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OUR PHILOSOPHY
OUR PHILOSOPHY
- Delineate Genotype-Phenotype Relationship in biological systems
- Use systems biology approaches through high throughput experimental technologies, acquiring heterogenous data types and mathematical/ computational techniques
- Model driven/Model Integrated approach
OUR VISION
OUR VISION
The Metabolic Inquiry and Cellular Engineering (MICE) Lab uses systems approaches to investigate complex biological systems at all levels of molecular heirarchy inherent in the central dogma. The intersection of multiple processes associated at the molecular level will allow delineation of mechanisms of function and emergent properties at the level of a single cell or population of cells.
Research INTERESTS
Research INTERESTS
We focus on three major areas of research.
1. SYSTEMS BIOLOGY AND DRUG RESISTANCE
1. SYSTEMS BIOLOGY AND DRUG RESISTANCE
We work on investigating the emergent property of antibiotic and chemotherapeutic drug resistance by probing cellular processes of growth, respiration and metabolism in response to drugs and other selection pressures. We use Glioblastoma multiforme a type of brain cancer and a zoonotic pathogen Chromobacterium violaceum as model systems for studying resistance.
2. SYNTHETIC BIOLOGY AND METABOLIC ENGINEERING
2. SYNTHETIC BIOLOGY AND METABOLIC ENGINEERING
We work on making value added products ranging from those indigenous, heterogenous or synthetic to host metabolism. Examples including drug molecules like violacein, kanamycin, penicillins and polymers like polyhydroxyalkanoates.
3. CONSTRAINTS-BASED FLUX BALANCE MODELING
3. CONSTRAINTS-BASED FLUX BALANCE MODELING
We build genome-scale metabolic network models to compute cell phenotypes using constraints-based flux balance modeling techniques. We also work on developing algorithms to incorporate experimental data as constraints in flux balance models. Of special interest is the problem of incorporating transcriptomic data as constraints for metabolic models.
We strive to practice model-driven/model-integrated science by validation of in silico discoveries experimentally at different levels of molecular organization in both prokaryotic and eukaryotic systems.
OUR TEAM
OUR TEAM
OPEN POSITIONS
OPEN POSITIONS
We are always seeking highly motivated individuals for exciting projects in our laboratory. Our lab values the career development of each member and provides ample opportunities for them to attend academic conferences or receive scientific training. If interested please send your CV to micelabatncl@gmail.com or contact Anu Raghunathan at the address below to explore potential opportunities.
Publications
Publications
COLLABORATions
COLLABORATions
MEETINGS ORGANIZED
MEETINGS ORGANIZED
BLOGS
BLOGS
MICELabatNCL
RESOURCES
RESOURCES
World Wide Web
GALLERY
GALLERY
EXTRACURRICULAR
EXTRACURRICULAR
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Contact
Contact
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