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Research  highlights of publications in  Nature, Nanotechweb, Hindu etc. 

American Institute of Physics (AIP, USA) Scilight  

https://aip.scitation.org/doi/10.1063/1.5119366

26 JULY 2019    

Research enhances cancer therapy applications of phosphate-coated superparamagnetic nanoparticles

Anashe Bandari

In situ orientation of chain-like structures of phosphate-coated iron oxide nanoparticles in a static magnetic field increases their heating efficiency, suggesting a way to improve magnetic hyperthermia-based cancer therapy.

Superparamagnetic particles are ideal for use in biomedical fields because of their tiny size, interesting magnetic properties and absence of remnant magnetism at room temperature. Through application of a radio-frequency (RF) magnetic field, they can be heated to produce local hyperthermia and kill cancer cells.

However, for magnetic hyperthermia-based cancer therapy applications, heating efficiency must be improved in order to reduce the RF field exposure time due to physiological limits. For their paper, Ranoo et al. enhanced the heating efficiency of phosphate-coated superparamagnetic Fe3O4 nanoparticles by orienting them in a static magnetic field.

To do this, the researchers coated a monolayer of phosphate ions over Fe3O4 nanoparticles and dispersed the material in water at biological pH conditions to ensure its biocompatibility. They found that with the application of a low, static magnetic field, the nanoparticles form chain-like structures that are oriented along the field direction. This in situ orientation of the particles improves the heating efficiency by 62% and was confirmed by atomic force microscopy.

The group also studied the material’s cytotoxicity to confirm its practical applicability. Though the phosphate coating increases the cytotoxicity at high concentrations, the sample remains significantly biocompatible.

This work suggests a route to enhancing the effectiveness of magnetic field hyperthermia for cancer treatment. The researchers plan further studies on the biocompatibility and long-term stability of the material. “Our approach is an innovative strategy to reduce exposure time and dosage during magnetic hyperthermia-based cancer therapy,” said author John Philip. “Having established the right kind of particle with required heating efficiency, we need to do further clinical trials in collaboration with medical institutions.”

Source: “Enhancement in hyperthermia efficiency under in situ orientation of superparamagnetic iron oxide nanoparticles in dispersions,” by Surojit Ranoo, B. B. Lahiri, T. Muthukumaran, and John Philip, Applied Physics Letters (2019).  

http://nanotechweb.org/cws/article/tech/70773

A community website from IOP Publishing

Nanotechweb (2018)

TECHNOLOGY UPDATE

Jan 4, 2018

Simple spectroscopic technique to study polymer behavior at interfaces

Researchers in India say they have discovered a new and simple way to probe how polymers behave at interfaces under different conditions. Their technique, which relies on magnetically polarizable nanoemulsions and visible spectroscopy, could benefit scientists working on developing colloidal formulations for improved food and cosmetic materials, drug-delivery systems and anti-bacterial surfaces, to name but a few.

Bragg peak position measurement

Understanding how adsorbed macromolecules behave at liquid–liquid interfaces under different physico-chemicial conditions is extremely important for a number of scientific disciplines,” explains team leader John Philip of the Indira Gandhi Centre for Atomic Research. “Since the stability of a colloidal dispersion depends on the behaviour of the adsorbed moieties (for example, polymers or polyelectrolytes), studying their behaviour can also help improve the shelf life of industrial formulations.”

At the moment, researchers mainly use expensive and complex techniques like atomic-force microscopy and cryo-transmission electron microscopy to study the conformational behaviour of polymer molecules at interfaces. The new technique developed by Philip and colleague AW Zaibudeen is much simpler.

Bragg spectra of emulsion stabilized with PAA (fig)

Measuring Bragg-peak position shifts

The researchers developed oil–water droplets that assemble into a periodic ID array under the influence of a weak magnetic field (with a strength of about 100 Gauss). “When we illuminate such 1D ordered structures with white light, they selectively reflect visible wavelengths when the Bragg condition is satisfied (that is, one colour is reflected),” explains Philip. “Since the droplet spacing falls in the submicron wavelength range (400–700 nm), the Bragg condition is satisfied at visible wavelengths (as opposed to X-ray wavelengths for metals) and the trick we have used in our work to probe conformational changes in polymers using this technique is quite simple.”

The researchers in fact attach the polymer they wish to study onto these droplets and then look at how the Bragg-peak position shifts when the droplets are placed in different environments – for example, in solutions of different pHs or ionic strengths, or at different temperatures. “All we need here is a mini fibre-optics-based spectrograph to measure the light wavelengths reflected by the drops,” says Philip.

In the lab(Photo)

Thanks to their technique, the researchers say they were able to observe conformational changes in the polymers under these different conditions, and determine how they behave, for example when they are extended and stretched or when they are collapsed.

Important for understanding biological processes

As well as being important for developing colloidal formulations for industrial applications, as mentioned, the way polyelectrolytes behave under various environmental conditions is also fundamentally important for understanding biological processes such as protein folding and DNA condensation, he states. This is because a polyelectrolyte adsorbed at a liquid–liquid interface mimics the in vivo conditions of charged macromolecules at cell–fluid interfaces.

The team, reporting its results in the Journal of Molecular Liquids doi.org/10.1016/j.molliq.2017.12.090, says that it is now busy developing a portable spectrograph that has magnetic field and temperature control options. “We are also trying to design a microfluidic set up incorporating the above features,” Philip tells nanotechweb.org.

