Publications & Patents

(2024)

184. Eunsang Lee, Donghee Kim, Yo Han Song, Kyujin Shin, Sanggeun Song, Minho Lee, Yeongchang Goh, Mi Hee Lim, Ji-Hyun Kim, Jaeyeong Sung*, Kang Taek Lee* Chem. Biomed. Imaging 2024, Accepted for Publication. "Real-Time Tracking of Vesicles in Living Cells Reveals That Tau-Hyperphosphorylation Suppresses Unidirectional Transport by Motor Proteins"

183. Sanghoon Lee, Arim Byun, Juhee Jo, Jong-Min Suh, Jeasang Yoo, Mi Hee Lim, Ji-wook Kim,* Tae-Hyun Shin,* Jin-sil Choi* Nanoscale Adv. 2024, Accepted for Publication. "Ultrasmall Mn-doped Iron Oxide Nanoparticles with Dual Hepatobiliary and Renal Clearances for T1 MR Liver Imaging"

182. Namhee Kim, Jun Su Kang, Taesuk Jun, Jong-Min Suh, Deok-Ho Roh, Won-Woo Park, Oh-Hoon Kwon, Tae-Hyuk Kwon, Mi Hee Lim, Du Yeol Ryu, Myungeun Seo, and Byeong-Su Kim* Macromolecules 2024, 57, 21-31. "Tailoring Dynamic Chiral Supramolecular Assembly with Photo-Triggered Radical Anions of C3-Symmetric Triphenylene Triimides" 

(2023)

180. Yelim Yi, Wooyeol Ryu, Bokyung Kim, Srinivasan Muniyappan, Kiyoung Park,* Jin Hae Kim,* Mi Hee Lim* ChemRxiv-Preprint 2023 - DOI: 10.26434/chemrxiv-2023-cx1zb. "Copper's Dual Influence: Self-Assembly and Anti-amyloidogenic Activity of Monomeric Transthyretin "

179. Chanju Na, Gunhee Kim, Wojciech Bal,* Eunju Nam,* Mi Hee Lim* ChemRxiv-Preprint 2023 - DOI: 10.26434/chemrxiv-2023-061jk. "Distinct Aggregation and Toxicity of N-Terminally Truncated Aβ4-42 over Aβ1-42 in the Presence of Zn(II)"

178. Jong-Min Suh, Wooyeol Ryu, Eunju Nam, Nam Kwon, Kyungmin Kim, Dongwook Kim, Jaeheung Cho,* Kiyoung Park,* Mi Hee Lim* ChemRxiv-Preprint 2023 - DOI: 10.26434/chemrxiv-2023-xd8cx-v2. "Dual Modification of Amyloid- Peptides by a Mononuclear Cobalt Complex and O2"

177. Mingeun Kim, Yuxi Lin, Eunju Nam, Sungsu Lim, Yun Kyung Kim, Young-Ho Lee,* Mi Hee Lim* ChemRxiv-Preprint 2023 - DOI: 10.26434/chemrxiv-2023-n5fv2. "Coupling the Coupling: Dissecting the Role of Tau’s Microtubule-Binding Repeats in Modulating Amyloid-β Aggregation and Toxicity Profiles in Alzheimer’s Disease "

176. Hoimin Jung, Jeonguk Kweon, Jong-Min Suh, Mi Hee Lim, Dongwook Kim,* and Sukbok Chang* Science 2023, 381, 525-532. "Mechanistic Snapshots of Rhodium-Catalyzed Acylnitrene Transfer Reactions"

169.  Vikram Singh,§ Seongyeon Kwon,§ Yunseop Choi,§ Seongmo Ahn, Gyumin Kang, Yelim Yi, Mi Hee Lim, Jongcheol Seo,* Mu-Hyun Baik,* Hye Ryung Byon* Adv. Mat. 2023, 35, 2210859 (§Equal Contribution). "Controlling π–π Interactions of Highly Soluble Naphthalene Derivatives for Neutral pH Aqueous Redox Flow Batteries"

168.  Minuk Yang, Jae Jue Lee, Dongju Yun, Haeri So, Yelim Yi, Mi Hee Lim, Hyojin Lee, Ki-Tae Kim,* Cheal Kim* J. Photochem. Photobiol. A: Chem. 2023, 434, 114249. "In Vitro and Vivo Application of a Rhodanine-Based Fluorescent Sensor for Detection and Bioimaging of In3+ at Neutral pH" 

(2022)

165. Yuxi Lin,* Dai Ito, Je Min Yoo, Mi Hee Lim, Wookyung Yu, Yasushi Kawata, Young-Ho Lee* Front. Cell. Dev. Biol. 2022, 10, 707417. "Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation"

164. Nancy AlHaddad, Evan Lelong, Jong-Min Suh, Marie Cordier, Mi Hee Lim, Guy Royal, Carlos Platas Iglesias,* Hélène Bernard and Raphaël Tripier* Dalton Trans. 2022, 51, 8640-8656. "Copper(II) and Zinc(II) Complexation with N-Ethylene Hydroxycyclams and Consequences on the Macrocyclic Backbone Configuration"

163. Zhi Du,§ Eunju Nam,§ Yuxi Lin, Mannkyu Hong, Tamás Molnár, Ikufumi Kondo, Koichiro Ishimori, Mu-Hyun Baik, Young-Ho Lee,* Mi Hee Lim* ChemRxiv-Preprint 2022 - DOI: 10.26464/chemrxiv-2022-3h55t (§Equal Contribution). "Cytochrome c as a Distinct Modulator of Amyloid-β Amyloidogenesis in a Peroxide-Dependent Manner"

162. Jun Su Kang, Sungwoo Kang, Jong-Min Suh, Soon Mo Park, Dong Ki Yoon, Mi Hee Lim, Woo Youn Kim, Myungeun Seo*, J. Am. Chem. Soc. 2022, 144, 6, 2657-2666. "Circularly Polarized Light can Override and Amplify Asymmetry in Supramolecular Helices"

(2021)

153.  Mannkyu Hong,§ Mingeun Kim,§ Jiwon Yoon, Seung-Hee Lee,* Mu-Hyun Baik,* Mi Hee Lim* ChemRxiv-Preprint 2021 - DOI: 10.33774/chemrxiv-2021-gtlkj (§Equal Contribution). "Excite-State Intramolecular Hydrogen Transfer of Compact Molecules Controls Amyloid Aggregation Profiles"

152. Mi Hee Lim,* Nak Cheon Jeong,* Kang Min Ok,* Ok-Sang Jung* Chem. Commun. 2021, 57, 10660. "Celebrating the 75th Anniversary of the Korean Chemical Society"

151. Evan Lelong, Jong-Min Suh, Gunhee Kim, David Esteban Gòmez, Marie Cordier, Mi Hee Lim, Rita Delgado, Guy Royal, Carlos Platas-Iglesias,* Hélène Bernard, Raphaël Tripier* Inorg. Chem. 2021, 60, 10857-10872. "Complexation of C-Functionalized Cyclams with Copper(II) and Zinc(II): Similarities and Changes When Compared to Parent Cyclam Analogues" 

150. Jiyeon Han, Eunju Nam, Jiwon Yoon, Tongrui Qian, Yulong Li, Seung-Hee Lee,* Mi Hee Lim* ChemRxiv-Preprint 2021 - DOI: 10.26434/chemrexiv.14736882.v1. "Functional Switching of a Native Neuropeptide through Interactions with Pathological Factors in Dementia" 

