MetalloNeuroChemistry Lab (MNCL)

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding of the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

5. Hyuck Jin Lee,§Masha G. Savelieff,§Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Shinjung C. Lee, Elizabeth M. Nolan, Mi Hee Lim* Metallomics 2018, In Press. "Calprotectin Influences the Aggregation of Metal-Free and Metal-Bound Amyloid-β by Direct Interaction” 
4. Masha G. Savelieff, Geewoo Nam, Juhye Kang, Hyuck Jin Lee, Misun Lee, Mi Hee Lim* Chem. Rev. 2018, Just Accepted. "Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade" 
3. Eunju Nam, Jeffrey S. Derrick, Seunghee Lee, Juhye Kang, Jiyeon Han, Shin Jung C. Lee, Su Wol Chung,* Mi Hee Lim* ACS Chem. Neurosci. 2018, Just Accepted. "Regulatory Activities of Dopamine and Its Derivatives towards Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease" 
2. Sonam Kim, Hyuck Jin Lee, Eunju Nam, Donghyun Jeong, Jaeheung Cho,* Mi Hee Lim,* Youngmin You* ACS Omega 2018, 3, 5141-5154. "Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring Amyloid-β Aggregation” 
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Recent News

100. July 2018: Congrats, Hyuck Jin, Masha, and Juhye, for publishing their work in Metallomics! 
99. June 2018: Congrats, Hyuck Jin, for the Best Poster Award from the 2018 Inorganic Chemistry Summer Symposium! 
98. June 2018: Congrats, Masha, Geewoo, Juhye, Hyuck Jin, and Misun, for publishing Chem. Rev.! 
97. May 30-June 1 2018: Successful Organization of The 2018 Korea-Taiwan-Japan Bioinorganic Chemistry Symposium at KAIST 
96. May 2018: Congrats, Eunju, Jeff, Juhye, and Jiyeon, for publishing their work in ACS Chem. Neurosci.! 
95. April 2018: Professor Lim becomes a Bentham Brand Ambassador. 
94. April 2018: Professor Lim becomes a Member of the Asian Chemical Biology Initiative. 
93. January 2018: Professor Lim becomes a Member of the IUPAC Inorganic Chemistry Division. 
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