About the author

Belle Dumé is contributing editor at nanotechweb.org

http://www.thehindu.com/todays-paper/tp-opinion/spotting-urea-in-the-flash-of-an-eye/article22439100.ece

THE HINDU (2018)

Spotting urea in the flash of an eye

R. Prasad

JANUARY 14, 2018 00:00 IST

A urea test in progress, using the probe (at right in each picture frame). 

The IGCAR-developed optical probe detects urea across a very broad range

Data on the concentration of urea in blood and urine helps in diagnosing renal and liver diseases. In a development that can enhance this, researchers at the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam, near Chennai, have now developed an inexpensive, highly sensitive optical probe that can almost instantaneously detect the presence of urea across a very broad range (0.003 to 334 grams per litre).

Analytical approaches currently available cannot measure urea in a large concentration range, and some methods need pre-treatment of the sample.

How it works?

The two-member team, led by Dr. John Philip from the Metallurgy and Materials Group, used a magnetic nanofluid emulsion (oil droplets finely dispersed in water) attached with certain macromolecules (polymers) for detecting urea. The polymer attached to the oil droplets appears like a ball with a shock of hair in all directions and keeps the droplets well separated. It is the attached polymer that interacts with urea. The nanoemulsion also contains superparamagnetic nanoparticles that remain suspended in the oil phase. These nanoparticles make the nanoemulsions magnetically responsive.

In the presence of a magnetic field, the emulsion forms a one-dimensional array due to the presence of superparamagnetic nanoparticles. The oil droplets in the array remain separated with a certain amount of spacing between them. “The distance of separation between the droplets is determined by the macromolecules used for functionalisation,” says Dr. Philip.

When urea is added to the emulsion, the spacing between the droplets changes and causes the droplets to move closer to each other. “There is a direct correlation between the concentration of urea present in the sample and the change in distance between the droplets,” says A.W. Zaibudeen, first author of the paper. The results of the study have been published in the journal, Sensors and Actuators B: Chemical .

The urea in the sample interacts with the polymer causing it to change shape; the hair-like structure of the polymer bends or collapses. The change in shape, in turn, reduces the net repulsion between the droplets, leading to a change in the spacing between the droplets. It takes less than a second for the spacing between the droplets to change when urea is added to the emulsion.

“The change in the spacing can be detected using a miniature optical spectroscopy. In principle, we can bring about a colour change in the presence of urea that is easily discernible to the naked eye by using a proper functional molecule,” says Dr. Philip.

“We have calibrated the detection range of urea by using a known concentration of urea. We attempted different macromolecules for functionalisation to achieve the best sensitivity and to cover a large range of urea concentration,” he adds.

To mimic urine and serum samples, the researchers added sodium, potassium and iron to the emulsion. “The probe was still able to detect urea but at a slightly reduced sensitivity,” says Dr. Philip.

In the next phase, they will try and identify appropriate polymers that will exhibit specificity to urea so that even in the presence of other ions, sensitivity is unaffected.

https://journosdiary.com/2018/01/14/igcar-probe-urea-serum/

IGCAR’s optical probe quickly detects urea in serum, environment

PRASAD RAVINDRANATH    POSTED ON  JANUARY 14, 2018

It takes less than a second for the spacing between the droplets to change when urea is added to the emulsion, say John Philip (right) and Zaibudeen.

Using magnetic nanofluid emulsion functionalised with certain macromolecules (polymers) IGCAR researchers have developed an optical probe that can in less than a second detect the presence of urea in a very broad range (0.003 to 334 grams per litre).

Researchers at the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam have developed an inexpensive, highly sensitive optical probe that can almost instantaneously detect the presence of urea in a very broad range (0.003 to 334 grams per litre). Currently available analytical approaches cannot measure urea in a large concentration range, and some methods need pre-treatment of the sample. Knowing the concentration of urea in the blood and urine helps in diagnosing renal and liver diseases.

Developing the sensor

The two-member team led by Dr. John Philip from the Metallurgy and Materials Group used magnetic nanofluid emulsion (oil droplets finely dispersed in water) attached (functionalised) with certain macromolecules (polymers) for detecting urea. The polymer attached to oil droplets appear like a ball with long hairs in all directions and keeps the droplets well separated. It is the attached polymer that interacts with urea. The nanoemulsion also contains superparamagnetic nanoparticles that remain suspend in the oil phase. These nanoparticles make the nanoemulsions magnetically responsive.

In the presence of a magnetic field, the emulsion itself forms a one-dimensional array due to the presence of superparamagnetic nanoparticles. The oil droplets in the array remain separated with certain spacing between them. “The distance of separation between the droplets is determined by the macromolecules used for functionalisation,” says Dr. Philip.

When urea is added to the emulsion, the spacing between the droplets changes causing the droplets to come closer to each other. “There is a direct correlation between the concentration of urea present in the sample and the change in distance between the droplets,” says A.W. Zaibudeen, first author of the paper. The results were published in the journal Sensors and Actuators B: Chemical.

The urea in the sample interacts with the polymer causing it to change shape — the hair-like structure of the polymer bends or collapses. The change in shape, in turn, reduces the net repulsion between the droplets leading to a change in the spacing between the droplets. It takes less than a second for the spacing between the droplets to change when urea is added to the emulsion.

“The change in the spacing can be detected using a miniature optical spectroscopy. In principle, we can bring about a colour change in the presence of urea that is easily discernible by the naked eyes by using a proper functional molecule,” says Dr. Philip.