149. Eunju Nam, Jiyong Park, Yuxi Lin, Hyunsu Do, Jiyeon Han, Jinju Han,* Young-Ho Lee,* Mu-Hyun Baik,* Mi Hee Lim* ChemRxiv-Preprint 2021 - DOI: 10.26434/chemrexiv.14610261.v1. "APP-C31 Is an Intracellular Promoter of Amyloid-β Aggregation and Toxicity" 

148. Minuk Yang, Su Chan Lee, Mingeun Kim, Mi Hee Lim,* Cheal Kim* Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2021, 245, 118899. "A Multi-functional Picolinohydrazide-Based Chemosensor for Colorimetric Detection of Iron and Dual Responsive Detection of Hypochlorite”

(2020)

140. Seongwoo Kim, Ha-Eun Lee, Jong-Min Suh, Mi Hee Lim,* Min Kim* Inorg. Chem. 2020, 59, 17573-17582. “Sequential Connection of Mutually Exclusive Catalytic Reactions by a Method Controlling the Presence of a MOF Catalyst: One-Pot Oxidation of Alcohols to Carboxylic Acids”

139. Haeri So, Hangyul Lee, Gyu Dong Lee, Mingeun Kim, Mi Hee Lim, Ki-Tae Kim,* Cheal Kim* J. Ind. Eng. Chem. 2020, 89, 436-441. "A Thiourea-Based Fluorescent Chemosensro for Bioimaging Hypochlorite”

138. Soyoung Park, Hangyul Lee, Yelim Yi, Mi Hee Lim, Cheal Kim* Inorg. Chim. Acta 2020, 513, 119936. "A Rhodanine-Based Fluorescent Chemosensor for Sensing Zn2+ and Cd2+: Applications to Water Sample and Cell Imaging”

137. Dongju Yun, Ju Byeong Chae, Haeri So, Trinh N. Do, Ki-Tae Kim,* Yelim Yi, Mi Hee Lim, Cheal Kim* Dyes Pigm. 2020, 183, 108704. "Ratiometric Fluorescence In3+ Sensing via In3+-Triggered Tautomerizaiton: Its Applications to Water Samples, Live Cells and Zebrafish”

(2019)

Projects of Alzheimer's and Other Diseases

136. Liliana Quintanar,* Mi Hee Lim* J. Biol. Inorg. Chem. 2019, 24, 1137-1139. "Editorial: Metal Ions and Degenerative Diseases"

135. Min Hee Park, Misun Lee, Geewoo Nam, Mingeun Kim, Juhye Kang, Byung Jo Choi, Min Seock Jeong, Kang Ho Parka, Wan Hui Hana, Eunyoung Tak, Min Sun Kim, Juri Lee, Yuxi Lin, Young-Ho Lee, Im-Sook Song, Min-Koo Choi, Joo-Yong Lee, Hee Kyung Jin*, Jae-sung Bae*, Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 23426-23436. "N,N′-Diacetyl-p-phenylenediamine Restores Microglial Phagocytosis and Improves Cognitive Defects in Alzheimer’s Disease Transgenic Mice" Note: This paper was highlighted in EurekAlert! (https://www.eurekalert.org/pub_releases/2019-11/potn-naa103019.php) & ALZFORUM (https://www.alzforum.org/news/research-news/acetaminophen-derivative-tempers-microglia-spurs-plaque-clearance).

134. Daniela Buccella,* Mi Hee Lim,* Janet R. Morrow* Inorg. Chem. 2019, 58, 13505-13508. "Editorial: Metals in Biology: From Metallomics to Trafficking" Note: This paper was featured as the Front Cover (https://pubs.acs.org/toc/inocaj/58/20?ref=feature).

133. Yuxi Lin, Bikash R. Sahoo, Daisaku Ozawa, Misaki Kinoshita, Juhye Kang, Mi Hee Lim, Masaki Okumura, Yang Hoon Huh, Eunyoung Moon, Jae Hyuck Jang, Hyun-Ju Lee, Ka-Young Ryu, Sihyun Ham, Hyung-Sik Won, Kyoung-Seok Ryu, Toshihiko Sugiki, Jeong Kyu Bang, Hyang-Sook Hoe, Toshimichi Fujiwara, Ayyalusamy Ramamoorthy, Young-Ho Lee* ACS Nano 2019, 13, 8766-8783. "Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-β (1-40)"

132. Catherine E. Housecroft*, Christine M. Thomas*, Mi Hee Lim* Dalton Trans. 2019, 48, 9405-9407. "Editorial: The Central Role of the d-Block Metals in the Periodic Table"

131. Geewoo Nam,§ Yonghwan Ji,§ Hyuck Jin Lee,§ Yelim Yi, Mingeun Kim, Yuxi Lin, Young-Ho Lee, Mi Hee Lim* ACS Chem. Neurosci. 2019, 10, 3380-3390 (§Equal Contribution). "Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease" 

130. Juhye Kang,§ Jung Seung Nam,§ Hyuck Jin Lee, Geewoo Nam, Hyun-Woo Rhee, Tae-Hyuk Kwon,* Mi Hee Lim* Chem. Sci. 2019, 10, 6855-6862. (§Equal Contribution). "Chemical Strategies to Modify Amyloidogenic Peptides by Iridium(III) Complexes: Coordination and Photo-Induced Oxidation" 

129. Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Junghyun Chae, Mi Hee Lim* ChemRxiv-Preprint 2019 - DOI: 10.26434/chemrexiv.8075105.v1. "Mechanistic Approaches for Modifying the Coordination Sphere of Metal–Amyloid-β Complexes: Covalent Adduct Formation and Oxidation" 

128. Mingeun Kim,§ Juhye Kang,§ Misun Lee,§ Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Joo-Young Lee,* Mi Hee Lim* ChemRxiv-Preprint 2019 - DOI: 10.26434/chemrexiv.8051639.v1. (§Equal Contribution). "Minimalistic Design Approach for Multi-Reactivity against Free Radicals and Metal-Free and Metal-Bound Amyloid-β Peptides: Redox-Based Substitutions of Benzene" 

127. Yelim Yi,§ Jiyeon Han,§ Min Hee Park, Nahye Park, Eunju Nam, Hee Kyung Jin,* Jae-sung Bae,* Mi Hee Lim* Chem. Commun. 2019, 55, 5847-5850 (§Equal Contribution). "Tunable Regulatory Activities of 1,10-Phenanthroline Derivatives towards Acid Sphingomyelinase and Zn(II)–Amyloid-β" Note: This paper was featured as the Front Cover (http://xlink.rsc.org/?DOI=C9CC01005J).

126. Geewoo Nam, Mi Hee Lim* Chem. Lett. 2019, 48, 951-960. "Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer's Disease: Metal–Amyloid-β" Note: This paper was featured as the Inside Cover

125. Masha G. Savelieff,§ Geewoo Nam,§ Juhye Kang,§ Hyuck Jin Lee, Misun Lee, Mi Hee Lim* Chem. Rev. 2019, 119, 1221-1322 (Invited Review; §Equal Contribution). "Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade" Note: This paper was for the Special Issue of “Metals in Medicine”.

124. Hyuck Jin Lee,§ Young Geun Lee,§ Juhye Kang,§ Seung Hyun Yang, Ju Hwan Kim, Amar B. T. Ghisaidoobe, Hyo Jin Kang,* Sang-Rae Lee,* Mi Hee Lim,* Sang J. Chung* Chem. Sci. 2019, 10, 1000-1007 (§Equal Contribution). "Monitoring Metal-Amyloid-β Complexation by a FRET-Based Probe: Design, Detection, and Inhibitor Screening" Note: This paper was selected as a Hot Article in Chem. Sci. in 2018 and featured as the Back Cover.

