2012.

US/JAPAN Neurosteroid SYMPOSIUM 2008

Haraguchi S, Matsunaga M, Inoue K, Miyabara H, Suzuki S, Ogura Y, Koyama T, Tsutsui K.

Rapid stimulation of locomotor activity by 7α-hydroxypregnenolone identified as a novel

neuronal activator

Gifu, Japan; September 8-11, 2008.

・国内

第94回日本生化学会大会

原口省吾「加齢に伴う皮膚ステロイドホルモン環境の変化とその皮膚疾患への関与」

2021年11月3-5日

第47回日本神経内分泌学会学術集会

次世代の会（NGENES）シンポジウム

原口省吾「光環境が発達期の脳に与える影響」

2021年10月30日

第92回日本動物学会

第5回ペプチド・ホルモン研究会シンポジウム

原口省吾、大滝博和、杉浦悠毅、原田一貴、坪井貴司「皮膚バリアを制御する皮脂腺の新たな働き」

2021年9月2日

第126回日本解剖学会総会・全国学術集会第98回日本生理学会大会合同大会

シンポジウム「脳発達に対する環境影響：内分泌系の関与」

原口省吾「夜間の照明が脳の発達に与える影響とその分子機構」

2021年3月29日

ほか～