Calibrating the detection range

“We have calibrated the detection range of urea by using known concentration of urea. We attempted different macromolecules for functionalisation to achieve the best sensitivity and to cover a large range of urea concentration,” says Dr. Philip.

The researchers used three different polymers in order to measure urea in a large concentration range — very minute concentration range of 0.003-0.6 grams per litre which covers the normal range of urea in human serum, mid concentration range of 0.18-33.3 grams per litre, and large concentration range of 2.4-334 grams per litre.

To mimic urine and serum samples, the researchers added sodium, potassium and iron to the emulsion. “The probe was still able to detect urea but at slightly reduced sensitivity,” Dr. John says.

In the next phase, they are trying to identify appropriate polymers that will exhibit specificity to urea so that even in the presence of other ions the sensitivity is not affected.

Published in The Hindu on January 13, 2018

Nature (India) 2017 

doi:10.1038/nindia.2017.158 Published online 22 December 2017

Magnetic nanosensor for detecting urea in human blood

Researchers have invented a fast, sensitive optical sensor that can be used to detect urea in human blood and various environmental samples1.

Urea, a major organic waste product of living organisms including humans, is excreted through the urine. An excessive level of urea is potentially harmful because it can break down DNA and protein molecules, triggering diseases such as diabetes, kidney failure and sepsis.

Existing methods for detecting urea cannot efficiently monitor urea concentrations in a wide range of biological and environmental samples.

To make a fast-response, versatile urea sensor, scientists from the Indira Gandhi Centre for Atomic Research, Kalapakkam in India, led by John Philip, made an oil-in-water magnetic nanoemulsion using iron oxide nanoparticles, polymers, a surfactant and water. They then explored the nanoemulsion’s potential to sense urea in a solution.     

The magnetic nanoemulsion selectively detected urea even in the presence of positively charged interfering ions that are usually found in human blood, such as calcium and sodium.  The nanoemulsion detected urea very rapidly, about 100 times faster than conventional crystal-based sensors.

It is possible to tweak the concentration of the oil droplets in the nanoemulsion, making it exhibit a colour change in the presence of urea. This, in turn, helps detect urea with the naked eye.  The urea sensor is non-enzymatic and can detect urea in a wide range of samples, says principal researcher Philip.

References

1. Zaibudeen, A. W. et al.  Magnetic nanofluid based non-enzymatic sensor for urea detection.Sensor. Actuator. B. Chem. 255, 720-728 (2018)

THE HINDU  Science & Technology (2017)    

Soon, doctors can ‘see’ a fever

R. PRASAD

Team at IGCAR makes visual monitoring of body temperature possible

Visual, non-invasive monitoring of body temperature of patients without using a thermometer may become a reality soon, thanks to the work carried out by a team of scientists led by John Philip, head of the smart materials section at the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam, near Chennai.

The concept is based on ferrofluid emulsion contained in a thin film that changes colour with rise in temperature within a narrow range — 30-40° C. The study was published in the journal Optical Materials. The emulsion has iron oxide nanoparticles containing oil droplets dispersed in water. “Till now ferrofluid was used as a magnetic stimuli-responsive material. We now found that in the presence of a temperature-sensitive polymer — poly(N-isopropylacrylamide), also known as PNIPAM) — the ferrofluid emulsion can be used as a thermally tunable grating to produce different colours,” says Dr. Philip. “Recently, we were looking at the interaction forces between droplets covered with thermo-responsive polymers. To our surprise, we found that the adsorbed polymer swells and collapses upon changing the temperature between 32° and 36° C. This change was clearly manifested as colour change. From this observation came the novel idea of using PNIPAM-stabilised emulsions as a multistimulii grating. This is a first of its kind approach where the grating spacing can be tuned either by changing the temperature or by changing the magnetic field strength,” says Dr. Philip.

Reversible change

Up to about 34° C, the polymer is highly hydrated and swollen due to repulsive interaction between individual monomer segments.But when the temperature crosses 34° C, the polymer becomes dehydrated leading to a collapsed state.

The polymer will once again become hydrated and swollen when the temperature falls below 34° C. “By using certain additives, we can tune the collapse of the polymer to higher temperature to reflect fever conditions,” clarifies A.W. Zaibudeen, senior research fellow at IGCAR and the first author of the paper.Using magnetic fields, the scientists first achieved a particular ordering (spacing between the arrays of emulsion droplets) of emulsion and got a particular colour. When polymer is added as a stabiliser and the temperature is increased, the grating spacing of the polymer changes and gives rise to a different colour or spacing. “The colour given off at normal temperature can be fixed by changing the emulsion property and magnetic field strength,” Dr. Philip says.If the normal temperature is fixed at yellow, the change will be to green when the temperature increases. Colour with higher wavelength is produced at lower temperature and colour of lower wavelength at higher temperature.

Elsevier

Optical Materials > Highlighted Articles (2017)

The magnetic attraction of a colour-changing thermometer

Scientists turn ferrofluids into environmental sensors

When the temperature rises, the particles in Philip and Zaibudeen's emulsion squeeze closer together, changing the overall colour – in this case from orange to yellow. 

Credit: J. Philip and A. W. Zaibudeen/Indira Gandhi Centre for Atomic Research (IGCAR)

Liquids that shift and morph when a magnet is brought near sound like the stuff of a science fiction movie. But “ferrofluids” are absolutely real. Scientists in India have trained them to form a coating that changes colour with temperature, publishing their results in Optical Materials.

