Embedded Files
'EvolOMICs' (short form of Evolutionary OMICs) is the group of young researchers and students which I lead in the Department of Molecular Biology and Biotechnology, at Tezpur University. We study complex phenomena of evolution in biological systems starting from the sub-cellular molecular levels (microscopic) to the whole organism and ecosystem level (macroscopic) level using Next Generation Sequencing, Big data and robust computer algorithms.
We are trying to solve few interesting questions such as-
How do certain cancers develop therapy resistance and evolve to high grade tumors?
Why certain diseases have population specific and/or geography specific incidence rates?
Being sessile in nature, how do plants perceive, respond, adapt and evolve during simultaneous exposure of harsh biotic and abiotic factors?
Do non-coding regions of the genome play crucial role in evolution of biological systems?
Can we utilize heterogenous high dimensional biological and clinical datasets (Big data) to identify translatable biomarkers using machine learning methods?
*(Figure adapted from: Barah P, Bones AM; J Exp Bot. 2015)
Key words: Computational systems biology, Bioinformatics, Structural systems biology, Evolutionary systems biology, Next Generation Sequencing (NGS), Big data in biology and medicine, Biological networks.
Computing Facilities: Big data lab@EvolOMICs is equipped with a high end HPE ProLiant XL170r Gen10 High Performance Computing (HPC) server (HPE Apollo 2000 system chassis) having 168 cores, 768 GB RAM with scale out architecture and a 110 TB Network Attached Storage (NAS), apart from several high end desktop workstations, and terminals. We mostly use open source software, codes, and platforms.
Currently our research group has fundings from following projects- (Principal Investigator: Dr. Pankaj Barah)
Ramalingaswamy Fellowship grant by the Department of Biotechnology (DBT) , Government of India (2017-2023)
DBT's TwinningProgramme for NER (2018-2021)
Science and Engineering Research Board (SERB) Department of Science and Technology, Govt. of India (2019-2021)
Indian Council of Medical Research (ICMR), Government of India (2021-2023)
The following are the driving force of the EvolOMICs group-
PhD CANDIDATES (CURRENT)
Nabanita Roy (MSc in Life Sc., PG Diploma in Bioinformatics)
Project: Cancer Systems Biology (coding and non-coding variations)
am a second year Doctoral student at Dr. Pankaj Barah’s lab, Tezpur University. I hold my both bachelors and masters degree in Biotechnology from Assam University. My research interest broadly lies in the field of systems biology and molecular oncology. Relating to the EvolOMICS group, I am specifically working in understanding the mechanistic role of coding and non coding variations in cancer development and subsequent identification of potential markers for therapeutic implications in cancer. Apart from research work, I like singing, watching movies and traveling.
Publications: Link
Ms. Cinmoyee Baruah
(MSc in Zoology, from Sikkim University)
Project: Systems Biology of autoimmune and neuropsychiatric disorders
Dreamer with an ambitious mind. Masters in Zoology, currently working in
Transcriptomic data at EvolOMICS Lab. My research aims to predict the molecular and genetic association between prevalent Autoimmune and Neuropsychiatric disorders to mitigate their combined effects.
Mr. Akash Das
(MSc in Molecular Biology and Biotechnology from Tezpur University)
Project: Systems Biology of Rice sheath blight disease. Climate change severely impacts crop productivity. I try to understand the molecular response signatures in rice plant in response to single R. solani and combined (R. solani + HT) stress conditions. The study will be able to identify common and unique molecular response signatures, pathways and processes, Transcriptional Regulatory Networks (TRNs), stress. responsive genes etc. in rice plant in response to single and dual stresses.