123. Jong-Min Suh,§ Gunhee Kim,§ Juhye Kang, Mi Hee Lim* Inorg. Chem. 2019, 58, 8-17 (§Equal Contribution). "Strategies Employing Transition Metal Complexes to Modulate Amyloid-β Aggregation"

122. Misun Lee,§ Mingeun Kim,§ Anjong Florence Tikum,§ Hyuck Jin Lee, Vijayan Thamilarasan, Mi Hee Lim,* Jinheung Kim* Dyes Pigm. 2019, 162, 97-103 (§Equal Contribution). "A Near-Infrared Fluorescent Probe for Amyloid-β Aggregates”

Projects of Sensors for Metal Ions and Anions

121. Min Seon Kim, Dongju Yun, Ju Byeong Chae, Hyojin Lee, Ki-Tae Kim,* Mingeun Kim, Mi Hee Lim, Cheal Kim* Sensors 2019, 19, 5458. "A Novel Thiophene-Based Fluorescent Chemosensor for the Detection of Zn2+ and CN–: Imaging Applications in Live Cells and Zebrafish”

120. Ju Byeon Chae, Dongju Yun, Sehoon Kim, Hyojin Lee, Mingeun Kim, Mi Hee Lim, Ki-Tae Kim,* Cheal Kim* Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2019, 219, 74-82. "Fluorescent Determination of Zinc by a Quinoline-Based Chemsensor in Aqueous Media and Zebrafish”

119. Dongju Yun, Ji Hye Kang, Min Seon Kim, Mingeun Kim, Mi Hee Lim, Cheal Kim* Sensor Lett. 2019, 17, 87-103. "A Multiple Target Chemsensor: Fluorescent Detection of Al(III) and Colorimetric Detection of Fe(II) and Cu(II)”

118. Suh Mi Hwang, Dongju Yun, Hyojin Lee, Mingeun Kim, Mi Hee Lim, Ki-Tae Kim,* Cheal Kim* Dyes Pigm. 2019, 165, 264-272. “Relay Detection of Zn2+ and S2– by a Quinoline-Based Fluorescent Chemsensor in Aqueous Media and Zebrafish”

117. Ji Hye Kang, Minuk Yang, Dongju Yun, Mingeun Kim, Hyojin Lee, Ki-Tae Kim,* Mi Hee Lim, Cheal Kim* New J. Chem. 2019, 43, 4029-4035. “A Dual-Responsible Sensor Based on NBD for the Highly Selective Determination of  Sulfide in Living Cells and Zebrafish”

116. Jin Yeong Yun, Ju Byeong Chae, Mingeun Kim, Mi Hee Lim, Cheal Kim* Photochem. Photobiol. Sci., 2019, 18, 166-176. “A Multiple Target Chemosensor for the Sequential Fluorescence Detection of Zn2+ and S2- and the Colorimetric Detection of Fe3+/2+ in Aqueous Media and Living Cells”

115. Min Seon Kim, Tae Geun Jo, Minuk Yang, Jiyeon Han, Mi Hee Lim,* Cheal Kim* Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2019, 211, 34-43. “A Fluorescent and Colorimetric Schiff Base Chemsensor for the Detection of Zn2+ and Cu2+: Application in Live Cell Imaging and Colorimetric Test Kit”

(2018)

Projects of Alzheimer's and Other Diseases

114. Sugyeong Hong,§ You Kyung Go,§ Jeffrey S. Derrick, Sanghun Han, Jin Kim, Mi Hee Lim,* Sun Hee Kim* Inorg. Chem. 2018, 57, 12665-12670 (§Equal Contribution). "Advanced Electron Paramagnetic Resonance Studies of a Ternary Complex of Copper, Amyloid-β and a Chemical Regulator” Note: This paper was featured as the Front Cover.

113. Hyuck Jin Lee,§ Masha G. Savelieff,§ Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Shin Jung C. Lee, Elizabeth M. Nolan*, Mi Hee Lim* Metallomics 2018, 10, 1116-1127 (§Equal Contribution). "Calprotectin Influences the Aggregation of Metal-Free and Metal-Bound Amyloid-β by Direct Interaction”

112. Eunju Nam,§ Jeffrey S. Derrick,§ Seunghee Lee,§ Juhye Kang, Jiyeon Han, Shin Jung C. Lee, Su Wol Chung,* Mi Hee Lim* ACS Chem. Neurosci. 2018, 9, 2655-2666 (§Equal Contribution). "Regulatory Activities of Dopamine and Its Derivatives towards Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease"

111. Sonam Kim,§ Hyuck Jin Lee,§ Eunju Nam,§ Donghyun Jeong, Jaeheung Cho,* Mi Hee Lim,* Youngmin You* ACS Omega 2018, 3, 5141-5154 (§Equal Contribution). "Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring Amyloid-β Aggregation”

110. Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Shin Jung C. Lee, Jaeheung Cho, Junghyun Chae,* Mi Hee Lim* ACS Chem. Neurosci. 2018, 9, 800-808. "Tuning Structures and Properties for Developing Novel Chemical Tools Toward Distinct Pathogenic Elements in Alzheimer's Disease"

109. Eunju Nam,§ Jiyeon Han,§ Jong-Min Suh, Yelim Yi, Mi Hee Lim* Curr. Opin. Chem. Biol. 2018, 43, 8-14 (§Equal Contribution). "Link of  Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons"

Projects of Sensors for Metal Ions and Anions

108. Ji Hye Kang, Jiyeon Han, Hyojin Lee, Mi Hee Lim,* Ki-Tae Kim, Cheal Kim* Dyes Pigm. 2018, 152, 131-138. “A Water-Soluble Fluorescence Chemosensor for the Sequential Detection of Zn2+ and Pyrophosphate in Living Cells and Zebrafish”

107. Jae Min Jung, Ji Hye Kang, Jiyeon Han, Hyojin Lee, Mi Hee Lim, Ki-Tae Kim,* Cheal Kim* Sensor Actuat B-Chem. 2018, 267, 58-69. "A Novel "Off-On" Type Fluorescent Chemosensor for Detection of Zn2+ and Its Zinc Complex for "On-Off" Fluorescent Sensing of Sulfide in Aqueous Solution, In Vitro and In Vivo.

106. Hyo Jung Jang, Ji Hye Kang, Misun Lee, Mi Hee Lim,* Cheal Kim* Ind. Eng. Chem. Res. 2018, 57, 54-62. "Fluorescent Sensor for Sequentially Monitoring Zinc(II) and Cyanide Anion in Near-Perfect Aqueous Media"

105. Jin Yeong Yun, Tae Geun Jo, Jiyeon Han, Hyo Jung Jang, Mi Hee Lim, Cheal Kim* Sensor Actuat B-Chem. 2018, 255, 3108-3116. "A Highly Sensitive and Selective Fluorescent Chemosensor for the Sequential Recognition of Zn2+ and S2- in Living Cells and Aqueous Media"

104. Hyo Jung Jang, Ahran Kim, Jae Min Jung, Misun Lee, Mi Hee Lim, Cheal Kim* Bull. Kor. Chem. Soc. 2018, 39, 1349-1471. “Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells”

(2017)

Projects of Alzheimer's and Other Diseases

103. Michael W. Beck, Jeffrey S. Derrick, Jong-Min Suh, Mingeun Kim, Kyle J. Korshavn, Richard A. Kerr, Woo Jong Cho, Scott D. Larsen, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy,* Mi Hee Lim* ChemMedChem 2017, 12, 1828-1838. “Minor Structural Variations of Metal Chelators Tune Regulatory Activities towards Pathological Factors in Alzheimer’s Disease” Note: This paper was featured as the Front Cover.