Ferrofluids were invented in the 1960s by NASA and typically consist of a suspension or emulsion of magnetic nanoparticles in a liquid. They have numerous current and potential applications: directing rocket fuel in zero gravity, honing in on cracks in containers, and guiding drugs to their target in the human body. More recently, scientists have combined ferrofluids with temperature-sensitive polymers such as poly(N-isopropylacrylamide), or PNIPAM, for even more interesting effects. Below 32°C, a chain of PNIPAM is coiled up into a neat little drug-containing vessel; a few degrees warmer and it collapses, squeezing the drug out. In this way, a PNIPAM ferrofluid can not only guide a drug to a certain location in the human body, but it can also release it on cue.

Now, however, John Philip and A. W. Zaibudeen of the Homi Bhabha National Institute in Kalpakkam, India, have shown that a PNIPAM ferrofluid can also be used as a temperature-sensitive diffraction grating. This is a series of microscopic ridges that diffract light into different colours depending on their spacing. The ferrofluid naturally forms a diffraction grating when placed in a glass cell and exposed to a small magnetic field. When the temperature rises, the PNIPAM component quickly pulls the ridges closer together, shifting the diffracted colour from the red end of the spectrum closer to the blue. "This is a first-of-its-kind approach where the grating spacing can be tuned by changing either the temperature or the magnetic field strength," says Philip. "Wonderful, isn’t it?"

One of the most obvious applications of the grating is a colour-changing thermometer that would clearly show the temperature of something at a glance. Philip thinks that a sticker version could be worn by patients in hospitals, for instance, to show if they have a fever and need medical attention. And he believes many other applications will beckon once the rest of the scientific community gets on board.

Article details:

Zaibudeen, A. W. and Philip, J.: "Thermally tunable grating using thermo-responsive magnetic fluid," Optical Materials (2017)

https://www.journals.elsevier.com/optical-materials/highlighted-articles/the-magnetic-attraction-of-a-colour-changing-thermometer

http://www.natureasia.com/en/nindia/article/10.1038/nindia.2014.140

 Nature (2014)  

doi:10.1038/nindia.2014.140 Published online 27 October 2014 

Research highlight

Magnetic nanoemulsions make glucose sensor

Researchers have fabricated a sensitive, enzyme-free sensor that can rapidly measure low concentrations of glucose1. They made the sensor using surfactant-containing magnetic nanoemulsions. It is potentially useful for measuring glucose levels in diabetic patients, foods and biochemical samples.

Existing glucose sensors employ enzymes such as glucose oxidase. These sensors take considerable time to detect glucose, making them unsuitable for many applications. To devise an effective and fast glucose sensor, the researchers encapsulated ferrimagnetic iron oxide nanoparticles with an oil-in-water emulsion. They then stabilized this nanoemulsion by adding the surfactant sodium dodecyl sulphate. Sophisticated imaging revealed that the magnetic nanoemulsions consist of nanoscale droplets.

The researchers evaluated the glucose-sensing efficacy of the magnetic nanoemulsions by exposing them to different concentrations of glucose in the presence of a constant external magnetic field and ambient light. They discovered that the magnetic field caused the droplets in nanoemulsions form one-dimensional chain-like structures.

The nanoscale droplets are separated by tiny distances, which vary depending on the glucose concentration. These changes in the average interdroplet distance caused the magnetic nanoemulsions to reflect light of different colours. For example, the magnetic nanoemulsions reflected green light at normal glucose levels, whereas they reflected orange light at diabetic glucose levels.

The researchers say that this method enables glucose detection by visual observation without the need to use electronic devices. “This enzyme-free method can detect glucose in milliseconds, making it suitable for developing the next generation of smart glucometers”, says John Philip, a senior author of the study.

References

1. Mahendran, V. & J.Philip, Non-enzymatic glucose detection using magnetic nanoemulsions. Appl. Phys. Lett. 105, 123110 (2014)

http://nanotechweb.org/cws/article/tech/58705

Nanotechweb (2014)

TECHNOLOGY UPDATE

Sep 26, 2014

Magnetic nanoemulsion measures blood glucose

A new type of glucose sensor that works using a magnetically polarizable nanoemulsion could help change the way blood sugar is measured. The new device does not rely on glucose oxidase enzymes, unlike conventional glucometers, but instead simply changes colour when it comes into contact with glucose.

A team of researchers, led by John Philip at the Indira Gandhi Centre for Atomic Research   in India, made the new sensor using a magnetically polarizable oil-in-water nanoemulsion of droplets that have a radius of around 100 nm. They made the emulsion by mixing together ferrimagnetic nanoparticles of iron oxide (around 10 nm across) with oil, a surfactant and water.

When the solution is exposed to glucose and a magnetic field applied, its colour simply changes.

“We stumbled on this effect quite by accident while working with magnetically polarizable nanoemulsions for fundamental physics studies,” explains Philip. “We then measured the colour (or diffracted light wavelength) of the nanoemulsion using a spectrograph and noticed that the shift (or change) in the diffracted wavelength (Δλmax) was quite high and that it varied linearly with glucose concentration.”

To our surprise, the Δλmax value at 30 mM glucose concentrations was as high as around 69 nm in the system under study, but this shift could be even larger with more suitably tailored emulsions, says Philip. “Since the Δλmax varies linearly with glucose concentration, we realized that the emulsion itself could be used as a biosensor,” he tellsnanotechweb.org.

The new device could help change the way diabetics monitor their blood sugar levels. Most existing glucometers are based on glucose oxidase enzyme platforms coupled to electromechanical systems in which the device response depends on enzyme activity or glucose mass transport. These techniques take a relatively long time to produce results and require quite complicated apparatus.

