Highlights

Review & Viewpoint Articles

• • Transl. Neurodeger. 2025, 14, 52. "Disease-Disease Interactions: Molecular Links of Neurodegenerative Diseases with Cancer, Viral Infections, and Type 2 Diabetes"

  • Chem. Sci. 2025, 16, 2105. "Multi-Target-Directed Therapeutic Strategies for Alzheimer's Disease: Controlling Amyloid-β Aggregation, Metal Ion Homeostasis, and Enzyme Inhibition"

  • Adv. Healthc. Mater. 2024, 13, 2401991. "Transition Metal Complexes as Therapeutics: A New Frontier in Combating Neurodegenerative Disorders through Protein Aggregation Modulation "

  • Trends Chem. 2023, 6, 128. "Amyloid-β-Interacting Proteins in Peripheral Fluids of Alzheimer's Disease"

  • Coord. Chem. Rev. 2023, 478, 214978. "Intercommunication between Metal Ions and Amyloidogenic Peptides or Proteins in Protein Misfolding Disorders"

  • Acc. Chem. Res. 2021, 54, 3930. "Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease"

  • Chem. Rev. 2019, 119, 1221. "Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade"

  • Inorg. Chem. 2019, 58, 8. "Strategies Employing Transition Metal Complexes to Modulate Amyloid-β Aggregation"

  • Curr. Opin. Chem. Biol. 2018, 43, 8. "Link of  Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons"

  • Chem. Soc. Rev. 2017, 46, 310. "Towards an Understanding of Amyloid-β Oligomers; Characterization, Toxicity Mechanism, and Inhibitors"

  • Acc. Chem. Res. 2014, 47, 2475. "The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer's Disease"

  • ACS Chem. Biol. 2013, 8, 856. “Alzheimer's Disease: Untangling Amyloid-β, Tau, and Metals”

  • Chem. Soc. Rev. 2014, 43, 6672. "Cholesterol and Metal Ions in Alzheimer's Disease"

  • Curr. Opin. Chem. Biol. 2012, 16, 67. “Metal-Associated Amyloid-β Species in Alzheimer’s Disease”

  • Chem. Soc. Rev. 2012, 41, 608. “Misfolded Proteins in Type II Diabetes and Alzheimer’s Disease” 

Research Articles

1. • Nature Chem. 2022, 14, 1021. "Conformational and Functional Changes of the Native Neuropeptide Somatostatin Occur in the Presence of Copper and Amyloid-β"

   • Nature Chem. Biol. 2025, 21, 1709. "Interactions with Tau's Microtubule-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity"

   • Nature Commun. 2016, 7, 13115. "Structure-Mechanism-Based Engineering of Chemical Regulators for Distinct Pathological Factors in Alzheimer's Disease"

   • J. Am. Chem. Soc. 2026, 148, 461. "Positional Isomerism Tunes Molecular Reactivities and Mechanisms toward Pathological Targets in Dementia"

   • J. Am. Chem. Soc. 2020, 142, 8183. “Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia” 

   • J. Am. Chem. Soc. 2017, 139, 2234. “Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides”

   • J. Am. Chem. Soc. 2015, 137, 14785. "A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms"

   • J. Am. Chem. Soc. 2014, 136, 299. “Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease”

   • J. Am. Chem. Soc. 2009, 131, 16663. “Small Molecule Modulators of Copper-Induced Aβ Aggregation”

   • Adv. Sci. 2024, 11, 2307182. "APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer’s Disease"

   • Small 2026, 22, e74013. "A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer’s Disease"

   • ACS Catal. 2024, 14, 14497. "Dual O2-Mediated Reactivity of a Mononuclear Cobalt Complex with Amyloid-β Peptides"

   • Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 5160. "Mechanistic Approaches for Chemically Modifying the Coordination Sphere of Copper–Amyloid-β Complexes"

   • Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 23426. "N,N′-Diacetyl-p-phenylenediamine Restores Microglial Phagocytosis and Improves Cognitive Defects in Alzheimer’s Disease Transgenic Mice" 

   • Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 3743. "Insights into the Antiamyloidogenic Properties of the Green Tea Extract (−)-Epigallocatechin-3-gallate toward Metal-associated Amyloid-β Species”

   • Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21990. “Development of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity”

Editorial (Guest Editors and Commentary)

• Chem. Sci. 2025, 16, 9561. "Introduction to the Spotlight Collection on Bioinorganic Chemistry"

• J. Biol. Inorg. Chem. 2019, 24, 1137. "Editorial: Metal Ions and Degenerative Diseases"

• Inorg. Chem. 2019, 58, 13505. "Editorial: Metals in Biology: From Metallomics to Trafficking"

• Dalton Trans. 2019, 48,  9405. "Editorial: The Central Role of the d-Block Metals in the Periodic Table" 

• Curr. Opin. Chem. Biol. 2015, 25, vii. "Editorial Overview: Bioinorganic Chemistry: Bioinorganic Catalysis for Renewable Energy"

• Chem. Soc. Rev. 2014, 43, 6668. Editorial: The Themed Issue of "Molecular Medicine and Neurodegenerative Diseases"

• ChemCommu. 2013, 49, 5910. Editorial: "Medicinal Inorganic Chemistry"

• Biophys. J. 2013, 105, 287. News & Notable (Commentary): “Structural Characterization and Inhibition of Toxic Amyloid-β Oligomeric Intermediates”