102. Taesu Choi,§ Hyuck Jin Lee,§ Jong Yoon Han, Mi Hee Lim,* Hugh I. Kim* J. Am. Chem. Soc. 2017, 139, 15437-15445 (§Equal Contribution). "Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-β in the Extracellular Region" Note: This paper was featured as the Front Cover.

101. Juhye Kang, Yelim Yi, Mi Hee Lim* Chemworld 2017, 8, 13-20. "Development of Small Molecules to Target Metal-Aβ in Alzheimer's Disease"

100. Jeffrey S. Derrick, Yujeong Kim, Hyeonwoo Tak, Kiyong Park,* Jaeheung Cho,* Sun Hee Kim,*  Mi Hee Lim* Dalton Trans. 2017, 46, 13166-13170. "Stereochemistry of Metal Tetramethylcyclam Complexes Directed by an Unexpected Anion Effect"  

99. Michael R. Jones, Emilie Mathieu, Christine Dyrager, Simon Faissner, Xavier Vaillancourt, Kyle J. Korshavn, Mi Hee Lim, Ayyalusamy Ramamoorthy, V. Wee Yong, Shigeki Tsutsui, Peter K. Stys,  Tim Storr* Chem. Sci. 2017, 8, 5636-5643. "Multi-target-Directed Phenol-Triazole Ligands as Therapeutic Agents for Alzheimer's Disease"

98. Yonghwan Ji,§ Hyuck Jin Lee,§ Minjeong Kim, Geewoo Nam, Shin Jung C. Lee, Jaeheung Cho, Cheol-Min Park,* Mi Hee Lim* Inorg. Chem. 2017, 56, 6695-6705 (§Equal Contribution). "Strategic Design of 2,2-Bipyridine Derivatives to Modulate Metal–Amyloid-β Aggregation"

97. Myeong-Gyun Kang, Jumi Park, Gianfranco Balboni, Mi Hee Lim, Changwoo Lee, Hyun-Woo Rhee* ACS Synth. Biol. 2017, 6, 667-677. "Genetically Encodable Bacterial Flavin Transferase for Fluorogenic Protein Modification in Mammalian Cells"

96. Jeffrey S. Derrick, Jiwan Lee, Shin Jung C. Lee, Yujeong Kim, Eunju Nam, Hyeonwoo Tak, Juhye Kang, Misun Lee, Sun Hee Kim,* Kiyoung Park,* Jaeheung Cho,* Mi Hee Lim* J. Am. Chem. Soc. 2017, 139, 2234-2244. “Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides” Note: This paper was featured in JACS Spotlights (Editors' Choice) and the Front Cover; highlighted in several media (KBS News, multiple newspapers); selected for 2017 국내 바이오분야 연구성과 및 뉴스 Top 5 (바이오융합부분) (BRIC).

95. Hyuck Jin Lee, Kyle J. Korshavn, Younwoo Nam, Juhye Kang, Thomas J. Paul, Richard A. Kerr, Il Seung Youn, Mehmet Ozbil, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,*  Mi Hee Lim* Chem. Eur. J. 2017, 23, 2706-2715. "Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer's Disease"

94. Juhye Kang,§ Shin Jung C. Lee,§ Jung Seung Nam,§ Hyuck Jin Lee, Myeong-Gyun Kang, Kyle J. Korshavn, Hyun-Tak Kim, Jaeheung Cho, Ayyalusamy Ramamoorthy, Hyun-Woo Rhee*, Tae-Hyuk Kwon*, Mi Hee Lim* Chem. Eur. J. 2017, 23, 1645-1653 (§Equal Contribution). "An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation" Note: This paper was selected as a “Hot Paper”. Editors' Choice: Spotlights from ChemPubSoc Europe and Asian Chemical Editorial Society (ACES)

93. Kyle J. Korshavn, Cristina Satriano, Yuxi Lin, Rongchun Zhang, Mark Dulchavsky, Anirban Bhunia, Magdalena Ivanova, Young-Ho Lee, Carmelo La Rosa, Mi Hee Lim, Ayyalusamy Ramamoorthy* J. Biol. Chem. 2017, 292, 4638-4650. "Reduced Lipid Bilayer Thickness Modulates the Aggregation and Cytotoxicity of Aβ"

92. Shin Jung C. Lee,§ Eunju Nam,§ Hyuck Jin Lee, Masha G. Savelieff, Mi Hee Lim* Chem. Soc. Rev. 2017, 46, 310-323 (§Equal Contribution). "Towards an Understanding of Amyloid-β Oligomers; Characterization, Toxicity Mechanism, and Inhibitors" 

Projects of Sensors for Metal Ions and Anions

91. Suh Mi Hwang, Min Seon Kim, Misun Lee, Mi Hee Lim, Cheal Kim* New J. Chem. 2017, 41, 15590-15600. "Single Fluorescent Chemosensor for Multiple Targets: Sequential Detection of Al3+ and Pyrophosphate and Selective Detection of F- in Near-perfect Aqueous Solution"

90. Tae Geun Jo, Jae Min Jung*, Jiyeon Han, Mi Hee Lim, Cheal Kim* RSC Adv. 2017, 7, 28723-28732. "A Single Fluorescent Chemosensor for Multiple Targets of Cu2+, Fe2+/3+ and Al3+ in Living Cells and a Near-Perfect Aqueous Solution"

89. Ha Young Jeong, Seong Youl Lee,* Jiyeon Han, Mi Hee Lim,* Cheal Kim* Tetrahedron 2017, 73, 2690-2697. "Thiophene and Diethylaminophenol-based "Turn-on" Fluorescence Chemosensor for Detection of Al3+ and F- in a near-perfect Aqueous Solution"

88. Jae Min Jung, Jae Jun Lee, Eunju Nam, Mi Hee Lim, Cheal Kim*, Roger G. Harrison* Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2017, 178, 203-211. "A Zinc Fluorescent Sensor Used to Detect Mercury(II) and Hydrosulfide"

87. Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim*, Cheal Kim* Sensor Actuat B-Chem. 2017, 244, 1045-1053. "A Highly Selective Turn-on Chemosensor for Zn2+ in Aqueous Media and Living Cells"

86. Tae Geun Jo, Kwon Hee Bok, Jiyeon Han, Mi Hee Lim, Cheal Kim* Dyes Pigm. 2017, 139, 136-147. "Colorimetric Detection of Fe3+ and Fe2+ and Sequential Fluorescent Detection of Al3+ and Pyrophosphate by an Imidazole-Based Chemosensor in a Near-Perfect Aqueous Solution"

(2016)

Projects of Alzheimer's and Other Diseases

85. Michael W. Beck,§ Jeffrey S. Derrick,§ Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim,* Joo-Yong Lee,* Brandon T. Ruotolo,* Mi Hee Lim* Nat. Commun. 2016, 7, 13115 (§Equal Contribution). "Structure-Mechanism-Based Engineering of Chemical Regulators for Distinct Pathological Factors in Alzheimer's Disease" Note: This paper was highlighted in multiple news media (Yonhap News; Dong-A Science; The Kyunghyang Sinhmun; The Korea Economic Daily).

84. Jong-Suk Park, Eunju Nam, Hye-Kyeong Lee, Mi Hee Lim,* Hyun-Woo Rhee* ACS Chem. Biol. 2016, 11, 2177-2185. "In Cellulo Mapping of Subcellular Localized Bilirubin"

83. Jung Seung Nam,§ Myeong-Gyun Kang,§ Juhye Kang,§ Sun-Young Park, Shin Jung C. Lee, Hyun-Tak Kim, Jeong Kon Seo, Oh-Hoon Kwon, Mi Hee Lim,* Hyun-Woo Rhee,* Tae-Hyuk Kwon* J. Am. Chem. Soc. 2016, 138, 10968-10977 (§Equal Contribution). "Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications" Note: This paper was highlighted in multiple news media (Dong-A Science; The Kyunghyang Sinhmun; Yonhap News; The Korea Economic Daily).

