Weekly Meetings

Unit 1 - Substitution and Elimination Reactions

• Solvents + pKa, Substitution vs. Elimination, E2 Stereochemistry

• Multistep Synthesis Practice, Epoxide Preparation

• Substitution of Alcohols

Unit 2 - Radical Reactions

• N-Bromosuccinimide (NBS)

• Photobromination, Multistep Synthesis Practice, Reactivity-Selectivity

• Multistep Synthesis Practice

Unit 3 - Simple Aromatic Reactions

• Molecular Orbitals, Aromaticity

• Electrophilic Aromatic Substitution, Friedel-Crafts

• Multistep Synthesis Practice

Unit 4 - Complex Aromatic Reactions

• Substituent Effects on Electrophilic Aromatic Substitution

• Nucleophilic Aromatic Substitution

Unit 5 - Acyl Substitutions

• Nucleophilic Acyl Substitution

• Multistep Synthesis Practice

Unit 6 - Organometallics, Carbonyl Additions

• Grignard Formation and Reaction

• Carbonyl Reductions with NaBH4, LiAlH4, DIBAL-H 

• Multistep Synthesis Practice, Direct vs. Conjugate Addition

Unit 7 - Oxidations and Reductions

• Alcohol Oxidations

• Oxidative Cleavage via Ozonolysis

• Multistep Synthesis Practice

Unit 8 - Carbonyl α-Carbon, Biochemistry

• Aldol Condensation