Systems Biomolecular Chemistry Laboratory
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Our 'Systems Biomolecular Chemistry' Laboratory explores the chemistry and biology of small molecules and proteins, drawing from core disciplines in inorganic, organic, and biological chemistry, as well as neuroscience.
Our research objectives are to (a) identify how biomolecular networks composed of small organic and inorganic molecules (e.g., organic neurotransmitters and metal ions), peptides or proteins, and mediators for oxidative stress and inflammation are linked to human neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington's, and Prion diseases; (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases.
Positions Available NOW (for Graduate Students and Postdoctoral Scholars)!
Positions Available NOW (for Graduate Students and Postdoctoral Scholars)!
(본 리더(창의) 연구단에서 화학적 접근 퇴행성 뇌질환 연구에 관심있는 대학원생 및 박사 후 연구원을 모집합니다)
Research Professors
Ph.D. scientists with expertise in bioinorganic chemistry, biochemistry, biophysical chemistry, chemical biology, or protein chemistry and experience in ~3-year postdoctoral research are welcome. Please send your application package (cover letter, CV, a research summary, copies of published papers, and a list of three reference letter writers with contact information) to Professor Mi Hee Lim via email for consideration.
Postdoctoral Scholars
Ph.D. scientists with expertise in bioorganic or bioinorganic chemistry, biochemistry, biophysical chemistry, protein chemistry, chemical biology, or chemical neuroscience are welcome. Please send your application package (cover letter, CV, a research summary, copies of published papers, and a list of three reference letter writers with contact information) to Professor Mi Hee Lim via email for consideration.
Graduate Students
Highly motivated graduate students who are interested in bioinorganic / bioorganic / bioanalytical / medicinal chemistry, biochemistry, biophysical chemistry, protein chemistry, chemical neuroscience, or chemical biology are welcome to join our group. Please contact Professor Mi Hee Lim via email.
Undergraduate Students
Undergraduate students who are interested in applying textbook knowledge on organic/inorganic chemistry and biochemistry to research in the laboratory are encouraged to be part of our group. Please contact Professor Mi Hee Lim via email.
Recent Publications
Recent Publications
Chanju Na,§ Jimin Lee,§ Jong-Min Suh, Jun Go, Juri Lee, Kyoung-Shim Kim,* Chul-Ho Lee,* Mingeun Kim,* Mi Hee Lim* J. Am. Chem. Soc. 2025, In Press. "Positional Isomerism Tunes Molecular Reactivities and Mechanisms toward Pathological Targets in Dementia"
Mingeun Kim, Young-Ho Lee,* Mi Hee Lim* et al., Nature Chem. Biol. 2025, 21, 1709. "Interactions with Tau's Microtuble-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity"
Eunju Nam, Jinju Han,* Mu-Hyun Baik,* Young-Ho Lee,* Mi Hee Lim* et al., Adv. Sci. 2024, 11, 2307182. "APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer’s Disease"
Jiyeon Han, Kiyoung Park,* Seung-Hee Lee,* Mi Hee Lim* et al., Nature Chem. 2022, 14, 1021. "Conformational and Functional Changes of the Native Neuropeptide Somatostatin Occur in the Presence of Copper and Amyloid-β"
Recent News & Press
Recent News & Press
December 10, 2025
Bomin Has Successfully Defended Her M.S.!
November 19, 2025
Seongmin Has Successfully Defended His Ph.D.!
October 23, 2025
Jimin K Won the Poster Award at the KCS!
October 23, 2025
Jeasang Won the Poster Award at the KCS!
October 20, 2025
Professor Lim Was Selected as One of the 100 Next-Generation Leaders in 2025!
July 16, 2025
Congrats to Professor Lim on the L’Oréal Korea-UNESCO for Women in Science Award (Academic Award, Grand Prize) (2025)!
July 4, 2025
Congrats to Dr. Mingeun Kim (Lim Lab, Current Member) on His Faculty Appointment at the Chonnam National University (CNU), Beginning September 1, 2025!
June 17, 2025
Congrats to Dr. Eunju Nam (Lim Lab, Alumnus) on Her Faculty Appointment at DGIST, Beginning November 24, 2025!
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