Detlef Weigel and Gerd Jürgens
doi:10.1038/434443a
See also: Editor's summary
24 March 2005
The principle of inheritance first observed by Mendel is clear enough. Genetic information passes from parent to offspring in the DNA carried in the chromosomes found in every cell of the organism — and to a lesser extent in auxiliary genomes in organelles such as mitochondria and chloroplasts. But analysis of revertant hothead gene mutants inArabidopsis thaliana suggests that these plants can inherit information not found in parental chromosomes, but identical to that of a grandparent or more distant forebear. This may involve template-directed restoration of ancestral DNA passed on in an RNA cache, like a web browser cache that delivers an old page. It will be intriguing to discover if this type of inheritance is widespread. On the cover, a hothead mutant inflorescence (SEM by M. A. Webb).
NEWS AND VIEWS
A previously unknown way of reversing genome-wide sequence changes in DNA has been revealed by an analysis of plants carrying mutations in a gene called HOTHEAD. The mechanism remains a mystery.
Detlef Weigel and Gerd Jürgens
doi:10.1038/434443a
LETTER
Susan J. Lolle, Jennifer L. Victor, Jessica M. Young and Robert E. Pruitt
doi:10.1038/nature03380
\bibitem{pcp102} Detlef Weigel & Gerd Jurgens. Genetics: Hotheaded healer // Nature 434, 443 (24 March 2005). N&V of \cite{pcp101} Горячий целитель - здесь буквально, исцеление геном HOTHEAD
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Genetics: Hotheaded healer p443
A previously unknown way of reversing genome-wide sequence changes in DNA has been revealed by an analysis of plants carrying mutations in a gene called HOTHEAD. The mechanism remains a mystery.