LINKS

Computational Systems Biology - NPTEL course

This course is available for free on YouTube (click here), NPTEL, and SWAYAM platforms. To get certified, one must enrol via SWAYAM online portal.

This course is offered by Prof Karthik Raman, Associate Professor at the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras. To visit Raman Lab, click here.

Every living cell is the result beautifully concerted interplay of metabolic, signaling and regulatory networks. Systems biology has heralded a systematic quantitative approach to study these complex networks, to understand, predict and manipulate biological systems. Systems biology has had a positive impact on metabolic engineering as well as the pharmaceutical industry. This course seeks to introduce key concepts of mathematical modelling, in the context of different types of biological networks. The course will cover important concepts from network biology, modelling of dynamic systems and parameter estimation, as well as constraint-based metabolic modelling. The course has a significant hands-on component, emphasizing various software tools and computational methods for systems biology. Pre-requisites: Basic knowledge of a high-level programming language (preferably MATLAB). Source: https://onlinecourses.nptel.ac.in/noc21_bt16/preview

Books and references

• Voit E (2012) A First Course in Systems Biology. Garland Science, 1/e. ISBN 0815344678

• Klipp E (2009) Systems biology: a textbook. Wiley-VCH, 1/e. ISBN 9783527318742

• Newman MEJ (2011) Networks: an introduction. Oxford Univ. Press. ISBN 9780199206650

Metabolic Engineering - NPTEL course

This course is available for free on YouTube, NPTEL, and SWAYAM platforms. To get certified, one must enrol via SWAYAM online portal.

This course is offered by Prof Pinaki Sar, Department of Biotechnology, IIT Kharagpur together with Prof Amit Ghosh, School of Energy Science and Engineering, IIT Kharagpur.

Metabolic engineering is an emerging field of biotechnology/ bioprocess engineering which aims towards the purposeful modification of cellular (metabolic, gene regulatory, and signaling) processes/networks to achieve desirable goals such as enhanced production of metabolites including pharmaceuticals, biofuels and biochemicals, and other biotechnology products. This course aims to provide fundamental and advanced knowledge in the development of microbial strain for bioproduction through metabolic engineering. Pre-requisites: Basics of Microbiology, Biochemistry, Genetics. Source: https://onlinecourses.nptel.ac.in/noc21_bt18/preview

Books and references

• Metabolic Engineering, Principles and Methodologies; G N Stephanopoulos, A A Aristidou, J Nielsen

• Advances in Biochemical Engineering/Biotechnology; Metabolic Engineering, Volume Editor: Jens Nielsen

• Systems Metabolic Engineering, Methods and Protocols; H S Alper

• Metabolic Pathway design, A Practical Guide; P Carbonell