82. Swapna Bera, Kyle J. Korshavn, Rajiv K. Kar, Mi Hee Lim, Ayyalusamy Ramamoorthy, Anirban Bhunia*  Phys. Chem. Chem. Phys. (PCCP)  2016, 18, 16890-16901. "Biophysical Insights into the Membrane Interaction of the Core Amyloid-Forming Aβ40 Fragment K16-K28 and its Role in the Pathogenesis of Alzheimer's Disease"

81. Shin Jung C. Lee,§ Tae Su Choi,§ Jong Wha Lee,§§Hyuck Jin Lee, Dong-Gi Mun, Satoko Akashi, Sang-Won Lee, Mi Hee Lim,* Hugh I. Kim* Chem. Sci. 2016, 7, 5398-5406 (§Equal Contribution). “Structure and Assembly Mechanism of Toxic Human Islet Amyloid Polypeptide Oligomers Associated with Copper”

80. Michael R. Jones, Christine Dyrager, Marie Hoarau, Kyle J. Korshavn, Mi Hee Lim, Ayyalusamy Ramamoorthy, Tim Storr* J. Inorg. Biochem. 2016, 158, 131-138. “Multifunctional Quinoline-Triazole Derivatives as Potential Modulator for Aβ Aggregation"

79. Jeffrey S. Derrick, Richard A. Kerr, Kyle J. Torshavn, Michael J. McLane, Juhye Kang, Eunju Nam, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, Mi Hee Lim* Inorg. Chem. 2016, 55, 5000-5013. “The Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease" Note: This paper was highlighted in ACS Inorganic Chemistry.

78. Hyuck Jin Lee, Richard A. Kerr, Kyle J. Korshavn, Jiyeon Lee, Juhye Kang,  Ayyalusamy Ramamoorthy,* Brandon T. Ruotolo,* Mi Hee Lim* Inorg. Chem. Front. 2016, 3, 381- 392. "Effects of Hydroxyl Group Variations on a Flavonoid Backbone toward Modulation of Metal-Free and Metal-Induced Amyloid-β Aggregation" (Theme Issue of the 2015 Emerging Investigators by RSC ICF)  Note: This paper was selected as the Themed Issue of HOT articles in Inorganic Chemistry Frontiers for 2016.

77. Kyle J. Korshavn, Anirban Bhutia, Mi Hee Lim, Ayyalusamy Ramamoorthy* Chem. Commun. 2016, 52, 882-885. "Amyloid-β Adopts a Conserved, Partially Folded Structure upon Binding to Zwitterionic Lipid Bilayers Prior to Amyloid Formation"

Projects of Sensors for Metal Ions and Anions

76. Tae Geun Jo, Jae Jun Lee, Eunju Nam, Kwon Hee Bok, Mi Hee Lim,* Cheal Kim* New J. Chem. 2016, 40, 8918-8927. "A Highly Selective Fluorescent Sensor for the Detection of Al3+ and CN- in Aqueous Solution: Biological Applications and DFT Calculations" 

75. Ye Won Choi, Jae Jun Lee, Eunju Nam, Mi Hee Lim, Cheal Kim* Tetrahedron 2016, 72, 1998-2005. "A Fluorescent Chemsensor for Al3+ Based on Julolidine and Tryptophan Moieties"

74. Jae Jun Lee, Yong Sung Kim, Eunju Nam, Sun Young Lee, Mi Hee Lim,* Cheal Kim* Dalton Trans. 2016, 45, 5700-12. "A PET-based Fluorometric Chemosensor for Determination of Mercury(II) and pH, and Hydrolysis Reaction-Based Colorimetric Detection of Hydrogen Sulfide"

(2015)

Projects of Alzheimer's and Other Diseases

73. Jeffrey S. Derrick, Richard A. Kerr, Younwoo Nam, Shin Bi Oh, Hyuck Jin Lee, Kaylin G. Earnest, Nayoung Suh, Kristy L. Peck, Mehmet Ozbil, Kyle J. Korshavn, Ayyalusamy Ramamoorthy, Rajeev Prabhakar, Edward J. Merino, Jason Shearer,* Joo-Yong Lee,* Brandon T. Ruotolo,* Mi Hee Lim* J. Am. Chem. Soc. 2015, 137, 14785-14797. "A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms" Note: This paper was highlighted in multiple news media (The Korea Economic Daily; Dong-A Science; The Kyunghyang Sinhmun; Yonhap News).

72. Kyle J. Korshavn, Milim Jang, Yeon Ju Kwak, Akiko Kochi, Silvia Vertuani, Stefano Manfredini,* Ayyalusamy Ramamoorthy,* Mi Hee Lim* Sci. Rep. 2015, 5, 17842. "Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives"

71. Mi Hee Lim* and Yi Lu* Curr. Opin. Chem. Biol. 2015, 25, vii-viii. "Editorial Overview: Bioinorganic Chemistry: Bioinorganic Catalysis for Renewable Energy"

70. Jeffrey Derrick and Mi Hee Lim* ChemBioChem 2015, 16, 887-898. "Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease"

69. Michael W. Beck,§ Shin Bi Oh,§ Richard A. Kerr, Hyuck Jin Lee, So Hee Kim, Sujeong Kim, Milim Jang, Brandon T. Ruotolo*, Joo-Yong Lee,* Mi Hee Lim* Chem. Sci. 2015, 6, 1879-1886 (§Equal Contribution). "A Rationally Designed Small Molecule for Identifying an In Vivo Link of Metal-Amyloid-β Complexes to the Pathogenesis of Alzheimer's Disease" Note: This paper was selected by F1000Prime.

68. Akiko Kochi, Hyuck Jin Lee, Sashiprabha M. Vithanarachchi, Vediappen Padmini, Matthew J. Allen,* Mi Hee Lim* Curr. Alzheimers Res. 2015, 12, 415-423. "Inhibitory Activity of Curcumin Derivatives Towards Metal-Free and Metal-Induced Amyloid-β Aggregation" 

67. Meghan R. Porter, Akiko Kochi, Jonathan A. Karty, Mi Hee Lim,* Jeffrey M. Zaleski* Chem. Sci. 2015, 6, 1018-1026. "Chelation-Induced Diradical Formation as an Approach to Modulation of the Amyloid-β Aggregation Pathway"

(2014)

Projects of Alzheimer's and Other Diseases 

66. Alaina S. DeToma, Christine M. Dengler-Crish, Aniruddha Deb, Joseph J. Braymer, James E. Penner-Hahn, Cornelis J. van der Schyf, Mi Hee Lim* and Samuel D. Crish* BioMetals 2014, 27, 1291-1301. "Abnormal Metal Levels in the Primary Visual Pathway of the DBA/2J Mouse Model of Glaucoma" 

65. Alaina S. DeToma, Janrthan Krishnamoorthy, Younwoo Nam, Hyuck Jin Lee, Jeffrey R. Brender, Akiko Kochi, Dongkuk Lee, Valentina Onnis, Cenzo Congiu, Stefano Manfredini, Silvia Vertuani, Gianfranco Balboni*, Ayyalusamy Ramamoorthy,* Mi Hee Lim* Chem. Sci. 2014, 5, 4851-4862. "Interaction and Reactivity of Synthetic Aminoisoflavones with Metal-Free and Metal-Associated Amyloid-β Species" 

