Publications

Barbieri, F.; Martina, M.G.; Giorgio, C.; Chiara, M.L.; Allodi, M.; Durante, J.; Berton, S.;* Radi, M.*

"Benzofuran-2-Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20-Induced Chemotaxis and Colon Cancer Growth"

Rubini, D.; Martina, M.G.; Incerti, M.; Barbieri, F.; Radi,M.*

"A Microwave-Assisted One-Pot Three-Step Metal-Free [4+2] Annulation for the Sustainable Synthesis of Highly Substituted 1,2,4-Triazines"

Barbieri, F.; Carlen, V.; Martina, M.G.; Sannio, F.; Cancade, S.;  Perini, C.; Restori, M.; Crespan, E.; Maga, G.; Docquier, J-D.; Cagno, V.*;  Radi,M.*

"Trifluormethyl Bithiazoles as Broad-Spectrum Antimicrobial Agents for Virus-Related Bacterial Infections or co-Infections"

Giannessi, L.; Lupo, M.G.; Rossi, I.; Martina, M.G.; Vilella, A.; Bodria, M.; Giuliani, D.; Zimetti, F.; Zanotti, I.; Potì, F.; Bernini, F.; Ferri, N.*; Radi, M.*

"Identification of 4-Amino-2-Pyridones as New Potent PCSK9 Inhibitors: From Phenotypic Hit Discovery to In Vivo Tolerability "

Russo, C.; Leech, M.C.; Walsh, J.; Higham, J.I.; Giannessi, L.; Lambert, E.; Kiaku, C.; Poole, D.L.; Mason, J.; Goodall, C.A.I.; Devo, P.; Giustiniano, M.; Radi, M.; Lam, K.G.*

"eHydrogenation: Electrochemical Hydrogen-free hydrogenation"

Martina, M.G.; Giammarino, F.; Vicenti, I.; Groaz, E.; Rozenski, J.; Incerti, M.; Sannio, F.; Docquier, J-D.; Zazzi, M.; Radi, M.*

"Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties"

Allodi, M., Giorgio, C., Incerti, M., Corradi, D., Flammini, L., Ballabeni, V., Barocelli, E., Radi M.,* Bertoni, S.*

"Probing the effects of MR120 in preclinical chronic colitis: a first-in-class anti-IBD agent targeting the CCL20/CCR6 axis"

Martina, M.G.; Giannessi, L.; Radi, M.*

"Multicomponent Synthesis of Purines and Pyrimidines: From the Origin of Life to New Sustainable Approaches for Drug-Discovery Applications"

Martina, M. G.; Sannio, F.; Crespan, E.; Pavone, M.; Simoncini, A.; Barbieri, F.; Perini, C.; Pesce, E.; Maga, G.; Pedemonte, N.; Docquier, J-D.; Radi, M.*

"Towards Innovative Antibacterial-Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect"

Martina MG, Giorgio C, Allodi M, Palese S, Barocelli E, Ballabeni V, Szpakowska M, Chevigné A, Piet van Hamburg J, Davelaar N, Lubberts E, Bertoni S, Radi M.*

"Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases"

The Front Cover shows bithiazole derivatives acting as broad-spectrum antiviral agents (BSAAs) by targeting human host cells. These molecules block the replication of human rhinoviruses (hRVs) and Zika virus (ZIKV) via inhibition of the intracellular protein PI4KIIIβ while the inhibition of SARS-CoV-2 entry and replication seems to be connected with the modulation of an additional target. Cover design by Marco Radi. 

More information can be found in the Communication by Maria Grazia Martina, Marco Radi et al.

Martina, M.G.; Vicenti, I.; Bauer, L.; Crespan, E.; Rango, E.; Boccuto, A.; Olivieri, N.; Incerti, M.; Zwaagstra, M.; Allodi, M.; Bertoni, S.; Dreassi, E.; Zazzi, M.; van Kuppeveld,F. J. M.;  Maga, G.; Radi, M.*

"Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus and Human Rhinoviruses"

Vicenti, I.; Martina, M.G.; Boccuto, A.; De Angelis, M.; Giavarini, G.; Dragoni, F.; Marchi, S.; Trombetta, C.M.; Crespan, E.; Maga, G.; Eydoux, C.; Decroly, E.; Montomoli, E.; Nencioni, L.; Zazzi, M.; Radi, M.*

"System-Oriented Optimization of Multi-target 2,6- Diaminopurine Derivatives: Easily Accessible Broad-Spectrum Antivirals Active Against Flaviviruses, Influenza Virus and SARS-CoV-2"

Djikic, T.; Vucicevic, J.; Laurila, J.; Radi, M.; Veljkovic, N.;  Xhaard, H.;  Nikolic, K.

