publications

101. Thapaliya, E.R. Mony, L., Serraz, B., Paoletti, P. and Ellis-Davies, G.C.R. (2021) Photochemical Control of Drug Efficacy: A Comparison of Uncaging and Photoswitching Ifenprodil on NMDA Receptors. ChemPhotoChem 5, 445-454.

100. Ellis-Davies, G.C.R. (2020) Useful caged compounds for cell physiology. Acc. Chem. Res. 53, 1593-1604.

99. Zhao, J., and Ellis-Davies, G.C.R. (2020) Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles. ChemComm. 56, 9445-8.

98. Durand-de Cuttoli, R., Chauhan, P.S., Pétriz Reyes, A., Faure, P., Mourot, A., and Ellis-Davies, G.C.R. (2020) Optofluidic control of rodent learning using cloaked caged glutamate. Proc. Natl. Acad. Sci. (USA) 117, 6831-5.

97. Passlick, S., and Ellis-Davies, G.C.R. (2019) Chromatically independent, two-color uncaging of glutamate and GABA with one- or two-photon excitation. Methods in Enzymology 624, 167-196.

96. Sansolone, L., Zhao, J., and Ellis-Davies, G.C.R. (2019)

Chemical tuning of photoswitchable azobenzenes: a photopharmacological case study using nicotinic transmission. Beilstein J. Org. Chem. 15, 2812-21.

95. Richers, M.T., Passlick, S., Agarwal, H., and Ellis-Davies, G.C.R. (2019) Dendrimer conjugation enables multiphoton chemical neurophysiology with an extended pi-electron caging chromophore. Angewandte Chemie 58, 12086-90.

94. Thapaliya, E.R., Zhao, J., and Ellis-Davies, G.C.R. (2019) Locked-AzoBenzene: testing the scope of a unique photoswitchable scaffold for cell physiology. ACS Chem. Neurosci. 10, 2481-8.

93. Passlick, S., Thapaliya, E.R., Chen, Z., Richers, M.T., and Ellis-Davies, G.C.R. (2018) Optical probing of dendritic and axonal Ca signaling on medial habenula neurons with a caged nicotine drug analogue. J. Physiol. 596, 5307-5318.

92. Passlick, S., Richers, M.T., and Ellis-Davies, G.C.R. (2018) Thermodynamically stable, photoreversible pharmacology in neurons with one- and two-photon excitation. Angewandte Chemie 57, 12554 –12557.

91. Richers, M.T., Tran, D., Wachtveitl, J., and Ellis-Davies, G.C.R. (2018) Coumarin-diene photoswitches for rapid and efficient isomerization with visible light. ChemComm 52, 4983-6.

90. Passlick, S., Kramer, P.F., Richers, M.T., Williams, J.T., and Ellis-Davies, G.C.R. (2017) Two-color, one-photon uncaging of glutamate and GABA. Plos ONE 12, e0187732.

89. Passlick, S. and Ellis-Davies, G.C.R. (2017) Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J. Neurosci. Meth. 293, 321-328

88. Agarwal, H.K., Zhai, S., Surmeier, D.J. and Ellis-Davies, G.C.R. (2017) Intracellular uncaging of cGMP with blue light. ACS Chem. Neurosci. 8, 2139-2144.

87. Howarth, C., Sutherland, B.A., Choi, H.B., Martin, C., Lind, B.L., Khennouf, L., LeDue, J.M., Pakan, J.M.P., Ellis-Davies, G.C.R., Lauritzen, M.J., Sibson, M.R., Buchan, A.M., and MacVicar, B.A. (2017) A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain. J. Neurosci. 37, 2403-2414.

86. Richers, M.T., Amatrudo, J.P., Olson, J.P. and Ellis-Davies, G.C.R. (2017) Cloaked caged compounds: chemical probes for two-photon optoneurobiology. Angewandte Chemie 56, 193-97.

85. Sajo, M., *Ellis-Davies, G.C.R. and *Morishita, H. (2016) Lynx1 limits dendritic spine turnover in the adult visual cortex. J. Neurosci. 36, 9472-8

*corresponding authors.

84. Agarwal, H.K., Janicek, R., Chi, S.H., Perry, J.W., Niggli, E. and Ellis-Davies, G.C.R., (2016) Calcium uncaging with visible light. J. Am. Chem. Soc. 138, 3687-93.

83. Kantevari, S., Passlick, S., Kwon, H.B., Richers, M., Sabatini, B.L., and Ellis-Davies, G.C.R., (2016) Development of anionically decorated caged neurotransmitters: in vitro comparison of 7-nitroindolinyl- and 2-(p-phenyl-o-nitrophenyl)-propyl-based photochemical probes. ChemBioChem 17, 953-961.

82. Wang, H. C., Lin, C-C., Cheung, R., Zhang-Hooks, Y., Agarwal, A., Ellis-Davies, G.C.R., Rock, J., Bergles, D. E. (2015) Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells. Cell 163, 1348-1359.

81. Amatrudo, J.M., Olson, J.P., Agarwal, H.K. and Ellis-Davies G.C.R. (2015) Caged compounds for multichromic optical interrogation of neural systems. Eur. J. Neurosci. 41, 5-16.