64. Christopher J. Chang,* Benjamin F. Cravatt,* Douglas S. Johnson,* Mi Hee Lim* Chem. Soc. Rev. 2014, 43, 6668-6671. Editorial: The Themed Issued of "Molecular Medicine and Neurodegenerative Diseases" 

63. Masha G. Savelieff, Alaina S. DeToma, Jeffrey S. Derrick, Mi Hee Lim* Acc. Chem. Res. 2014, 47, 2475-2482. "The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer's Disease" 

62. Werner J. Geldenhuys*, Akiko Kochi, Li Lin, Vijay Sutariya, Dean E. Dluzen, Cornelis J. Van der Schyf, Mi Hee Lim* ChemBioChem 2014, 15, 1591-1598. "Methyl Yellow: a Potential Drug Scaffold for Parkinson's Disease" 

61. Hyuck Jin Lee, Younwoo Nam, Mi Hee Lim* Chemworld 2014, 54, 22-27, "알츠하이머 질병에 관련된 금속-아밀로이드 베타 펩타이드 착물의 반응성을 조절할 수 있는 화학도구 개발" 

60. Hyuck Jin Lee, Kyle J. Korshavn, Akiko Kochi, Jeffrey S. Derrick, Mi Hee Lim* Chem. Soc. Rev. 2014, 43, 6672-6682. "Cholesterol and Metal Ions in Alzheimer's Disease" 

59. Sanghyun Lee, Xueyun Zheng, Janarthanan Krishnamoorthy, Hyun Min Park, Jeffrey R. Brender, Masha G. Savelieff, Jin Hoon Kim, Jeffrey S. Derrick, Akiko Kochi, Hyuck Jin Lee, Cheal Kim, Ayyalusamy Ramamoorthy*, Michael T. Bowers,* Mi Hee Lim* J. Am. Chem. Soc. 2014, 136, 299-310. “Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease” Note: This paper was highlighted in multiple news media (UBC broadcast); in March and April of 2016, this paper was highly cited as 1% of the Chemistry field (Web of Science).

58. Masha G. Savelieff, Yuzhong Liu, Russell R. P. Senthamarai, Kyle J. Korshavn, Hyuck Jin Lee, Ayyalusamy Ramamoorthy,* Mi Hee Lim* Chem. Commun. 2014, 50, 5301-5303. “A Small Molecule that Displays Marked Reactivity with Copper- versus Zinc-Amyloid-β Implicated in Alzheimer’s Disease” (Selected in Chem. Commun. "Contributors to the Emerging Investigators Issue 2014") Note: This paper was selected as the top 10% of highly cited articles from the RSC General Chemistry portfolio of journals.

57. Michael W. Beck, Amit S. Pithadia, Alaina S. DeToma, Kyle J. Korshavn, Mi Hee Lim* Chapter 10: “Ligand Design to Target and Modulate Metal-Protein Interactions in Neurodegenerative Diseases” in “Ligand Design in Medicinal Inorganic Chemistry” (John Wiley & Sons, LTD., Chichester, West Sussex PO19 8SQ), 2014, Chapter 10, 257-286. Note: This book is featured in Angew. Chem. Int. Ed. 2015, 54, 2324.

(2013)

Projects of Alzheimer's and Other Diseases

56. Akiko Kochi,§ Todd J. Eckroat,§ Keith D. Green, Abdelrahman S. Mayhoub, Mi Hee Lim,* Sylvie Garneau-Tsodikova* Chem. Sci. 2013, 4, 4137-4145 (§Equal Contribution). "A Novel Hybrid of 6-Chlorotacrine and Metal-Amyloid-β Modulator for Inhibition of Acetylcholine and Metal-Induced Amyloid-β Aggregation"

55. Amy M. Barrios*, Seth M. Cohen,* Mi Hee Lim* ChemCommu. 2013, 49, 5910-5911. Editorial: "Medicinal Inorganic Chemistry"

54. Ayyalusamy Ramamoorthy* and Mi Hee Lim* Biophys. J. 2013, 105, 287-288. News & Notable (Commentary): “Structural Characterization and Inhibition of Toxic Amyloid-β Oligomeric Intermediates”

53. Yuzhong Liu, Akiko Kochi, Amit S. Pithadia, Sanghyun Lee, Younwoo Nam, Michael W. Beck, Xiaoming He, Dongkuk Lee, Mi Hee Lim* Inorg. Chem. 2013, 52, 8121-30. “Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications”

52. Molly T. Soper, Alaina S. DeToma, Suk-Joon Hyung, Mi Hee Lim,* Brandon T. Ruotolo* PCCP 2013, 15, 8952-8961. “Amyloid-β/Neuropeptide Interactions Assessed by Ion Mobility-Mass Spectrometry”

51. Masha G. Savelieff, Sanghyun Lee, Yuzhong Liu, Mi Hee Lim* ACS Chem. Biol. 2013, 8, 856-865. “Alzheimer's Disease: Untangling Amyloid-β, Tau, and Metals” Note: This paper was one of the top 10 most read articles from ACS Chem. Biol. between April and June 2013.

50. Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Ayyalusamy Ramamoorthy*, Brandon T. Ruotolo,* Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 3743-3748. "Insights into the Antiamyloidogenic Properties of the Green Tea Extract (−)-Epigallocatechin-3-gallate toward Metal-associated Amyloid-β Species” Note: This paper was highlighted to several scientific and health news. This paper was selected for F1000Prime.

(2012)

Projects of Alzheimer's and Other Diseases

49. Amit S. Pithadia, Akiko Kochi, Molly T. Soper, Michael W. Beck, Sanghyun Lee, Alaina S. DeToma, Brandon T. Ruotolo,* Mi Hee Lim* Inorg. Chem. 2012, 51, 12959-12967. “Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-Species” Note: This work was featured as the cover artwork.

48. Michael R. Jones, Erin L. Service, John R. Thompson, Michael C. P. Wang, Isaac, J. Kimsey, Alaina S. DeToma, Ayyalusamy Ramamoorthy, Mi Hee Lim,* Tim Storr* Metallomics 2012, 4, 910-920.  “Dual-Function Triazole-Pyridine Derivatives as Inhibitors of Metal-Induced Amyloid-β Aggregation” Note: This paper was contributed to the Special Issue of Metallomics Emerging Investigators.

47. Joseph J. Braymer, Kevin P. O’Neill, Jan-Uwe Rohde,* Mi Hee Lim* Angew. Chem. Int. Ed. 2012, 51, 5376-5380. “The Reaction of a High-Valent Nonheme Oxoiron(IV) Intermediate with Hydrogen Peroxide” 

46. Xiaoming He, Hyun Min Park, Suk-Joon Hyung, Alaina S. DeToma, Cheal Kim, Brandon T. Ruotolo, Mi Hee Lim* Dalton Trans. 2012, 41, 6558–6566. “Investigation of Flavonoid Compounds as Modulators for Metal-Associated Amyloid-β Species” Note: This paper was contributed to the Themed Issue on Application of Inorganic Chemistry for non-Cancer Therapeutics.

45. Amit S. Pithadia and Mi Hee Lim* Curr. Opin. Chem. Biol. 2012, 16, 67-73. “Metal-Associated Amyloid-β Species in Alzheimer’s Disease”

44. Joseph J. Braymer, Nathan M. Merrill and Mi Hee Lim* Inorg. Chim. Acta 2012, 380, 261-268. “Characterization of Pyridinylimine and Pyridinylmethylamine Derivatives and Their Corresponding Metal Complexes” Note: This paper was contributed to the Special Issue on Future Young Investigators. 