"Deciphering Imidazoline Off-Targets by Fishing in the Class A of GPCR field"

Tassini S, Langron E, Delang L, Mirabelli C, Lanko K, Crespan E, Kissova M, Tagliavini G, Fontò G, Bertoni S, Palese S, Giorgio C, Ravanetti F, Ragionieri L, Zamperini C, Mancini A, Dreassi E, Maga G, Vergani P, Neyts J, Radi M.*

"Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach"

Vincetti, P.; Costantino, G.; Martina, M.G. and Radi, M.*

“Probing the reactivity of 2,4-dichlorofuro[3,4-d]pyrimidin-7-one: a versatile and underexploited scaffold to generate substituted or fused pyrimidine derivatives"

Vincetti, P.; Kaptein, S. J. F.; Costantino, G.; Neyts, J. and Radi, M.*

“Scaffold Morphing Approach to Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/ZIka Replication" 

Bruno, A.; Costantino, G.; Sartori, L.; Radi, M.*

“The in silico drug discovery toolbox: applications in lead discovery and optimization”

The Cover Feature shows how a single purine derivative inhibits the replication of multiple mosquito-borne flaviviruses by targeting a conserved allosteric pocket on NS5 polymerase, which is needed to bind NS3 helicase/protease and generate the functional replication complex. These inexpensive non-nucleoside broad-spectrum antivirals inhibit the replication of Zika virus and all serotypes of dengue virus (DENV 1–4) in infected cells at low micromolar concentration, with no adverse effect on a panel of selected host kinases. 

More information can be found in the Communication by Marco Radi et al. on page 1371 in Issue 14, 2018 (DOI: 10.1002/cmdc.201800178).

Kaptein, S. J. F.; Vincetti, P.; Crespan, E.; Armijos-Rivera, J. I.; Costantino, G.; Maga, G.; Neyts, J. and Radi, M.*

“Identification of broad-spectrum dengue/Zika virus replication inhibitors by functionalization of quinoline and 2,6-diaminopurine scaffolds”

Botta, L.; Rivara, M.; Zuliani, V.; Radi, M.*

“Drug repurposing approaches to fight Dengue Virus infection and related diseases”

Aiello, F.; Carullo, G.; Giordano, F.; Spina, E.; Nigro, A.; Garofalo, A.; Tassini, S.; Costantino, G.; Vincetti, P.; Bruno, A,; Radi, M.*

“Towards the Identification of Novel Breast Cancer Inhibitors Specific for GPER-Expressing Cells”

Tassini, S.; Sun, L.; Lanko, K.; Crespan, E.; Langron, E.; Falchi, F.; Kissova, M.; Armijos-Rivera, J. I.; Delang, L.; Mirabelli, C.; Neyts, J.; Pieroni, M.; Cavalli, A.; Costantino, G.; Maga, G.; Vergani,P.; Leyssen, P.; Radi, M.*

“Discovery of Multi-Target Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) for Associated Pulmonary Diseases”

Bruno, A.; Aiello, F.; Costantino, G.; Radi, M.*

“Homology Modeling, Validation and Dynamics of the G Protein-Coupled Estrogen Receptor 1 (GPER-1)”

Radi, M.;* Schneider, R.; Fallacara, A.L.; Botta, L.; Tintori, C.; Crespan, E.; Maga, G.; Kissova, M.; Calgani, A.; Richters, A.; Musumeci, F.; Rauh, D.; Schenone, S.

"A Cascade Screening Approach for the Identification of Bcr-Abl Myristate Pocket Binders Active Against Wild Type and T315I Mutant." 

Scalacci, N.; Pelloja, C.; Radi, M.; Castagnolo, D.

“Microwave assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines”

Vucicevic, J.; Srdic-Rajic, T.; Pieroni, M.; Laurila, J.M.M.; Perovic, V.; Tassini, S.; Azzali, E.; Costantino, G.; Glisic, S.; Agbaba, D.; Scheinin, M.; Nikolic, K.; Radi, M.*; Veljkovic, N.

