Welcome to the Lim Group!
Exploring Inorganic Life through Chemistry
Welcome to the Lim Group!
Exploring Inorganic Life through Chemistry
The Lim laboratory explores 'Inorganic Life', investigating how metal ions, small molecules, and proteins interact to shape biological function and dysfunction. Integrating inorganic, organic, and biological chemistry with neuroscience, we uncover fundamental molecular mechanisms underlying complex biological systems and develop new chemical strategies to understand and control disease-associated processes.
Multifactorial Molecular Mechanisms of Neurodegenerative Diseases
Bioinorganic Chemistry of Metal Homeostasis, Coordination, and Redox Reactivity
Multi-Target Chemical Modulators for Pathological Network Regulation
Protein–Protein Interactions, Phase Transitions, and Systems Biomolecular Chemistry
(본 리더(창의) 연구단에서 화학적 접근 퇴행성 뇌질환 연구에 관심있는 대학원생 및 박사 후 연구원을 모집합니다)
Research Professors
Ph.D. scientists with expertise in bioinorganic chemistry, biochemistry, biophysical chemistry, chemical biology, or protein chemistry and experience in ~3-year postdoctoral research are welcome. Please send your application package (cover letter, CV, a research summary, copies of published papers, and a list of three reference letter writers with contact information) to Professor Mi Hee Lim via email for consideration.
Postdoctoral Scholars
Ph.D. scientists with expertise in bioorganic or bioinorganic chemistry, biochemistry, biophysical chemistry, protein chemistry, chemical biology, or chemical neuroscience are welcome. Please send your application package (cover letter, CV, a research summary, copies of published papers, and a list of three reference letter writers with contact information) to Professor Mi Hee Lim via email for consideration.
Graduate Students
Highly motivated graduate students who are interested in bioinorganic / bioorganic / bioanalytical / biophysical / medicinal chemistry, biochemistry, bprotein chemistry, chemical neuroscience, and chemical biology are welcome to join our group. Please contact Professor Mi Hee Lim via email.
We also welcome applications from students who are interested in Industry–Academia Collaboration Programs, including CEPP, EPLL, EPSD, KEPSI, KSBP, LGenius, SKBEP, and S-EPSS.
Undergraduate Students
Undergraduate students who are interested in applying textbook knowledge on organic/inorganic chemistry and biochemistry to research in the laboratory are encouraged to be part of our group. Please contact Professor Mi Hee Lim via email.
Yelim Yi, Jin Hae Kim,* Kiyoung Park,* Mi Hee Lim* et al., ACS Cent. Sci. 2026, Accepted for Publication.
"O2-Coupled Copper–Cysteine Redox Chemistry Drives Oxidative Modifications and Higher-order Assembly of Monomeric Transthyretin"
Jimin Kwak,§ Seongmin Park,§ Mi Hee Lim* Curr. Opin. Chem. Biol. 2026, Accepted for Publication.
"Effects of metal ions on amyloid liquid–liquid phase separation and liquid-to-solid phase transition"
Seongmin Park,§ Yunha Hwang,§ Jimin Kwak,§ Jiyong Park,* Young-Ho Lee,* Kyoung-Shim Kim,* Chul-Ho Lee,* Seung Jae Lee,* Mi Hee Lim* et al., Adv. Sci. 2026, In Press.
"Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions"
Eunseo Hong,§ Seongmin Park,§ Yuxi Lin,§ Young-Ho Lee,* Mi Hee Lim* et al., Cell Rep. Phys. Sci. 2026, In Press.
"A Glitazone-Based Chemical Platform for Mechanistic Modulation of Amyloid-β Aggregation and Associated Pathology"
Byeongha Ahn,§ Jimin Lee,§ Seongmin Park,* Mingeun Kim,* Mi Hee Lim* Inorg. Chem. Front. 2026, In Press (link).
"Reactivities of Endocannabinoids toward Metal-Induced Amyloid-β Aggregation and Oxidative Stress Associated with Alzheimer’s Disease "
Jimin Lee,§ Euneso Hong,§ Kyoung-Shim Kim,* Chul-Ho Lee,* Mingeun Kim,* Mi Hee Lim* et al., Small 2026, 22, e74013 (link).
"A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer’s Disease"
Chanju Na,§ Jimin Lee,§ Kyoung-Shim Kim,* Chul-Ho Lee,* Mingeun Kim,* Mi Hee Lim* et al., J. Am. Chem. Soc. 2026, 148, 461 (link).
"Positional Isomerism Tunes Molecular Reactivities and Mechanisms toward Pathological Targets in Dementia"
Mingeun Kim, Young-Ho Lee,* Mi Hee Lim* et al., Nature Chem. Biol. 2025, 21, 1709 (link).
"Interactions with Tau's Microtuble-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity"
June 23, 2026
Congrats, Professor Lim, for Receiving the College of Natural Sciences Excellence in Teaching Award!
April 16, 2026
Congrats, Professor Lim, for Receiving the Outstanding Research Award in the KCS Inorganic Chemistry Division!
February 20, 2026
Congrats, Dr. Seongmin Park (Ph.D.) and Bomin Kim (M.S.), for Their Graduation!