Research Overview

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).

Recent Publications

Jiyeon Han, Zhi Du, Mi Hee Lim* Acc. Chem. Res. 2021, 54, 3930-3940. "Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease"

Geewoo Nam,§ Jong-Min Suh,§ Yelim Yi, Mi Hee Lim* J. Inorg. Biochem. 2021, 224, 111592. "Drug Repurposing: Small Molecules against Cu(II)–Amyloid-β and Free Radicals"

Mingeun Kim, Mi Hee Lim* Bull. Korean Chem. Soc. 2021, 42, 1277-1280. "Redox Properties of Small Molecules Essential for Mulitple Reactivities with Pathological Factors in Alzheimer's Disease"

Eunju Nam, Jiyeon Han, Sunhee Choi, Mi Hee Lim* Chem. Commun. 2021, 57, 7637-7640. "Distinct Impact of Glycation towards the Aggregation and Toxicity of Murine and Human Amyloid-β" Note: This paper was contributed to the Special Issue of "Multimolecular Crowding in Biosystems"

Yelim Yi, Yuxi Lin,§ Jiyeon Han,§ Hyuck Jin Lee, Nahye Park, Geewoo Nam, Young S. Park, Young-Ho Lee,* Mi Hee Lim* Chem. Sci. 2021, 12, 2456-2466. "Impact of Sphingoshine and Acetylsphingosines on the Aggregation and Toxicity of Metal-Free and Metal-Treated Amyloid-β"

Seongmin Park,§ Yelim Yi,§ Mi Hee Lim* Bull. Korean Chem. Soc. 2021, 42, 17-24. "Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal-Free and Metal-Induced Amyloid-β"

Recent News

June 1, 2022: Congrats, Professor Lim and the Lim Lab, for the 9-Year Creative Research Initiative Funding [Center for MetalloNeuroProteinoChemistry (금속신경단백질화학 연구단)]!

May 26, 2022: Congrats, Mingeun, for his successful Ph. D. defense!

May 26, 2022: Congrats, Yelim, for the Global Competency Reinforce Program (GPF)!

May 2022: Congrats, Jiyeon, for the NRF Postdoctoral Fellowship!

May 2022: Congrats, Jimin & Junhyeok, for Being Selected for the 2022 Venture Research Program!

May 15, 2022: Good luck, Dr. Eunju Nam, for Your New Adventure as a Postdoctoral Scholar at the Harvard Medical School, MA, USA!

March 2, 2022: Welcome, Drs. Eunju Nam & Jiyeon Han as a Postdoctoral Scholar in the Lim Lab!

February 14, 2022: Welcome, Kseniia as an Undergraduate Researcher to the Lim lab!

January 21, 2022: Good luck, Dr. Mannkyu Hong, for Your New Adventure as a Postdoctoral Scholar at the Scripps Research Institute, CA, USA!

December 21, 2021: Welcome, Caroline as a Visiting Researcher, in the Lim Lab!

November 18, 2021: Congrats, Professor Lim, for receiving The Year Award for Women in Science and Technology!


Postdoctoral Associates

Ph.D. scientists with exceptional expertise in organic/inorganic chemistry, biochemistry/biophysical chemistry, or chemical biology/protein chemistry are welcome. Please send your application package (cover letter, CV, a research summary, copies of published papers, and a list of three reference letter writers with contact information) to Professor Mi Hee Lim via email for consideration as a postdoctoral associate in our group.

Graduate Students

Highly motivated graduate students who are interested in organic/inorganic chemistry, medicinal chemistry, biochemistry/biophysical chemistry, or chemical biology/protein chemistry are welcome to join our group. Please contact Professor Mi Hee Lim via email.

Undergraduate Students

Undergraduate students who are interested in applying textbook knowledge on organic/inorganic chemistry and biochemistry to research in the laboratory are encouraged to be part of our group. Please contact Professor Mi Hee Lim via email.

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