“A Combined Ligand- and Structure-Based approach for the identification of rilmenidine-like compounds which synergize the antitumor effects of doxorubicin”

Vincetti, P.; Brianza, A.; Scalacci, N.; Costantino, G.; Castagnolo, D.; Radi, M.*

“A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides”

Tassini, S.; Castagnolo,D.; Scalacci, N.; Kissova, M.; Armijos-Rivera, J.I.; Giagnorio, F.; Maga, G.; Costantino, G.; Crespan, E.; Radi, M.*

“A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes”

Magri, A.; Reilly, R.; Scalacci, N.; Radi, M.; Hunter, M.; Ripoll, M.; Patel, A.H.; Castagnolo, D.

“Rethinking the old antiviral drug moroxydine: discovery of novel analogues as potent anti-hepatitis C virus (HCV) agents”

Vincetti, P.; Caporuscio, F.; Kaptein, S.; Gioiello, A.; Mancino, V.; Suzuki, Y.; Yamamoto, N.; Crespan, E.; Lossani, A.; Maga, G.; Rastelli, G.; Castagnolo, D.; Neyts, J.; Leyssen, P.; Costantino, G.; Radi, M.*

“Discovery of multi-target antivirals acting on both the dengue virus NS5-NS3 interaction and the host Src/Fyn kinases”

Veljkovic, N.; Vucicevic, J.; Tassini, S.; Glisic, S.; Veljkovic, V.; Radi, M.

“The preclinical discovery and development of maraviroc for the treatment of HIV”

Tintori, C.; La Sala, G.; Vignaroli, G.; Botta, L.; Fallacara, A.L.; Falchi, F.; Radi, M.; Zamperini, C.; Dreassi, E.; Dello Iacono, L.; Orioli, D.; Biamonti, G.; Garbelli, M.; Lossani, A.; Gasparrini, F.; Tuccinardi, T.; Laurenzana, I.; Angelucci, A.; Maga, G.; Schenone, S.; Brullo, C; Musumeci, F.; Desogus, A.; Crespan, E.; Botta, M.

“Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors”

Tintori, C.; Fallacara, A.L.; Radi, M.; Zamperini, C.; Dreassi, E.; Crespan, E.; Maga, G.; Schenone, S.; Musumeci, F.; Brullo, C.; Richters, A.; Gasparrini, F.; Angelucci, A.; Festuccia, C.; Delle Monache, S.; Rauh, D.; Botta, M.

“Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma”

Zamperini, C.; Dreassi, E.; Vignaroli, G.; Radi, M.; Dragoni, S.; Schenone, S.; Musumeci, F.; Valoti, M.; Antiochia, R.; Botta, M. 

“CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction”

Schenone, S.; Radi, M.; Musumeci, F.; Brullo, C.; Botta, M.

“Biologically-driven synthesis of pyrazolo[3,4-d]pyrimidines: an old scaffold as a new tool for medicinal chemistry and chemical biology studies”

Fallacara, A.L.; Tintori, C.; Radi, M.; Schenone, S.; Botta, M.

“Insight into the allosteric inhibition of Abl kinase”

Vignaroli, G.; Mencarelli, M.; Sementa, D.; Crespan, E.; Kissova, M.; Maga, G.; Schenone, S.; Radi, M.; Botta, M.

“Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: towards novel allosteric inhibitors of T315I-mutated Abl”

Radi, M.*; Vallerini, G. P.; Petrelli, A.; Vincetti, P.; Costantino, G.

“Development of an optimized one-pot two- steps microwave-assisted strategy for the synthesis of highly substituted 5,6-ring-fused 2- pyridones"

Bellucci, L.; Angeli, L.; Tafi, A.; Radi, M.; Botta, M.

“The unconventional plasticity of HIV-1 Reverse Transcriptase: how inhibitors could open a connection “Gate” between the allosteric and catalytic sites”

Radi, M.; Bernardo, V.; Vignaroli, G.; Brai, A.; Biava, M.; Schenone, S.; Botta, M.

“An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines”

Radi, M.; Tintori, C.; Musumeci, F.; Brullo, C.; Zamperini, C.; Dreassi, E.; Fallacara, A. L.; Vignaroli, G.; Crespan, E.; Zanoli, S.; Laurenzana, I.; Filippi, I.; Maga, G.; Schenone, S.; Angelucci, A.; Botta, M.

“Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant.”

Vignaroli, G.; Zamperini, C.; Dreassi, E.; Radi, M.; Angelucci, A.; Sanita,̀ P.; Crespan, E.; Kissova M.; Maga, G.; Schenone, S.; Musumeci, F.; Botta, M.