80. Yagishita, S., A. Hayashi-Takagi, A., Ellis-Davies, G.C.R., Urakubo, H., Ishii, S. and Kasai, H. (2014) A critical time window for dopamine actions on the structural plasticity of dendritic spines. Science 345, 1616-1620.

79. Crowe, S.E. and Ellis-Davies, G.C.R. (2014) Longitudinal in vivo two-photon fluorescence imaging. J. Com. Neurol. 522, 1708-1727.

78. Watkins, S. Robel, S. Kimbrough, I.F., Robert, S.M., Ellis-Davies, G.C.R. and Sontheimer, H. (2014) Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells. Nature Commun. 5, e4196.

77. Crowe, S.E. and Ellis-Davies, G.C.R. (2014) Spine pruning in 5xFAD mice starts on basal dendrites of layer 5 pyramidal neurons. Brain Struct. Funct. 219, 571-580.

76. Amatrudo, J.M., Olson, J.P., Lur, G., Chiu, C.Q., Higley, M.J. and Ellis-Davies G.C.R. (2014) Wavelength-selective one- and two-photon uncaging of GABA. ACS Chem. Neurosci. 5, 64-70.

75. Olson, J.P., Banghart, M.R., Sabatini, B.L. and Ellis-Davies G.C.R. (2013) Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. J. Am. Chem. Soc. 135, 135, 15948-15954.

74. Buskila, Y., Crowe, S.E. and Ellis-Davies, G.C.R. (2013) Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice. Neuroscience 254, 152-159.

73. Hayama, T., Noguchi, J., Watanabe, S., Takahashi, N., Hayashi-Takagi, A., Ellis-Davies, G.C.R., Matsuzaki, M. and Kasai, H. (2013) GABA promotes the competitive selection of dendritic spines by controlling local Ca signaling Nature Neurosci. 16, 1409-1416.

72. Olson, J.P., Kwon, H-B., Takasaki, K.T., Chiu, C.Q., Higley, M.J., Sabatini, B.L. and Ellis-Davies G.C.R. (2013) Optically selective two-photon uncaging of glutamate at 900 nm. J. Am. Chem. Soc. 135, 5954-5957.

71. Gross, G.G., Junge, J.A., Mora, R.J. Kwon, HB, Olson, C.A., Takahashi, T.T., Emily R. Liman, E.R., Ellis-Davies, G.C.R., McGee, A., Sabatini, B.L., Roberts, R.W. and Arnold, D.A. (2013) Recombinant probes for visualizing endogenous synaptic proteins in living neurons. Neuron 78, 971-85.

70. Chiu, C.Q. Lur, G., Morse, T.M., Carnevale, N.T., Ellis-Davies, G.C.R. and Higley, M.J. (2013) Compartmentalization of GABAergic inhibition by dendritic spines. Science 340, 759-762.

69. Crowe, S.E. and Ellis-Davies, G.C.R. (2013) In vivo characterization of a bigenic fluorescent mouse model of Alzheimer’s disease with neurodegeneration. J. Com. Neurol. 521, 2181-2194.

68. Figueroa, L., Shkryl, V.M., Zhou, J., Manno, C., Momotake, A., Brum, G., Blatter, L.A., Ellis-Davies, G.C.R. Ríos, E. (2012) Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle. J. Physiol. 590, 1389-1411.

67. Kantevari, S., Buskila, Y. and Ellis-Davies, G.C.R. (2012) Synthesis and characterization of cell-permeant 6-nitrodibenzofuranyl-caged IP3. Photochem. Photobiolog. Sci. 11, 508-513.

66. Noguchi, J., Nagaoka, A., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. and Kasai, H. (2011) In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice. J. Physiol. 589, 2447-2457.

65. *Matsuzaki M., Ellis-Davies, G.C.R., Kanemoto, Y. and Kasai H. (2011) Simultaneous two-photon activation of presynaptic cells and calcium imaging in postsynaptic dendritic spines. Neural Systems & Circuits 1:2. *corresponding author.

64. Ellis-Davies, G.C.R. (2011) A practical guide to the synthesis dinitroindolinyl-caged neurotransmitters. Nature Protocols 6, 314-326.

63. Kantevari, S., Gordon, B.J., MacVicar, B.A. and Ellis-Davies, G.C.R. (2011) A practical guide to the synthesis and use of caged membrane-permeant acetoxymethyl esters of inositol-polyphosphates. Nature Protocols 6, 327-337.

62. Tritsch, N.X., Zhang, Y.X., Ellis-Davies, G. and Bergles, D.E. (2010) ATP-induced morphological changes in supporting cells of the developing cochlea. Purinergic Signal 6, 155-166.

61. Crowe, S.E., Kantevari, S. and Ellis-Davies, G.C.R. (2010) Photochemically initiated intracellular astrocytic calcium waves in living mice using two-photon uncaging of IP3. ACS Chem. Neurosci. 1, 575-585.

60. Matsuzaki M., Hayama, T., Kasai H. and Ellis-Davies, G.C.R. (2010) Two-photon uncaging of ϒ-aminobutyric acid in intact brain tissue. Nature Chemical Biology. 6, 255-257.