Label free and fast

“The novelty of our technique is that it is label (or enzyme) free and fast (it works within just milliseconds rather than minutes),” says Philip. “It also allows us to detect glucose concentrations visually without any electronic equipment.”

The device is also portable. “For qualitative glucose testing, you simply need to look at the colours in the nanoemulsion upon mixing with a fraction of blood or urine under a magnetic field that you might generate with a tiny magnet or solenoid. For quantitative sensing, all you would need is about 200 microlitres of nanoemulsion and a pocket sized fibre-optic spectrograph for testing your samples.”

How it works

So how does the sensor actually work? At a constant applied magnetic field, the nanoemulsion droplets form 1D chain-like structures that diffract light in the visible region of the electromagnetic spectrum, explains Philip. “The diffracted wavelength depends on the distance between the droplets. When glucose concentrations in a sample reach the 1–30 mM range, the diffracted wavelength shifts and since it varies linearly with glucose concentration, we can accurately determine this concentration using a calibration curve.”

Without an external magnetic field, the nanoemulsion droplets move about randomly (thanks to ordinary Brownian motion) but an applied magnetic field induces a dipole moment in each droplet, orienting it along the field direction. “Linear chain-like structures are formed along the field direction when the repulsive forces between the droplets exactly balance the attractive forces between them,” says Philip. “For perfectly aligned droplets spaced a distance dapart, the so-called first order Bragg condition is 2d = λmax/n, where λmax is the Bragg peak wavelength and n is the refractive index of water.”

As the droplets and the spaces between the droplets are about the same size as the wavelength of visible light, we see a Bragg peak in the visible wavelength range – which manifests itself as a colour change in these fluids that we can actually see with naked eye.”

The researchers are now busy trying to improve the sensitivity of their device. “We also need to work with companies that are interested in developing the sensor into a marketable product,” adds team member Vellaichamy Mahendran.

The current work is published in Applied Physics Letters.

About the author

Belle Dumé is contributing editor atnanotechweb.org

http://www.nature.com/nindia/2013/130312/full/nindia.2013.35.html 

Nature (2013)   

doi:10.1038/nindia.2013.35; Published online 12 March 2013 

Research highlight 

Optical toxic-gas detector 

Researchers have invented a novel, fast and ultrasensitive magnetic-nanofluid-based optical sensor that changes colour on exposure to extremely low concentrations of ammonia 1. The sensor will be useful in detecting minute traces of ammonia in industrial and environmental samples.

Ammonia is an important ingredient in explosives, fertilizers and industrial coolants. However, high concentrations of ammonia gas are harmful to humans and other living organisms. Existing techniques for monitoring ammonia levels in industrial and environmental samples are expensive, complex and time-consuming.

To design a portable and fast detection technique, the researchers synthesized a magnetic nanofluid by dispersing ferrimagnetic iron oxide nanoparticles in a mixture of oil, water and surfactant. This nanofluid consists of nanodroplets suspended in water.

They then placed the magnetic nanofluid in a vial, which was put inside a solenoid coil connected to a current supply. At a fixed magnetic field, a fibre-optic light source illuminated the nanofluid to which varying concentrations of ammonia were gradually added.

The colour of the nanofluid changes depending on the ammonia concentration. This color change occurs within a second after exposure to ammonia, much faster than other ammonia-sensing methods that could take several minutes. "The sensor shows a fast response because the nanodroplets in the nanofluid are suspended in water," says lead researcher John Philip. In the future, this sensor could also be used to detect other toxic ions and gases, he adds.

References

1.    Mahendran, V. et al. An optical technique for fast and ultrasensitive detection of ammonia using magnetic nanofluids. Appl. Phys. Lett. 102, 063107 (2013)

http://nanotechweb.org/cws/article/tech/52633

A community website from IOP Publishing

Nanotechweb (2013)

TECHNOLOGY UPDATE   Mar 7, 2013

Colour changing nanofluid senses ammonia

Researchers at the Indira Gandhi Centre for Atomic Research (IGCAR) in India have made a new type of optical sensor from magnetically polarizable nanofluids and have used the device to detect tiny amounts of ammonia in solution. The sensor, which quickly changes colour in the presence of the analyte, could come in useful for many practical applications, such as monitoring pollution levels in rivers around industrial plants.

The sensor is made of an oil-in water nanoemulsion, produced by emulsifying ferrimagnetic iron oxide nanoparticles, around 10 nm in size, suspended in octane and in the presence of an anionic surfactant of sodium dodecylsulphate in water. The nanoparticle droplets align to form a 1D array when a magnetic field of around 90 Gauss is applied, and the sensor is illuminated with a fibre-optic based light source.

When ammonia is present in the surrounding solution, the lattice periodicity of the droplet array changes thanks to the fact that ammonia penetrates into the electric double layer around the emulsion droplets. This causes the wavelength of light reflected from the sensor to be significantly shifted towards the blue end of the electromagnetic spectrum – something that can be easily monitored using a digital camera.

“We plotted the reflected Bragg peak for different ammonia concentrations, and found that it blue shifts monotonically, increasing with concentrations of ammonia,” team leader John Philip told nanotechweb.org. “We can calculate the exact concentration of ammonia present from a Bragg shift calibration curve. This is a standard procedure in which the Bragg shift for a few different known concentrations of ammonia are first measured. Since the curve follows a linear trend, any unknown concentration can then be determined.”