“Pyrazolo [3, 4-d] pyrimidine prodrugs: strategic optimization of the aqueous solubility of dual Src/Abl inhibitors”

Mori, M.; Tintori, C.; Christopher, R. S.; Radi, M.; Schenone, S.; Musumeci, F.; Brullo, C.; Sanità, P.; Delle Monache, S.; Angelucci, A.; Kissova, M.; Crespan, E.; Maga, G.; Botta, M.

“A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.”

Radi, M.;Schenone, S.; Botta, M.

“Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders.”

Musumeci, F.; Radi, M.; Brullo, C.; Schenone, S.

“Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and New Inhibitors.”

Radi, M.; Evensen, L.; Dreassi, E.; Zamperini, C.; Caporicci, M.; Falchi, F.; Musumeci, F.; Schenone, S.; Lorens, J. B.; Botta, M.

“A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation.”

Radi, M.; Pagano, M.; Franchi, L.; Castagnolo, D.; Schenone, S.; Casaluce, G.; Zamperini, C.; Dreassi, E.; Maga, G.; Samuele, A.; Gonzalo, E.; Clotet, B.; Esté, J. A.; Botta, M.

“Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors”

Radi, M.; Falchi, F.; Garbelli, A.; Samuele, A.; Bernardo, V.; Paolucci, S.; Baldanti, F., Schenone, S.; Manetti, F.; Maga, G.; Botta, M.

“Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.”

Schenone, S.; Brullo, C.; Musumeci, F.; Radi, M.; Castagnolo, D.

“Src kinase inhibitors: an update on patented compounds”

Corradi, V.; Mancini, M.; Santucci, M. A.; Carlomagno, T.; Sanfelice, D.; Mori, M.; Vignaroli, G.; Falchi, F.; Manetti, F.; Radi, M.; Botta, M.

“Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case”

Radi, M.; Brullo, C.; Crespan, E.; Tintori, C.; Musumeci, F.; Biava, M.; Schenone, S.; Dreassi, E.; Zamperini, C.; Maga, G.; Pagano, D.; Angelucci, A.; Bologna, M.; Botta, M.

“Identification of Potent c-Src Inhibitors Strongly Affecting the Proliferation of Human Neuroblastoma Cells”

Radi, M.; Casaluce, G.; Botta, M.

“A Tandem Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones”

Maga, G.; Falchi, F.; Radi, M.; Botta, L.; Casaluce, G.; Bernardini, M.; Irannejad, H.; Manetti, F.; Garbelli, A.; Zanoli, S.; Esté, J. A.; González, E.; Zucca, E.; Paolucci, S.; Baldanti, F.; De Rijck, J.; Debyser, Z.; Botta, M.

“Toward the Discovery of Novel Anti-HIV Drugs. Second Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation.”

Garbelli, A.; Radi, M.; Falchi, F.; Beermann, S.; Zanoli, S.; Manetti, F.; Dietrich, U.; Botta, M.; Maga, G.

“Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication”

Schenone, S.; Brullo, C.; Musumeci, F.; Radi, M.; Botta, M.

“ATP-Competitive Inhibitors of mTOR: An Update”

Radi, M.; Dreassi, E.; Brullo, C.; Crespan, E.; Tintori, C.; Bernardo, V.; Valoti, M.; Zamperini, C.; Daigl, H.; Musumeci, F.; Carraro, F.; Naldini, A.; Filippi, I.; Maga, G.; Schenone, S.; Botta, M.

“Design, Synthesis, Biological Activity and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: a Lead Optimization Study”

Schenone, S.; Botta, M.; Radi, M.; Bruno, O.

“New insight into small molecules inhibitors of Bcr-Abl”

Krüwel, T.;1 Schenone, S.;1 Radi, M.;1 Maga, G.; Rohrbeck, A.; Botta, M.; Borlak, J.

“Identification and characterization of novel c-Abl / c-Src dual kinase inhibitors which are active against a large panel of tumour progenitor cells that express stem cell marker”

Radi, M.; Crespan, E.; Falchi, F.; Bernardo, V.; Zanoli, S.; Manetti, F.; Schenone, S.; Maga, G.;  Botta, M.

“Design and synthesis of new thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false-positive to ATP non-competitive inhibitors”

Franchi, L.; Innitzer, A.; Rinaldi, M.; Vignaroli, G.; Radi, M.; Botta, M.

“Arylation of 2-Furyl-(4-Fluorophenyl)-Ketone. An Extension of the Heck Chemistry Towards Novel Integrase Inhibitors”

Crespan, E.; Radi, M.; Zanoli, S.; Schenone, S.; Botta, M.; Maga, G.

