Highlights

Review & Viewpoint Articles

• • Trends. Chem. 2023, 6, 128-143. "Amyloid-β-Interacting Proteins in Peripheral Fluids of Alzheimer's Disease"

  • Coord. Chem. Rev. 2023, 478, 214978. "Intercommunication between Metal Ions and Amyloidogenic Peptides or Proteins in Protein Misfolding Disorders"

  • Acc. Chem. Res. 2021, 54, 3930-3940. "Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease"

  • Chem. Rev. 2019, 119, 1221-1322. "Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade"

  • Inorg. Chem. 2019, 58, 8-17. "Strategies Employing Transition Metal Complexes to Modulate Amyloid-β Aggregation"

  • Curr. Opin. Chem. Biol. 2018, 43, 8-14. "Link of  Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons"

  • Chem. Soc. Rev. 2017, 46, 310-323. "Towards an Understanding of Amyloid-β Oligomers; Characterization, Toxicity Mechanism, and Inhibitors"

  • Acc. Chem. Res. 2014, 47, 2475-2482. "The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer's Disease"

  • ACS Chem. Biol. 2013, 8, 856-865. “Alzheimer's Disease: Untangling Amyloid-β, Tau, and Metals”

  • Chem. Soc. Rev. 2014, 43, 6672-6682. "Cholesterol and Metal Ions in Alzheimer's Disease"

  • Curr. Opin. Chem. Biol. 2012, 16, 67-73. “Metal-Associated Amyloid-β Species in Alzheimer’s Disease”

  • Chem. Soc. Rev. 2012, 41, 608-621. “Misfolded Proteins in Type II Diabetes and Alzheimer’s Disease” 

Research Articles

1. • Nat. Chem. 2022, 14, 1021-1030. "Conformational and Functional Changes of the Native Neuropeptide Somatostatin Occur in the Presence of Copper and Amyloid-β"

   • J. Am. Chem. Soc. 2020, 142, 8183-8193. “Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia” 

   • Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 5160-5167. "Mechanistic Approaches for Chemically Modifying the Coordination Sphere of Copper–Amyloid-β Complexes"

   • Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 23426-23436. "N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice" 

   • J. Am. Chem. Soc. 2017, 139, 2234-2244. “Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides”

   • Nat. Commun. 2016, 7, 13115. "Structure-Mechanism-Based Engineering of Chemical Regulators for Distinct Pathological Factors in Alzheimer's Disease"

   • J. Am. Chem. Soc. 2015, 137, 14785-14797. "A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms"

   • Chem. Sci. 2015, 6, 1879-1886. "A Rationally Designed Small Molecule for Identifying an In Vivo Link of Metal-Amyloid-β Complexes to the Pathogenesis of Alzheimer's Disease"

   • J. Am. Chem. Soc. 2014, 136, 299-310. “Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease”

   • Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 3743-3748. "Insights into the Antiamyloidogenic Properties of the Green Tea Extract (−)-Epigallocatechin-3-gallate toward Metal-associated Amyloid-β Species”

   • Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21990-21995. “Development of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity”

   • J. Am. Chem. Soc. 2009, 131, 16663-16665. “Small Molecule Modulators of Copper-Induced Aβ Aggregation”

Editorial (Guest Editors and Commentary)

•  J. Biol. Inorg. Chem. 2019, 24, 1137-1139. "Editorial: Metal Ions and Degenerative Diseases"

• Inorg. Chem. 2019, 58, 13505-13508. "Editorial: Metals in Biology: From Metallomics to Trafficking"

• Dalton Trans. 2019, 48,  9405-9407. "Editorial: The Central Role of the d-Block Metals in the Periodic Table" 

• Curr. Opin. Chem. Biol. 2015, 25, vii-viii. "Editorial Overview: Bioinorganic Chemistry: Bioinorganic Catalysis for Renewable Energy"

• Chem. Soc. Rev. 2014, 43, 6668-6671. Editorial: The Themed Issued of "Molecular Medicine and Neurodegenerative Diseases"

• ChemCommu. 2013, 49, 5910-5911. Editorial: "Medicinal Inorganic Chemistry"

• Biophys. J. 2013, 105, 287-288. News & Notable (Commentary): “Structural Characterization and Inhibition of Toxic Amyloid-β Oligomeric Intermediates”