The device can detect concentrations as low as 1ppm of ammonia and is much easier to fabricate and use than existing ammonia sensors that rely on ion-selective electrodes, infrared gas analysers, detectors based on semiconductor films such as SnO2 ad MoO3, and optical gas sensors that exploit the reaction of ammonia vapour with either a pH-dependent dye material or film. “In these techniques, the target ammonia molecules interact with the sensing element and produce changes in the light absorbance or emission spectra of the sample that are then monitored using suitable instruments,” explains team member Vellaichamy Mahendran. “Ours is a much more simple, sensitive, faster and inexpensive set up."

Ammonia is found in explosives, fertilizers and indusial coolants, among other things, and the new optical sensor could be used to continuously monitor environments in which the chemical is present - such as rivers around industrial plants, for example, says Philip.

The team, which has published its results in Applied Physics Letters, now hopes to further improve the sensitivity of its sensor and use it to detect other toxic analytes. Another important goal is to make the sensor in a reusable thin film form, adds Philip.

About the author

Belle Dumé is contributing editor at nanotechweb.org 

THE HINDU Science and Technology (2012)    

IGCAR develops sensors to inspect defects in materials

R. PRASAD

Special Arrangement Test specimens with two circular defects – one big and one small (right) and a rectangular and a circular defect (left) imaged using nanofluid optical sensor developed by Dr. John Philip, IGCAR, Kalapakkam

Defective regions produce magnetic resistance, which in turn leads to leakage of magnetic flux

Detecting and imaging structural defects like cracks, holes etc, present in components made of ferromagnetic materials like pipelines, railway tracks and tubes has now become easy with optical sensors. These sensors were developed by Dr. John Philip and his team at the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam near Chennai. The results of their work were published recently in the Applied Physics Letters journal.

The work provides a “methodology for extracting defect feature information from optical images,” notes the paper.

The optical sensor has oil droplets (about 200 nanometres in diameter) containing a few nanoparticles of magnetic materials, about 6.5 nanometres in size. The oil droplets are present as an emulsion with water. Since the sensor contains magnetic particles, it responds to magnetic fields. “The sensor is magnetically polarizable,” said Dr. Philip, Head of SMART Section at IGCAR. He is the senior author of the paper.

The sensor works on the principle that defective regions in a material produce magnetic resistance, and this in turn leads to leakage of magnetic flux (field lines). “The leakage of magnetic flux will be right outside the point where the defect in the material is present,” Dr. Philip explained. “The nanofluid-based optical sensor can detect such leakages.”The material whose structural integrity is to be evaluated has to be first magnetised. This can be done by using two strong magnets kept on either ends of the material to be tested. The sensor, which is sandwiched between two glass plates, is kept on top of the magnetised material. The sensor is then illuminated with white light.

Magnetic flux passes through the material the moment it is magnetised. The magnetic flux leaks if the material has any structural defects, and the nanofluid inside the optical sensor immediately forms an one dimensional array or chain along the direction of the magnetic field. “When it forms an one dimensional array, the spacing between the droplets satisfies the criterion to diffract one particular colour in white light,” he said. The colour that is diffracted or reflected depends on the inter-droplet spacing. “When the defect is large, the magnetic flux leakage is more, and the spacing between the droplets is smaller. The reflected colour is violet,” he explained. Alternatively, if the defect is small, the spacing between the droplets is more and the reflected light is red or orange.

While the optical sensor can provide the result immediately, the dimension of the defect can be found using certain modelling. “We can map different shapes (geometry) of the defects,” Dr. Philip said. “Future perspectives include the fabrication of large flexible films for the inspection of large components and development of suitable pattern recognition software for rapid inspection of components,” the paper notes.

Advantages

The sensor has several advantages over existing techniques. For instance, the optical sensor can be repeatedly used as the one-dimensional array formed in the nanofluid is “perfectly reversible.” “It takes less time to detect flaws in the material, allows direct visual inspection of the defects, and does not destroy the material being tested,” he explained. “The sensors are very cheap — a one inch by one inch sensor would cost just a few hundred rupees.”

Keywords: optical sensors, material science

http://www.nature.com/nindia/2012/120215/full/nindia.2012.21.html

doi:10.1038/nindia.2012.21; Published online 15 February 2012

Research highlight 

NATURE (2012)    

Sensor detects cracks in magnetic matter

Researchers have developed a new kind of optical sensor from an emulsion of magnetic nanofluid containing droplets of iron oxide nanoparticles1. The sensor could be used to image defects such as cracks, corrosion and erosion buried in rail tracks, pipelines and tubes.

External magnetic fields generate magnetic flux leakage signals near defects in magnetic materials. This signal can be used in a device such as a hall probe sensor to provide information on the defect. However, scientists have yet to develop a visual and non-contact sensor for this purpose. To design such a sensor, the researchers first employed a simple emulsification process to prepare a magnetic nanofluid from oil-based ferric oxide in the presence of water and sodium dodecyl sulphate, a surface-active molecule. They then made a thin-film sensor by placing the nanofluid between two microscopic glass plates. The nanofluid droplets contained ferric oxide nanoparticles of around 6.5 nm in size. The researchers placed the head of the sensor near the rear surface of mild steel plates containing artificial defects. They magnetized the steel plate and sensor using a horseshoe-sized bar magnet. Applying an external magnetic field generated magnetic flux lines around the defective region of steel plate, which led to the formation of one-dimensional nanodroplet arrays in the direction of the field. The droplets generated bright colours when irradiated with white light, thus providing a signature of the defects buried in the material. Violet light was produced where the magnetic flux leakage signal was at a maximum. "The most important aspect of this technique is the reusability of the flux sensor due to perfectly reversible one-dimensional arrays of droplets formed in the fluid," says lead researcher John Philip.

