Several key differences between my book and all other full-year organic books:

1. Most organic texts begin with a 1-2 chapter review of the important stuff the students should remember from last year's General Chem course. Since my (freshman) students have not just had such a course, I have expanded this material into 8 or so chapters, treating it as if it were new instead of review, and placing it into the context of organic chemistry.
2. Most organic texts devote the last four or so chapters to biochemistry: carbohydrates, amino acids, proteins, nucleic acids, etc. Many organic courses never get to these last chapters because they have run out of time. But most organic courses are populated with 60-90% biology majors, for whom this is the most important material. I have integrated the biochemistry into the organic chemistry wherever possible. I have also tried very hard to ensure that the biochemistry will be treated and not deleted.
3. To make room for the intro material at the beginning and the integrated biochemistry, I have had to delete a fair amount of the material that goes into a traditional sophomore organic course. It is still a rigorous treatment, requiring a thorough understanding of energy, mechanism, synthesis and spectroscopy, but with a reduced vocabulary. Many name reactions are omitted. Nevertheless, our students do well on MCAT and other standardized tests.
4. The book is written as if I am talking directly to the students. It is very conversational, more so than any other book I have seen. This is an aspect which the students in general love, but some faculty have reported that they find it disconcerting, even unprofessional. I don't apologize for this: the book is written for students, not faculty.
5. It turns out that college freshmen have a lot in common with advanced high school students, and several of my former students who teach at the high school level have begun using my book to teach organic courses. Even at Juniata we did this: local HS students who had exhausted the HS curriculum came to Juniata to take our freshman organic course along with our freshmen (and typically kicked butt). The book works very well for HS students. All other organic books begin with a one-chapter review of the General Chem necessary to understand for Organic. Since college freshmen (and HS students) have not just completed a Gen Chem course, this is not review for them. My book does not treat it as review, instead it teaches the necessary background material. It also works well for independent study. I remember one HS student who had a scheduling conflict and could not come to my class. She simply read the book, did the problems, took my exams and got A’s.