Selected Papers

  • Oslund, R. C.; Su, X.; Haugbro, M.; Kee, J.-M.; Esposito, M.; David, Y.; Wang, B.; Ge, E.; Perlman,D. P.; Kang,Y.; Muir, T. W.*; Rabinowitz, J. D.* "Bisphosphoglycerate Mutase Controls Serine Pathway Flux via 3-Phosphoglycerate"  
               Nature. Chem. Biol. 2017, 13, 1081–1087. [Full Text Link]  


  
  • Kee, J.-M.; Oslund, R. C.; Couvillon, A. D.; Muir, T. W.* "A Second-Generation Phosphohistidine Analog for Production of Phosphohistidine Antibodies"  
               Org. Lett. 2015, 17, 187-189. [Full Text Link]
  

  • Wender, P. A.*; Axtman, A. D.; Golden, J. E.; Kee, J. -M.; Sirois, L. E.; Quiroz, R. V.; Stevens, M. C. "Function through Bio-Inspired, Synthesis-Informed Design: Step-Economical Syntheses of Designed Kinase Inhibitors"  
Org. Chem. Front. 2014, 1, 1166-1171. [Full Text Link] (Invited article for Max Malacria's 65th birthday)



  • Oslund, R. C.; Kee, J.-M.; Anthony D. Couvillon, A. D.; Bhatia, V. N.; Perlman, D. H.; Muir, T. W.* "A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-phase Phosphopeptide Fragmentation Mechanism" (co-first authors)
     J. Am. Chem. Soc. 2014, 136, 12899–12911 . [Full Text Link]
      • Highlighted in Nat. Methods 2014, 11, 1091 [Link]
    
http://pubs.acs.org/doi/abs/10.1021/ja507614f

  • Kee, J.-M.; Oslund, R. C.; Perlman, D. H.; Muir, T. W.* “A Pan-specific Antibody for Direct Detection of Protein Histidine Phosphorylation”
                Nature Chemical Biology, 2013, 9, 416–421. [Full Text Link]
        •   Nominated as one of “Signaling Breakthroughs of Year 2013”, Sci. Signaling 7 (307), eg1
        •   Featured in Nat. Chem. Biol. 2013, 9, 411, Nat. Methods 2013, 10, 604, and Chem. Eng. News, 91(22), June 3, 2013, p 30.



http://www.nature.com/nchembio/journal/v9/n7/full/nchembio.1259.html

  • Kee, J.-M.; Muir, T. W.* “Chasing Phosphohistidine, An Elusive Sibling in the Phosphoamino Acid Family”, 
                ACS Chemical Biololgy 2012, 7, 44-51. [Full Text Link]

  • Wender, P. A.*; Buschmann, N.; Cardin, N. B.; Jones, L. R.; Kan, C.; Kee, J.-M.; Kowalski, J. A.; Longcore, K. E. “Gateway Synthesis of Daphnane Congeners and their Protein Kinase C Affinities and Cell-growth Activities” 
                Nature Chemistry 2011, 3, 615-619. [Full Text Link]
      • Featured in Nature Chem. 2011, 3,575.

http://www.nature.com/nchem/journal/v3/n8/abs/nchem.1074.html

  • Kee, J.-M.; Villani, B.; Carpenter, L. R.; Muir, T. W.* “Development of Stable Phosphohistidine Analogues” 
               J. Am. Chem. Soc. 2010, 132, 14327-14329. [Full Text Link]
      •  Selected as “News of the Week” in Chem. Eng. News, 88(41), October 11, 2010, p 11. [Link]
      •  Selected by Faculty of 1000 Biology as “Must Read”.



  • Wender, P. A.*; Kee, J.-M.; Warrington, J. M. “Practical Synthesis of Prostratin, DPP, and their Analogs, Adjuvant Leads against Latent HIV” 
                Science, 2008, 320, 649-652. [Full Text Link]
      • Selected as Research Highlights in Nature, 2008, 453, 136 and Nat. Chem. Biol. 2008, 4, 340.


    •  Lee, H.-Y.*; Kim, H. Y.; Kim, B.; Kee, J.-M. “The Stereoselective Dimerization Reaction of Oxidopyrylium Ions” 
                            Synthesis 2007, 2360-2364. [Full Text Link]



    • Wender, P. A.*; Bi, F. C.; Buschmann, N.; Gosselin, F.; Kan, C.; Kee, J.-M.; Ohmura, H. “Studies on Oxidopyrylium [5+2] Cycloadditions: Towards a General Synthetic Route to the C12-Hydroxy Daphnetoxins” 
                            Organic Letters 2006, 8, 5373-5376. [Full Text Link]




Patents


  • U.S. Patent 9,035,068  (WO 2012040523) “Phosphohistidine Analogs”; issued on May 19th, 2015. [Link]
    • The technology has been licensed for commercialization (Millipore).
  • U. S. Patent Application 14/708,677 “Phosphohistidine Analogs”; Filed on May 11th, 2015.
  • U.S. Patent Application 14/58758 “Phosphohistidine Mimetics and Antibodies to Same”; filed on October 2nd, 2014
  • U.S. Patent Application 61/981,569 “Method for Detecting Cancer and Metabolic Disease using Novel Phosphohistidine Antibodies”; provisional application filed on April 18th, 2014
  • U.S. Patent 8,536,378 “Prostratin and Structural or Functional Analogs Thereof”; issued on September 17, 2013 [Link]
  • U.S. Patent 8,067,632 “A Process to Produce Prostratin and Structural or Functional Analogs Thereof”; issued on November 29, 2011 [Link]
    • The technology is licensed to AIDS Research Alliance (Los Angeles, CA) in February 2010. [Link]


Miscellaneous
  • 기정민, "고에너지 인산화아미노산 - 단백질 인산화 연구의 미개척지", 화학세계, 2015년 12월호 (Mini-review in Korean) [Link]
  • 최이건, 기정민 "인산화아르기닌 - 고전적 생체분자의 재조명", 화학세계, 2017년 4월호 (Mini review in Korean) [Link]