References

Mahendran, V. & John Philip, Nanofluid based optical sensor for rapid visual inspection of defects in ferromagnetic materials. Appl. Phys. Lett. 100, 073104 (2012)

http://nanotechweb.org/cws/article/tech/48783

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Nanotechweb (2012)

TECHNOLOGY UPDATE

Feb 27, 2012

Nanofluid sensor images defect

A new optical sensor that can image internal defects in ferromagnetic materials has been invented by researchers in India. The photonic eye, as it has been dubbed, is based on a magnetically polarizable nano-emulsion that changes colour when it comes into contact with a defective region in a sample. The device might be used to monitor structures such as rail tracks and pipelines.

The sensor will be able to locate defects and discontinuities such as fatigue, cracks, corrosion pits, metallic inclusions and abrasion in ferromagnetic components and structures, says team leader John Philip of the Indira Gandhi Centre for Atomic Research (IGCAR) in Tamilnada. It might also be used to inspect magnetic materials used in the aircraft industry, such as those used to make turbines, for example.

Current techniques, such as "magnetic flux leakage" (MFL), that detect defects in ferromagnetic materials work by measuring stray fields near cracks using a sensor. However, such methods require sophisticated instrumentation and complex signal processing to correlate the MFL signal with the defect signature. Moreover, sophisticated algorithms are then needed to recreate a 2D or 3D image of the defect. Alternative techniques that employ magnetic particles to visualize flux lines around an inclusion, for example, are messy because the magnetic particles must adhere to the component being tested and are difficult to remove afterwards.

"Our new sensor overcomes all of these challenges because it does not come into contact with a sample – it is placed a few millimetres above – and does not involve any complex signal collection or analysis," said Philip. "It is a simple visual test for relatively large defects (a few millimetres in size) buried inside a sample." Philip's team developed a special nano-emulsion to make its sensor that consists of a colloidal suspension of single-domain superparamagnetic Fe3O4 nanoparticles around 6.5 nm in size that are magnetically polarizable – that is, they respond to a weak magnetic field. The particles are capped with a monolayer of anionic surfactant (sodium dodecyl sulphate) so that they do not agglomerate.

In the absence of a magnetic field, the nanodroplets are randomly oriented but when the nanofluid comes into contact with a magnetic defect, the droplets align in a chain-like fashion along the field created by the defective region. This chain of particles diffracts incident white light to produce bright colours and the colours obtained depend on the defect features. "This approach allows us to directly visualize the defect, with a violet colour being seen at the point where the magnetic flux leakage reaches its maximum – that is at the edge of the defect," explained Philip.

Rectangular and cylindrical defects

The researchers tested their technique on steel plate specimens containing artificially fabricated rectangular and cylindrical defects. The samples were magnetized prior to the experiments. The images obtained clearly show a colour spectrum on both sides of the defects that follows their shape – straight lines are seen for the rectangular defects and curved lines for the cylindrical ones.

Spurred on by these results, the team now plans to make a large-area flexible-film-based sensor using its nanofluid and develop the appropriate pattern recognition software. Such a device could be used by non-specialists to rapidly analyse defective regions in a wide variety of ferromagnetic materials, says Philip.

The current work is detailed in Applied Physics Letters.

About the author

Belle Dumé is contributing editor at nanotechweb.org

http://www.nature.com/nindia/2011/110926/full/nindia.2011.136.html

doi:10.1038/nindia.2011.136; Published online 26 September 2011

Research highlight 

NATURE (2011)  

Nanofluids as power savers

Researchers have produced a new viscous nanofluid containing magnetic nanoparticles that conducts heat efficiently when under an intense magnetic field1. This magnetic nanofluid could be useful as a super-coolant or for damping unwanted vibrations in optoelectronic devices.

Magnetic nanofluids exhibit both liquid and magnetic properties. Such fluids can be easily tailored using external magnetic fields for applications such as optical switches and drug-delivery devices. However, existing magnetic nanofluids exhibit low thermal conductivity.

The researchers produced their magnetic nanofluid by first capping magnetite nanoparticles with oleic acid and then dispersing the resulting nanoparticles in kerosene and hexadecane. They studied the thermal conductivity and viscosity of their nanofluid by varying the strength of the external magnetic field while also changing the size and concentration of the nanoparticles.

Nanofluids with a higher concentration of nanoparticles exhibited larger thermal conductivity when under a strong magnetic field. Applying the magnetic field parallel to the nanofluid aligned them along the direction of the field, forming chain-like structures with lengths ranging from tens of nanometres to several micrometres.

Increasing the magnetic field strength increased the chain length, resulting in the formation of evenly spaced single-nanoparticle chains throughout the nanofluid volume. This reduced the space between the nanoparticle chains, thus allowing for efficient heat flow.

Increasing the magnetic field strength also caused the viscosity of the nanofluid to rise. The nanofluid with the largest nanoparticle size (9.5 nm) exhibited the largest enhancement in thermal conductivity.

"This magnetic nanofluid could be used to design multifunctional smart materials for cooling-cum-damping applications," says lead researcher John Philip. Such fluids can also be used to improve the heat transfer of solar collectors used to harness solar energy, he adds.