“Dual SRC and ABL inhibitors target wild type ABL and the ABLT315I imatinib-resistant mutant with different mechanisms”

Maga, G.; Radi, M.; Gerard, M. A.; Botta, M.; Ennifar, E.

“HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that are competing with the nucleotide substrate”

Freisz, S.; Bec, G.; Radi, M.; Wolff, P.; Crespan, E.; Angeli, L.; Dumas, P.; Maga, G.; Botta, M.; Ennifar, E.

“Crystal Structure of the HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action”

Radi, M.; Botta, L.; Casaluce, G.; Bernardini, M.; Botta, M.

“A Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives”

Santucci, M. A.; Corradi, V.; Mancini, M.; Manetti, F.; Radi, M.; Schenone, S.; Botta, M.

“C-6 Unsubstituted Pyrazolo[3,4-d]Pyrimidines are Dual Src/Abl Inhibitors Effective Against Imatinib Mesylate-Resistant Chronic Myeloid Leukemia, Including that Arising from T315I Mutation.”

Radi, M.; Maga, G.; Alongi, M.; Angeli, L.; Samuele, A.; Zanoli, S.; Bellucci, L.; Tafi, A.; Casaluce, G.; Giorgi, G.; Armand-Ugon,  M.; González-Ortega, E.; Esté, J. A.; Baltzinger, M.; Bec, G.; Dumas, P.; Ennifar, E.; Botta, M.

"Discovery of chiral cyclopropyl S-DABO derivatives as potent HIV-1 Reverse Transcriptase Inhibitors with improved potency against clinically relevant mutants"

Castagnolo, D.; Radi, M.; Dessì, F.; Manetti, F.; Saddi, M.; Meleddu, R.; De Logu, A.; Botta, M.

“Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis”

Schenone, S.; Bruno, O.; Radi, M.; Botta, M.

“4-Amino-substituted pyrazolo[3,4-d]pyrimidines: synthesis and biological properties”

Radi, M.; Schenone, S.; Botta, M.

“Recent highlights in the synthesis of highly functionalized pyrimidines”

Castagnolo, D.; Manetti, F.; Radi, M.; Bechi, B.; Pagano, M.; De Logu, A.; Meleddu, R.; Saddi, M.; Botta, M.

“Synthesis biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2.”

Radi, M.; Rao, J. R.; Jha, A. K.; Chu, C. K.

“A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions”

Radi, M.; Bernardo, V.; Bechi, B.; Castagnolo, D.; Pagano, M.; Botta, M.

“Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles”

Radi, M.; Falciani, C.; Contemori, L.; Petricci, E.; Maga, G.; Samuele, A.; Zanoli, S.; Terrazas, M.; Castria, M.; Togninelli, A.; Esté, J. A.; Clotet-Codina, I.; Armand-Ugón, M.; Botta, M.

“A Multidisciplinary Approach for the Identification of Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: S-DABOCs and DAVPs ”

Radi, M.; Crespan,E.; Botta, G.; Falchi, F.; Maga, G.; Manetti, F.; Corradi, V.; Mancini, M.; Santucci, M. A.; Schenone, S.; Botta, M. 

"Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl Tyrosine Kinase inhibitors and cytodifferentiating agents”

Avramova, S. I.; Galletti, E.; Renzulli, M. L.; Giorgi, g.; Sgaragli, G. P.; Alderighi, D.; Ghiron, C.; Corelli, F.; ∫; Botta, M

”Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non Natural” Natural Product with Remarkable P-gp Modulating Activity”

Radi, M.; Saletti, S.; Botta, M.

“A One-Pot, Two-Steps Microwave-Assisted Synthesis of Highly Functionalized Benzoxazoles using Solid-Supported Reagents (SSRs)”

Castagnolo, D.; De Logu, A.; Radi, M.; Bechi, B.; Manetti, F.; Magnani, M.; Supino, S.; Meleddu, R.; Chisu, L.; Botta, M.

“Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis”

Radi, M.; Angeli, L.; Franchi, L.; Contemori, L.; Maga, G.; Samuele, A.; Zanoli, S.; Armand-Ugon, M.; Gonzalez, E.; Llano, A.; Esté, J. A.; Botta, M.

“Towards Novel S-DABOC Inhibitors: Synthesis, Biological Investigation and Molecular Modeling Studies."

Castagnolo, D.; Dessì, F.; Radi, M.; Botta, M.

“Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents ”

Radi, M.;  Contemori, L.; Castagnolo, D.; Spinosa, R.; Este, J. A.; Botta, M.