59. Kantevari, S., Matsuzaki, M, Kanemoto, Y., Kasai, H. and Ellis-Davies, G.C.R. (2010) Two-color, two-photon uncaging of glutamate and GABA. Nature Methods 7, 123-125.

58. Gordon, B.J., Iremonger, K.J., Kantevari, S., Ellis-Davies, G.C.R., MacVicar, B.A. and Bains, J.S. (2009) Astrocytes regulate distributed plasticity at central glutamatergic synapses. Neuron 64, 391-403.

57. Alvina, K. Ellis-Davies, G. and Khodakhah (2009) T-type calcium channels mediate rebound firing in intact deep cerebellar neurons Neuroscience 158, 635-641.

56. Gordon, B.J., Choi, H.B., Rungta, R.L. Ellis-Davies, G.C.R. and MacVicar, B.A. (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles Nature 455, 745-9.

55. Alvina, K., A. Kohn, A., Walter, J. Ellis-Davies, G.C.R. and Khodakhah, K. (2008) Questioning the role of rebound firing in the cerebellum. Nature Neurosci. 11, 1256-1258.

54. Tanaka, J., Horiike, Y., Matsuzaki, M., Miyazaki, T., Miyazaki, T., Ellis-Davies, G.C.R. and Kasai, H. (2008) Protein synthesis and neurotrophin dependent structural plasticity of single dendritic spines Science 319, 1683-1687.

53. Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G.C.R. and Kasai, H. (2008) The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines. Neuron 57, 719-729.

52. *Matsuzaki M., Ellis-Davies, G.C.R. and Kasai H. (2008) Three-dimensional mapping of unitary synaptic connections by two-photon macro photolysis of caged glutamate. J. Neurophysiology 99, 1535-1544. *corresponding author.

51. Tanaka, K., Khiroug, L., Santamaria, F., Doi, T., Ogasawara, H., Ellis-Davies, G.C.R., Kawato, M. and Augustine, G.J. (2007) Calcium requirements cerebellar long-term synaptic depression: a role for a postsynaptic leaky integrator. Neuron 54, 787-800.

50. *Ellis-Davies G.C.R., Matsuzaki, M., Paukert, M., Kasai, H. and Bergles, D.E. (2007) 4-Carboxymethoxy-5,7-dinitroindolinyl-Glu: an improved caged glutamate for expeditious ultraviolet and 2-photon photolysis in brain slices. J. Neurosci. 27, 6601-6604. *corresponding author.

49. Glowatzki, E., N. Cheng, N.,Hiel, H., Yi, E., Tanaka, K., Ellis-Davies, G.C.R., Rothstein, J.D. and Bergles, D.E. (2006) The Glutamate-aspartate transporter (GLAST) mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. J. Neurosci. 26, 7659-7664.

48. Momotake, A., Lindegger, N., Niggli, E., Barsotti, R.J. and Ellis-Davies, G.C.R.(2006) The nitrodibenzofuran chromophore-a new caging group for ultra efficient photolysis in living cells. Nature Methods 3, 35-41.

47. Kantevari, S., Hoing, C., Ogrodnik, J., Egger, M., Niggli, E. and Ellis-Davies, G.C.R. (2006) Synthesis and 2-photon photolysis of 6-(ortho-nitroveratryl)-caged IP3 in living cells. ChemBioChem 7, 174-180.

46. *Ellis-Davies, G.C.R. and Barsotti, R.J. (2006) Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium 35, 75-83, *corresponding author.

45. Noguchi, J., M. Matsuzaki, M., Ellis-Davies, G.C.R. and Kasai, H. (2005) Spine-neck geometry determines NMDA-receptor dependent Ca2+ signaling in dendrites. Neuron 46, 609-622.

44. Millar, A.G., Zucker, R.S., Ellis-Davies, G.C.R., Charlton, M.P. and Atwood, H.L. (2005) Different calcium sensitivities of neurotransmitter release or priming at phasic and tonic synapses. J. Neurosci. 25, 3113-3125.

43. Bell M.G., Lankford E.B., Gonye GE.., Ellis-Davies G.C.R., Martyn D.A., Regnier M., and Barsotti RJ. (2006) Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned ginea pig trabeculae. Biophys. J. 90, 531-43.

42. Fedoryak, O., Sul, J-Y., Haydon, P.G, and Ellis-Davies, G.C.R. (2005) Synthesis of a caged glutamate for efficient one and two-photon photorelease on living cells. Chem. Comm. 3664-3666.

41. Huang, Y. H., Sinha, S.R., Fedoryak, O.D. *Ellis-Davies, G.C.R. and *Bergles, D.E. (2005) Synthesis and characterization of MNI-D-aspartate, a caged compound for selective activation of glutamate transporters and NMDA receptors in brain tissue. Biochemistry 44, 3316-3326. *corresponding authors.

40. Matsuzaki, M., Honkura, N., Ellis-Davies, G.C.R. and Kasai, H. (2004) Structural basis of functional synaptic plasticity in single dendritic spines. Nature 429, 761-766.