43. Alaina S. DeToma,§ Samer Salemekh,§§Ayyalusamy Ramamoorthy* and Mi Hee Lim* Chem. Soc. Rev. 2012, 41, 608–621 (§Equally contributed this work). “Misfolded Proteins in Type II Diabetes and Alzheimer’s Disease”

(2011)

Projects of Alzheimer's and Other Diseases

42. Joseph J. Braymer, Jung-Suk Choi, Alaina S. DeToma, Chen Wang, Kisoo Nam, Jeff W. Kampf, Ayyalusamy Ramamoorthy, Mi Hee Lim* Inorg. Chem. 2011, 50, 10724-10734. “Development of Bifunctional Stilbene Derivatives for Metal-Aβ Species”

41. Jaeheung Cho, Sujin Jeon, Samuel A. Wilson, Lei V. Liu, Eun A Kang, Joseph J. Braymer, Mi Hee Lim, Britt Hedman, Keith O. Hodgson, Joan S. Valentine, Edward I. Solomon, Wonwoo Nam. Nature 2011, 478, 502-505. “Structure and Reactivity of a Mononuclear Nonheme Iron(III)-Peroxo Complex”

40. Werner J. Geldenhuys, Kristin S. Ko, Hilary Stinnett, Cornelis J. Van der Schyf,* Mi Hee Lim* Med. Chem. Commun. 2011, 2, 1099-1103. “Identification of Small Molecule-Based Reversible Monoamine Oxidase Inhibitors to Combat Human Neurodegenerative Disorders”

39. Alaina S. DeToma,§ Jung-Suk Choi,§ Joseph J. Braymer, Mi Hee Lim* ChemBioChem 2011, 12, 1198-11201 (§Equal contribution). “Myricetin: A Naturally Occurring Regulators for Metal-Induced Amyloid-β Species and Neurotoxicity”

38. Jung-Suk Choi, Joseph J. Braymer, Se Kyung Park, Shaik Mustafa, Junghyun Chae,* Mi Hee Lim* Metallomics 2011, 3, 284-291. “Synthesis and Characterization of IMPY Derivatives that Regulate Metal-Induced Amyloid-β Aggregation” Note: This work was featured as the Front Cover.

37. Joseph J. Braymer,§ Alaina, S. DeToma,§ Jung-Suk Choi, Kristin S. Ko, Mi Hee Lim* Int. J. Alzheimers Dis. 2011, 2011/623051 (§Equal contribution). “Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-Species in Alzheimer’s Disease” Note: This paper was contributed to the Special Issue on Metals and Alzheimer’s Disease.

(2010)

Projects of Alzheimer's and Other Diseases

36. Jung-Suk Choi,§ Joseph J. Braymer,§ Ravi P. R. Nanga, Ayyalusamy Ramamoorthy, Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21990-21995 (§Equal contribution). “Development of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity” Note: This paper was highlighted to several scientific news (C&EN).

(2009)

Projects of Alzheimer's and Other Diseases

35. Sarmad S. Hindo, Allana M. Mancino, Joseph J. Braymer, Yihong Liu, Subramanian Vivekanandan, Ayyalusamy Ramamoorthy,* Mi Hee Lim* J. Am. Chem. Soc. 2009, 131, 16663–16665. “Small Molecule Modulators of Copper-Induced Aβ Aggregation” Note: This paper was highlighted to several scientific news. This article was highlighted in ChemBioChem 2010 (Hureau C, Sasaki I, Gras E, Faller P.).

34. Allana M. Mancino, Sarmad S. Hindo, Akiko Kochi, Mi Hee Lim* Inorg. Chem. 2009, 48, 9596-9598. “Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited”

Publications From B.S., M.Sc., Ph.D., and Postdoc.:

33. Anna J. McConnell, Mi Hee Lim, Hang Song, Eric D. Olmon, Elizabeth E. Dervan, Jacqueline K. Barton, Inorg. Chem. 2012, 51, 12511-12520. “Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects”

32. Mi Hee Lim, Hang Song, Eric D. Olmon, Elizabeth E. Dervan, Jacqueline K. Barton, Inorg. Chem. 2009, 48, 5392-5397. “Sensitivity of Ru(bpy)2(dppz)2+ Luminescence to DNA Defects”

31. Mi Hee Lim, Irvin H. Lau, Jacqueline K. Barton, Inorg. Chem. 2007, 46, 9528-9530. “DNA Strand Cleavage near a CC Mismatch Directed by a Metalloinsertor”

30. Mi Hee Lim* Nat. Protocols 2007, 2, 408-415. “Preparation of a Copper-Based Fluorescent Probe for Nitric Oxide and Its Use in Mammalian Cultured Cells”

29. Mi Hee Lim, Stephen J. Lippard, Acc. Chem. Res. 2007, 40, 41-51. “Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide”

28. Mi Hee Lim, Brian A. Wong, William H. Pitcock, Deepa Mokshagundam, Mu-Hyun Baik, Stephen J. Lippard, J. Am. Chem. Soc. 2006, 128, 14364-14373. “Direct Nitric Oxide Detection In Aqueous Solution by Copper(II) Fluorescein Complexes”

27. Mi Hee Lim, Stephen J. Lippard, Inorg. Chem. 2006, 45, 8980-8989. “Fluorescent Nitric Oxide Detection by Copper Complexes Bearing Anthracenyl and Dansyl Fluorophore Ligands”

26. Mi Hee Lim, Chaoyuan Kuang, Stephen J. Lippard, ChemBioChem 2006, 7, 1571-1576. “Nitric Oxide-Induced Fluorescence Enhancement by Displacement of Dansylated Ligands from Cobalt”

25. Mi Hee Lim, Dong Xu, Stephen J. Lippard, Nat. Chem. Biol. 2006, 2, 375-380. “Visualization of Nitric Oxide in Living Cells by a Copper-Based Fluorescent Probe”

24. Na Young Oh, Mi Sook Seo, Mi Hee Lim, Mark B. Consugar, Mi Joo Park, Jan-Uwe Rohde, Jaehong Han, Kwan Mook Kim, Jinheung Kim, Lawrence, Jr. Que, Wonwoo Nam Chem. Commun. 2005, 5644-5646. “Self-Hydroxylation of Perbenzoic Acids at a Nonheme Iron(II) Center”

23. Mi Hee Lim, Stephen J. Lippard, J. Am. Chem. Soc. 2005, 127, 12170-12171. “Copper Complexes for Fluorescence-Based NO Detection in Aqueous Solution”

22. Rhett C. Smith, Andrew G. Tennyson, Mi Hee Lim, Stephen J. Lippard, Org. Lett. 2005, 7, 3573-3575. “Conjugated Polymer-Based Fluorescence Turn-On Sensor for Nitric Oxide”

21. Scott A. Hilderbrand, Mi Hee Lim, Stephen J. Lippard, In Topics in Fluorescence Spectroscopy; C. D. Geddes, J. R. Lakowicz, Eds; Springer, 2005, Vol. 9, pp. 163-188. “Fluorescence-Based Nitric Oxide Detection”

20. Carolyn C. Woodroofe, Mi Hee Lim, Weiming Bu, Stephen J. Lippard, Tetrahedron 2005, 61, 3097-3105. “Synthesis of Isomerically Pure Carboxylate- and Sulfonate-Substituted Xanthene Fluorophores”

19. Se-Eun Park, Woon Ju Song, Yon Ok Ryu, Mi Hee Lim, Rita Song, Kwan Mook Kim, Wonwoo Nam, J. Inorg. Biochem. 2005, 99, 424-431. “Parallel Mechanistic Studies on the Counterion Effect of Manganese Salen and Porphyrin Complexes on Olefin Epoxidation by Iodosylarenes”

