Cullin-RING E3-Ligases in cell division

Cullin-RING E3-ligases (CRL) represent the largest family of E3 ubiquitin-ligases targeting the degradation of key cell cycle regulators in space and time, contributing to the orderly progression of the cell division cycle. We are interested in understanding how these enzymes regulate cell cycle progression in a developmental context.

o CRL in the regulation of the Bora-Aurora-Plk1 pathway

o CRL in the regulation of Katanin activity

o CRL in the maintenance of DNA replication integrity