Pathology

• Disorders of Primary Hemostasis

  • Platelet dysfunction

    • Bernard Soulier syndrome

    • Glanzmans syndrome

  • Thrombocytopenia

    • Heparin-Induced Thrombocytopenia (HIT)

    • Immune thrombocytopenia (ITP)

    • Thrombotic microangiopathies (HUS, TTP)

  • Von Willebrand Disease

• Disorders of Secondary Hemostasis

  • Hemophilia

• Hypercoagulable Disorders

• Leukocytosis

• Leukopenia

  • Inherited Neutropenia

Complications of Hematologic Malignancies

• • Hyperviscosity Syndrome

  • Tumour Lysis Syndrome

Leukemia

Malignant Clonal Proliferations

Myelodysplastic Syndromes

Myeloproliferative Neoplasms

• Macrocytic anemia

  • Megaloblastic anemia

    • Folate deficiency

    • Vitamin B12 deficiency

  • Nonmegaloblastic macrocytic anemias

• Microcytic anemia

  • Anemia of chronic disease

  • Iron deficiency

  • Sideroblastic anemia

  • Thalassemias

• Normocytic anemia

  • Anemias of chronic disorders

  • Pancytopenia

    • Aplastic anemia = stem cell failure

      • Diamond-Blackfan anemia (DBA)

      • Fanconi anemia

    • Myelodysplastic Syndromes

    • Myelophthisic anemia

    • Paroxysmal nocturnal hemoglobinuria

  • Pure red cell aplasia

  • Sideroblastic anemia