Pancytopenia

Etiologies

• Hypocellular bonemarrow (nl cellularity ~100 – age): aplastic anemia, hypoplastic MDS

• Cellular bone marrow: MDS, aleukemic leukemia, PNH, severe megaloblastic anemia

• Marrow replacement (myelophthisis): myelofibrosis, metastatic solid tumors, granulomas

• Systemicdiseases: hypersplenism, sepsis, alcohol, toxins

Clinical manifestations

• Anemia → fatigue

• Neutropenia → recurrent infections

• Thrombocytopenia → mucosal bleeding & easy bruisability