Publications: Link
Asutosh Mishra (MSc Life Sciences with specialisation in Plant Sciences from Central University of Punjab Bathinda)
Project: Combined stress in crop plants
PROJECT FELLOWS
1. Mr. Ankur Sahu
(Currently in Leibniz Institute of Plant Genetics and Crop Plant Research, Germany)
Project: Biotic and abiotic stress interactions in plants
2. Mr. Mrinmoy Kshattry
Project: Variations in cis-regulatory regions of Arabidopsis thaliana across its accessions and its role in local climate adaptation
A curious, restless and impatient mind trying to push itself ahead of the curve. Currently, the curiosity is lodged in the domain of plant stress interactions where my study revolves around the cis-regulatory regions of Arabidopsis thaliana and their role in local climate adaptation
MSc THESIS STUDENTS
MSc THESIS STUDENTS (PAST)
1. Mr. Mrinmoy Kshattry
(Int. MSc. Bio Sc. & Bioinfo. 2018 )
Project: Variations in cis-regulatory regions of Arabidopsis thaliana across its accessions and its role in local climate adaptation
EMail: mrinmoy3012@gmail.com
2. Mr. Akash Das. (MSc Molecular Biology and Biotechnology 2018)
Project: Systems biology of Rice sheath blight disease
3. John Taylor (MSc Molecular biology and Biotechnology)
(Currently in Edith Cowan University)
Project: RNA Seq analysis of SLE
4. 1. Mr. Chiranjeev Das (Int. MSc. Bio Sc. & Bioinfo. 2019)
Project: Implementation of Big data analysis pipelines in HPC environment
EMail: chiranjeevdas1996@gmail.com
A tinkerer; love finding how how things work. I am currently involved in designing a protocol for end to end analysis of RNASeq data which is easy to use for even those not technically inclined.
Find me on: Instagram LinkedIn
PAST MEMBERS
1. Mithil Gaikwad (MSc. Bioinformatics): Project JRF
Non-coding mutations and evolution of gene regulatory networks in human gliomas.
2. Shefali Singh (B.Tech & M. Tech Bioinformatics):
Project JRF: Analysing large scale RNA-seq data and developing tools for OMICs data integration
3. Mr. Chen Chongtham (completed) (MSc MBBT 2017 )
Currently pursing PhD at National Institute of Immunology
Project: Gene co-expression networks in neuropsychiatric disorders
4 Mr. Rupjyoti Das (M. Tech in Information Technology)
Currently: System administrator in Assam Agriculture University
Project: Developing and configuring computational pipelines in High Performance Computing environment for analysing Next Generation Sequencing Data
Collaborators:
1. Hussain Ahmed Chowdhury (PhD candidate in Comp. Sci. & Engineering, TU): Analysing large scale RNA-seq data
Collaborating groups:
Prof. D K Bhattacharyya, Department of Computer Sc & Engineering, Tezpur University
Prof. Atle M Bones, Norwegian University of Science and Technology (NTNU) , Norway
Prof. Jugal K Kalita, Department of Computer Science, University of Colorado, Colorado Springs, USA
Prof. (Dr.) Sangitanjan Dutta, Head, Department of Medicine, Gauhati Medical College and Hospital, Assam.
Prof. (Dr.) Amal chandra Kataki, Directo Dr. B. Borooah Cancer Institute
Prof. (Dr.) Anupam Sharma, MBBS, MD, Head, Oncopathology, Dr. B. Borooah Cancer Institute
Dr. Ram Rup Sarkar - CSIR-National Chemical Laboratory, Pune, India
Prof. P. B. Kirti, University of Hyderabad, India
Dr. Kumarasamy Thangaraj, CSIR - Centre for Cellular & Molecular Biology, Hyderabad, India
Prof. R. Sowdhamini, National Centre for Biological Sciences (NCBS), Bangalore, India
Dr. Mohit Kumar Jolly, Centre for BioSystems Science and Engineering, Indian Institute of Science, Bengaluru
Dr. Anil Mukund Limaye, Indian Institute of Technology Guwahati
Prof (Dr.) Subhash Khanna, a former professor of Surgery, Gauhati Medical College and Hospital
Prof. S K Ray, Dept. of Molecular Biology and Biotechnology, Tezpur University
Interns:
Page updated
Google Sites
Report abuse