“A versatile route to C-6 arylmethyl functionalized S-DABO and related analogues”

Adema, A. D.; Radi, M.; Daft, J. R.; Narayanasamy, J.; Hoebe, E. K.; Alexander, L. M. M.; C. K. Chu and Peters, G. J.

“Troxacitabine Prodrugs for Pancreatic Cancer”

Radi, M.; Petricci, E.; Corelli, F. and Botta, M.

“Stereoselective syntheis of N1-6-methyluridine and related 2-substituted analogues”

Maga, G.; Radi, M.; Zanoli, S.; Manetti, F.; Cancio, R.; Hübscher, U.; Spadari, S.; Falciani, C.; Terrazas, M.; Vilarrasa, J. and Botta, M.

“Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase (RT) Competing with the Nucleotide Substrate”

Radi, M.; Daft, J. R.; Cho, J. H.; Adema, A. D.; Hoebe, E. K.; Alexander, L. M. M.; Peters, G. J. and C. K. Chu

“In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,2-dioxolane-cytidine, prodrugs.”

Petricci, E.; Mugnaini, C.; Radi, M.; Togninelli, A.; Bernardini, C.; Manetti, F.; Parlato, M. C.; Renzulli, M. L.; Alongi, M.; Falciani, C.; Corelli, F. and Botta, M.

“Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones”

Radi, M.; Spinosa, R.; Parlato, M. C.; Corelli, F. and Botta, M.

“Exploring the synthesis of masked phosphoramido 6-vinylcytidine derivatives as building blocks for cross-linking oligonucleotides”

Radi, M.; Petricci, E.; Maga, G.; Corelli, F. and Botta, M.

“Parallel Liquid-Phase synthesis of 2-methylsulfonyl-4-dialkylamino-6-vinyl pyrimidines” 

Radi, M.; Mugnaini, C.; Petricci, E.; Corelli, F. and Botta, M.

“Synthesis of reactive cytidine derivatives containing Michael acceptor in the C-6 position as building blocks for cross-linking oligonucleotides”

Petricci, E.; Mugnaini, C.; Radi, M.; Corelli, F. and Botta, M.

"Microwave assisted acylation of amines, alcohols and phenols by the use of solid supported reagents (SSRs)"

Petricci, E.; Radi, M.; Corelli, F.; Botta, M.

“Microwave-Enhanced Sonogashira Coupling Reaction of Substituted Pyrimidinones and Pyrimidine Nucleosides”.

Petricci, E.; Radi, M.; Renzulli, M. L.; Corelli, F.; Botta, M.

“Solid Phase Synthesis (SPS) of Substituted Uracils via Oxone® Cleavage Methodology”

Botta, M.; Angeli, L.; Radi, M.; Maga, G.

”The fight against AIDS: new avenues for inhibiting Reverse Transcriptase (RT), an old target" 

Medicinal Chemistry: Chemical and Molecular Aspects of Drug Design and Action

Schenone, S.; Radi, M.; Botta, M.

“Pyrazolopyrimidines: old molecules, new targets”

Botta, M.; Corelli, F.; Petricci, E.; Radi, M.; Maga, G.; Mai, A. “4-Pyrimidinone derivatives and their use as anti-HIV agents.” EP2388250

Radi, M.; Freiisz, S.; Bec, G.; Wolff, P.; Angeli, L.; Dumas, P.; Maga, G.; Botta, M.; Ennifar, E. “Crystal structure of the HIV-1 reverse transcriptase bound to a nucleotide-competitive inhibitor and uses thereof” WO/2011/073959

Radi, M.; Botta, M.; Maga, G.; Falchi, F.; Baldanti, F.; Paolucci, S. “Compounds with DDX3 inhibitory activity and uses thereof” US 2012/0202814

Schenone, S.; Bondavalli, F.; Bruno, O.; Botta, M.; Manetti, F.; Radi, M.; Santucci, M. A.; Maga, G.; Bologna, M.; Angelucci, A.; Santucci, A.; Spreafico, A.; Carraro, F. “New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof” WO/2009/034547

Botta, M.; Corelli, F.; Petricci, E.; Radi, M.; Maga, G.; Este’, J. A.; Mai, A. “6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof” WO/2007/043094

Botta, M.; Radi, M.; Manetti, F.; Botta, G.; Maga, G.; Borlak, J. “Derivati 1,3,4-tiadiazolici, metodi di preparazione e uso di essi” RM2007A000222