Publications

From independent research at IISER (all Kalia lab members' names are shown in bold)

24) Singh, Y., Sarkar, D., Duari, S., Shashaank, G., Guru, P. K. I., Hrishikesh, M. V., Singh, D., Bharadwaj, S., and Kalia, J.* (2023) Dissecting the contributions of membrane affinity and bivalency of the spider venom protein DkTx to its sustained mode of TRPV1 activation. J. Biol. Chem.  299: 104903.

23) Khatik, S. Y., Sudhakar, S., Mishra, S., Kalia, J., Pradeepkumar, P. I., and Srivatsan, S. G. (2023) Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy. Chem. Sci. 14: 56275637. Press coverage here.

22) Dixit, A. and Kalia, J.* (2023) Protein-Metabolite Interactions: Discovery and Significance.  ChemBioChem 24: e202200755.

21) Sarkar, D., Mishra, S., Nisal, R., Majhi, S., Shrivas, R., Singh, Y., Anusree, V. S., and Kalia, J.* (2022) Site-specific fluorescent labeling of the cysteine-rich toxin, DkTx, for TRPV1 ion channel imaging and membrane binding studies. Bioconjugate Chem. 33: 17611770.

20) Dixit, A., Jose, G. P., Shanbhag, C., Tagad, N., and Kalia, J.* (2022) Metabolic labeling-based chemoproteomics establishes choline metabolites as protein function modulators. ACS Chem. Biol. 17: 22722283.

19) Umar, D., Das, A., Gupta, S., Chattopadhyay, S., Sarkar, D., Mirji, G., Kalia, J., Arimbasseri, G. A., Durdik, J. M., Rath, S., George, A., and Bal, V. (2020) Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated Notch-dependent pathway. Proc. Natl. Acad. Sci., USA 117: 2235722366.

18) Sarkar, D., Singh, Y., and Kalia J.*  (2018) Protein-lipid interfaces can drive the functions of membrane-embedded protein-protein complexes. ACS Chem. Biol. 13: 2689–2698.

17) Nisal, R., Jose, G. P., Shanbhag, C., and Kalia, J.*  (2018) Rapid and reversible hydrazone bioconjugation in cells without the use of extraneous catalysts. Org. Biomol. Chem. 16: 4304–4310.

16) Kalia, J., Milescu, M., Salvatierra, J., Wagner, J., Klint, J. K., King, G. F., Olivera, B. M., and Bosmans, F. (2015) From foe to friend: Using animal toxins to investigate ion channel function. J. Mol. Biol. 427: 158–175.

15) Gilchrist, J., Dutton, S., Diaz-Bustamante, M., McPherson, A., Olivares, N., Kalia J., Escayg, A., and Bosmans, F. (2014) Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents. ACS Chem. Biol. 9: 1204–1212.

From PhD and postdoctoral work

14)  Bae, C., Anselmi, C., Kalia, J., Jara-Oseguera, A., Schwieters, C. D., Krepkiy, D., Lee, C. W., Kim, E-H., Kim, J. I., Faraldo-Gómez, J. D., and Swartz, K. J. (2016) Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin. eLife. 5. pii: e11273. doi: 10.7554/eLife.11273.

13) Marshall, C., Agarwal, N., Kalia, J., Grosskopf, V., McGrath, N., Abbott, N. L., Raines, R. T., and Shusta, E. V. (2013) Facile chemical functionalization of proteins through intein-linked yeast display. Bioconjugate Chem. 24: 1634–1644. 

12) Kalia, J. and Swartz K. J. (2013) The design principles of paddle motifs in voltage sensors. Nat. Struct. Mol. Biol. 20: 534–535.

11) Kalia, J. and Swartz, K. J. (2013) Exploring structure-function relationships between TRP and Kv channels. Sci. Rep. 3: 1523.

10) Kalia, J. and Swartz K. J. (2013) Common principles of voltage-dependent gating for Hv and Kv channels. Neuron, 77: 214–216.

9) Bae, C., Kalia, J., Song, I., Yu, J. H., Kim, H. H., Swartz, K. J., and Kim, J. I. (2012) High yielding production and refolding of the double-knot toxin, an activator of TRPV1 channels. PLoS One 7: e51516.

8) Kalia, J.. and Swartz, K. J. (2011) Elucidating the mechanism of action of a classical drug: Guanidine compounds as inhibitors of voltage-gated potassium channels. Mol. Pharmacol., 80: 1085–1095.

7) Kalia, J. and Raines, R. T. (2010) Advances in bioconjugation. Current Organic Chemistry. 14: 138–147.

6) Kalia, J. and Raines, R. T. (2009) 1,9-Bis(2-pyridyl)-1,2,8,9-tetrathia-5-oxanone. Molbank. M642.

5) Kalia, J. and Raines, R. T. (2008) Hydrolytic stability of hydrazones and oximes. Angew. Chem. Int. Ed. Engl. 47: 7523–7526.

4) Bertics, P. J., Ozer, B. H., Wiepz, G. J., Guadarrama, A. G., Abbott, N. L., Lowe, A. M., Bai, Y., Shusta E. V., Agrawal, N., Raines, R. T., and Kalia, J. (2007) Liquid crystal-based analytic technology: Enabling a molecular view of cancer. BIOforum Europe 11: 42–45.

3) Kalia, J. and Raines, R. T. (2007) Catalysis of imido-group hydrolysis in a maleimide conjugate. Bioorg. Med. Chem. Lett. 17: 6286–6289.

2) Kalia, J., Abbott, N. L., and Raines, R. T. (2007) General method for site‑specific protein immobilization by Staudinger ligation. Bioconjugate Chem. 18: 1064–1069.

1) Kalia, J. and Raines, R. T. (2006) Reactivity of intein thioesters: Appending a functional group to a protein. ChemBioChem 7: 1375–1383.

Patents

2) Bosmans F. and Kalia, J.  Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels. U.S. Patent US9771335 (filed July 31, 2015; issued September 26, 2017).

1) Raines, R. T. and Kalia, J. Reagents and methods for appending functional groups to proteins. U.S. Patent US8242058 (filed July 23, 2007; issued August 14, 2012).