The aim of this project is to design a new open-source platform (with interface, plugins and hardware control) to build SPIM/DSLM/OPT microscopes in an easy and inexpensive manner, and help bring these technologies to imaging facilities with minimum technical capabilities, or allow adaptions to user’s specific needs. The image acquisition and analysis are all based on free software such as microManager and open source hardware such as Arduino micro-controllers.
If you are not already familiar with SPIM/DSLM (ie, Selective-plane illumination microscopy / Digitally Scanned Light-Sheet Microscopy) or OPT (Optical Projection Tomography), or want to learn more about these techniques, check these references:
Huisken et al 2004. Science
Keller et al 2008. Science 322: 1065-1069 http://www.sciencemag.org/content/322/5904/1065.short
Sharpe et al 2002. Science 296: 541-545 http://www.sciencemag.org/content/296/5567/541.short