MetalloNeuroChemistry Lab (MNCL)

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding of the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

9. Hyuck Jin Lee, Young Geun Lee, Juhye Kang, Seung Hyun Yang, Ju Hwan Kim, Amar B. T. Ghisaidoobe, Hyo Jin Kang,* Sang-Rae Lee,* Mi Hee Lim,* Sang J. Chung* Chem. Sci. 2019, In Press. "Monitoring Metal–Amyloid-β Complexation by a FRET-Based Probe: Design, Detection, and Inhibitor Screening" 
8. Jong-Min Suh, Gunhee Kim, Juhye Kang, Mi Hee Lim* Inorg. Chem. 2018, In Press. "Strategies Employing Transition Metal Complexes to Modulate Amyloid-β Aggregation" 
7. Misun Lee,§ Mingeun Kim,§ Anjong Florence Tikum,§ Hyuck Jin Lee, Vijayan Thamilarasan, Mi Hee Lim,* Jinheung Kim* Dyes Pigm. 2019, 162, 97-103 (§ Equal Contribution). "A Near-Infrared Fluorescent Probe for Amyloid-β Aggregates” 
6. Sugyeong Hong, You Kyung Go, Jeffrey S. Derrick, Sanghun Han, Jin Kim, Mi Hee Lim,* Sun Hee Kim* Inorg. Chem. 2018, 57, 12665-12670. "Advanced EPR Studies of a Ternary Complex of Copper, Amyloid-β and a Chemical Regulator” 
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Recent News

109. December 2018: Congrats, Professor Lim, for receiving the 2018 SBIC Early Career Award! ( 
108. December 2018: Congrats, Hyuck Jin and Juhye, for publishing their work in Chem. Sci.! 
107. December 2018: Congrats, Misun and Mingeun, for their successful MS defense! 
106. November 2018: Congrats, Jong-Min, Gunhee, and Juhgye, for publishing a Viewpoint Article in Inorg. Chem.! 
105. October 2018: Welcome Evan, a visiting student from France! 
104. October 2018: Congrats, Professor Lim, for receiving the 2018 Young Inorganic Chemist Award, KCS Inorganic Division! 
103. October, 2018: Congrats, Misun, Mingeun, and Dr. Lee, for publishing our collaborative work in Dyes Pigs.! 
102. September, 2018: Congrats, Jeff, for publishing our collaborative work in Inorg. Chem.! 
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