References

Shima, P. D. & J.Philip Tuning of thermal conductivity and rheology of nanofluids using an external stimulus. J. Phys. Chem. C doi:10.1021/jp204827q (2011) 

http://nanotechweb.org/cws/article/tech/47381

NANOTECHWEB (2011)    

Technology update  

Sep 30, 2011

"Intelligent" nanofluids could cool computer chips

Certain nanofluids can be made to conduct heat extremely well when a magnetic field is applied to them, says a duo of researchers at the Indira Gandhi Centre for Atomic Research in Tamilnadi, India. The phenomenon may be used to cool down miniature devices like micro- and nano-electromechanical systems, and computer chips. 

"Nanofluids could be ideal coolants for future electronic devices but for such applications, the fluids need to have large thermal conductivities," explained team leader John Philip. "This is why we need to develop novel nanofluids."  The materials studied by the researchers are a colloidal suspension of single-domain superparamagnetic Fe3O4 nanoparticles between 3 and 10 nm in size that are magnetically polarizable – that is, they respond to a weak magnetic field. The particles are capped with a monolayer of surfactant molecules so that they do not agglomerate – something that is crucial for the experiments subsequently performed.

In the absence of a magnetic field, the magnetic moments of the particles are oriented in random directions. When a field is applied, the particles align in the direction of the field when the magnetic dipolar interaction energy between the particles overcomes the thermal energy of the particles. The dipolar interaction energy depends on the distance between neighbouring particles and their mutual orientation.

Chain-like structure

As soon as the dipolar interaction becomes sufficiently strong, the magnetic particles form a chain-like structure as they line up in the direction of the applied field. The thermal conductivity of the nanofluid then increases because heat can then flow very efficiently along the chain, says Philip.

The increase in the thermal conductivity in these fluids is extremely high – several hundred times that of traditional nanofluids. What is more, the increase is perfectly reversible and can be tuned from high to low values by applying the magnetic field either parallel to the direction of particle chains or perpendicular to them. These properties mean that the nanofluids could be ideal for use as "intelligent" coolants, states Philip.

Programming the magnetic field strength

"Depending on the heat load of the fluid, you can simply programme the magnetic field strength to achieve higher cooling," he told nanotechweb.org. "All you need is a feedback control circuit in a device that automatically senses and varies the magnetic field strength depending on the amount of cooling needed." The set-up could be used to cool computer chips, for instance, or cool down MEMS and NEMS devices.

The team now plans to further develop and test these fluids through microchannels to test the cooling efficiencies under flow. "We are also working on developing a new class of nanofluid that can work at very high temperatures and react quickly," revealed team member P D Shima.

The current work is reported in The Journal of Physical Chemistry C.

About the author

Belle Dumé is contributing editor at nanotechweb.org

https://www.nature.com/articles/nnano.2008.38 

Published online: 8 February 2008 | doi:10.1038/nnano.2008.38

Nature Nanotechnology (2008) 

Magnetic nanofluids: Chain reaction

Adarsh Sandhu

Abstract

Fluids containing magnetic nanoparticles can display potentially useful thermal properties

Introduction

Colloid suspensions containing magnetic nanoparticles are known to exhibit higher thermal conductivities than liquids with larger particles or no particles at all. The enhanced thermal conductivity of these magnetic nanofluids could have applications in controlling the flow of heat in various devices if it can be controlled in a reversible manner.

Now, John Philip and colleagues1 of the Indira Gandhi Center for Atomic Research have demonstrated such control over a suspension of hexadecane containing 6.7-nm superparamagnetic particles. When a magnetic field of 101 Gauss is applied to a nanofluid that contains 4.5% nanoparticles by volume, the thermal conductivity was enhanced by 216%. The magnetic field caused the nanoparticles to form chains in the direction of the magnetic field, with the chains falling apart when the field was switched off.

Evidence that this mechanism is indeed responsible for the enhanced thermal conductivity was provided by measurements showing that the efficiency of heat flow along the chains increased in the presence of the magnetic field.

REFERENCE

1.    Philip, J., Shima, P. D. & Raj, B. Nanofluid with tunable thermal properties. Appl. Phys. Lett. 92, 043108 (2008). |  

Nanotechweb (2008)

TECHNOLOGY UPDATE

Apr 4, 2008

Nanofluid could cool tiny electronic devices  

Researchers in India have shown that the thermal properties of a magnetic nanofluid can be tuned by applying a magnetic field. The effect comes thanks to the magnetic particles lining up in chains when the field is applied. The nanofluid, which is made from a colloidal suspension of magnetite nanoparticles, could find use in a variety of technology applications, including "smart" cooling devices.

Magnetic nanofluids are unique materials that can be used in applications such as optical modulators, optical fibre filters, optical switches and gratings. Many of the physical properties of these materials can be tuned by simply varying the applied magnetic field. Now, John Philip, PD Shima and Baldev Raj of the Indira Gandhi Centre for Atomic Research in Tamilnadu have shown that the nanofluid's thermal properties can be tuned in this way as well. This new result could be useful because nanofluids are often touted as being ideal coolants for future electronic devices and engines.

Philip and co-workers developed a stable colloidal suspension of Fe3O4 nanoparticles, with an average diameter of 6.7 nm. "The observed reversibly tunable thermal property of our nanofluid may find many technological applications in nanoelectromechanical and microelectromechanical-based devices," Raj told nanotechweb.org. "For example, depending on the cooling requirement, the magnetic field can be precisely programmed to obtain the desired level of thermal conductivity enhancement or cooling," added Philip.

The work was published in Applied Physics Letters.

About the author

Belle Dumé is contributing editor at nanotechweb.org