Lim Laboratory

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

6. Geewoo Nam, Yonghwan Ji, Hyuck Jin Lee, Yelim Yi, Mingeun Kim, Yuxi Lin, Young-Ho Lee, Mi Hee Lim* ACS Chem. Neurosci. 2019, In Press. "Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease"  
5. Juhye Kang, Jung Seung Nam, Hyuck Jin Lee, Geewoo Nam, Hyun-Woo Rhee, Tae-Hyuk Kwon,* Mi Hee Lim* Chem. Sci. 2019, In Press. "Chemical Strategies to Modify Amyloidogenic Peptides by Iridium(III) Complexes: Coordination and Photo-Induced Oxidation"  
4. Yelim Yi, Jiyeon Han, Min Hee Park, Nahye Park, Eunju Nam, Hee Kyung Jin,* Jae-sung Bae,* Mi Hee Lim* Chem. Commun. 2019, 55, 5847-5850. "Tunable Regulatory Activities of 1,10-Phenanthroline Derivatives towards Acid Sphingomyelinase and Zn(II)–Amyloid-β" 
3. Geewoo Nam, Mi Hee Lim* Chem. Lett. 2019, Accepted for Publication (Invited Review). "Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer's Disease: Metal–Amyloid-β" 
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Recent News

June 2019: Congrats, Geewoo, Yonghwan, Hyuck Jin, Juhye, Yelim and Mingeun, for publishing their work in ACS Chem. Neurosci.! 
June 2019: Eunju, Congrats for the Poster Awards in the International Conference on Bioinspired Small Molecule Activation (Seoul, Korea).! 
June 2019: Congrats, Juhye Kang, Hyuck Jin Lee, and Geewoo Nam, for publishing their work in Chem. Sci.! 
June 2019: Geewoo, Congrats for the Poster Awards in the 15th International Sympsoium on Applied Bioinorganic Chemsitry 
May 2019: Congrats, Yelim Yi, Jiyeon Han, Nahye Park, and Eunju Nam, for their work being featured as a Front Cover in Chem. Commu.! 
April 2019: Congrats, Yelim Yi, Jiyeon Han, Nahye Park, and Eunju Nam, for publishing their studies in Chem. Commun.! 
April 2019: Congrats, Geewoo Nam, for publishing an invited review article in Chem. Lett.! 
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