Lim Laboratory

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

4. Geewoo Nam, Yuxi Lin, Mi Hee Lim,* Young-Ho Lee* Chem 2020, In Press. "Key Physicochemical and Biological Factors of the Phase Behavior of Tau" 
3. Geewoo Nam, Mannkyu Hong, Juri Lee, Hyuck Jin Lee, Yonghwan Ji, Juhye Kang, Mu-Hyun Baik,* Mi Hee Lim* Chem. Sci. 2020, In Press. "Multiple Reactivities of Flavonoids towards Pathological Factors in Alzheimer's Disease: Structure-Activity Relationship" 
2. Gunhee Kim, Evan Lelong, Juhye Kang, Jong-Min Suh, Nathalie Le Bris, Hélène Bernard, Dongwook Kim, Raphaël Tripier,* Mi Hee Lim* Inorg. Chem. Front. 2020, In Press. "Reactivities of Cyclam Derivatives with Metal–Aβ" 
1. Mingeun Kim, Juhye Kang, Misun Lee, Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Jiyoung Park, Joo-Young Lee,* Mu-Hyun Baik,* Mi Hee Lim* J. Am. Chem. Soc. 2020, In Press. “Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia" 
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Recent News

October 1, 2020: Congrats, Zhi Du as a Postdoctoral Scholar in the Lim Lab! 
September 15, 2020: Congrats, Geewoo, for publishing a review article in Chem.! 
September 8, 2020: Congrats, Geewoo, Mannkyu, Juri, Hyuck Jin, Yonghwan, and Juhye, for publishing their work in Chem. Sci.! 
September 7, 2020: Congrats, Gunhee, Juhye, and Jong-Min, for publishing their work in Inorg. Chem. Front.!  
September 1, 2020: Welcome Dr. Geewoo Nam as a Postdoctoral Scholar in the Lim Lab! 
August 20, 2020: Congrats, Professor Lim, for receiving the AsBIC James Hoeschele Award!  
August 17, 2020: Congrats, Jong-Min, for publishing his work in Chem. Sci.!  
June 15, 2020: Congrats, Geewoo, for his successful Ph.D. thesis defense! 
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Postdoctoral Associates

Ph.D. scientists with exceptional expertise in organic/inorganic chemistry, biochemistry/biophysical chemistry, or chemical biology/protein chemistry are welcome. Please send your application package (cover letter, CV, a research summary, copies of published papers, and a list of three reference letter writers with contact information) to Professor Mi Hee Lim via email for a consideration as a postdoctoral associate in our group.

Graduate Students

Highly motivated graduate students who are interested in organic/inorganic chemistry, medicinal chemistry, biochemistry/biophysical chemistry, or chemical biology/protein chemistry are welcome to join our group. Please contact Professor Mi Hee Lim via email.

Undergraduate Students

Undergraduate students who are interested in applying textbook knowledge on organic/inorganic chemistry and biochemistry to research in the laboratory are encouraged to be part of our group. Please contact Professor Mi Hee Lim via email.