Pure red cell aplasia

Destructive antibodies or lymphocytes → ineffective erythropoiesis

Associated with thymoma, CLL,and parvovirus infection

Diagnostic studies: lack of erythroid precursors on BM bx, other lines normal

Treatment: thymectomy if thymus enlarged; IVIg if parvovirus infection;

immunosuppression if CLL or idiopathic; supportive care with PRBC transfusions;

? erythropoietin receptor agonist if due to antierythropoietin Ab