18. Mi Hee Lim, Stephen J. Lippard, Inorg. Chem. 2004, 43, 6366-6370. “Fluorescence-Based Nitric Oxide Detection by Ruthenium Porphyrin Fluorophore Complexes”

17. Jan-Uwe Rohde, Stephane Torelli, Xiaopeng Shan, Mi Hee Lim, Eric J. Klinker, Jozsef Kaizer, Kui Chen, Wonwoo Nam, Lawrence Que, Jr., J. Am. Chem. Soc. 2004, 126, 16750-16761. “Structural Insights into Nonheme Alkylperoxoiron(III) and Oxoiron(IV) Intermediates by X-ray Absorption Spectroscopy”

16. Scott A. Hilderbrand, Mi Hee Lim, Stephen J. Lippard, J. Am. Chem. Soc. 2004, 126, 4972-4978. “Dirhodium Tetracarboxylate Scaffolds as Reversible Fluorescence-Based Nitric Oxide Sensors”

15. Wonwoo Nam, Se-Eun Park, In Kyung Lim, Mi Hee Lim, Jongki Hong, Jinheung Kim, J. Am. Chem. Soc. 2003, 125, 14674-14675. “First Direct Evidence for Stereospecific Olefin Epoxidation and Alkane Hydroxylation by an Oxoiron(IV) Porphyrin Complex”

14. Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, Lawrence Que, Jr., Proc. Natl. Acad. Sci. U.S.A., 2003, 100, 3665-3670. “An FeIV=O Complex of a Tetradentate Tripodal Nonheme Ligand”

13. Jan-Uwe Rohde, Jun-Hee In, Mi Hee Lim, William W. Brennessel, Michael R. Bukowski, Audria Stubna, Eckard Münck, Wonwoo Nam, Lawrence Que, Jr., Science, 2003, 299, 1037-1039. “Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex”

12. Wonwoo Nam, Sun Kyung Choi, Mi Hee Lim, Jan-Uwe Rohde, Inwoo Kim, Jinheung Kim, Cheal Kim, Lawrence Que, Jr., Angew. Chem. Int. Ed. 2003, 42, 109-111. “Reversible Formation of Iodosylbenzene-Iron Porphyrin Intermediates in the Reaction of Oxoiron(IV) Porphyrin p-Cation Radicals and Iodobenzene”

11. Wonwoo Nam, Sook Won Jin, Mi Hee Lim, Ju Yeon Ryu, Cheal Kim, Inorg. Chem. 2002, 14, 3647-3652. “Anionic Ligand Effect on the Nature of Epoxidizing Intermediates in Iron Porphyrin Complex-Catalyzed Epoxidation Reactions”

10. Wonwoo Nam, Inwoo Kim, Mi Hee Lim, Hye Jin Choi, Jeseung Lee, Ho G. Jang, Chem.-Eur. J. 2002, 8, 2067-2071. “Isolation of an Oxomanganese(V) Porphyrin Intermediate in the Reaction of a Manganese(III) Porphyrin Complex and H2O2 in Aqueous Solution”

9. Youngmee Kim, Wonwoo Nam, Mi Hee Lim, Sook Won Jin, Alan J. Loungh, Sung-Jin Kim, Acta Crystallogr. 2001, C57, 556-557. “Methoxy[meso-5,10,15,20-tetrakis(2,6-diflurorophenyl)porphyrinato]iron(III), [Fe(TDFPP)(OCH3)]”

8. Mi Hee Lim, Sook Won Jin, Yoon Jung Lee, Gil-Ja Jhon, Wonwoo Nam, Cheal Kim, Bull. Korean Chem. Soc. 2001, 22, 93-96. “Electronic Effect of Iron(III) Porphyrin Complexes on the Epoxidation of Cyclohexene: Epoxidation versus Hydroxylation”

7. Wonwoo Nam, Mi Hee Lim, So-Young Oh, Inorg. Chem. 2000, 39, 5572-5575. “Effect of Anionic Axial Ligands on the Formation of Oxoiron(IV) Porphyrin Intermediates”

6. Wonwoo Nam, Mi Hee Lim, Sun Kyung Moon, Cheal Kim, J. Am. Chem. Soc. 2000, 122, 10805-10809. “Participation of Two Distinct Hydroxylating Intermediates in Iron(III) Porphyrin Complex-Catalyzed Hydroxylation of Alkanes”

5. Wonwoo Nam, Mi Hee Lim, So-Young Oh, Jung Hwa Lee, Ha Jin Lee, Seung Kyun Woo, Cheal Kim, Woonsup Shin, Angew. Chem. Int. Ed. 2000, 39, 3646-3649. “Remarkable Anionic Axial Ligand Effects of Iron(III) Porphyrin Complexes on the Catalytic Oxygenations of Hydrocarbons by H2O2 and the Formation of Oxoiron(IV) Porphyrin Intermediates by m-Chloroperoxybenzoic Acid”

4. Wonwoo Nam, So-Young Oh, Mi Hee Lim, Mee-Hwa Choi, So-Yeop Han, Gil-Ja Jhon, Chem. Commun. 2000, 1787-1788. “Temperature Effect on the Epoxidation of Olefins by Iron(III) Porphyrin Complex and tert-Alkyl Hydroperoxides”

3. Wonwoo Nam, Mi Hee Lim, Ha Jin Lee, Cheal Kim, J. Am. Chem. Soc. 2000, 122, 6641-6647. “Evidence for the Participation of Two distinct Reactive Intermediates in Iron(III) Porphyrin Complex-Catalyzed Epoxidation Reactions”

2. Wonwoo Nam, Yeong Mee Goh, Yoon Jung Lee, Mi Hee Lim, Cheal Kim, Inorg. Chem. 1999, 38, 3238-3240. “Biomimetic Alkane Hydroxylations by an Iron(III) Porphyrin Complex with H2O2 and a High-Valent Iron(IV) Oxo Porphyrin Cation Radical Complex”

1. Mi Hee Lim, Yoon Jung Lee, Yeong Mee Goh, Wonwoo Nam, Cheal Kim, Bull. Chem. Soc. Jpn. 1999, 72, 707-713. “Hydroxylation of Aliphatic Hydrocarbons with m-Chloroperbenzoic Acid Catalyzed by Electron-Deficient Iron(III) Porphyrin Complexes”

Patents: 

5. Mi Hee Lim* US Patent Application No.: 14/967,376; Filed: 14-December-2015" (2015) "Pharmaceutical Composition for Treating or Preventing Degenerative Brain Disease Comprising Multi-Targeting Compounds"

4. Mi Hee Lim* Korea Appl. Publ. (10-2015-0026202) (2015) “다중 타겟을 표적으로 하는 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 치료 또는 예방용 약학조성물” 

3. Mi Hee Lim,* Katayoun Saatchi, Urs Hafeli, Joo-Yong Lee, US Patent Application No.: 14/362,339; Filed: 02-Jun-2014 “Compositions and Methods for the Treatment and Analysis of Neurological Disorders”

2. Jacqueline K. Barton, Brian M. Zeglis, Irvin H. Lau, Jonathan R. Hart, Mi Hee Lim, U.S. Pat. Appl. Publ. 2007, US20070224612. “Compounds and Methods for Nucleic Acid Mismatch Detection” 

1. Stephen J. Lippard, Mi Hee Lim Int. Pat. Appl. Publ. 2007, WO/2007/149105 (PCT/US2006/030227). “Fluorescein Based Sensors for Tracking Nitric Oxide in Live Cells”